The network for 'maintenance of cell polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

maintenance of cell polarity

The maintenance of established anisotropic intracellular organization or cell growth patterns.

Homo sapiens
Name Description Probability Func Analog Organism
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.996
APC adenomatous polyposis coli 0.993
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.959
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.833
INADL InaD-like (Drosophila) 0.816
ARHGAP1 Rho GTPase activating protein 1 0.721
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.690
LAT linker for activation of T cells 0.666
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.540
GAS7 growth arrest-specific 7 0.434
PRKCZ protein kinase C, zeta 0.389
CD247 CD247 molecule 0.334
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.318
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.317
ITGB4 integrin, beta 4 0.291
JUP junction plakoglobin 0.265
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.257
RANBP2 RAN binding protein 2 0.252
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.231
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.222
STRADA STE20-related kinase adaptor alpha 0.221
VAV1 vav 1 guanine nucleotide exchange factor 0.186
DLG1 discs, large homolog 1 (Drosophila) 0.176
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.174
SKA3 spindle and kinetochore associated complex subunit 3 0.174
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.155
LCK lymphocyte-specific protein tyrosine kinase 0.142
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.136
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.134
STRN3 striatin, calmodulin binding protein 3 0.121
GRB2 growth factor receptor-bound protein 2 0.119
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.119
SMAD1 SMAD family member 1 0.118
YAP1 Yes-associated protein 1 0.114
ATF7IP activating transcription factor 7 interacting protein 0.111
RHOA ras homolog gene family, member A 0.110
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.107
ERBB2IP erbb2 interacting protein 0.103
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.097
SH2D3C SH2 domain containing 3C 0.095
IQGAP1 IQ motif containing GTPase activating protein 1 0.095
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.094
KIF5B kinesin family member 5B 0.087
RHOC ras homolog gene family, member C 0.085
ARHGAP5 Rho GTPase activating protein 5 0.078
TJP1 tight junction protein 1 (zona occludens 1) 0.075
EXOC5 exocyst complex component 5 0.074
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.072
STRADB STE20-related kinase adaptor beta 0.069
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.068
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.067
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.067
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.067
SOS1 son of sevenless homolog 1 (Drosophila) 0.063
FBXO30 F-box protein 30 0.062
ABI1 abl-interactor 1 0.061
LLGL2 lethal giant larvae homolog 2 (Drosophila) 0.061
BCAR1 breast cancer anti-estrogen resistance 1 0.060
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.059
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.058
PTK2 PTK2 protein tyrosine kinase 2 0.058
LGALS1 lectin, galactoside-binding, soluble, 1 0.058
SRCIN1 SRC kinase signaling inhibitor 1 0.057
FLNA filamin A, alpha 0.057
DMAP1 DNA methyltransferase 1 associated protein 1 0.056
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.056
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.054
EXOC1 exocyst complex component 1 0.053
TNIK TRAF2 and NCK interacting kinase 0.051
RHOG ras homolog gene family, member G (rho G) 0.049
RAB21 RAB21, member RAS oncogene family 0.048
CD151 CD151 molecule (Raph blood group) 0.047
CAB39 calcium binding protein 39 0.046
ADAM15 ADAM metallopeptidase domain 15 0.046
