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Danio rerio

11 genes annotated in zebrafish

response to oxidative stress

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to oxidative stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to oxidative stress" (in gray)

Name	Description	Probability	Func Analog Organism
mapk1	mitogen-activated protein kinase 1	0.773	Fly
bcl2l1	bcl2-like 1	0.712
per2	period homolog 2 (Drosophila)	0.426
pitx3	paired-like homeodomain transcription factor 3	0.339
jun	jun proto-oncogene	0.305	Rat
per3	period homolog 3 (Drosophila)	0.295	Zebrafish
tp53	tumor protein p53	0.287	Human Mouse Worm
copeb	core promoter element binding protein	0.268	Rat
igf1rb	insulin-like growth factor 1b receptor	0.263	Worm Fly
adipor2	adiponectin receptor 2	0.259
cry1a	cryptochrome 1a	0.251
cry2b	cryptochrome 2b	0.227
pafah1b1a	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a	0.186
stmn2b	stathmin-like 2b	0.181
mapk3	mitogen-activated protein kinase 3	0.176	Fly
sgk1	serum/glucocorticoid regulated kinase 1	0.172	Yeast
ptf1a	pancreas specific transcription factor, 1a	0.167	Worm
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.140
ef1a	elongation factor 1-alpha	0.132
cyp3c1	cytochrome P450, family 3, subfamily c, polypeptide 1	0.129
trim13	tripartite motif-containing 13	0.128
idh1	isocitrate dehydrogenase 1 (NADP+), soluble	0.125	Mouse
tardbp	TAR DNA binding protein	0.124
ddb2	damage-specific DNA binding protein 2	0.114
sod1	superoxide dismutase 1, soluble	0.111
pafah1b1b	platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b	0.110
odc1	ornithine decarboxylase 1	0.105
tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.103
qk	quaking	0.102
elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	0.097
ctsba	cathepsin B, a	0.096
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.095
hif1ab	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b	0.093	Human Mouse Rat
pcsk1	proprotein convertase subtilisin/kexin type 1	0.092
cry3	cryptochrome 3	0.088	Zebrafish
pgd	phosphogluconate hydrogenase	0.087
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.084
bmp4	bone morphogenetic protein 4	0.079	Rat
gstp1	glutathione S-transferase pi	0.077	Mouse Worm
cdh23	cadherin-like 23	0.075
prdx2	peroxiredoxin 2	0.072	Human Mouse Worm
aplp2	amyloid beta (A4) precursor-like protein 2	0.071
prdx3	peroxiredoxin 3	0.069	Human Mouse
smad2	MAD homolog 2 (Drosophila)	0.069
slc5a5	solute carrier family 5 (sodium iodide symporter), member 5	0.068
abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	0.068
hspd1	heat shock 60kD protein 1 (chaperonin)	0.066
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.065
sepw1	selenoprotein W, 1	0.064
junbl	jun B proto-oncogene, like	0.062
runx1	runt-related transcription factor 1	0.060
cdipt	CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)	0.057
bbc3	BCL2 binding component 3	0.056
gclc	glutamate-cysteine ligase, catalytic subunit	0.056	Human
chat	choline acetyltransferase	0.054
adipoql	adiponectin, C1Q and collagen domain containing, like	0.054	Mouse
pcsk2	proprotein convertase subtilisin/kexin type 2	0.053
nr1h3	nuclear receptor subfamily 1, group H, member 3	0.053
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.051	Human
sdha	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.050
bactin1	bactin1	0.050	Yeast
stac3	SH3 and cysteine rich domain 3	0.049
ndufb8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8	0.047
igfbp1a	insulin-like growth factor binding protein 1a	0.046
pdlim1	PDZ and LIM domain 1 (elfin)	0.045
zbtb4	zinc finger and BTB domain containing 4	0.044
evx1	even-skipped homeobox 1	0.044
myhc4	myosin heavy chain 4	0.044
pikfyve	phosphoinositide kinase, FYVE finger containing	0.044
prox1	prospero-related homeobox gene 1	0.044
zgc:101071	zgc:101071	0.043
cdh1	cadherin 1, epithelial	0.043
grb10a	growth factor receptor-bound protein 10a	0.042
zgc:64133	zgc:64133	0.042
gpx4b	glutathione peroxidase 4b	0.041
