IMP
Process View
The network for 'positive regulation of tumor necrosis factor biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of tumor necrosis factor biosynthetic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.981 | |
| Clec4d | C-type lectin domain family 4, member d | 0.834 | |
| Lyz2 | lysozyme 2 | 0.828 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.741 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.654 | |
| C3ar1 | complement component 3a receptor 1 | 0.556 | |
| Cd44 | CD44 antigen | 0.467 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.327 | |
| Tlr4 | toll-like receptor 4 | 0.309 | |
| Tlr2 | toll-like receptor 2 | 0.293 | |
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.273 | |
| P2rx7 | purinergic receptor P2X, ligand-gated ion channel, 7 | 0.261 | |
| Msr1 | macrophage scavenger receptor 1 | 0.229 | |
| Clec4e | C-type lectin domain family 4, member e | 0.165 | |
| Clec4n | C-type lectin domain family 4, member n | 0.161 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.156 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.151 | |
| Klra2 | killer cell lectin-like receptor, subfamily A, member 2 | 0.135 | |
| Selp | selectin, platelet | 0.132 | |
| Ear2 | eosinophil-associated, ribonuclease A family, member 2 | 0.131 | |
| C5ar1 | complement component 5a receptor 1 | 0.116 | |
| Cd14 | CD14 antigen | 0.110 | |
| Emr1 | EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | 0.097 | |
| Folr2 | folate receptor 2 (fetal) | 0.092 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.090 | |
| Cybb | cytochrome b-245, beta polypeptide | 0.089 | |
| Tlr8 | toll-like receptor 8 | 0.086 | |
| Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.084 | |
| Mmp9 | matrix metallopeptidase 9 | 0.084 | |
| Csf3r | colony stimulating factor 3 receptor (granulocyte) | 0.083 | |
| Ccl6 | chemokine (C-C motif) ligand 6 | 0.078 | |
| Fpr2 | formyl peptide receptor 2 | 0.076 | |
| Fcrla | Fc receptor-like A | 0.076 | |
| Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | 0.075 | |
| Siglec1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.074 | |
| Blk | B lymphoid kinase | 0.074 | |
| Ccr3 | chemokine (C-C motif) receptor 3 | 0.074 | |
| Mmp8 | matrix metallopeptidase 8 | 0.072 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.072 | |
| Il6 | interleukin 6 | 0.069 | |
| AF251705 | cDNA sequence AF251705 | 0.069 | |
| Cd180 | CD180 antigen | 0.064 | |
| Pik3cg | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 0.062 | |
| Ccl9 | chemokine (C-C motif) ligand 9 | 0.062 | |
| Cd300ld | CD300 molecule-like family member d | 0.059 | |
| Ifng | interferon gamma | 0.058 | |
| Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 0.056 | |
| Il1b | interleukin 1 beta | 0.053 | |
| Myd88 | myeloid differentiation primary response gene 88 | 0.051 | |
| Itgam | integrin alpha M | 0.048 | |
| Klra9 | killer cell lectin-like receptor subfamily A, member 9 | 0.042 | |
| Fpr1 | formyl peptide receptor 1 | 0.041 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.039 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.038 | |
| Clec4a2 | C-type lectin domain family 4, member a2 | 0.038 | |
| Elane | elastase, neutrophil expressed | 0.038 | |
| Cd7 | CD7 antigen | 0.038 | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.037 | |
| Lair1 | leukocyte-associated Ig-like receptor 1 | 0.036 | |
| Klrb1b | killer cell lectin-like receptor subfamily B member 1B | 0.036 | |
| Trem3 | triggering receptor expressed on myeloid cells 3 | 0.034 | |
| Tlr7 | toll-like receptor 7 | 0.034 | |
| Ccl24 | chemokine (C-C motif) ligand 24 | 0.034 | |
