IMP

Process View

Danio rerio

2 genes annotated in zebrafish

response to nicotine

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "response to nicotine"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "response to nicotine" (in gray)

Name	Description	Probability	Func Analog Organism
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.704
uts1	urotensin 1	0.580
drd2b	dopamine receptor D2b	0.532	Rat
dab1a	disabled homolog 1a (Drosophila)	0.522
avpl	arginine vasopressin-like	0.415	Rat
drd2l	dopamine receptor D2 like	0.336
tfe3b	transcription factor binding to IGHM enhancer 3b	0.292
wnt9b	wingless-type MMTV integration site family, member 9B	0.252
wnt10a	wingless-type MMTV integration site family, member 10a	0.225
drd3	dopamine receptor D3	0.213
gfra1b	gdnf family receptor alpha 1b	0.210
sim1a	single-minded homolog 1a (Drosophila)	0.208
dbh	dopamine beta hydroxylase	0.197
pgd	phosphogluconate hydrogenase	0.171
satb2	SATB homeobox 2	0.169
chrna4	cholinergic receptor, nicotinic, alpha 4	0.168	Mouse
gria2b	glutamate receptor, ionotropic, AMPA 2b	0.158
ins	preproinsulin	0.156
gdnf	glial cell derived neurotrophic factor	0.138
sst2	somatostatin 2	0.131
prl	prolactin	0.127
snapc1b	small nuclear RNA activating complex, polypeptide 1b	0.119
ctsz	cathepsin Z	0.118
lhx3	LIM homeobox 3	0.113
efna5b	ephrin A5b	0.110
crestin	crestin	0.109
oxtl	oxytocin-like	0.096	Rat
spon1a	spondin 1a	0.091
gh1	growth hormone 1	0.088
arx	aristaless related homeobox	0.082
wnt9a	wingless-type MMTV integration site family, member 9A	0.077
si:ch211-212m21.5	si:ch211-212m21.5	0.076
pou4f2	POU domain, class 4, transcription factor 2	0.075
glra1	glycine receptor, alpha 1	0.069
mnx1	motor neuron and pancreas homeobox 1	0.069
per2	period homolog 2 (Drosophila)	0.066
gli2b	GLI-Kruppel family member GLI2b	0.063
adra2c	adrenergic, alpha-2C-, receptor	0.062
tgfb3	transforming growth factor, beta 3	0.062
nadl1.2	neural adhesion molecule L1.2	0.060
gad2	glutamate decarboxylase 2	0.057
nkx6.2	NK6 transcription factor related, locus 2	0.056
mc4r	melanocortin 4 receptor	0.055
ctrb1	chymotrypsinogen B1	0.054
stc1l	stanniocalcin 1, like	0.053
pax7a	paired box gene 7a	0.049
gfra1a	gdnf family receptor alpha 1a	0.048
wu:fc31g04	wu:fc31g04	0.048
chpf	chondroitin polymerizing factor	0.048
tfeb	transcription factor EB	0.047
npas2	neuronal PAS domain protein 2	0.046
ncam1b	neural cell adhesion molecule 1b	0.045
th	tyrosine hydroxylase	0.045	Rat
ela2l	elastase 2 like	0.044
ryr2a	ryanodine receptor 2a (cardiac)	0.043
fgf20a	fibroblast growth factor 20a	0.041
nog3	noggin 3	0.040
hlxb9la	homeo box HB9 like a	0.040
sst1.1	somatostatin 1, tandem duplicate 1	0.038
hcrt	hypocretin (orexin) neuropeptide precursor	0.038
adipor1b	adiponectin receptor 1b	0.038
flj13639	flj13639	0.037
otpa	orthopedia homolog a	0.037
nadl1.1	neural adhesion molecule L1.1	0.037
pax4	paired box 4	0.036
stap2b	signal transducing adaptor family member 2b	0.036
ctgf	connective tissue growth factor	0.035
rel	v-rel reticuloendotheliosis viral oncogene homolog	0.035
cnr1	cannabinoid receptor 1	0.035	Rat
th2	tyrosine hydroxylase 2	0.035
tln1	talin 1	0.033
mchr1a	melanin-concentrating hormone receptor 1a	0.033
rhogb	ras homolog gene family, member Gb	0.033
rx1	retinal homeobox gene 1	0.033
drd1	dopamine receptor D1	0.033	Rat
sox4b	SRY-box containing gene 4b	0.033
gcga	glucagon a and glucagon a-like	0.033
sema3ab	semaphorin 3ab	0.032
prkcz	protein kinase C, zeta	0.032
LOC790901	glucose-dependent insulinotropic polypeptide	0.031
