IMP

Process View

Danio rerio

26 genes annotated in zebrafish

sarcomere organization

The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "sarcomere organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "sarcomere organization" (in gray)

Name	Description	Probability	Func Analog Organism
mef2cb	myocyte enhancer factor 2cb	0.991	Mouse
smyd1b	SET and MYND domain containing 1b	0.987
tnnc1b	troponin C type 1b (slow)	0.987
unc45b	unc-45 homolog B (C. elegans)	0.939	Worm
ttna	titin a	0.903
stac3	SH3 and cysteine rich domain 3	0.887
myhz1.1	myosin, heavy polypeptide 1.1, skeletal muscle	0.828	Mouse Fly
hsp90a.1	heat shock protein 90-alpha 1	0.797
xirp1	xin actin-binding repeat containing 1	0.734	Mouse
vmhc	ventricular myosin heavy chain	0.728
tnni2a.4	troponin I, skeletal, fast 2a.4	0.629	Worm Fly
myl1	myosin, light chain 1, alkali; skeletal, fast	0.628	Zebrafish
smyd1a	SET and MYND domain containing 1a	0.569
actn1	actinin, alpha 1	0.550	Zebrafish Fly
chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1	0.547
zgc:66286	zgc:66286	0.523	Zebrafish
tnni1b	troponin I, skeletal, slow b	0.484	Worm Fly
ttnb	titin b	0.465
gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.444
dag1	dystroglycan 1	0.437
mef2ca	myocyte enhancer factor 2ca	0.435	Mouse
smyhc1l	slow myosin heavy chain 1, like	0.418
myhz1.2	myosin, heavy polypeptide 1.2, skeletal muscle	0.412
myog	myogenin	0.409
tnni1al	troponin I, skeletal, slow like	0.404	Worm Fly
tnnt3b	troponin T3b, skeletal, fast	0.378
actc1b	actin, alpha, cardiac muscle 1b	0.375
atp2a2a	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2a	0.366
jam2a	junctional adhesion molecule 2a	0.361
tnnc1a	troponin C type 1a (slow)	0.325
pdlim7	PDZ and LIM domain 7	0.325
neb	nebulin	0.325
mylz2	myosin, light polypeptide 2, skeletal muscle	0.322	Zebrafish
desma	desmin a	0.317
dmd	dystrophin	0.308
pxn	paxillin	0.306
actc1a	actin, alpha, cardiac muscle 1a	0.265
itgb1a	integrin, beta 1a	0.254	Mouse
actn2	actinin, alpha 2	0.246
acta1a	actin, alpha 1a, skeletal muscle	0.226
tpm3	tropomyosin 3	0.222
cav3	caveolin 3	0.216
hspg2	heparan sulfate proteoglycan 2	0.213
pabpc4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.192
anxa6	annexin A6	0.191
fxr1	fragile X mental retardation, autosomal homolog 1	0.190
actn3b	actinin alpha 3b	0.187	Zebrafish Fly
rbfox1l	RNA binding protein, fox-1 homolog (C. elegans) 1-like	0.180
ilk	integrin linked kinase	0.169
tpm4	tropomyosin 4	0.161
smyhc2	slow myosin heavy chain 2	0.143	Mouse Fly
myl10	myosin, light chain 10, regulatory	0.132	Zebrafish
tmem38a	transmembrane protein 38A	0.128
zgc:136894	zgc:136894	0.127
ckma	creatine kinase, muscle a	0.122
srl	sarcalumenin	0.120
tnnc2	troponin C type 2 (fast)	0.120
nppa	natriuretic peptide precursor A	0.113
zgc:165344	zgc:165344	0.111
znf148	zinc finger protein 148	0.110
kbtbd10b	kelch repeat and BTB (POZ) domain containing 10b	0.108
tpm2	tropomyosin 2 (beta)	0.100
smyhc1	slow myosin heavy chain 1	0.099	Mouse Fly
xirp2a	xin actin-binding repeat containing 2a	0.094	Zebrafish
atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.091
tpma	alpha-tropomyosin	0.090
pomt2	protein-O-mannosyltransferase 2	0.090
smyd2b	SET and MYND domain containing 2b	0.087	Zebrafish
frem3	Fras1 related extracellular matrix 3	0.086
mybpc3	myosin binding protein C, cardiac	0.086
tnni2b.1	troponin I, skeletal, fast 2b.1	0.080
wnt11r	wingless-type MMTV integration site family, member 11, related	0.079