| Nphp4 | nephronophthisis 4 (juvenile) homolog (human) | 0.033 | |
| Fgd3 | FYVE, RhoGEF and PH domain containing 3 | 0.032 | |
| Tbxas1 | thromboxane A synthase 1, platelet | 0.032 | |
| Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.031 | |
| Il10 | interleukin 10 | 0.031 | |
| Clec7a | C-type lectin domain family 7, member a | 0.031 | |
| Cd209g | CD209g antigen | 0.030 | |
| Pf4 | platelet factor 4 | 0.030 | |
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.029 | |
| Cd33 | CD33 antigen | 0.029 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.028 | |
| Ms4a1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.028 | |
| Clec4b1 | C-type lectin domain family 4, member b1 | 0.027 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.027 | |
| Spp1 | secreted phosphoprotein 1 | 0.027 | |
| Clec5a | C-type lectin domain family 5, member a | 0.026 | |
| Cd209b | CD209b antigen | 0.026 | |
| Ms4a6d | membrane-spanning 4-domains, subfamily A, member 6D | 0.026 | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.025 | |
| Sfpi1 | SFFV proviral integration 1 | 0.024 | |
| Prg3 | proteoglycan 3 | 0.024 | |
| Ifitm6 | interferon induced transmembrane protein 6 | 0.022 | |
| Cd5l | CD5 antigen-like | 0.022 | |
| Cd209a | CD209a antigen | 0.022 | |
| Nos2 | nitric oxide synthase 2, inducible | 0.022 | |
| F2rl2 | coagulation factor II (thrombin) receptor-like 2 | 0.021 | |
| Cryab | crystallin, alpha B | 0.020 | |
| Lepr | leptin receptor | 0.020 | |
| Slpi | secretory leukocyte peptidase inhibitor | 0.019 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.019 | |
| Efna1 | ephrin A1 | 0.019 | |
| Fcna | ficolin A | 0.019 | |
| Sell | selectin, lymphocyte | 0.019 | |
| Mefv | Mediterranean fever | 0.018 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.018 | |
| Fpr3 | formyl peptide receptor 3 | 0.018 | |
| Il1f9 | interleukin 1 family, member 9 | 0.018 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| HSPB8 | heat shock 22kDa protein 8 | 0.319 | |
| TRAF5 | TNF receptor-associated factor 5 | 0.111 | |
| LY96 | lymphocyte antigen 96 | 0.096 | |
| SYK | spleen tyrosine kinase | 0.085 | |
| TICAM2 | toll-like receptor adaptor molecule 2 | 0.079 | |
| BAG3 | BCL2-associated athanogene 3 | 0.072 | |
| CYBB | cytochrome b-245, beta polypeptide | 0.048 | |
| CRYAB | crystallin, alpha B | 0.045 | |
| MYD88 | myeloid differentiation primary response gene (88) | 0.033 | |
| TRAF2 | TNF receptor-associated factor 2 | 0.030 | |
| LY86 | lymphocyte antigen 86 | 0.027 | |
| TLR4 | toll-like receptor 4 | 0.024 | |
| MS4A6A | membrane-spanning 4-domains, subfamily A, member 6A | 0.023 | |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.023 | |
| CCR1 | chemokine (C-C motif) receptor 1 | 0.022 | |
| TLR1 | toll-like receptor 1 | 0.021 | |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 0.020 | |
| FGL2 | fibrinogen-like 2 | 0.019 | |
| TIRAP | toll-interleukin 1 receptor (TIR) domain containing adaptor protein | 0.018 | |
| RNASE6 | ribonuclease, RNase A family, k6 | 0.017 | |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.016 | |
| IGSF6 | immunoglobulin superfamily, member 6 | 0.015 | |
| FCGR2C | Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) | 0.014 | |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.013 | |
| CD33 | CD33 molecule | 0.013 | |
| PLEK | pleckstrin | 0.012 | |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.011 | |
| TLR2 | toll-like receptor 2 | 0.011 | |
| HSF1 | heat shock transcription factor 1 | 0.011 | |
| CLEC4A | C-type lectin domain family 4, member A | 0.010 |