IMP

Process View

Mus musculus

7 genes annotated in mouse

cellular response to osmotic stress

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to osmotic stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to osmotic stress" (in gray)

Name	Description	Probability	Func Analog Organism
Mapk14	mitogen-activated protein kinase 14	0.912	Yeast
Atf2	activating transcription factor 2	0.839
Ryr2	ryanodine receptor 2, cardiac	0.750
Rac1	RAS-related C3 botulinum substrate 1	0.707
Ren1	renin 1 structural	0.631
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.571
Mapk9	mitogen-activated protein kinase 9	0.541	Yeast
Mapkapk2	MAP kinase-activated protein kinase 2	0.524
Mef2c	myocyte enhancer factor 2C	0.509	Yeast
Hdac4	histone deacetylase 4	0.463
Wnk4	WNK lysine deficient protein kinase 4	0.404
Vcl	vinculin	0.227
Hdac5	histone deacetylase 5	0.220
Slc12a2	solute carrier family 12, member 2	0.215
Gja1	gap junction protein, alpha 1	0.206
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.196
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.195
Nos1	nitric oxide synthase 1, neuronal	0.190
Slc12a1	solute carrier family 12, member 1	0.184
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.181
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.162
Tjp1	tight junction protein 1	0.141
Adora3	adenosine A3 receptor	0.134
Agtrap	angiotensin II, type I receptor-associated protein	0.127
Mapk1	mitogen-activated protein kinase 1	0.126
Pten	phosphatase and tensin homolog	0.120
Mapk8	mitogen-activated protein kinase 8	0.115	Yeast
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.115
Flot1	flotillin 1	0.098
Umod	uromodulin	0.098
Slc4a7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	0.088
Hdac7	histone deacetylase 7	0.084
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.080
Map2k3	mitogen-activated protein kinase kinase 3	0.078
Agtr1a	angiotensin II receptor, type 1a	0.072	Mouse
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.070
Uox	urate oxidase	0.069
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.068
Nfix	nuclear factor I/X	0.066
Dlg1	discs, large homolog 1 (Drosophila)	0.063
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.062
Mknk1	MAP kinase-interacting serine/threonine kinase 1	0.061
Gpx1	glutathione peroxidase 1	0.057
Tbx5	T-box 5	0.053
Stk39	serine/threonine kinase 39, STE20/SPS1 homolog (yeast)	0.053
Rgs12	regulator of G-protein signaling 12	0.052
Flii	flightless I homolog (Drosophila)	0.052
Alb	albumin	0.051
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.047
Klc1	kinesin light chain 1	0.046
Set	SET nuclear oncogene	0.046
Aifm1	apoptosis-inducing factor, mitochondrion-associated 1	0.046
Cys1	cystin 1	0.046
Gys1	glycogen synthase 1, muscle	0.046
Cd36	CD36 antigen	0.044
Mef2d	myocyte enhancer factor 2D	0.044	Yeast
Kif5c	kinesin family member 5C	0.042
Bdkrb2	bradykinin receptor, beta 2	0.042
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.039
Cldn16	claudin 16	0.037
Scarb2	scavenger receptor class B, member 2	0.035
Hdac9	histone deacetylase 9	0.035
Mapk3	mitogen-activated protein kinase 3	0.034
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.034
Gjd3	gap junction protein, delta 3	0.033
Aprt	adenine phosphoribosyl transferase	0.033
Prkce	protein kinase C, epsilon	0.032
Tgfb2	transforming growth factor, beta 2	0.032
Tgfbr1	transforming growth factor, beta receptor I	0.031
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.031
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.029
Pcsk1	proprotein convertase subtilisin/kexin type 1	0.029
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.029
