IMP

Process View

Mus musculus

8 genes annotated in mouse

positive regulation of tumor necrosis factor biosynthetic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of tumor necrosis factor biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of tumor necrosis factor biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
Ccr2	chemokine (C-C motif) receptor 2	0.981
Clec4d	C-type lectin domain family 4, member d	0.834	Mouse
Lyz2	lysozyme 2	0.828
Ccr1	chemokine (C-C motif) receptor 1	0.741	Mouse
Ccl2	chemokine (C-C motif) ligand 2	0.654
C3ar1	complement component 3a receptor 1	0.556
Cd44	CD44 antigen	0.467
Ccr5	chemokine (C-C motif) receptor 5	0.327	Mouse
Tlr4	toll-like receptor 4	0.309	Human Mouse
Tlr2	toll-like receptor 2	0.293
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.273
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.261
Msr1	macrophage scavenger receptor 1	0.229
Clec4e	C-type lectin domain family 4, member e	0.165	Mouse
Clec4n	C-type lectin domain family 4, member n	0.161	Mouse
Ccl3	chemokine (C-C motif) ligand 3	0.156
Ccr6	chemokine (C-C motif) receptor 6	0.151	Mouse
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.135
Selp	selectin, platelet	0.132
Ear2	eosinophil-associated, ribonuclease A family, member 2	0.131
C5ar1	complement component 5a receptor 1	0.116
Cd14	CD14 antigen	0.110
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.097
Folr2	folate receptor 2 (fetal)	0.092
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.090
Cybb	cytochrome b-245, beta polypeptide	0.089
Tlr8	toll-like receptor 8	0.086	Mouse
Cxcr2	chemokine (C-X-C motif) receptor 2	0.084	Mouse
Mmp9	matrix metallopeptidase 9	0.084
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.083
Ccl6	chemokine (C-C motif) ligand 6	0.078
Fpr2	formyl peptide receptor 2	0.076
Fcrla	Fc receptor-like A	0.076	Mouse
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.075
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.074
Blk	B lymphoid kinase	0.074
Ccr3	chemokine (C-C motif) receptor 3	0.074	Mouse
Mmp8	matrix metallopeptidase 8	0.072
Cxcl13	chemokine (C-X-C motif) ligand 13	0.072
Il6	interleukin 6	0.069
AF251705	cDNA sequence AF251705	0.069
Cd180	CD180 antigen	0.064	Mouse
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.062
Ccl9	chemokine (C-C motif) ligand 9	0.062
Cd300ld	CD300 molecule-like family member d	0.059
Ifng	interferon gamma	0.058
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.056	Mouse
Il1b	interleukin 1 beta	0.053
Myd88	myeloid differentiation primary response gene 88	0.051
Itgam	integrin alpha M	0.048
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.042
Fpr1	formyl peptide receptor 1	0.041
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.039
Fasl	Fas ligand (TNF superfamily, member 6)	0.038
Clec4a2	C-type lectin domain family 4, member a2	0.038	Mouse
Elane	elastase, neutrophil expressed	0.038
Cd7	CD7 antigen	0.038
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.037
Lair1	leukocyte-associated Ig-like receptor 1	0.036
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.036
Trem3	triggering receptor expressed on myeloid cells 3	0.034
Tlr7	toll-like receptor 7	0.034
Ccl24	chemokine (C-C motif) ligand 24	0.034
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.033
Fgd3	FYVE, RhoGEF and PH domain containing 3	0.032
Tbxas1	thromboxane A synthase 1, platelet	0.032
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.031
Il10	interleukin 10	0.031
Clec7a	C-type lectin domain family 7, member a	0.031
Cd209g	CD209g antigen	0.030
Pf4	platelet factor 4	0.030
Ncr1	natural cytotoxicity triggering receptor 1	0.029
Cd33	CD33 antigen	0.029
Il18rap	interleukin 18 receptor accessory protein	0.028
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.028
Clec4b1	C-type lectin domain family 4, member b1	0.027	Mouse
