IMP

Process View

Mus musculus

2 genes annotated in mouse

atrioventricular node cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of an atrioventricular (AV) node cell. AV node cells are pacemaker cells that are found in the atrioventricular node.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "atrioventricular node cell differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "atrioventricular node cell differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	0.999
Hand2	heart and neural crest derivatives expressed transcript 2	0.999
Fgf8	fibroblast growth factor 8	0.996
Hand1	heart and neural crest derivatives expressed transcript 1	0.995
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.939
Mesp1	mesoderm posterior 1	0.905
Sox9	SRY-box containing gene 9	0.869
Gata4	GATA binding protein 4	0.864
Pitx2	paired-like homeodomain transcription factor 2	0.822
Tbx1	T-box 1	0.798
Fgfr2	fibroblast growth factor receptor 2	0.688
Isl1	ISL1 transcription factor, LIM/homeodomain	0.687
Foxc2	forkhead box C2	0.636
Pitx1	paired-like homeodomain transcription factor 1	0.555
Pax3	paired box gene 3	0.461
Tcfap2a	transcription factor AP-2, alpha	0.448
Nog	noggin	0.444
Foxc1	forkhead box C1	0.426
Tbx5	T-box 5	0.423
Nkx3-2	NK3 homeobox 2	0.419	Mouse
Otp	orthopedia homolog (Drosophila)	0.383
Rxra	retinoid X receptor alpha	0.370
Omp	olfactory marker protein	0.369
Gsc	goosecoid homeobox	0.362
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.354
Scn5a	sodium channel, voltage-gated, type V, alpha	0.342
Nkx2-6	NK2 transcription factor related, locus 6 (Drosophila)	0.333	Mouse
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.295	Mouse
Vax1	ventral anterior homeobox containing gene 1	0.280
Nkx6-1	NK6 homeobox 1	0.276
Msx1	homeobox, msh-like 1	0.273
Chrd	chordin	0.260
Hoxd3	homeobox D3	0.239
Atoh7	atonal homolog 7 (Drosophila)	0.237
Lhx3	LIM homeobox protein 3	0.217
Pitx3	paired-like homeodomain transcription factor 3	0.205
Ntf3	neurotrophin 3	0.203
Lmx1b	LIM homeobox transcription factor 1 beta	0.196
Fgf3	fibroblast growth factor 3	0.195
Gli2	GLI-Kruppel family member GLI2	0.191
Tgfb2	transforming growth factor, beta 2	0.189
Pax9	paired box gene 9	0.188
Otx2	orthodenticle homolog 2 (Drosophila)	0.172
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.171
Gh	growth hormone	0.167
Vegfa	vascular endothelial growth factor A	0.166
Bmp4	bone morphogenetic protein 4	0.163
Efnb2	ephrin B2	0.153
Tlx2	T-cell leukemia, homeobox 2	0.137
Alx4	aristaless-like homeobox 4	0.129
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.123
Hoxa13	homeobox A13	0.117
Gata6	GATA binding protein 6	0.116
Gja5	gap junction protein, alpha 5	0.116
Hoxd13	homeobox D13	0.115
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.114	Mouse
Npas1	neuronal PAS domain protein 1	0.113
Rara	retinoic acid receptor, alpha	0.112
Foxe3	forkhead box E3	0.107
Galr3	galanin receptor 3	0.101
6030468B19Rik	RIKEN cDNA 6030468B19 gene	0.100
Jag1	jagged 1	0.097
Barx1	BarH-like homeobox 1	0.096
Alx3	aristaless-like homeobox 3	0.094
Dmrtb1	DMRT-like family B with proline-rich C-terminal, 1	0.090
Utf1	undifferentiated embryonic cell transcription factor 1	0.086
Akp3	alkaline phosphatase 3, intestine, not Mn requiring	0.086
Nodal	nodal	0.085
Sox3	SRY-box containing gene 3	0.082
Hoxd12	homeobox D12	0.082
Evx2	even skipped homeotic gene 2 homolog	0.078
Amh	anti-Mullerian hormone	0.077
Wnt3a	wingless-related MMTV integration site 3A	0.077
Rarb	retinoic acid receptor, beta	0.075
Hist1h1t	histone cluster 1, H1t	0.074