Mapk11	mitogen-activated protein kinase 11	0.028	Yeast
Adrbk1	adrenergic receptor kinase, beta 1	0.028
Fbn1	fibrillin 1	0.028
Wdr26	WD repeat domain 26	0.028
Kl	klotho	0.027
Chrne	cholinergic receptor, nicotinic, epsilon polypeptide	0.026
Ptpn9	protein tyrosine phosphatase, non-receptor type 9	0.026	Yeast
Mybph	myosin binding protein H	0.026
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.025
Fgf13	fibroblast growth factor 13	0.025
Gga2	golgi associated, gamma adaptin ear containing, ARF binding protein 2	0.024
Sstr3	somatostatin receptor 3	0.023
Kif5b	kinesin family member 5B	0.023
Mb	myoglobin	0.022
Pou3f4	POU domain, class 3, transcription factor 4	0.021
Cit	citron	0.021
Qk	quaking	0.021
Kcnab3	potassium voltage-gated channel, shaker-related subfamily, beta member 3	0.020
Tgfbr2	transforming growth factor, beta receptor II	0.020
Slc12a6	solute carrier family 12, member 6	0.020	Human
Lnx1	ligand of numb-protein X 1	0.020
Aldoa	aldolase A, fructose-bisphosphate	0.020
Rnpepl1	arginyl aminopeptidase (aminopeptidase B)-like 1	0.020
Ndp	Norrie disease (pseudoglioma) (human)	0.020
Xirp1	xin actin-binding repeat containing 1	0.020
Clock	circadian locomotor output cycles kaput	0.019
Map2k4	mitogen-activated protein kinase kinase 4	0.019
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.019
Snap25	synaptosomal-associated protein 25	0.019
Mtap1b	microtubule-associated protein 1B	0.019
Scn1a	sodium channel, voltage-gated, type I, alpha	0.019	Mouse
Map2k1	mitogen-activated protein kinase kinase 1	0.018	Yeast
Apbb1	amyloid beta (A4) precursor protein-binding, family B, member 1	0.018
Ncoa6	nuclear receptor coactivator 6	0.018
Astn1	astrotactin 1	0.018
Pkm2	pyruvate kinase, muscle	0.018
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.017
Alox12	arachidonate 12-lipoxygenase	0.017
Smyd1	SET and MYND domain containing 1	0.017
Foxc1	forkhead box C1	0.017
Sugp2	SURP and G patch domain containing 2	0.017
Raf1	v-raf-leukemia viral oncogene 1	0.017
Sntb1	syntrophin, basic 1	0.017
Il12b	interleukin 12b	0.016
Pitpna	phosphatidylinositol transfer protein, alpha	0.016
Gabra3	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3	0.016
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.016
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.016
Ldlr	low density lipoprotein receptor	0.016
Eprs	glutamyl-prolyl-tRNA synthetase	0.016
Myo1c	myosin IC	0.015
Gpi1	glucose phosphate isomerase 1	0.015
Tro	trophinin	0.015
Akr1b3	aldo-keto reductase family 1, member B3 (aldose reductase)	0.015
Map2k7	mitogen-activated protein kinase kinase 7	0.015
Cntnap4	contactin associated protein-like 4	0.015
Adam9	a disintegrin and metallopeptidase domain 9 (meltrin gamma)	0.015
Tph1	tryptophan hydroxylase 1	0.015
Mas1	MAS1 oncogene	0.015
D19Wsu162e	DNA segment, Chr 19, Wayne State University 162, expressed	0.014
Arrb1	arrestin, beta 1	0.014
Jun	Jun oncogene	0.014
Vim	vimentin	0.014
Reck	reversion-inducing-cysteine-rich protein with kazal motifs	0.014
Kif3b	kinesin family member 3B	0.014
Dnajc5	DnaJ (Hsp40) homolog, subfamily C, member 5	0.014
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.014
Nrsn1	neurensin 1	0.014
Bcl2l10	Bcl2-like 10	0.014
Fez2	fasciculation and elongation protein zeta 2 (zygin II)	0.014
Plec	plectin	0.014
Agtr2	angiotensin II receptor, type 2	0.014	Mouse
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.014
Ret	ret proto-oncogene	0.014
Alx3	aristaless-like homeobox 3	0.014
Clvs1	clavesin 1	0.013
Ttn	titin	0.013
Megf8	multiple EGF-like-domains 8	0.013
Atp6v0e2	ATPase, H+ transporting, lysosomal V0 subunit E2	0.013
Scg2	secretogranin II	0.013