cbr1l	carbonyl reductase 1-like	0.031
adra2a	adrenergic, alpha-2A-, receptor	0.031
grin1a	glutamate receptor, ionotropic, N-methyl D-aspartate 1a	0.030
rpl9	ribosomal protein L9	0.030
gdf6b	growth differentiation factor 6b	0.030
pcp4a	Purkinje cell protein 4a	0.030
si:dkey-78p20.2	si:dkey-78p20.2	0.029
ela3l	elastase 3 like	0.029
tbx15	T-box 15	0.028
cldnk	claudin k	0.027
ncam2	neural cell adhesion molecule 2	0.027
chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.027	Human Mouse
zgc:66382	zgc:66382	0.027
ca2	carbonic anhydrase II	0.026
caspa	caspase a	0.026
slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	0.026
bmp7b	bone morphogenetic protein 7b	0.026
cx27.5	connexin 27.5	0.026
mtnr1ba	melatonin receptor type 1B a	0.025
nrp1b	neuropilin 1b	0.025
dlx6a	distal-less homeobox gene 6a	0.025
ctrl	chymotrypsin-like	0.025
si:ch211-209p5.2	si:ch211-209p5.2	0.025
mpp1	membrane protein, palmitoylated 1	0.025
si:dkey-228g21.4	si:dkey-228g21.4	0.025
mmp9	matrix metalloproteinase 9	0.024
egr1	early growth response 1	0.024
dio2	deiodinase, iodothyronine, type II	0.024
tshb	thyroid stimulating hormone, beta subunit	0.024
zgc:92590	zgc:92590	0.024
tcf21	transcription factor 21	0.024
pomca	proopiomelanocortin a	0.023
syf2	SYF2 homolog, RNA splicing factor (S. cerevisiae)	0.023
cpa5	carboxypeptidase A5	0.023
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.023
runx2b	runt-related transcription factor 2b	0.023
drd2a	dopamine receptor D2a	0.023	Rat
zgc:92041	zgc:92041	0.023
im:7138016	im:7138016	0.023
wt1a	wilms tumor 1a	0.023
cpa4	carboxypeptidase A4	0.023
igf2a	insulin-like growth factor 2a	0.023
junb	jun B proto-oncogene	0.023
sc:d411	sc:d411	0.022
zgc:123180	zgc:123180	0.022
pdcd6	programmed cell death 6	0.022
gsx1	GS homeobox 1	0.022
npy8ar	neuropeptide Y receptor Y8a	0.022
il1b	interleukin 1, beta and interleukin 1, beta	0.022
adora2aa	adenosine A2a receptor a	0.022
kbtbd10b	kelch repeat and BTB (POZ) domain containing 10b	0.022
esr1	estrogen receptor 1	0.021
LOC556647	GDNF family receptor alpha-4-like	0.021
styk1	serine/threonine/tyrosine kinase 1	0.021
cpa2	carboxypeptidase A2 (pancreatic)	0.021
chrna6	cholinergic receptor, nicotinic, alpha 6	0.021
neurod2	neurogenic differentiation 2	0.021
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.021
napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.021
rpl37	ribosomal protein L37	0.021
scinla	scinderin like a	0.021
rs1	retinoschisis (X-linked, juvenile) 1	0.020
vps33b	vacuolar protein sorting 33B	0.020
ccbl1	cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase)	0.020
plagl2	pleiomorphic adenoma gene-like 2	0.020
smyd3	SET and MYND domain containing 3	0.020
wnt2ba	wingless-type MMTV integration site family, member 2Ba	0.020
chrm2a	cholinergic receptor, muscarinic 2a	0.020
runx2a	runt-related transcription factor 2a	0.020
nr4a2b	nuclear receptor subfamily 4, group A, member 2b	0.020
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.020
slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.020
cnga5	cyclic nucleotide gated channel alpha 5	0.020
hsd3b7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase	0.019
cct7	chaperonin containing TCP1, subunit 7 (eta)	0.019
adcyap1r1	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	0.019
tyr	tyrosinase	0.019
socs3a	suppressor of cytokine signaling 3a	0.019
mafk	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)	0.019
pyya	peptide YYa	0.018
cryaa	crystallin, alpha A	0.018