Ptprc	protein tyrosine phosphatase, receptor type, C	0.027
Spp1	secreted phosphoprotein 1	0.027
Clec5a	C-type lectin domain family 5, member a	0.026
Cd209b	CD209b antigen	0.026
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.026
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.025
Sfpi1	SFFV proviral integration 1	0.024
Prg3	proteoglycan 3	0.024
Ifitm6	interferon induced transmembrane protein 6	0.022
Cd5l	CD5 antigen-like	0.022
Cd209a	CD209a antigen	0.022	Mouse
Nos2	nitric oxide synthase 2, inducible	0.022
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.021
Cryab	crystallin, alpha B	0.020	Mouse
Lepr	leptin receptor	0.020
Slpi	secretory leukocyte peptidase inhibitor	0.019
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.019
Efna1	ephrin A1	0.019
Fcna	ficolin A	0.019
Sell	selectin, lymphocyte	0.019
Mefv	Mediterranean fever	0.018
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.018
Fpr3	formyl peptide receptor 3	0.018
Il1f9	interleukin 1 family, member 9	0.018
Mrc1	mannose receptor, C type 1	0.018
Vpreb3	pre-B lymphocyte gene 3	0.017
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.017
Aoah	acyloxyacyl hydrolase	0.017
Lox	lysyl oxidase	0.017
Cd40	CD40 antigen	0.017
Apoe	apolipoprotein E	0.016
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.016
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.016
Slfn4	schlafen 4	0.016
Fcgr4	Fc receptor, IgG, low affinity IV	0.015
Ifngr1	interferon gamma receptor 1	0.015
Cd6	CD6 antigen	0.015
Mc2r	melanocortin 2 receptor	0.015
Il12a	interleukin 12a	0.015
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.015
Bag3	BCL2-associated athanogene 3	0.015
Xcr1	chemokine (C motif) receptor 1	0.015	Mouse
2210010C04Rik	RIKEN cDNA 2210010C04 gene	0.015
Mgl2	macrophage galactose N-acetyl-galactosamine specific lectin 2	0.014
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.014
Cysltr1	cysteinyl leukotriene receptor 1	0.014
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.014
Mmp12	matrix metallopeptidase 12	0.014
S1pr4	sphingosine-1-phosphate receptor 4	0.014
Gpr132	G protein-coupled receptor 132	0.014
Cmklr1	chemokine-like receptor 1	0.014
Gzma	granzyme A	0.013
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.013
Retn	resistin	0.013
Hspb1	heat shock protein 1	0.013
Itga4	integrin alpha 4	0.013
Fcgr1	Fc receptor, IgG, high affinity I	0.013	Mouse
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.013
Wisp2	WNT1 inducible signaling pathway protein 2	0.013
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.013
Tnfrsf17	tumor necrosis factor receptor superfamily, member 17	0.013
Il1r1	interleukin 1 receptor, type I	0.013
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.012
Lilrb4	leukocyte immunoglobulin-like receptor, subfamily B, member 4	0.012
Vsig4	V-set and immunoglobulin domain containing 4	0.012
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.012
H2-Ob	histocompatibility 2, O region beta locus	0.012
Serpinb7	serine (or cysteine) peptidase inhibitor, clade B, member 7	0.012
Cx3cr1	chemokine (C-X3-C) receptor 1	0.012	Mouse
Plau	plasminogen activator, urokinase	0.012
Mpo	myeloperoxidase	0.011
Itgax	integrin alpha X	0.011
Cd86	CD86 antigen	0.011
Cd209f	CD209f antigen	0.011
Bex6	brain expressed gene 6	0.011
Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	0.011
Pilra	paired immunoglobin-like type 2 receptor alpha	0.011
Pla2g2d	phospholipase A2, group IID	0.011
Trem1	triggering receptor expressed on myeloid cells 1	0.011
Ccr9	chemokine (C-C motif) receptor 9	0.011	Mouse
Gcet2	germinal center expressed transcript 2	0.011
Mmp3	matrix metallopeptidase 3	0.010
Ccl8	chemokine (C-C motif) ligand 8	0.010
Siglece	sialic acid binding Ig-like lectin E	0.010
Cd4	CD4 antigen	0.010
Havcr2	hepatitis A virus cellular receptor 2	0.010
Cd207	CD207 antigen	0.010	Mouse
Bst1	bone marrow stromal cell antigen 1	0.010