IMP

Process View

Mus musculus

1 genes annotated in mouse

Multi-species View

activation of mapkkk activity

GO:0000185

Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activation of mapkkk activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "activation of mapkkk activity" (in gray)

Name	Description	Probability	Func Analog Organism
Rac1	RAS-related C3 botulinum substrate 1	0.995
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.987
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.958
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.615
Arhgap1	Rho GTPase activating protein 1	0.595
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.546
Bcl10	B-cell leukemia/lymphoma 10	0.420
Sertad1	SERTA domain containing 1	0.402
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.331
Fos	FBJ osteosarcoma oncogene	0.309
Junb	Jun-B oncogene	0.264
Ier3	immediate early response 3	0.249
Dab1	disabled homolog 1 (Drosophila)	0.239
Dusp1	dual specificity phosphatase 1	0.237
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.216
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.175
Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.139
Zfp36	zinc finger protein 36	0.116
Stat3	signal transducer and activator of transcription 3	0.114
Gadd45g	growth arrest and DNA-damage-inducible 45 gamma	0.111	Human
Gadd45b	growth arrest and DNA-damage-inducible 45 beta	0.109	Human
Jun	Jun oncogene	0.108
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.105
Nfil3	nuclear factor, interleukin 3, regulated	0.103
Atf3	activating transcription factor 3	0.091
Klf6	Kruppel-like factor 6	0.076
Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	0.062
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.059
Cdc42se1	CDC42 small effector 1	0.059
Neurod6	neurogenic differentiation 6	0.052
Csnk1e	casein kinase 1, epsilon	0.052
Atf4	activating transcription factor 4	0.050
Per1	period homolog 1 (Drosophila)	0.045
Rnf111	ring finger 111	0.044
Cpne1	copine I	0.044
Ppp1r15a	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.043
Mt2	metallothionein 2	0.043
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.040
Adm	adrenomedullin	0.039
Fas	Fas (TNF receptor superfamily member 6)	0.037
Csrnp1	cysteine-serine-rich nuclear protein 1	0.037
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.036
Tiparp	TCDD-inducible poly(ADP-ribose) polymerase	0.036
Pxn	paxillin	0.036
Bhlhe40	basic helix-loop-helix family, member e40	0.035
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.035
Ddb1	damage specific DNA binding protein 1	0.034
Rhob	ras homolog gene family, member B	0.034
Fam107b	family with sequence similarity 107, member B	0.031
4933426M11Rik	RIKEN cDNA 4933426M11 gene	0.031
Ets2	E26 avian leukemia oncogene 2, 3' domain	0.031
Slc2a1	solute carrier family 2 (facilitated glucose transporter), member 1	0.031
Rnd3	Rho family GTPase 3	0.030
Sptlc2	serine palmitoyltransferase, long chain base subunit 2	0.030
Mtap1b	microtubule-associated protein 1B	0.030
Homer1	homer homolog 1 (Drosophila)	0.029
Clvs1	clavesin 1	0.029
Astn1	astrotactin 1	0.028
Map4k4	mitogen-activated protein kinase kinase kinase kinase 4	0.028
Btg2	B-cell translocation gene 2, anti-proliferative	0.027
Mapkapk2	MAP kinase-activated protein kinase 2	0.027
Map3k4	mitogen-activated protein kinase kinase kinase 4	0.027
Cadps	Ca2+-dependent secretion activator	0.027
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.026
Cbfb	core binding factor beta	0.025
Mfsd10	major facilitator superfamily domain containing 10	0.025
Ap1g1	adaptor protein complex AP-1, gamma 1 subunit	0.025
Pik3cb	phosphatidylinositol 3-kinase, catalytic, beta polypeptide	0.025