slc17a7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.018
acvr2a	activin receptor IIa	0.018
neurog3	neurogenin 3	0.018
cx35	connexin 35	0.018
mgp	matrix Gla protein	0.018
es1	es1 protein	0.018
ctsc	cathepsin C	0.018
nphs2	nephrosis 2, idiopathic, steroid-resistant (podocin)	0.018
esrrga	estrogen-related receptor gamma a	0.018
LOC799612	prolactin 2	0.018
pdlim4	PDZ and LIM domain 4	0.018
irf6	interferon regulatory factor 6	0.017
hapln1a	hyaluronan and proteoglycan link protein 1a	0.017
glud1a	glutamate dehydrogenase 1a	0.017
tgm2b	transglutaminase 2b	0.017
zgc:195195	zgc:195195	0.017
or115-15	odorant receptor, family F, subfamily 115, member 15	0.017
mkxa	mohawk homeobox a	0.017
cx55.5	connexin 55.5	0.017
ccdc65	coiled-coil domain containing 65	0.017
im:7154842	im:7154842	0.017
prox2	prospero homeobox 2	0.017
gnat1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	0.017
cpne3	copine III	0.017
gnrh2	gonadotropin-releasing hormone 2	0.017
sh3bp4a	SH3-domain binding protein 4a	0.017
foxa	forkhead box A sequence	0.017
sema3fb	semaphorin 3fb	0.016
nr0b1	nuclear receptor subfamily 0, group B, member 1	0.016
crygm2d1	crystallin, gamma M2d1	0.016
sp7	Sp7 transcription factor	0.016
tsc22d3	TSC22 domain family, member 3	0.016
entpd3	ectonucleoside triphosphate diphosphohydrolase 3	0.016
has3	hyaluronan synthase 3	0.016
zgc:158494	zgc:158494	0.016
zgc:152830	zgc:152830	0.016
ripk2	receptor-interacting serine-threonine kinase 2	0.016
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.016
LOC572430	e3 ubiquitin-protein ligase HACE1-like	0.016
sst3	somatostatin 3	0.016
lhx6	LIM homeobox 6	0.015
tert	telomerase reverse transcriptase	0.015
foxa1	forkhead box A1	0.015
eif4a1b	eukaryotic translation initiation factor 4A, isoform 1B	0.015
pth2	parathyroid hormone 2	0.015
ddc	dopa decarboxylase	0.015
ikbkg	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.015
mstnb	myostatin b	0.015
znf536	zinc finger protein 536	0.015
esrrb	estrogen-related receptor beta	0.015
mt2	metallothionein 2	0.015
nr1d1	nuclear receptor subfamily 1, group d, member 1	0.015
sult2st1	sulfotransferase family 2, cytosolic sulfotransferase 1	0.015
zgc:66286	zgc:66286	0.015
tas1r1	taste receptor, type 1, member 1	0.015
nfasca	neurofascin homolog (chicken) a	0.015
aldoca	aldolase C, fructose-bisphosphate, a	0.015
zgc:112072	zgc:112072	0.015
cart1	cartilage paired-class homeoprotein 1	0.015
uts2b	urotensin 2, beta	0.015
wipi2	WD repeat domain, phosphoinositide interacting 2	0.015
ctsba	cathepsin B, a	0.014
zgc:110343	zgc:110343	0.014
gnpnat1	glucosamine-phosphate N-acetyltransferase 1	0.014
cadm1a	cell adhesion molecule 1a	0.014
grm5a	glutamate receptor, metabotropic 5a	0.014
plce1	phospholipase C, epsilon 1	0.014
ntf7	neurotrophin 7	0.014
LOC566572	novel protein similar to H.sapiens LRRC4, leucine rich repeat containing 4 (LRRC4)	0.014
tph2	tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)	0.014
lrig3	leucine-rich repeats and immunoglobulin-like domains 3	0.014
acot11a	acyl-CoA thioesterase 11a	0.014
mhc2dcb	major histocompatibility complex class II DCB gene	0.014
hspb8	heat shock protein, alpha-crystallin-related, b8	0.014
ptp4a1	protein tyrosine phosphatase type IVA, member 1	0.014
ca10a	carbonic anhydrase Xa	0.014
zgc:163093	zgc:163093	0.014
efhc1	EF-hand domain (C-terminal) containing 1	0.014
grm1a	glutamate receptor, metabotropic 1a	0.014
crygs2	crystallin, gamma S2	0.014
im:7148468	im:7148468	0.014
reln	reelin	0.014