tnni1al	troponin I, skeletal, slow like	0.041
col4a5	collagen, type IV, alpha 5 (Alport syndrome)	0.041
fam60al	family with sequence similarity 60, member A, like	0.040
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.039
tcf7l2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.038
rpsa	ribosomal protein SA	0.038
appa	amyloid beta (A4) precursor protein a	0.037	Mouse
hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase	0.037
rpz	rapunzel	0.037
col12a1	collagen, type XII, alpha 1	0.037
tpma	alpha-tropomyosin	0.037
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.036
mdm2	transformed 3T3 cell double minute 2 homolog (mouse)	0.035
btg1	B-cell translocation gene 1	0.035
arl6	ADP-ribosylation factor-like 6	0.034
hbaa1	hemoglobin alpha adult-1	0.033
dvl3	dishevelled, dsh homolog 3 (Drosophila)	0.033
tbx20	T-box 20	0.032
mapk7	mitogen-activated protein kinase 7	0.031	Human
smc1al	structural maintenance of chromosomes 1A, like	0.031
gapdhs	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.030
cyp1a	cytochrome P450, family 1, subfamily A	0.030
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.030
tkt	transketolase	0.030
mstnb	myostatin b	0.029
zgc:55813	zgc:55813	0.029
zgc:101724	zgc:101724	0.029
limk2	LIM domain kinase 2	0.028
aldocb	aldolase C, fructose-bisphosphate, b	0.028
nr4a1	nuclear receptor subfamily 4, group A, member 1	0.028
LOC567131	calcitonin gene-related peptide type 1 receptor-like	0.028
pdlim3b	PDZ and LIM domain 3b	0.028
zgc:66391	zgc:66391	0.028
itgb1a	integrin, beta 1a	0.026
zgc:64114	zgc:64114	0.026	Fly
spred1	sprouty-related, EVH1 domain containing 1	0.026
ncoa2	nuclear receptor coactivator 2	0.026
mapk14a	mitogen-activated protein kinase 14a	0.026
tnnt3b	troponin T3b, skeletal, fast	0.026
tg	thyroglobulin	0.025
suclg1	succinate-CoA ligase, GDP-forming, alpha subunit	0.025
nme2b.1	non-metastatic cells 2b.1, protein (NM23B) expressed in	0.025
ndel1a	nudE nuclear distribution gene E homolog like 1 (A. nidulans) A	0.025
mapk6	mitogen-activated protein kinase 6	0.025
actn1	actinin, alpha 1	0.025
phox2a	paired-like homeobox 2a	0.025
dag1	dystroglycan 1	0.024
ubb	ubiquitin B	0.024
pou4f1	POU domain, class 4, transcription factor 1	0.024
cryba1l	crystallin, beta A1, like	0.024
tyr	tyrosinase	0.024
crh	corticotropin releasing hormone	0.024
zgc:73198	zgc:73198	0.024
zgc:73293	zgc:73293	0.024
junb	jun B proto-oncogene	0.024
dcc	deleted in colorectal carcinoma	0.024
gro2	groucho 2	0.024
tshr	thyroid stimulating hormone receptor	0.023
mcl1a	myeloid cell leukemia sequence 1a	0.023	Human Mouse
elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.023
tk2	thymidine kinase 2, mitochondrial	0.023
ash2l	ash2 (absent, small, or homeotic)-like (Drosophila)	0.023
micall1	MICAL-like 1	0.023
trpc6	transient receptor potential cation channel, subfamily C, member 6	0.022
cdh4	cadherin 4, retinal	0.022
barhl1.2	BarH-like 1.2	0.022
etfa	electron-transfer-flavoprotein, alpha polypeptide	0.022
igf1ra	insulin-like growth factor 1a receptor	0.022	Worm Fly
cacnb2a	calcium channel, voltage-dependent, beta 2a	0.022
hmga1a	high mobility group AT-hook 1a	0.022
ahr2	aryl hydrocarbon receptor 2	0.022
celsr1b	cadherin EGF LAG seven-pass G-type receptor 1b	0.022
mknk2b	MAP kinase-interacting serine/threonine kinase 2b	0.021
ar	androgen receptor	0.021
uxs1	UDP-glucuronic acid decarboxylase 1	0.021
spg11	spastic paraplegia 11	0.021
echs1	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	0.021
bactin2	bactin2	0.021	Yeast
txnrd1	thioredoxin reductase 1	0.021
cx43	connexin 43	0.021
mrpl38	mitochondrial ribosomal protein L38	0.021
ctsl1a	cathepsin L, 1 a	0.021
itgb1b.2	integrin, beta 1b.2	0.020
nr0b1	nuclear receptor subfamily 0, group B, member 1	0.020
calca	calcitonin/calcitonin-related polypeptide, alpha	0.020
rasgef1ba	RasGEF domain family, member 1Ba	0.020
nrg2b	neuregulin 2b	0.020
LOC568107	Iodotyrosine dehalogenase 1-like	0.020
hadha	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit	0.020