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.045
SERTAD4 SERTA domain containing 4 0.045
APIP APAF1 interacting protein 0.044
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.043
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.043
LRRK2 leucine-rich repeat kinase 2 0.042
KCNE3 potassium voltage-gated channel, Isk-related family, member 3 0.042
RDX radixin 0.042
ZFP106 zinc finger protein 106 homolog (mouse) 0.040
RERE arginine-glutamic acid dipeptide (RE) repeats 0.040
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.040
SPTBN1 spectrin, beta, non-erythrocytic 1 0.039
ELL elongation factor RNA polymerase II 0.039
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.038
RANBP9 RAN binding protein 9 0.038
GIGYF2 GRB10 interacting GYF protein 2 0.037
OSBPL11 oxysterol binding protein-like 11 0.037
LLGL1 lethal giant larvae homolog 1 (Drosophila) 0.036
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.036
SCRIB scribbled homolog (Drosophila) 0.035
TJP2 tight junction protein 2 (zona occludens 2) 0.035
PRKCI protein kinase C, iota 0.035
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.033
CHAC1 ChaC, cation transport regulator homolog 1 (E. coli) 0.032
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.032
MACF1 microtubule-actin crosslinking factor 1 0.032
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
CELE_F53C11.4 Protein F53C11.4 0.020
ari-1 Protein ARI-1 0.015
F09E5.7 Protein F09E5.7 0.012
vps-32.1 Protein VPS-32.1 0.011
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Danio rerio
Name Description Probability Func Analog Organism
crb2a crumbs homolog 2a 0.973
ilk integrin linked kinase 0.646
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.615
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.391
prkci protein kinase C, iota 0.150
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.128
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.086
si:dkey-97i18.2 si:dkey-97i18.2 0.079
mxi1 max interacting protein 0.076
tmem2 transmembrane protein 2 0.070
skia nuclear oncoprotein skia 0.070
map2k4a mitogen-activated protein kinase kinase 4a 0.059
vsx1 visual system homeobox 1 homolog, chx10-like 0.057
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.055
rp2 retinitis pigmentosa 2 (X-linked recessive) 0.055
mib mind bomb 0.052
si:ch211-272f3.4 si:ch211-272f3.4 0.052
si:ch211-232m7.1 si:ch211-232m7.1 0.052
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.050
prkcq protein kinase C, theta 0.048
prkcbb protein kinase C, beta b 0.046
ift88 intraflagellar transport 88 homolog 0.045
zgc:110298 zgc:110298 0.044
b4galt4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 0.043
zgc:123010 zgc:123010 0.043
scrib scribbled homolog (Drosophila) 0.039
suv420h2 suppressor of variegation 4-20 homolog 2 (Drosophila) 0.038
LOC100003514 protein kinase C alpha type-like 0.036
rap2c RAP2C, member of RAS oncogene family 0.036
gabarapa GABA(A) receptor-associated protein a 0.036
rhoab ras homolog gene family, member Ab 0.035
utrn utrophin 0.035
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.034
csad cysteine sulfinic acid decarboxylase 0.033
LOC100359374 BCL-WAV 0.033
ncoa2 nuclear receptor coactivator 2 0.031
lama1 laminin, alpha 1 0.030
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.029
rcn1 reticulocalbin 1, EF-hand calcium binding domain 0.029
ythdf1 YTH domain family, member 1 0.029
sb:cb472 sb:cb472 0.027
pob partial optokinetic response b 0.026
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.026
vcl vinculin 0.026
chm choroideremia 0.025
grk7a G-protein-coupled receptor kinase 7a 0.024
hpca hippocalcin 0.022
atoh7 atonal homolog 7 0.021
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.021
ptk2.1 protein tyrosine kinase 2a 0.020
far1 fatty acyl CoA reductase 1 0.020
cxadr coxsackie virus and adenovirus receptor 0.019
dynlt3 dynein, light chain, Tctex-type 3 0.019