serpinb1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.014
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.014
si:ch211-89p1.1	si:ch211-89p1.1	0.013
phox2b	paired-like homeobox 2b	0.013
zgc:112986	zgc:112986	0.013
eif4ebp3	eukaryotic translation initiation factor 4E binding protein 3	0.013
top2b	topoisomerase (DNA) II beta	0.013
pdx1	pancreatic and duodenal homeobox 1	0.013
ndrg1	N-myc downstream regulated gene 1	0.013
cul2	cullin 2	0.013
rhof	ras homolog gene family, member F	0.013
hoxa13a	homeo box A13a	0.013
tm4sf4	transmembrane 4 L six family member 4	0.013
cldn15lb	claudin 15-like b	0.013
tal2	T-cell acute lymphocytic leukemia 2	0.013
ppdpfb	pancreatic progenitor cell differentiation and proliferation factor b	0.013
foxe3	forkhead box E3	0.013
vipr2	vasoactive intestinal peptide receptor 2	0.013
ihhb	Indian hedgehog homolog b	0.013
zgc:101650	zgc:101650	0.013
zgc:162165	zgc:162165	0.013
per1b	period homolog 1b (Drosophila)	0.013
rwdd3	RWD domain containing 3	0.013
rab5c	RAB5C, member RAS oncogene family	0.013
mid2	midline 2	0.013
oprk1	opioid receptor, kappa 1	0.013
zgc:86757	zgc:86757	0.012
LOC568484	glutamate receptor, metabotropic	0.012
zfp36l1b	zinc finger protein 36, C3H type-like 1b	0.012
adrb3a	adrenergic receptor, beta 3a	0.012
zgc:92758	zgc:92758	0.012
pitrm1	pitrilysin metalloproteinase 1	0.012
npy8br	neuropeptide Y receptor Y8b	0.012
tmem68	transmembrane protein 68	0.012
ivd	isovaleryl Coenzyme A dehydrogenase	0.012
hs3st3b1b	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b	0.012
ca5	carbonic anhydrase V	0.012
zgc:77906	zgc:77906	0.012
igfbp2b	insulin-like growth factor binding protein 2b	0.012
arfgap3	ADP-ribosylation factor GTPase activating protein 3	0.012
zfyve27	zinc finger, FYVE domain containing 27	0.012
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.012
ntrk3b	neurotrophic tyrosine kinase, receptor, type 3b	0.012
pls3	plastin 3 (T isoform)	0.012
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.012
renbp	renin binding protein	0.012
opn1lw1	opsin 1 (cone pigments), long-wave-sensitive, 1	0.012
cp	ceruloplasmin	0.012
entpd2a.2	ectonucleoside triphosphate diphosphohydrolase 2 a.2	0.012
LOC556841	novel protein similar to vertebrate potassium voltage-gated channel, KQT-like subfamily, member 5 (KCNQ5)	0.012
acox1	acyl-Coenzyme A oxidase 1, palmitoyl	0.012
pou4f1	POU domain, class 4, transcription factor 1	0.012
nedd4l	neural precursor cell expressed, developmentally down-regulated 4-like	0.012
atoh1a	atonal homolog 1a	0.012
becn1	beclin 1 (coiled-coil, myosin-like BCL2 interacting protein)	0.012
bsk146	brain specific kinase 146	0.012
adra2b	adrenergic, alpha-2B-, receptor	0.012
zgc:113312	zgc:113312	0.012
utx	ubiquitously transcribed tetratricopeptide repeat, X chromosome	0.011
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.011
cul1b	cullin 1b	0.011
lpin1	lipin 1	0.011
osr2	odd-skipped related 2 (Drosophila)	0.011
crabp1b	cellular retinoic acid binding protein 1b	0.011
LOC559012	transglutaminase 2-like	0.011
fam49bb	family with sequence similarity 49, member Bb	0.011
olfm2	olfactomedin 2	0.011
LOC798577	NT-3 growth factor receptor-like	0.011
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.011
LOC556849	ectonucleoside triphosphate diphosphohydrolase 5-like	0.011
cyb5r3	cytochrome b5 reductase 3	0.011
cadm1b	cell adhesion molecule 1b	0.011
gclc	glutamate-cysteine ligase, catalytic subunit	0.011
zgc:172101	zgc:172101	0.011
ophn1	oligophrenin 1	0.011
ocrl	oculocerebrorenal syndrome of Lowe	0.011
