The network for 'regulation of stress fiber assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of stress fiber assembly

Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.000
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 1.000
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.993
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.992
FN1 fibronectin 1 0.968
RHOA ras homolog gene family, member A 0.965
BAIAP2 BAI1-associated protein 2 0.915
S100A8 S100 calcium binding protein A8 0.791
S100A6 S100 calcium binding protein A6 0.783
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.778
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.710
ZYX zyxin 0.670
FLNA filamin A, alpha 0.567
S100B S100 calcium binding protein B 0.502
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.491
S100A11 S100 calcium binding protein A11 0.437
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.437
S100A9 S100 calcium binding protein A9 0.431
FBLN1 fibulin 1 0.430
S100A1 S100 calcium binding protein A1 0.401
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.393
RHOC ras homolog gene family, member C 0.377
ANXA2 annexin A2 0.347
ARHGAP1 Rho GTPase activating protein 1 0.319
ACTB actin, beta 0.315
CTGF connective tissue growth factor 0.267
S100A4 S100 calcium binding protein A4 0.262
FYN FYN oncogene related to SRC, FGR, YES 0.254
LMNA lamin A/C 0.245
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.238
HTT huntingtin 0.238
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.230
LGALS1 lectin, galactoside-binding, soluble, 1 0.229
PXN paxillin 0.218
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.202
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.186
ACTG1 actin, gamma 1 0.176
SH3KBP1 SH3-domain kinase binding protein 1 0.164
VAV1 vav 1 guanine nucleotide exchange factor 0.162
EZR ezrin 0.158
PFN1 profilin 1 0.151
MYO10 myosin X 0.139
PALLD palladin, cytoskeletal associated protein 0.137
EPS8 epidermal growth factor receptor pathway substrate 8 0.132
NCF2 neutrophil cytosolic factor 2 0.122
EMP3 epithelial membrane protein 3 0.119
SH3RF3 SH3 domain containing ring finger 3 0.103
RHOG ras homolog gene family, member G (rho G) 0.102
HP haptoglobin 0.101
PLEC plectin 0.099
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.097
IQGAP1 IQ motif containing GTPase activating protein 1 0.096
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.092
MSN moesin 0.091
SFN stratifin 0.087
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.085
ANXA5 annexin A5 0.082
MYH9 myosin, heavy chain 9, non-muscle 0.079
ENG endoglin 0.077
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.075
SCHIP1 schwannomin interacting protein 1 0.075
NCKAP1 NCK-associated protein 1 0.075
APOC1 apolipoprotein C-I 0.073
RAP1A RAP1A, member of RAS oncogene family 0.069
SORBS3 sorbin and SH3 domain containing 3 0.067
ACTN1 actinin, alpha 1 0.062
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.060
TMSB10 thymosin beta 10 0.060
ALB albumin 0.057
CYR61 cysteine-rich, angiogenic inducer, 61 0.056
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.055
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.053
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.052
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.051
A2M alpha-2-macroglobulin 0.049
CAPG capping protein (actin filament), gelsolin-like 0.047
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.047
VASP vasodilator-stimulated phosphoprotein 0.047
APOC3 apolipoprotein C-III 0.046
CD44 CD44 molecule (Indian blood group) 0.045
FLNB filamin B, beta 0.044
WASL Wiskott-Aldrich syndrome-like 0.044
DLG5 discs, large homolog 5 (Drosophila) 0.044
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.042
LCAT lecithin-cholesterol acyltransferase 0.041
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.041
WASF1 WAS protein family, member 1 0.040
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.039
AREG amphiregulin 0.039
SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 0.039
AGTPBP1 ATP/GTP binding protein 1 0.039
FMNL1 formin-like 1 0.039
DIAPH1 diaphanous homolog 1 (Drosophila) 0.038
RPTOR regulatory associated protein of MTOR, complex 1 0.038
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.038
AMOTL2 angiomotin like 2 0.036
CALD1 caldesmon 1 0.036
UNC119 unc-119 homolog (C. elegans) 0.035
BCAR1 breast cancer anti-estrogen resistance 1 0.035
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.035
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
msn misshapen 0.516
Cip4 CG15015 gene product from transcript CG15015-RA 0.356
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.199
htl heartless 0.134
mys myospheroid 0.116
Rac1 CG2248 gene product from transcript CG2248-RA 0.086
Ras85D Ras oncogene at 85D 0.069
Cdc42 CG12530 gene product from transcript CG12530-RA 0.060
par-1 CG8201 gene product from transcript CG8201-RA 0.059
if inflated 0.056
ttk tramtrack 0.056
mbc myoblast city 0.054
katanin-60 katanin 60 0.050
Pak PAK-kinase 0.047
Pten CG5671 gene product from transcript CG5671-RB 0.047
Rho1 CG8416 gene product from transcript CG8416-RB 0.042
drpr draper 0.039
Akt1 CG4006 gene product from transcript CG4006-RA 0.036
plexB plexin B 0.027
CG17082 CG17082 gene product from transcript CG17082-RD 0.026
Rab5 Rab-protein 5 0.024