lama2	laminin, alpha 2	0.074
actn3a	actinin alpha 3a	0.074	Zebrafish Fly
itgb1b	integrin, beta 1b	0.072	Mouse
isl1	islet1	0.068
casrl	calcium-sensing receptor, like	0.067
vmhcl	ventricular myosin heavy chain-like	0.065
ndrg4	N-myc downstream regulated gene 4	0.063
flncb	filamin C, gamma b (actin binding protein 280)	0.063
aldoab	aldolase a, fructose-bisphosphate, b	0.063
itgb1b.2	integrin, beta 1b.2	0.062	Mouse
fabp3	fatty acid binding protein 3, muscle and heart	0.061
alpi	alkaline phosphatase, intestinal	0.060
col15a1b	collagen, type XV, alpha 1b	0.059
si:dkey-261h17.1	si:dkey-261h17.1	0.058
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.057
fabp2	fatty acid binding protein 2, intestinal	0.056
myhz2	myosin, heavy polypeptide 2, fast muscle specific	0.055	Mouse Fly
fgf10a	fibroblast growth factor 10a	0.054
zgc:92061	zgc:92061	0.054
ldb3a	LIM-domain binding factor 3a	0.053
ryr1b	ryanodine receptor 1b (skeletal)	0.053
pdlim5	PDZ and LIM domain 5	0.053
txlnba	taxilin beta a	0.053
mapk4	mitogen-activated protein kinase 4	0.053
anxa1a	annexin A1a	0.052
chrnd	cholinergic receptor, nicotinic, delta polypeptide	0.051
acta1b	actin, alpha 1b, skeletal muscle	0.051
anxa2a	annexin A2a	0.050
slc5a5	solute carrier family 5 (sodium iodide symporter), member 5	0.048
sb:cb560	sb:cb560	0.048
arpc5b	actin related protein 2/3 complex, subunit 5B	0.047
lamb2	laminin, beta 2 (laminin S)	0.046
ldb3b	LIM domain binding 3b	0.046
cx36.7	connexin 36.7	0.045
lrrc10	leucine rich repeat containing 10	0.043
zgc:66097	zgc:66097	0.041
itga7	integrin, alpha 7	0.041
synpo2lb	synaptopodin 2-like b	0.041
cftr	cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)	0.040
myf6	myogenic factor 6	0.039
pikfyve	phosphoinositide kinase, FYVE finger containing	0.038
myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.038	Zebrafish
sgcd	sarcoglycan, delta (dystrophin-associated glycoprotein)	0.037
pygma	phosphorylase, glycogen (muscle) A	0.037
pvalb4	parvalbumin 4	0.036
grifin	galectin related inter-fiber protein	0.035
zgc:171553	zgc:171553	0.035
dtnb	dystrobrevin, beta	0.034
musk	muscle, skeletal, receptor tyrosine kinase	0.034
LOC100149148	novel protein similar to myosin heavy chain 4 (myhc4)	0.034
hhatlb	hedgehog acyltransferase-like, b	0.033
sh3gl1b	SH3-domain GRB2-like 1b	0.033
pdlim1	PDZ and LIM domain 1 (elfin)	0.033
matn1	matrilin 1	0.032
LOC557062	hypothetical protein LOC557062	0.032
slc25a4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	0.032
th	tyrosine hydroxylase	0.031
fn1	fibronectin 1	0.031
cmlc1	cardiac myosin light chain-1	0.031
tnni2b.2	troponin I, skeletal, fast 2b.2	0.031	Worm Fly
dspa	desmoplakin a	0.031
popdc1	popeye domain containing 1	0.031
myod1	myogenic differentiation 1	0.030
col12a1	collagen, type XII, alpha 1	0.030
vgll2b	vestigial like 2b	0.030
foxo3a	forkhead box O3A	0.030
hs3st3b1b	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b	0.030
mnx1	motor neuron and pancreas homeobox 1	0.030
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.029
jun	jun proto-oncogene	0.029
cthrc1a	collagen triple helix repeat containing 1a	0.029
qk	quaking	0.028	Fly
large	like-glycosyltransferase	0.028
dysf	dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)	0.028
pfn1	profilin 1	0.028
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.027
popdc2	popeye domain containing 2	0.027
tbx5b	T-box 5b	0.026
rbm24b	RNA binding motif protein 24b	0.026
sst3	somatostatin 3	0.026