cdc34a cell division cycle 34 homolog (S. cerevisiae) a 0.019
grk1b G protein-coupled receptor kinase 1 b 0.019
lrrfip2 leucine rich repeat (in FLII) interacting protein 2 0.018
guca1c guanylate cyclase activator 1C 0.018
uchl1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.018
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.018
syt9a synaptotagmin IXa 0.017
ppm1aa protein phosphatase, Mg2+/Mn2+ dependent, 1Aa 0.015
krit1 KRIT1, ankyrin repeat containing 0.015
zgc:114199 zgc:114199 0.015
dlg4 discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila) 0.015
LOC561662 Golgi phosphoprotein 3-like 0.014
zgc:85727 zgc:85727 0.014
dpysl2b dihydropyrimidinase-like 2b 0.014
crb1 crumbs homolog 1 (Drosophila) 0.014
dpp7 dipeptidyl-peptidase 7 0.014
tpm1 tropomyosin 1 (alpha) 0.014
ube2i2 ubiquitin-conjugating enzyme E2I2 0.014
spry2 sprouty homolog 2 0.014
cdc73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.013
vangl2 vang-like 2 (van gogh, Drosophila) 0.013
ppp3cca protein phosphatase 3, catalytic subunit, gamma isozyme, a 0.013
si:ch211-207m11.1 si:ch211-207m11.1 0.013
pfn2 profilin 2 0.013
pkp2 plakophilin 2 0.012
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.012
cldn12 claudin 12 0.012
lasp1 LIM and SH3 protein 1 0.012
zgc:92758 zgc:92758 0.012
slc35b2 solute carrier family 35, member B2 0.012
opn4x1 opsin 4x1 0.012
hug HuG 0.011
cyt1 type I cytokeratin, enveloping layer 0.011
mst1 macrophage stimulating 1 (hepatocyte growth factor-like) 0.011
acp5b acid phosphatase 5b, tartrate resistant 0.011
slc14a2 solute carrier family 14 (urea transporter), member 2 0.011
aldh4a1 aldehyde dehydrogenase 4 family, member A1 0.011
bida BH3 interacting domain death agonist 0.011
LOC799274 kinesin heavy chain isoform 5A-like 0.011
xirp2b xin actin-binding repeat containing 2b 0.011
LOC569128 hypothetical protein LOC569128 0.010
slc24a5 solute carrier family 24, member 5 0.010
dlg1 discs, large (Drosophila) homolog 1 0.010
sp2 sp2 transcription factor 0.010
zgc:86759 zgc:86759 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Cdc42 CG12530 gene product from transcript CG12530-RA 0.896
baz bazooka 0.880
Rac1 CG2248 gene product from transcript CG2248-RA 0.873
sqh spaghetti squash 0.716
kst karst 0.546
gho ghost 0.397
aPKC atypical protein kinase C 0.306
rok Rho-kinase 0.286
Rab5 Rab-protein 5 0.275
par-1 CG8201 gene product from transcript CG8201-RA 0.269
crb crumbs 0.200
SNF1A SNF1A/AMP-activated protein kinase 0.195
dia diaphanous 0.126
Pkn Protein kinase related to protein kinase N 0.109
msn misshapen 0.101
Jra Jun-related antigen 0.095
Syx7 Syntaxin 7 0.094
Ggamma1 G protein gamma 1 0.093
scb scab 0.085
vib vibrator 0.083
l(2)gl lethal (2) giant larvae 0.071
chic chickadee 0.066
Sop2 Suppressor of profilin 2 0.061
RhoL rho-like 0.059
cno canoe 0.059
wun wunen 0.058
par-6 CG5884 gene product from transcript CG5884-RA 0.056
Eb1 CG3265 gene product from transcript CG3265-RF 0.052
cora coracle 0.047
Vhl von Hippel-Lindau 0.046
rhea CG6831 gene product from transcript CG6831-RA 0.045
gammaCop gamma-coatomer protein 0.044
Dlic Dynein light intermediate chain 0.041
sec23 CG1250 gene product from transcript CG1250-RA 0.040
tok tolkin 0.038
frc fringe connection 0.038
Rho1 CG8416 gene product from transcript CG8416-RB 0.037
CDase Ceramidase 0.036
Rbsn-5 Rabenosyn-5 0.036
14-3-3zeta CG17870 gene product from transcript CG17870-RB 0.033
Moe Moesin 0.033
CG4567 CG4567 gene product from transcript CG4567-RA 0.033
Krn Keren 0.030
kon kon-tiki 0.028
wdb widerborst 0.025
Vps28 Vacuolar protein sorting 28 0.025
Vrp1 Verprolin 1 0.025
lkb1 CG9374 gene product from transcript CG9374-RJ 0.025
Sgt1 CG9617 gene product from transcript CG9617-RA 0.024
Chd64 CG14996 gene product from transcript CG14996-RB 0.024
vps2 CG14542 gene product from transcript CG14542-RA 0.022
regucalcin CG1803 gene product from transcript CG1803-RA 0.022
Rab11 Rab-protein 11 0.021