Eya1	eyes absent 1 homolog (Drosophila)	0.072
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.070
Sall4	sal-like 4 (Drosophila)	0.070
Avp	arginine vasopressin	0.069
Tlx3	T-cell leukemia, homeobox 3	0.068
Fgf10	fibroblast growth factor 10	0.068
Hes2	hairy and enhancer of split 2 (Drosophila)	0.068
Hoxa1	homeobox A1	0.067
Hmx1	H6 homeobox 1	0.067
Ighmbp2	immunoglobulin mu binding protein 2	0.066
Rax	retina and anterior neural fold homeobox	0.062
Fgf17	fibroblast growth factor 17	0.062
Dlx5	distal-less homeobox 5	0.062
Col2a1	collagen, type II, alpha 1	0.062
Rarg	retinoic acid receptor, gamma	0.060
Mzf1	myeloid zinc finger 1	0.060
Foxb2	forkhead box B2	0.059
Pdx1	pancreatic and duodenal homeobox 1	0.059
4930527J03Rik	RIKEN cDNA 4930527J03 gene	0.056
Ucn	urocortin	0.055
Sct	secretin	0.053
Btbd17	BTB (POZ) domain containing 17	0.052
Cdx1	caudal type homeobox 1	0.049
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.047
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.046
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.046
Gbx2	gastrulation brain homeobox 2	0.045
Odf3	outer dense fiber of sperm tails 3	0.045
Smo	smoothened homolog (Drosophila)	0.043
Sycn	syncollin	0.042
Tssk1	testis-specific serine kinase 1	0.042
Fgfr1	fibroblast growth factor receptor 1	0.041
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.041	Mouse
Hes3	hairy and enhancer of split 3 (Drosophila)	0.041
Wnt6	wingless-related MMTV integration site 6	0.040
Prrx2	paired related homeobox 2	0.039
Tcf15	transcription factor 15	0.039
Fgf15	fibroblast growth factor 15	0.039
Bdkrb2	bradykinin receptor, beta 2	0.039
BC057022	cDNA sequence BC057022	0.038
Pnoc	prepronociceptin	0.038
Lhx5	LIM homeobox protein 5	0.037
Tbx3	T-box 3	0.037
Foxb1	forkhead box B1	0.036
Gipc3	GIPC PDZ domain containing family, member 3	0.036
Grid2ip	glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1	0.035
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.034
Pax6	paired box gene 6	0.034
Prrx1	paired related homeobox 1	0.034
Neurog1	neurogenin 1	0.033
Cabp2	calcium binding protein 2	0.033
Foxh1	forkhead box H1	0.032
T	brachyury	0.032
Neurog3	neurogenin 3	0.032
Spdef	SAM pointed domain containing ets transcription factor	0.032
Sall3	sal-like 3 (Drosophila)	0.032
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.031
Egr4	early growth response 4	0.031
Hoxd11	homeobox D11	0.031
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.030
Pyy	peptide YY	0.030
Socs1	suppressor of cytokine signaling 1	0.030
Esx1	extraembryonic, spermatogenesis, homeobox 1	0.030
Bmp8b	bone morphogenetic protein 8b	0.029
Acvr1	activin A receptor, type 1	0.029
Insm1	insulinoma-associated 1	0.028
Gip	gastric inhibitory polypeptide	0.028
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.028
Mmp24	matrix metallopeptidase 24	0.028
Hcrt	hypocretin	0.027
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.027
Etv2	ets variant gene 2	0.027
Msx2	homeobox, msh-like 2	0.027
Pou2f2	POU domain, class 2, transcription factor 2	0.027
Foxa2	forkhead box A2	0.027
Dlx2	distal-less homeobox 2	0.027
Foxe1	forkhead box E1	0.026
Znrf4	zinc and ring finger 4	0.026
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.026
Defa-rs12	defensin, alpha, related sequence 12	0.026
Cd70	CD70 antigen	0.025
Foxg1	forkhead box G1	0.025
4921517D21Rik	RIKEN cDNA 4921517D21 gene	0.025
Emx1	empty spiracles homolog 1 (Drosophila)	0.025
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.025
Sox4	SRY-box containing gene 4	0.025
Galr2	galanin receptor 2	0.025