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.026
duox	dual oxidase	0.026
hhatla	hedgehog acyltransferase-like, a	0.026
cdk10	cyclin-dependent kinase 10	0.026
zgc:114164	zgc:114164	0.025	Zebrafish
mapk12	mitogen-activated protein kinase 12	0.025
dtng	dystrobrevin, gamma and dystrobrevin, gamma-like	0.025	Worm
mapta	microtubule-associated protein tau a	0.025
zgc:85975	zgc:85975	0.025
gle1	GLE1 RNA export mediator homolog (yeast)	0.025
col7a1l	collagen type VII alpha 1-like	0.024
dmrt2b	doublesex and mab-3 related transcription factor 2b	0.023
angptl7	angiopoietin-like 7	0.023
tgfb1a	transforming growth factor, beta 1a	0.023
tgfbr2	transforming growth factor, beta receptor II	0.023
foxc1b	forkhead box C1b	0.023
copeb	core promoter element binding protein	0.023
col1a1b	collagen, type I, alpha 1b	0.023
ckmb	creatine kinase, muscle b	0.023
meox2a	mesenchyme homeobox 2a	0.023
col6a2	collagen, type VI, alpha 2	0.022
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.022	Fly
egfl6	EGF-like-domain, multiple 6	0.022
cotl1	coactosin-like 1 (Dictyostelium)	0.022
mapk6	mitogen-activated protein kinase 6	0.022
im:6908257	im:6908257	0.022
mef2d	myocyte enhancer factor 2d	0.022
b2m	beta-2-microglobulin	0.021
ampd1	adenosine monophosphate deaminase 1 (isoform M)	0.021
il8	interleukin 8	0.021
mylz3	myosin, light polypeptide 3, skeletal muscle	0.021	Zebrafish
tagln2	transgelin 2	0.021
fxr2	fragile X mental retardation, autosomal homolog 2	0.020
vcam1	vascular cell adhesion molecule 1	0.020
zfpm1	zinc finger protein, multitype 1	0.020
myom1a	myomesin 1a (skelemin)	0.020
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.020
rras	related RAS viral (r-ras) oncogene homolog	0.020
selm	selenoprotein M	0.020
actn4	actinin, alpha 4	0.020
zgc:92429	zgc:92429	0.019
tnnt3a	troponin T3a, skeletal, fast	0.019
rnasel1	ribonuclease like 1	0.019
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.019
flot1b	flotillin 1b	0.019
hspb8	heat shock protein, alpha-crystallin-related, b8	0.019
cdh7	cadherin 7, type 2	0.019
ccng1	cyclin G1	0.019
smyd2a	SET and MYND domain containing 2a	0.019
myca	myelocytomatosis oncogene a	0.019
si:dkey-27i16.2	si:dkey-27i16.2	0.019
dscam	Down syndrome cell adhesion molecule	0.019
cldn11b	claudin 11b	0.019
me2	malic enzyme 2, NAD(+)-dependent, mitochondrial	0.019
wu:fb01h12	wu:fb01h12	0.018
utrn	utrophin	0.018
mylk3	myosin light chain kinase 3	0.018
lgals1l1	lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1	0.018
zgc:113625	zgc:113625	0.018
flna	filamin A, alpha (actin binding protein 280) and filamin A, alpha	0.018
cyyr1	cysteine and tyrosine-rich protein 1	0.018
zgc:63587	zgc:63587	0.018
rnd3a	Rho family GTPase 3a	0.018
mapk1	mitogen-activated protein kinase 1	0.018
rp42-pen	rp42 homolog (pending) and rp42 homolog	0.018
ubiad1	UbiA prenyltransferase domain containing 1	0.018
fstb	follistatin b	0.018
limk1	LIM domain kinase 1	0.017
zgc:65851	zgc:65851	0.017	Zebrafish
tmem161a	transmembrane protein 161A	0.017
im:6801444	im:6801444	0.017
calm1a	calmodulin 1a	0.017
rln3b	relaxin 3b	0.017
im:6896270	im:6896270	0.017
slc8a1a	solute carrier family 8 (sodium/calcium exchanger), member 1a	0.017
cap2	CAP, adenylate cyclase-associated protein, 2 (yeast)	0.016
bactin1	bactin1	0.016
zgc:112242	zgc:112242	0.016	Worm Fly
drp2	dystrophin related protein 2	0.016
scxa	scleraxis homolog A (mouse)	0.016
xirp2b	xin actin-binding repeat containing 2b	0.016
ccdc80	coiled-coil domain containing 80	0.016