Mast2	microtubule associated serine/threonine kinase 2	0.025
Smad2	MAD homolog 2 (Drosophila)	0.025
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.025
Scn1a	sodium channel, voltage-gated, type I, alpha	0.024
Gdap1	ganglioside-induced differentiation-associated-protein 1	0.024
Spna2	spectrin alpha 2	0.024
Ubc	ubiquitin C	0.023
Egr1	early growth response 1	0.023
Tgif1	TGFB-induced factor homeobox 1	0.023
Ppp4r1	protein phosphatase 4, regulatory subunit 1	0.023
Ptpn1	protein tyrosine phosphatase, non-receptor type 1	0.022
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.022
Kctd10	potassium channel tetramerisation domain containing 10	0.022
Dlg2	discs, large homolog 2 (Drosophila)	0.022
Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	0.022
Ier2	immediate early response 2	0.021
Msn	moesin	0.021
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.021
Lphn1	latrophilin 1	0.020
Nalcn	sodium leak channel, non-selective	0.020
Dlg3	discs, large homolog 3 (Drosophila)	0.020
Tmem165	transmembrane protein 165	0.019
Ina	internexin neuronal intermediate filament protein, alpha	0.019
Phc2	polyhomeotic-like 2 (Drosophila)	0.019
Tnfrsf12a	tumor necrosis factor receptor superfamily, member 12a	0.019
Sh3gl1	SH3-domain GRB2-like 1	0.019
Tmod3	tropomodulin 3	0.019
Cenpt	centromere protein T	0.019
Rbms1	RNA binding motif, single stranded interacting protein 1	0.019
Ddit4	DNA-damage-inducible transcript 4	0.018
Edc4	enhancer of mRNA decapping 4	0.018
Mdm2	transformed mouse 3T3 cell double minute 2	0.018
Kbtbd2	kelch repeat and BTB (POZ) domain containing 2	0.018
Raf1	v-raf-leukemia viral oncogene 1	0.018
Anapc2	anaphase promoting complex subunit 2	0.018
Trp53	transformation related protein 53	0.018
Cobra1	cofactor of BRCA1	0.017
Phf23	PHD finger protein 23	0.017
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.017
Wdr1	WD repeat domain 1	0.017
Jup	junction plakoglobin	0.017
Plec	plectin	0.017
Mcl1	myeloid cell leukemia sequence 1	0.017
Cacnb3	calcium channel, voltage-dependent, beta 3 subunit	0.017
Gap43	growth associated protein 43	0.017
Shank2	SH3/ankyrin domain gene 2	0.017
Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.017
Snap25	synaptosomal-associated protein 25	0.017
Add1	adducin 1 (alpha)	0.017
Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	0.016
Dag1	dystroglycan 1	0.016
Cttn	cortactin	0.016
N4bp1	NEDD4 binding protein 1	0.016
Tacc2	transforming, acidic coiled-coil containing protein 2	0.016
Map2k1	mitogen-activated protein kinase kinase 1	0.016
Smurf2	SMAD specific E3 ubiquitin protein ligase 2	0.016
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.016
Xpo6	exportin 6	0.016
Mt1	metallothionein 1	0.016
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.015	Human
Pxk	PX domain containing serine/threonine kinase	0.015
Flot1	flotillin 1	0.015
Agrn	agrin	0.015
Sgk1	serum/glucocorticoid regulated kinase 1	0.015
Gabra5	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5	0.015
Ilk	integrin linked kinase	0.015
Pgm1	phosphoglucomutase 1	0.015
Lrp8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	0.015
Klf4	Kruppel-like factor 4 (gut)	0.015
Zfp804a	zinc finger protein 804A	0.015
Gpr85	G protein-coupled receptor 85	0.015
Sept3	septin 3	0.014
Syt16	synaptotagmin XVI	0.014
Ptprf	protein tyrosine phosphatase, receptor type, F	0.014
Ctnnb1	catenin (cadherin associated protein), beta 1	0.014
Ier5	immediate early response 5	0.014
Rnf44	ring finger protein 44	0.014
Cdc42se2	CDC42 small effector 2	0.014
Nudt11	nudix (nucleoside diphosphate linked moiety X)-type motif 11	0.014
Tpra1	transmembrane protein, adipocyte asscociated 1	0.014
Pim3	proviral integration site 3	0.013
Jdp2	Jun dimerization protein 2	0.013
Abr	active BCR-related gene	0.013