Nos3	nitric oxide synthase 3, endothelial cell	0.024
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.024
Ribc2	RIB43A domain with coiled-coils 2	0.024
Cort	cortistatin	0.024
Pax2	paired box gene 2	0.024
Chrm4	cholinergic receptor, muscarinic 4	0.024
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.023
Adra1b	adrenergic receptor, alpha 1b	0.023
Fgfr3	fibroblast growth factor receptor 3	0.023
Sox1	SRY-box containing gene 1	0.023
Prm1	protamine 1	0.023
Ms4a15	membrane-spanning 4-domains, subfamily A, member 15	0.022
Shank1	SH3/ankyrin domain gene 1	0.022
Gp9	glycoprotein 9 (platelet)	0.022
Ppy	pancreatic polypeptide	0.022
Foxl1	forkhead box L1	0.022
AI118078	expressed sequence AI118078	0.022
Prop1	paired like homeodomain factor 1	0.021
Gpr27	G protein-coupled receptor 27	0.021
Pax1	paired box gene 1	0.021
Guca2b	guanylate cyclase activator 2b (retina)	0.021
Padi3	peptidyl arginine deiminase, type III	0.021
Mdfi	MyoD family inhibitor	0.020
Slurp1	secreted Ly6/Plaur domain containing 1	0.020
Lactbl1	lactamase, beta-like 1	0.020
Gata5	GATA binding protein 5	0.020
Zfpm2	zinc finger protein, multitype 2	0.020
Bmp7	bone morphogenetic protein 7	0.020
Spert	spermatid associated	0.019
Ednra	endothelin receptor type A	0.019
Pou3f4	POU domain, class 3, transcription factor 4	0.019
Tgfbr2	transforming growth factor, beta receptor II	0.019
Ret	ret proto-oncogene	0.019
Dlx6	distal-less homeobox 6	0.019
Rsph6a	radial spoke head 6 homolog A (Chlamydomonas)	0.019
Foxl2	forkhead box L2	0.019
Msgn1	mesogenin 1	0.018
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.018
Oprd1	opioid receptor, delta 1	0.018
Fgf16	fibroblast growth factor 16	0.018
Onecut3	one cut domain, family member 3	0.018
Fam65c	family with sequence similarity 65, member C	0.018
Nobox	NOBOX oogenesis homeobox	0.018
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.018
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.018
Hoxa3	homeobox A3	0.018
Foxd2	forkhead box D2	0.018
Pax8	paired box gene 8	0.018
Arx	aristaless related homeobox	0.017
Nrtn	neurturin	0.017
Bmp10	bone morphogenetic protein 10	0.017
Pth2	parathyroid hormone 2	0.017
Tigd5	tigger transposable element derived 5	0.017
Gjc2	gap junction protein, gamma 2	0.017
Dlx1	distal-less homeobox 1	0.017
Rhox6	reproductive homeobox 6	0.017
Hoxb13	homeobox B13	0.017
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.017
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.017
Defa-rs2	defensin, alpha, related sequence 2	0.017
Tnf	tumor necrosis factor	0.016
Chd7	chromodomain helicase DNA binding protein 7	0.016
Syngr4	synaptogyrin 4	0.016
Wap	whey acidic protein	0.016
Lgals7	lectin, galactose binding, soluble 7	0.016
Zscan2	zinc finger and SCAN domain containing 2	0.016
Ptf1a	pancreas specific transcription factor, 1a	0.016
Gsg1	germ cell-specific gene 1	0.016
Tacr2	tachykinin receptor 2	0.016
Lalba	lactalbumin, alpha	0.016
Sac3d1	SAC3 domain containing 1	0.016
Figla	folliculogenesis specific basic helix-loop-helix	0.016
Chrng	cholinergic receptor, nicotinic, gamma polypeptide	0.016
Art5	ADP-ribosyltransferase 5	0.016
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.015
4930404N11Rik	RIKEN cDNA 4930404N11 gene	0.015
Fgf5	fibroblast growth factor 5	0.015
Wnt2b	wingless related MMTV integration site 2b	0.015
Cfc1	cripto, FRL-1, cryptic family 1	0.015
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.015
Klk6	kallikrein related-peptidase 6	0.015
Mybpc3	myosin binding protein C, cardiac	0.015
Msx3	homeobox, msh-like 3	0.015
Gja1	gap junction protein, alpha 1	0.015