ivd	isovaleryl Coenzyme A dehydrogenase	0.020
yod1	YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae)	0.020
arntl1a	aryl hydrocarbon receptor nuclear translocator-like 1a	0.020	Mouse
mt2	metallothionein 2	0.020
sat1b	spermidine/spermine N1-acetyl transferase 1b	0.020
rhoab	ras homolog gene family, member Ab	0.019
cry2a	cryptochrome 2a	0.019	Zebrafish
nf1a	neurofibromin 1a	0.019	Fly
cbr1l	carbonyl reductase 1-like	0.019
hmbsb	hydroxymethylbilane synthase, b	0.019
atp2a1l	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 like	0.019
atp5g	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9)	0.019
mmp9	matrix metalloproteinase 9	0.019
gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.019
zgc:162126	zgc:162126	0.019
frem3	Fras1 related extracellular matrix 3	0.018
baxa	bcl2-associated X protein, a	0.018
ncf1	neutrophil cytosolic factor 1	0.018
ptprsa	protein tyrosine phosphatase, receptor type, s, a	0.018
ihha	Indian hedgehog homolog a	0.018
zgc:56136	zgc:56136	0.018
zgc:92533	zgc:92533	0.018
nfe2l3	nuclear factor (erythroid-derived 2)-like 3	0.017
p2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.017
zgc:101000	zgc:101000	0.017
eml2	echinoderm microtubule associated protein like 2	0.017
ogt.1	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 1	0.017
lingo1a	leucine rich repeat and Ig domain containing 1a	0.017
xylt1	xylosyltransferase 1	0.017
LOC100004946	transient receptor potential cation channel subfamily M member 4-like	0.017
col5a1	procollagen, type V, alpha 1	0.016
notch1b	notch homolog 1b	0.016
actn3a	actinin alpha 3a	0.016
adora2aa	adenosine A2a receptor a	0.016
fundc1	FUN14 domain containing 1	0.016
pias4a	protein inhibitor of activated STAT, 4a	0.016
rps6ka1	ribosomal protein S6 kinase a, polypeptide 1	0.016
bmp2b	bone morphogenetic protein 2b	0.016
prkci	protein kinase C, iota	0.016
ndufb6	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6	0.015
nfe2l2	nuclear factor (erythroid-derived 2)-like 2	0.015
zgc:153063	zgc:153063	0.015
yes1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.015
naa50	N(alpha)-acetyltransferase 50, NatE catalytic subunit	0.015
igf2a	insulin-like growth factor 2a	0.015
socs3a	suppressor of cytokine signaling 3a	0.015
zmynd11	zinc finger, MYND domain containing 11	0.015
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.015
mbnl2	muscleblind-like 2 (Drosophila)	0.015
chrna6	cholinergic receptor, nicotinic, alpha 6	0.015
ckmt2	creatine kinase, mitochondrial 2 (sarcomeric)	0.015
zgc:92903	zgc:92903	0.015	Human
ndufs7	NADH dehydrogenase (ubiquinone) Fe-S protein 7, (NADH-coenzyme Q reductase)	0.015
vsx2	visual system homeobox 2	0.015
apoeb	apolipoprotein Eb	0.015	Mouse
cbx1a	chromobox homolog 1a (HP1 beta homolog Drosophila)	0.015
zgc:56518	zgc:56518	0.015
cdc37	cell division cycle 37 homolog (S. cerevisiae)	0.014
ptena	phosphatase and tensin homolog A	0.014
ptprn2l	protein tyrosine phosphatase, receptor type, N polypeptide 2, like	0.014
zgc:103652	zgc:103652	0.014
slc12a9	solute carrier family 12 (potassium/chloride transporters), member 9	0.014
ccdc151	coiled-coil domain containing 151	0.014
acta1b	actin, alpha 1b, skeletal muscle	0.014
atp1a3b	ATPase, Na+/K+ transporting, alpha 3b polypeptide	0.014
ctbp2l	C-terminal binding protein 2, like	0.014
mycbp2	MYC binding protein 2	0.014
wnt11r	wingless-type MMTV integration site family, member 11, related	0.013
tufm	Tu translation elongation factor, mitochondrial	0.013
ndufa9	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9	0.013
cyp1b1	cytochrome P450, family 1, subfamily B, polypeptide 1	0.013	Mouse
ndufa8	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8	0.013
smad3b	MAD, mothers against decapentaplegic homolog 3b (Drosophila)	0.013
zgc:73329	zgc:73329	0.013
dync1h1	dynein, cytoplasmic 1, heavy chain 1	0.013
slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.013
igf1	insulin-like growth factor 1	0.013
cyb5r3	cytochrome b5 reductase 3	0.013