Kctd5	potassium channel tetramerisation domain containing 5	0.013
Hbegf	heparin-binding EGF-like growth factor	0.013
Id1	inhibitor of DNA binding 1	0.013
6430704M03Rik	RIKEN cDNA 6430704M03 gene	0.013
Nras	neuroblastoma ras oncogene	0.013
Gripap1	GRIP1 associated protein 1	0.013
Cyr61	cysteine rich protein 61	0.013
Vwc2l	von Willebrand factor C domain-containing protein 2-like	0.013
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.013
Errfi1	ERBB receptor feedback inhibitor 1	0.013
Dlgap4	discs, large homolog-associated protein 4 (Drosophila)	0.013
Jak1	Janus kinase 1	0.013
Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.013
Klf7	Kruppel-like factor 7 (ubiquitous)	0.013
Dusp4	dual specificity phosphatase 4	0.013
Rab15	RAB15, member RAS oncogene family	0.012
Znrf1	zinc and ring finger 1	0.012
Numa1	nuclear mitotic apparatus protein 1	0.012
Rbm42	RNA binding motif protein 42	0.012
Mtap2	microtubule-associated protein 2	0.012
Llgl1	lethal giant larvae homolog 1 (Drosophila)	0.012
App	amyloid beta (A4) precursor protein	0.012
Tubb3	tubulin, beta 3	0.012
Scg5	secretogranin V	0.012
Klf13	Kruppel-like factor 13	0.012
Rnf19b	ring finger protein 19B	0.012
F3	coagulation factor III	0.012
Tpm4	tropomyosin 4	0.012
Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.012
Osbpl5	oxysterol binding protein-like 5	0.012
Slc3a2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.012
Fstl5	follistatin-like 5	0.012
Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.012
Rab9b	RAB9B, member RAS oncogene family	0.012
Slitrk5	SLIT and NTRK-like family, member 5	0.012
Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3	0.012
Flii	flightless I homolog (Drosophila)	0.012
Lrrc8a	leucine rich repeat containing 8A	0.011
Synpr	synaptoporin	0.011
Map2k4	mitogen-activated protein kinase kinase 4	0.011
Trim25	tripartite motif-containing 25	0.011
Rhoa	ras homolog gene family, member A	0.011
Olfm3	olfactomedin 3	0.011
Prpf8	pre-mRNA processing factor 8	0.011
Ndrg1	N-myc downstream regulated gene 1	0.011
S100a6	S100 calcium binding protein A6 (calcyclin)	0.011
Gna13	guanine nucleotide binding protein, alpha 13	0.011
Csnk1d	casein kinase 1, delta	0.011
Csrp1	cysteine and glycine-rich protein 1	0.011
Slc17a6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.011
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.011
Fam19a2	family with sequence similarity 19, member A2	0.011
Mtap7d2	MAP7 domain containing 2	0.011
Lzts2	leucine zipper, putative tumor suppressor 2	0.011
Cyth2	cytohesin 2	0.011
Casp8	caspase 8	0.011
Hecw1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	0.011
Pgs1	phosphatidylglycerophosphate synthase 1	0.011
Phactr1	phosphatase and actin regulator 1	0.011
Dctn1	dynactin 1	0.011
Actn4	actinin alpha 4	0.011
Dusp8	dual specificity phosphatase 8	0.011
Rgl2	ral guanine nucleotide dissociation stimulator-like 2	0.011
Axin1	axin 1	0.010
Myo1c	myosin IC	0.010
Iqgap1	IQ motif containing GTPase activating protein 1	0.010
Skil	SKI-like	0.010
Wfs1	Wolfram syndrome 1 homolog (human)	0.010
Lrrtm3	leucine rich repeat transmembrane neuronal 3	0.010
Tmem130	transmembrane protein 130	0.010
Ctgf	connective tissue growth factor	0.010
Brpf1	bromodomain and PHD finger containing, 1	0.010
Glg1	golgi apparatus protein 1	0.010
Rab3c	RAB3C, member RAS oncogene family	0.010
Vasp	vasodilator-stimulated phosphoprotein	0.010
Celf4	CUGBP, Elav-like family member 4	0.010
Grk6	G protein-coupled receptor kinase 6	0.010
Stk17b	serine/threonine kinase 17b (apoptosis-inducing)	0.010
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.010
Clstn1	calsyntenin 1	0.010
Nf2	neurofibromatosis 2	0.010
Nde1	nuclear distribution gene E homolog 1 (A nidulans)	0.010