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.015
Tcam1	testicular cell adhesion molecule 1	0.014
Lmx1a	LIM homeobox transcription factor 1 alpha	0.014
Kcnk3	potassium channel, subfamily K, member 3	0.014
Fgf22	fibroblast growth factor 22	0.014
Wnt7a	wingless-related MMTV integration site 7A	0.014
Fut7	fucosyltransferase 7	0.014
BC024139	cDNA sequence BC024139	0.014
Theg	testicular haploid expressed gene	0.014
Adam17	a disintegrin and metallopeptidase domain 17	0.014
Hhat	hedgehog acyltransferase	0.014
Sox11	SRY-box containing gene 11	0.014
Gli3	GLI-Kruppel family member GLI3	0.014
Capn9	calpain 9	0.014
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.013
Sstr3	somatostatin receptor 3	0.013
Barx2	BarH-like homeobox 2	0.013
Fgf4	fibroblast growth factor 4	0.013
Kcnk7	potassium channel, subfamily K, member 7	0.013
Trp53	transformation related protein 53	0.013
Zeb1	zinc finger E-box binding homeobox 1	0.013
Cdx2	caudal type homeobox 2	0.013
Vangl2	vang-like 2 (van gogh, Drosophila)	0.013
Rtn4r	reticulon 4 receptor	0.013
Epx	eosinophil peroxidase	0.013
Tff1	trefoil factor 1	0.013
Tsks	testis-specific serine kinase substrate	0.013
Atoh1	atonal homolog 1 (Drosophila)	0.012
Sox10	SRY-box containing gene 10	0.012
Ccr10	chemokine (C-C motif) receptor 10	0.012
Krt15	keratin 15	0.012
Hmx3	H6 homeobox 3	0.012
Oxt	oxytocin	0.012
Pax4	paired box gene 4	0.012
Ptgdr	prostaglandin D receptor	0.012
Cdh15	cadherin 15	0.012
Papln	papilin, proteoglycan-like sulfated glycoprotein	0.012
Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	0.012
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.012
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.012
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
Runx2	runt related transcription factor 2	0.012
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.012
Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	0.012
Mpl	myeloproliferative leukemia virus oncogene	0.012
Foxn4	forkhead box N4	0.012
Isl2	insulin related protein 2 (islet 2)	0.012
1700008P20Rik	RIKEN cDNA 1700008P20 gene	0.012
Foxd3	forkhead box D3	0.012
Pla2g10	phospholipase A2, group X	0.012
Gata1	GATA binding protein 1	0.012
Ctnnb1	catenin (cadherin associated protein), beta 1	0.012
Rbpjl	recombination signal binding protein for immunoglobulin kappa J region-like	0.011
Krt84	keratin 84	0.011
Klhl35	kelch-like 35 (Drosophila)	0.011
Tcp11	t-complex protein 11	0.011
Hapln3	hyaluronan and proteoglycan link protein 3	0.011
Gja3	gap junction protein, alpha 3	0.011
Drd4	dopamine receptor D4	0.011
Oc90	otoconin 90	0.011
Krt16	keratin 16	0.011
Ece1	endothelin converting enzyme 1	0.011
Glis1	GLIS family zinc finger 1	0.011
Ryr2	ryanodine receptor 2, cardiac	0.011
Hoxa7	homeobox A7	0.011
Uncx	UNC homeobox	0.011
Bhlhe23	basic helix-loop-helix family, member e23	0.011
Gabrd	gamma-aminobutyric acid (GABA) A receptor, subunit delta	0.011
1700018B08Rik	RIKEN cDNA 1700018B08 gene	0.011
Zfp444	zinc finger protein 444	0.011
Prss44	protease, serine, 44	0.011
1700029H14Rik	RIKEN cDNA 1700029H14 gene	0.011
Pou3f2	POU domain, class 3, transcription factor 2	0.011
Aanat	arylalkylamine N-acetyltransferase	0.010
Fndc7	fibronectin type III domain containing 7	0.010
Col11a2	collagen, type XI, alpha 2	0.010
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.010
1700011A15Rik	RIKEN cDNA 1700011A15 gene	0.010
Tead3	TEA domain family member 3	0.010
Ccin	calicin	0.010
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.010
Adra2b	adrenergic receptor, alpha 2b	0.010