ulk2	unc-51-like kinase 2 (C. elegans)	0.013
epas1b	endothelial PAS domain protein 1b	0.013	Mouse
tgif1	TGFB-induced factor homeobox 1	0.013
id3	inhibitor of DNA binding 3	0.013
mcl1b	myeloid cell leukemia sequence 1b	0.013	Human Mouse
tef	thyrotroph embryonic factor	0.013
tgfbr2	transforming growth factor, beta receptor II	0.013
zgc:152873	zgc:152873	0.013
sps2	selenophosphate synthetase 2	0.013
npy8ar	neuropeptide Y receptor Y8a	0.013
edc4	enhancer of mRNA decapping 4	0.012
pth1a	parathyroid hormone 1a	0.012
rorca	RAR-related orphan receptor C a	0.012
eif3ea	eukaryotic translation initiation factor 3, subunit E, a	0.012
ldhba	lactate dehydrogenase Ba	0.012
alcama	activated leukocyte cell adhesion molecule a	0.012
lgi1b	leucine-rich, glioma inactivated 1b	0.012
aanat2	arylalkylamine N-acetyltransferase	0.012
tmf1	TATA element modulatory factor 1	0.012
hspe1	heat shock 10 protein 1 (chaperonin 10)	0.012
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.012
pbrm1l	polybromo 1, like	0.012
gpx4a	glutathione peroxidase 4a	0.012
ddx42	DEAD (Asp-Glu-Ala-Asp) box polypeptide 42	0.012
wisp1b	WNT1 inducible signaling pathway protein 1b	0.012
hoxc13b	homeo box C13b	0.012
cry4	cryptochrome 4	0.012	Zebrafish
tecrb	trans-2,3-enoyl-CoA reductase b	0.012
rspo3	R-spondin 3 homolog (Xenopus laevis)	0.012
smyhc2	slow myosin heavy chain 2	0.012	Rat
st3gal5l	ST3 beta-galactoside alpha-2,3-sialyltransferase 5, like	0.012
zgc:55262	zgc:55262	0.012
bnip3lb	BCL2/adenovirus E1B interacting protein 3-like b	0.012
tfe3a	transcription factor binding to IGHM enhancer 3a	0.012
lyrm1	LYR motif containing 1	0.012
cry-dash	cryptochrome DASH	0.012
insra	insulin receptor a	0.012	Worm Fly
nr1d1	nuclear receptor subfamily 1, group d, member 1	0.012
nr1d2b	nuclear receptor subfamily 1, group D, member 2b	0.012
adrb3a	adrenergic receptor, beta 3a	0.011
ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.011
baxb	bcl2-associated X protein, b	0.011
aif1l	allograft inflammatory factor 1-like	0.011
adh5	alcohol dehydrogenase 5	0.011
smyhc3	slow myosin heavy chain 3	0.011	Rat
nkx2.1a	NK2 homeobox 1a	0.011
olig4	oligodendrocyte transcription factor 4	0.011
gro1	groucho 1	0.011
ndufs8a	NADH dehydrogenase (ubiquinone) Fe-S protein 8a	0.011	Human
top2a	topoisomerase (DNA) II alpha	0.011
slu7	SLU7 splicing factor homolog (S. cerevisiae)	0.011
zgc:165373	zgc:165373	0.011
rbl1	retinoblastoma-like 1 (p107)	0.011
dedd1	death effector domain-containing 1	0.011
grnb	granulin b	0.011
pard3	par-3 partitioning defective 3 homolog (C. elegans)	0.011
thraa	thyroid hormone receptor alpha a	0.011
im:7138629	im:7138629	0.011
rps26l	ribosomal protein S26, like	0.011
uqcrc2a	ubiquinol-cytochrome c reductase core protein IIa	0.011
gdi2	GDP dissociation inhibitor 2	0.011
ube2r2	ubiquitin-conjugating enzyme E2R 2	0.011
pygl	phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)	0.011
mapk15	mitogen-activated protein kinase 15	0.011
ckma	creatine kinase, muscle a	0.011
golga1	golgin A1	0.011
nr5a1b	nuclear receptor subfamily 5, group A, member 1b	0.011
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.011
csnk1db	casein kinase 1, delta b	0.010
csnk1g2a	casein kinase 1, gamma 2a	0.010
slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.010
ndufb4	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4	0.010	Human
brd2a	bromodomain-containing 2a	0.010
rrm2b	ribonucleotide reductase M2 b	0.010	Mouse
slc16a3	solute carrier family 16 (monocarboxylic acid transporters), member 3	0.010
zbtb10	zinc finger and BTB domain containing 10	0.010
eng2a	engrailed 2a	0.010
polrmt	polymerase (RNA) mitochondrial (DNA directed)	0.010
tpm1	tropomyosin 1 (alpha)	0.010
inhbaa	inhibin, beta Aa	0.010
ptpra	protein tyrosine phosphatase, receptor type, A	0.010
oprd1b	opioid receptor, delta 1b	0.010
atf3	activating transcription factor 3	0.010
ptpro	protein tyrosine phosphatase, receptor type, O	0.010
srrm4	serine/arginine repetitive matrix 4	0.010