nav3	neuron navigator 3	0.016
sgcg	sarcoglycan, gamma	0.016
prrx1a	paired related homeobox 1a	0.016
mbnl1	muscleblind-like (Drosophila)	0.016
fhla	four and a half LIM domains a	0.016
slc8a4a	solute carrier family 8 (sodium/calcium exchanger), member 4a	0.016	Zebrafish
rbp1a	retinol binding protein 1a, cellular	0.015
wu:fc31e07	wu:fc31e07	0.015
tpm1	tropomyosin 1 (alpha)	0.015
acbd4	acyl-CoA binding domain containing 4	0.015
jag1a	jagged 1a	0.015
im:7137300	im:7137300	0.015
plcxd3	phosphatidylinositol-specific phospholipase C, X domain containing 3	0.015
itgb3a	integrin beta 3a	0.015
dnaja	DnaJ (Hsp40) homolog, subfamily A member	0.015
trim3a	tripartite motif-containing 3a	0.015
col9a1	collagen, type IX, alpha 1	0.015
zgc:100799	zgc:100799	0.015
bckdk	branched chain alpha-ketoacid dehydrogenase kinase	0.015
LOC567640	similar to laminin alpha 3	0.015
jph2	junctophilin 2	0.015
krt4	keratin 4	0.015	Rat
cacna1da	calcium channel, voltage-dependent, L type, alpha 1D subunit, a	0.015
smtnb	smoothelin b	0.015
bmp10	bone morphogenetic protein 10	0.015
cd151	CD151 molecule	0.015
tuba2	tubulin, alpha 2	0.014
sb:cb247	sb:cb247	0.014
zgc:86759	zgc:86759	0.014
pdlim2	PDZ and LIM domain 2 (mystique)	0.014
zgc:103639	zgc:103639	0.014	Zebrafish
zgc:101050	zgc:101050	0.014
smad9	MAD homolog 9 (Drosophila)	0.014
im:7151449	im:7151449	0.014
hs3st1l2	heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 2	0.014
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.014
sb:cb166	sb:cb166	0.014
ccnh	cyclin H	0.014
sec31a	sec31 homolog A (S. cerevisiae)	0.014
sb:cb176	sb:cb176	0.014
si:ch211-57k11.10	si:ch211-57k11.10	0.014
pvalb7	parvalbumin 7	0.014
zgc:91957	zgc:91957	0.014
wu:fb63c04	wu:fb63c04	0.014
mapk3	mitogen-activated protein kinase 3	0.013
zgc:195154	zgc:195154	0.013
tbx20	T-box 20	0.013
ckmt2	creatine kinase, mitochondrial 2 (sarcomeric)	0.013
sb:eu783	sb:eu783	0.013
sb:eu1077	sb:eu1077	0.013
pgam2	phosphoglycerate mutase 2 (muscle)	0.013
zp3	zona pellucida glycoprotein 3	0.013
cdh15	cadherin 15, M-cadherin (myotubule)	0.013
im:7154736	im:7154736	0.013
igfbp6a	insulin-like growth factor binding protein 6a	0.013
lgals3l	lectin, galactoside-binding, soluble, 3 (galectin 3)-like	0.013
smyd5	SMYD family member 5	0.013
zgc:112359	zgc:112359	0.013	Zebrafish
macf1	microtubule-actin crosslinking factor 1	0.013
wu:fk24c07	wu:fk24c07	0.013
calcrla	calcitonin receptor-like a	0.013
ns:zf-e68	ns:zf-e68	0.013
myoz2b	myozenin 2b	0.013
tbx5a	T-box 5a	0.013
sdprb	serum deprivation response b	0.013
col18a1	collagen type XVIII, alpha 1	0.013
ap1b1	adaptor-related protein complex 1, beta 1 subunit	0.013
ctbp2	C-terminal binding protein 2	0.013
cenpn	centromere protein N	0.013
scn1ba	sodium channel, voltage-gated, type I, beta a	0.013
si:ch211-166a6.5	si:ch211-166a6.5	0.013
defbl3	defensin, beta-like 3	0.013
zgc:65890	zgc:65890	0.013	Fly
dpf3	D4, zinc and double PHD fingers, family 3	0.013
fabp11a	fatty acid binding protein 11a	0.013
LOC100006361	galanin-like	0.012
abca1b	ATP-binding cassette, sub-family A (ABC1), member 1B	0.012
smyd3	SET and MYND domain containing 3	0.012	Zebrafish
npm4	nucleophosmin/nucleoplasmin, 4	0.012
csrp3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.012
pvalb2	parvalbumin 2	0.012
si:ch211-142k18.1	si:ch211-142k18.1	0.012
fktn	fukutin	0.012
lims1	LIM and senescent cell antigen-like domains 1	0.012
prkcq	protein kinase C, theta	0.012
eya4	eyes absent homolog 4 (Drosophila)	0.012