Ephrin CG1862 gene product from transcript CG1862-RA 0.020
babo baboon 0.020
Hnf4 Hepatocyte nuclear factor 4 0.020
how held out wings 0.019
CG14869 CG14869 gene product from transcript CG14869-RB 0.017
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.017
arr arrow 0.016
neur neuralized 0.016
Dab Disabled 0.015
bsk basket 0.015
trio CG18214 gene product from transcript CG18214-RA 0.015
Atg1 Autophagy-specific gene 1 0.015
Pak3 CG14895 gene product from transcript CG14895-RA 0.014
crb crumbs 0.014
wun wunen 0.014
csw corkscrew 0.014
RhoL rho-like 0.013
Dad Daughters against dpp 0.012
usp ultraspiracle 0.012
Abl Abl tyrosine kinase 0.012
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.012
puc puckered 0.012
scb scab 0.011
ttv tout-velu 0.011
Pkn Protein kinase related to protein kinase N 0.011
drk downstream of receptor kinase 0.011
dia diaphanous 0.011
Pvr PDGF- and VEGF-receptor related 0.011
ena enabled 0.011
baz bazooka 0.011
Btk29A Btk family kinase at 29A 0.011
CG10743 CG10743 gene product from transcript CG10743-RB 0.010
Rala Ras-related protein 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Apc adenomatosis polyposis coli 0.776
Ctnnb1 catenin (cadherin associated protein), beta 1 0.754
Rac1 RAS-related C3 botulinum substrate 1 0.711
Efnb2 ephrin B2 0.503
Nf2 neurofibromatosis 2 0.455
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.401
Ephb2 Eph receptor B2 0.366
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.356
Tsc2 tuberous sclerosis 2 0.355
Gdnf glial cell line derived neurotrophic factor 0.295
Ret ret proto-oncogene 0.245
Lepr leptin receptor 0.234
Apoe apolipoprotein E 0.209
Lama5 laminin, alpha 5 0.208
Itga3 integrin alpha 3 0.189
Ptgs2 prostaglandin-endoperoxide synthase 2 0.171
Itgb3 integrin beta 3 0.170
Vdr vitamin D receptor 0.167
Bcl2 B-cell leukemia/lymphoma 2 0.161
Pxn paxillin 0.161
Wnt4 wingless-related MMTV integration site 4 0.160
Rnd3 Rho family GTPase 3 0.151
Ephb3 Eph receptor B3 0.138
Actb actin, beta 0.125
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.101
Amhr2 anti-Mullerian hormone type 2 receptor 0.098
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.097
Wnt2b wingless related MMTV integration site 2b 0.089
Vasp vasodilator-stimulated phosphoprotein 0.087
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.084
Wdr1 WD repeat domain 1 0.084
Enah enabled homolog (Drosophila) 0.083
Capzb capping protein (actin filament) muscle Z-line, beta 0.082
Nf1 neurofibromatosis 1 0.081
Jup junction plakoglobin 0.078
Plec plectin 0.078
Wnt6 wingless-related MMTV integration site 6 0.076
Efnb1 ephrin B1 0.076
Esr2 estrogen receptor 2 (beta) 0.075
Tsc1 tuberous sclerosis 1 0.074
Tead3 TEA domain family member 3 0.070
Rictor RPTOR independent companion of MTOR, complex 2 0.070
Tbx2 T-box 2 0.068
Kit kit oncogene 0.060
Mapkap1 mitogen-activated protein kinase associated protein 1 0.059
Eng endoglin 0.059
Efna4 ephrin A4 0.056
Hic1 hypermethylated in cancer 1 0.055
Gata5 GATA binding protein 5 0.054
Trp73 transformation related protein 73 0.053
Ar androgen receptor 0.053
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.050
Lhx1 LIM homeobox protein 1 0.050
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.047
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.047
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.046
Fzd2 frizzled homolog 2 (Drosophila) 0.045
Notch2 Notch gene homolog 2 (Drosophila) 0.043
Lrp5 low density lipoprotein receptor-related protein 5 0.043
Col13a1 collagen, type XIII, alpha 1 0.042
Fgf18 fibroblast growth factor 18 0.042
Porcn porcupine homolog (Drosophila) 0.042
Rint1 RAD50 interactor 1 0.042
Wnt2 wingless-related MMTV integration site 2 0.041
Capn2 calpain 2 0.041
Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.041
Cd151 CD151 antigen 0.040
Smad6 MAD homolog 6 (Drosophila) 0.040
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.040
Cdc42ep1 CDC42 effector protein (Rho GTPase binding) 1 0.039
Vav2 vav 2 oncogene 0.038
Ptk2 PTK2 protein tyrosine kinase 2 0.037
Tenc1 tensin like C1 domain-containing phosphatase 0.037
Vhl von Hippel-Lindau tumor suppressor 0.037
Wnt10b wingless related MMTV integration site 10b 0.037
Plxna4 plexin A4 0.036
Rhoa ras homolog gene family, member A 0.036
Trp53 transformation related protein 53 0.036
Arhgef2 rho/rac guanine nucleotide exchange factor (GEF) 2 0.035
Snai1 snail homolog 1 (Drosophila) 0.035
Gp9 glycoprotein 9 (platelet) 0.034
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.034
Anxa2 annexin A2 0.034
Epha2 Eph receptor A2 0.032
Socs1 suppressor of cytokine signaling 1 0.032
Plxna1 plexin A1 0.031
Rem1 rad and gem related GTP binding protein 1 0.031
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.031
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.031
Bmpr1a bone morphogenetic protein receptor, type 1A 0.030
Acan aggrecan 0.030
Acvrl1 activin A receptor, type II-like 1 0.030
Fzd8 frizzled homolog 8 (Drosophila) 0.029
Pax8 paired box gene 8 0.029
Ctdsp2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.029
Irs1 insulin receptor substrate 1 0.029
Tgfbr3 transforming growth factor, beta receptor III 0.028
Nos3 nitric oxide synthase 3, endothelial cell 0.028
Mpz myelin protein zero 0.028
Cyr61 cysteine rich protein 61 0.028
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism