IMP
Process View
The network for 'negative regulation of leukocyte activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of leukocyte activation
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| B2M | beta-2-microglobulin | 0.965 | |
| HLA-C | major histocompatibility complex, class I, C | 0.964 | |
| HLA-B | major histocompatibility complex, class I, B | 0.949 | |
| CD80 | CD80 molecule | 0.929 | |
| HLA-A | major histocompatibility complex, class I, A | 0.875 | |
| PSTPIP1 | proline-serine-threonine phosphatase interacting protein 1 | 0.825 | |
| HLA-G | major histocompatibility complex, class I, G | 0.793 | |
| HLA-E | major histocompatibility complex, class I, E | 0.785 | |
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.746 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.698 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.611 | |
| CCR5 | chemokine (C-C motif) receptor 5 | 0.477 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.470 | |
| HLA-F | major histocompatibility complex, class I, F | 0.419 | |
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 | 0.396 | |
| LILRB1 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | 0.373 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.319 | |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.299 | |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.259 | |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.230 | |
| CD86 | CD86 molecule | 0.226 | |
| PILRA | paired immunoglobin-like type 2 receptor alpha | 0.210 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.199 | |
| FSTL1 | follistatin-like 1 | 0.193 | |
| IL2RG | interleukin 2 receptor, gamma | 0.188 | |
| IL4R | interleukin 4 receptor | 0.174 | |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | 0.172 | |
| UBC | ubiquitin C | 0.168 | |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.167 | |
| IL10 | interleukin 10 | 0.157 | |
| POU5F1 | POU class 5 homeobox 1 | 0.148 | |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.143 | |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.138 | |
| BLNK | B-cell linker | 0.133 | |
| CASP9 | caspase 9, apoptosis-related cysteine peptidase | 0.131 | |
| DRD2 | dopamine receptor D2 | 0.125 | |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.123 | |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 0.122 | |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.119 | |
| CD33 | CD33 molecule | 0.117 | |
| LILRB2 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 | 0.116 | |
| LILRB3 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 | 0.106 | |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.106 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.106 | |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.105 | |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 0.104 | |
| RNF11 | ring finger protein 11 | 0.103 | |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.102 | |
| PAX3 | paired box 3 | 0.094 | |
| SYK | spleen tyrosine kinase | 0.091 | |
| POU3F2 | POU class 3 homeobox 2 | 0.088 | |
| GAS6 | growth arrest-specific 6 | 0.086 | |
| IL10RA | interleukin 10 receptor, alpha | 0.083 | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.081 | |
| SIGLEC7 | sialic acid binding Ig-like lectin 7 | 0.081 | |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.080 | |
| CTLA4 | cytotoxic T-lymphocyte-associated protein 4 | 0.080 | |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.079 | |
| EPOR | erythropoietin receptor | 0.079 | |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.078 | |
| TRAF6 | TNF receptor-associated factor 6 | 0.075 | |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.072 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.071 | |
| TFF1 | trefoil factor 1 | 0.065 | |
| CCR1 | chemokine (C-C motif) receptor 1 | 0.063 | |
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.063 | |
| IL2RA | interleukin 2 receptor, alpha | 0.061 | |
| ICAM1 | intercellular adhesion molecule 1 | 0.060 | |
| CCL7 | chemokine (C-C motif) ligand 7 | 0.058 | |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.058 | |
| LAT | linker for activation of T cells | 0.058 | |
| XIAP | X-linked inhibitor of apoptosis | 0.058 | |
| APAF1 | apoptotic peptidase activating factor 1 | 0.057 | |
| HK3 | hexokinase 3 (white cell) | 0.056 | |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.056 | |
| GHR | growth hormone receptor | 0.054 | |
| IL22RA1 | interleukin 22 receptor, alpha 1 | 0.053 | |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.051 | |
| TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.051 | |
| CD163 | CD163 molecule | 0.048 | |
| TAPBP | TAP binding protein (tapasin) | 0.048 | |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.047 | |
| PINK1 | PTEN induced putative kinase 1 | 0.047 | |
| LILRA2 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | 0.047 | |
| CSK | c-src tyrosine kinase | 0.046 | |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.045 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.045 | |
| NLRP3 | NLR family, pyrin domain containing 3 | 0.043 | |
| IL4 | interleukin 4 | 0.042 | |
| CCR4 | chemokine (C-C motif) receptor 4 | 0.042 | |
| FPR3 | formyl peptide receptor 3 | 0.042 | |
| MICA | MHC class I polypeptide-related sequence A | 0.042 | |
| CCL11 | chemokine (C-C motif) ligand 11 | 0.042 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.041 | |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.041 | |
| TAP2 | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) | 0.041 | |
| HCK | hemopoietic cell kinase | 0.040 | |
| FASLG | Fas ligand (TNF superfamily, member 6) | 0.040 | |
| TNF | tumor necrosis factor | 0.039 | |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.038 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| RT1-Ba | RT1 class II, locus Ba | 0.540 | |
| Cd74 | Cd74 molecule, major histocompatibility complex, class II invariant chain | 0.293 | |
| RT1-Da | RT1 class II, locus Da | 0.269 | |
| RT1-DMb | RT1 class II, locus DMb | 0.170 | |
| RT1-Db1 | RT1 class II, locus Db1 | 0.083 | |
| RT1-Bb | RT1 class II, locus Bb | 0.048 | |
| Lyz2 | lysozyme 2 | 0.022 | |
| Cd5 | Cd5 molecule | 0.022 | |
| Cd2 | Cd2 molecule | 0.017 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.015 | |
| Dchs1 | dachsous 1 (Drosophila) | 0.015 | |
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.013 | |
| Il17ra | interleukin 17 receptor A | 0.013 | |
| Aif1 | allograft inflammatory factor 1 | 0.012 | |
| Aebp1 | AE binding protein 1 | 0.010 |