mapk7	mitogen-activated protein kinase 7	0.012
elovl1b	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b	0.012
znf503	zinc finger protein 503	0.012
smyhc3	slow myosin heavy chain 3	0.012	Mouse Fly
zgc:91999	zgc:91999	0.012
micall1	MICAL-like 1	0.012
sgcb	sarcoglycan, beta (dystrophin-associated glycoprotein)	0.012
mmrn2a	multimerin 2a	0.012
hk1	hexokinase 1	0.012
bbc3	BCL2 binding component 3	0.012
sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.012
LOC100001530	isotocin receptor-like 2	0.012
fgf2	fibroblast growth factor 2	0.012
ap2a1	adaptor-related protein complex 2, alpha 1 subunit	0.011
nog2	noggin 2	0.011
gfap	glial fibrillary acidic protein	0.011	Zebrafish
nkx2.5	NK2 transcription factor related 5	0.011
zgc:56376	zgc:56376	0.011
zgc:92518	zgc:92518	0.011
ppargc1al	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like	0.011
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.011
arpc4l	actin related protein 2/3 complex, subunit 4, like	0.011
cacna1sa	calcium channel, voltage-dependent, L type, alpha 1S subunit, a	0.011
eif3jb	eukaryotic translation initiation factor 3, subunit Jb	0.011
chst11	carbohydrate (chondroitin 4) sulfotransferase 11	0.011
grem1a	gremlin 1 homolog a, cysteine knot superfamily (Xenopus laevis)	0.011
tnni2a.2	troponin I, skeletal, fast 2a.2	0.011	Worm Fly
mxra8a	matrix-remodelling associated 8a	0.011
emd	emerin (Emery-Dreifuss muscular dystrophy)	0.011
hlxb9la	homeo box HB9 like a	0.011
itgb1b.1	integrin, beta 1b.1	0.011	Mouse
LOC569583	tumor suppressor candidate 5 homolog	0.011
im:7151827	im:7151827	0.011
zgc:110298	zgc:110298	0.011
ggcx	gamma-glutamyl carboxylase	0.011
slc38a7	solute carrier family 38, member 7	0.011
crybb1l2	crystallin, beta B1, like 2	0.011
LOC795319	kelch repeat and BTB domain-containing protein 5-like	0.011
tjp2b	tight junction protein 2b (zona occludens 2)	0.011
wu:fb15e04	wu:fb15e04	0.011
tpte	transmembrane phosphatase with tensin homology	0.011
prkcea	protein kinase C, epsilon a	0.011
uts2a	urotensin 2, alpha	0.011
LOC796298	isotocin receptor-like 1	0.011
rdh5	retinol dehydrogenase 5 (11-cis/9-cis)	0.011
cryba1b	crystallin, beta A1b	0.011
ucn3l	urocortin 3, like	0.011
postn	periostin, osteoblast specific factor	0.011
sept7a	septin 7a	0.011
zgc:110380	zgc:110380	0.011
limk2	LIM domain kinase 2	0.010
csad	cysteine sulfinic acid decarboxylase	0.010
zgc:110434	zgc:110434	0.010
adrb2a	adrenergic receptor, beta 2a	0.010
prdm4	PR domain containing 4	0.010
arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.010
dfna5	deafness, autosomal dominant 5	0.010
zgc:171495	zgc:171495	0.010
mal	mal, T-cell differentiation protein	0.010
ankrd1b	ankyrin repeat domain 1b (cardiac muscle)	0.010
chrne	cholinergic receptor, nicotinic, epsilon	0.010
sox6	SRY-box containing gene 6	0.010
nfia	nuclear factor I/A	0.010
capza1a	capping protein (actin filament) muscle Z-line, alpha 1a	0.010
mobkl1ab	MOB1, Mps One Binder kinase activator-like 1A (yeast), genome duplicate b	0.010
mapk15	mitogen-activated protein kinase 15	0.010
agtpbp1	ATP/GTP binding protein 1	0.010
eif2c4	eukaryotic translation initiation factor 2C, 4	0.010
zgc:110176	zgc:110176	0.010
LOC560602	novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)	0.010
nexn	nexilin (F actin binding protein)	0.010
LOC563228	novel protein similar to vertebrate potassium channel, subfamily K, member 10 (KCNK10)	0.010
etv7	ets variant 7	0.010
cul5a	cullin 5a	0.010