bmp6	bone morphogenetic protein 6	0.011
itm2bb	integral membrane protein 2Bb	0.011
unc5c	unc-5 homolog C (C. elegans)	0.011
ttc22	tetratricopeptide repeat domain 22	0.011
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.011
egln3	egl nine homolog 3 (C. elegans)	0.011
map4k5	mitogen-activated protein kinase kinase kinase kinase 5	0.011
phospho1	phosphatase, orphan 1	0.011
sqstm1	sequestosome 1	0.011
barhl1.1	BarH-like 1.1	0.011
sat1a	spermidine/spermine N1-acetyltransferase 1a	0.011
chrnb3b	cholinergic receptor, nicotinic, beta polypeptide 3b	0.011
psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.011
crebbpb	CREB binding protein b	0.011
taf13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.011
usp9	ubiquitin specific peptidase 9	0.011
msi1	musashi homolog 1 (Drosophila)	0.011
dnm2	dynamin 2	0.011
zgc:162630	zgc:162630	0.011
slc4a2b	solute carrier family 4, anion exchanger, member 2b	0.011
mtmr6	myotubularin related protein 6	0.011
glra4b	glycine receptor, alpha 4b	0.011
loxl3b	lysyl oxidase-like 3b	0.011
ncf1	neutrophil cytosolic factor 1	0.011
tnip1	TNFAIP3 interacting protein 1	0.011
hcrtr2	hypocretin (orexin) receptor 2	0.011
sra1	steroid receptor RNA activator 1	0.011
adrb2a	adrenergic receptor, beta 2a	0.011
crh	corticotropin releasing hormone	0.011
ociad1	OCIA domain containing 1	0.010
zgc:171872	zgc:171872	0.010
pi4kaa	phosphatidylinositol 4-kinase, catalytic, alpha a	0.010
lgi1b	leucine-rich, glioma inactivated 1b	0.010
adh5	alcohol dehydrogenase 5	0.010
hdc	histidine decarboxylase	0.010
rhag	Rhesus blood group-associated glycoprotein	0.010
csnk1g2a	casein kinase 1, gamma 2a	0.010
entpd2a.1	ectonucleoside triphosphate diphosphohydrolase 2 a.1	0.010
slc26a6l	solute carrier family 26, member 6, like	0.010
cyp3a65	cytochrome P450, family 3, subfamily A, polypeptide 65	0.010
vps13a	vacuolar protein sorting 13 homolog A (S. cerevisiae)	0.010
h2afy	H2A histone family, member Y	0.010
LOC100002494	relaxin/insulin-like family peptide receptor 3-like	0.010
crb3b	crumbs homolog 3b	0.010
COX1	cytochrome c oxidase subunit I	0.010
rab11bb	RAB11B, member RAS oncogene family, b	0.010
ntrk2a	neurotrophic tyrosine kinase, receptor, type 2a	0.010
tipin	timeless interacting protein	0.010
jak1	Janus kinase 1	0.010
LOC100330335	uncharacterized protein C8orf74 homolog	0.010
zgc:91890	zgc:91890	0.010
ap3m1	adaptor-related protein complex 3, mu 1 subunit	0.010
aldh2a	aldehyde dehydrogenase 2 family (mitochondrial)a	0.010
cpa1	carboxypeptidase A1 (pancreatic)	0.010
sort1a	sortilin 1a	0.010
slc18a2	solute carrier family 18 (vesicular monoamine), member 2	0.010
mical3	flavoprotein oxidoreductase MICAL3	0.010
greb1l	growth regulation by estrogen in breast cancer-like	0.010
exoc2	exocyst complex component 2	0.010
nek4	NIMA (never in mitosis gene a)-related kinase 4	0.010
zgc:158387	zgc:158387	0.010
LOC567384	interferon-induced protein with tetratricopeptide repeats 5-like	0.010
cel.1	carboxyl ester lipase, tandem duplicate 1	0.010
stxbp2	syntaxin binding protein 2	0.010
nt5c2b	5'-nucleotidase, cytosolic IIb	0.010
guca1d	guanylate cyclase activator 1d	0.010
crb2b	crumbs homolog 2b	0.010
stx1b	syntaxin 1B	0.010
cript	cysteine-rich PDZ-binding protein	0.010
fgf6a	fibroblast growth factor 6a	0.010
lamb2l	laminin, beta 2-like	0.010
c6	complement component 6	0.010
acadvl	acyl-Coenzyme A dehydrogenase, very long chain	0.010
tas2r200.1	taste receptor, type 2, member 200.1	0.010
cdh4	cadherin 4, retinal	0.010