HspB8 CG14207 gene product from transcript CG14207-RB 0.020
SdhA Succinate dehydrogenase A 0.020
CG1115 CG1115 gene product from transcript CG1115-RA 0.020
bsk basket 0.020
Hph HIF prolyl hydroxylase 0.019
scf supercoiling factor 0.019
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.019
if inflated 0.018
CG31352 CG31352 gene product from transcript CG31352-RA 0.018
ttk tramtrack 0.017
PHGPx CG12013 gene product from transcript CG12013-RC 0.017
raw CG12437 gene product from transcript CG12437-RB 0.017
Rala Ras-related protein 0.017
yki yorkie 0.017
Ilk Integrin linked kinase 0.016
Myo31DF Myosin 31DF 0.016
CG11009 CG11009 gene product from transcript CG11009-RB 0.016
Mmp1 Matrix metalloproteinase 1 0.016
Nrx-IV Neurexin IV 0.016
ens ensconsin 0.015
Cnx99A Calnexin 99A 0.015
Pvr PDGF- and VEGF-receptor related 0.015
sgl sugarless 0.014
CG13117 CG13117 gene product from transcript CG13117-RA 0.014
Tsp42Ed Tetraspanin 42Ed 0.014
GstD1 Glutathione S transferase D1 0.014
HSPC300 CG30173 gene product from transcript CG30173-RA 0.014
CG17838 CG17838 gene product from transcript CG17838-RA 0.014
trc tricornered 0.013
Flo-2 flotillin 2 0.013
Vps25 Vacuolar protein sorting 25 0.013
mmy mummy 0.013
Crag Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein 0.013
nudE CG8104 gene product from transcript CG8104-RB 0.012
Prosalpha1 Proteasome alpha1 subunit 0.012
TSG101 tumor suppressor protein 101 0.012
CG6776 CG6776 gene product from transcript CG6776-RA 0.012
hpo hippo 0.012
CG13994 CG13994 gene product from transcript CG13994-RA 0.012
mfrn mitoferrin 0.012
Pak PAK-kinase 0.012
Crc Calreticulin 0.012
CG10373 CG10373 gene product from transcript CG10373-RA 0.011
loco locomotion defects 0.011
Xbp1 X box binding protein-1 0.011
Fps85D Fps oncogene analog 0.011
Syb Synaptobrevin 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC11 Cdc11p 0.911
RHO1 Rho1p 0.625
CDC12 Cdc12p 0.621
CDC3 Cdc3p 0.336
VPS28 Vps28p 0.273
CDC10 Cdc10p 0.267
RDI1 Rdi1p 0.247
OSH7 Osh7p 0.167
CDC55 Cdc55p 0.131
RSR1 Rsr1p 0.085
VPS36 Vps36p 0.084
OSH2 Osh2p 0.051
MDS3 Mds3p 0.043
PRS2 Prs2p 0.038
KEL1 Kel1p 0.036
EXO70 Exo70p 0.036
BSP1 Bsp1p 0.031
SGE1 Sge1p 0.030
UBC9 Ubc9p 0.028
GIC2 Gic2p 0.028
NNT1 Nnt1p 0.026
NDD1 Ndd1p 0.026
COQ1 Coq1p 0.025
SCS2 Scs2p 0.024
URA3 Ura3p 0.024
SRD1 Srd1p 0.024
STE4 Ste4p 0.024
RGD1 Rgd1p 0.023
YGL242C hypothetical protein 0.022
YLR264C-A hypothetical protein 0.021
MNN9 Mnn9p 0.021
YOL038C-A hypothetical protein 0.021
OSH6 Osh6p 0.020
LDB17 Ldb17p 0.020
YLR162W hypothetical protein 0.020
BRN1 Brn1p 0.018
MER1 Mer1p 0.018
ARP10 Arp10p 0.018
CUP1-1 Cup1-1p 0.018
CAB4 Cab4p 0.018
LEU2 Leu2p 0.018
AXL2 Axl2p 0.018
CUE4 Cue4p 0.017
BEM4 Bem4p 0.017
ECM25 Ecm25p 0.017
YIR035C hypothetical protein 0.017
SPL2 Spl2p 0.016
TPM2 Tpm2p 0.016
YAR068W hypothetical protein 0.015
TGL1 Tgl1p 0.015
FAA1 Faa1p 0.015
YLR042C hypothetical protein 0.015
INN1 Inn1p 0.015
YLR049C hypothetical protein 0.015
ALO1 Alo1p 0.015
RRP15 Rrp15p 0.014
TPO4 Tpo4p 0.014
CHA1 Cha1p 0.014
ATP6 Atp6p 0.014
FSH1 Fsh1p 0.014
WSC4 Wsc4p 0.014
YBR013C hypothetical protein 0.014
YGR035C hypothetical protein 0.014
GIC1 Gic1p 0.014
PHM6 Phm6p 0.013
CPD1 Cpd1p 0.013
VAC17 Vac17p 0.013
YML053C hypothetical protein 0.013
HPF1 Hpf1p 0.013
YPL014W hypothetical protein 0.013
TSC3 Tsc3p 0.013
SWC7 Swc7p 0.013
CRP1 Crp1p 0.013
YGR017W hypothetical protein 0.013
YIL151C hypothetical protein 0.012
YPR157W hypothetical protein 0.012
AUA1 Aua1p 0.012
UPS3 Ups3p 0.012
DIF1 Dif1p 0.012
FMT1 Fmt1p 0.012
PCL9 Pcl9p 0.012
ZPS1 Zps1p 0.012
REE1 Ree1p 0.012
FUI1 Fui1p 0.012
ARG8 Arg8p 0.011
OPT2 Opt2p 0.011
YER186C hypothetical protein 0.011
MF(ALPHA)2 Mf(alpha)2p 0.011
SSO2 Sso2p 0.011
HXT3 Hxt3p 0.011
DIC1 Dic1p 0.011
NRG2 Nrg2p 0.011
YLR040C hypothetical protein 0.010
YJR120W hypothetical protein 0.010
GPI11 Gpi11p 0.010
SCM4 Scm4p 0.010
YOL013W-A hypothetical protein 0.010
RRN5 Rrn5p 0.010
CDC1 Cdc1p 0.010
SWH1 Swh1p 0.010