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.013
Sp1	trans-acting transcription factor 1	0.013
Padi3	peptidyl arginine deiminase, type III	0.013
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.013
Gripap1	GRIP1 associated protein 1	0.013
Wt1	Wilms tumor 1 homolog	0.013
Art5	ADP-ribosyltransferase 5	0.013
Add1	adducin 1 (alpha)	0.013
Pabpc4	poly(A) binding protein, cytoplasmic 4	0.013
Oprd1	opioid receptor, delta 1	0.013
Nos2	nitric oxide synthase 2, inducible	0.013
Kcnj3	potassium inwardly-rectifying channel, subfamily J, member 3	0.013
Mtmr1	myotubularin related protein 1	0.013
Rtn2	reticulon 2 (Z-band associated protein)	0.013
Dpp6	dipeptidylpeptidase 6	0.012
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.012
Cldn4	claudin 4	0.012
Alox8	arachidonate 8-lipoxygenase	0.012
Hdgf	hepatoma-derived growth factor	0.012
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.012
Ighmbp2	immunoglobulin mu binding protein 2	0.012
Gucy1a3	guanylate cyclase 1, soluble, alpha 3	0.012
Slc12a8	solute carrier family 12 (potassium/chloride transporters), member 8	0.012
Dmd	dystrophin, muscular dystrophy	0.012
Prkar1b	protein kinase, cAMP dependent regulatory, type I beta	0.012
Selm	selenoprotein M	0.012
Prdx1	peroxiredoxin 1	0.012
Taok1	TAO kinase 1	0.012
Tacr2	tachykinin receptor 2	0.012
Cckbr	cholecystokinin B receptor	0.012
Gdap1	ganglioside-induced differentiation-associated-protein 1	0.012
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.012
Syt4	synaptotagmin IV	0.012
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.012
D730040F13Rik	RIKEN cDNA D730040F13 gene	0.012
S100a10	S100 calcium binding protein A10 (calpactin)	0.012
Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.011
Sult5a1	sulfotransferase family 5A, member 1	0.011
Myom2	myomesin 2	0.011
Slc26a4	solute carrier family 26, member 4	0.011
Zfhx4	zinc finger homeodomain 4	0.011
Rasal1	RAS protein activator like 1 (GAP1 like)	0.011
Plg	plasminogen	0.011
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, subunit beta 1	0.011
Mmel1	membrane metallo-endopeptidase-like 1	0.011
Plekhg6	pleckstrin homology domain containing, family G (with RhoGef domain) member 6	0.011
Krt12	keratin 12	0.011
Gja5	gap junction protein, alpha 5	0.011
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.011
Tulp2	tubby-like protein 2	0.011
Lipc	lipase, hepatic	0.011
Ano1	anoctamin 1, calcium activated chloride channel	0.011
Met	met proto-oncogene	0.011
Rit2	Ras-like without CAAX 2	0.011
Il1r2	interleukin 1 receptor, type II	0.011
Kcna6	potassium voltage-gated channel, shaker-related, subfamily, member 6	0.011
Bhlhe40	basic helix-loop-helix family, member e40	0.011
Ndrg1	N-myc downstream regulated gene 1	0.011
Myadm	myeloid-associated differentiation marker	0.011
Sult4a1	sulfotransferase family 4A, member 1	0.011
Cntn1	contactin 1	0.011
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.011
Cstb	cystatin B	0.011
Inpp5k	inositol polyphosphate 5-phosphatase K	0.011
Fgf14	fibroblast growth factor 14	0.010
Scg3	secretogranin III	0.010
Ryr1	ryanodine receptor 1, skeletal muscle	0.010
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.010
Mfsd4	major facilitator superfamily domain containing 4	0.010
Nenf	neuron derived neurotrophic factor	0.010
Ina	internexin neuronal intermediate filament protein, alpha	0.010
Phka1	phosphorylase kinase alpha 1	0.010
Ate1	arginyltransferase 1	0.010
Svop	SV2 related protein	0.010
Zeb2	zinc finger E-box binding homeobox 2	0.010
Tars	threonyl-tRNA synthetase	0.010
Gabrg2	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	0.010
Gm16517	predicted gene, Gm16517	0.010