The network for 'alpha beta t cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

alpha beta t cell differentiation

The process in which a precursor cell type acquires the specialized features of an alpha-beta T cell. An alpha-beta T cell is a T cell that expresses an alpha-beta T cell receptor complex.

Homo sapiens
Name Description Probability Func Analog Organism
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.999
IL4R interleukin 4 receptor 0.997
LCK lymphocyte-specific protein tyrosine kinase 0.996
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.994
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.911
NCOR2 nuclear receptor corepressor 2 0.877
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.862
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.753
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.738
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.729
BIRC3 baculoviral IAP repeat containing 3 0.689
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.574
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.553
LIN9 lin-9 homolog (C. elegans) 0.443
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.329
CD247 CD247 molecule 0.320
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.316
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.312
RXRA retinoid X receptor, alpha 0.294
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.259
BCL3 B-cell CLL/lymphoma 3 0.238
TRAF1 TNF receptor-associated factor 1 0.224
PPARA peroxisome proliferator-activated receptor alpha 0.188
IL23A interleukin 23, alpha subunit p19 0.181
PML promyelocytic leukemia 0.133
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.119
IL4 interleukin 4 0.110
IL2RG interleukin 2 receptor, gamma 0.103
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.089
EP300 E1A binding protein p300 0.078
HDAC7 histone deacetylase 7 0.078
CTBP1 C-terminal binding protein 1 0.076
RUNX3 runt-related transcription factor 3 0.070
VAV1 vav 1 guanine nucleotide exchange factor 0.069
PDZD11 PDZ domain containing 11 0.065
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.064
SMAD4 SMAD family member 4 0.064
SPRR2A small proline-rich protein 2A 0.057
MEOX1 mesenchyme homeobox 1 0.054
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.051
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.050
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.046
LIN54 lin-54 homolog (C. elegans) 0.046
HDAC4 histone deacetylase 4 0.043
IL2RB interleukin 2 receptor, beta 0.042
CSNK1G1 casein kinase 1, gamma 1 0.040
TNIP2 TNFAIP3 interacting protein 2 0.038
IL6R interleukin 6 receptor 0.037
CCR7 chemokine (C-C motif) receptor 7 0.037
GRAP2 GRB2-related adaptor protein 2 0.033
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.032
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.030
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.030
IL7R interleukin 7 receptor 0.030
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.030
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.028
TRAF3 TNF receptor-associated factor 3 0.028
HDAC9 histone deacetylase 9 0.028
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.027
TRAT1 T cell receptor associated transmembrane adaptor 1 0.026
PRKCE protein kinase C, epsilon 0.026
PIAS1 protein inhibitor of activated STAT, 1 0.026
LAT linker for activation of T cells 0.025
ICAM1 intercellular adhesion molecule 1 0.025
CD2 CD2 molecule 0.023
ARAF v-raf murine sarcoma 3611 viral oncogene homolog 0.023
MED25 mediator complex subunit 25 0.022
TGFB3 transforming growth factor, beta 3 0.022
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.022
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.021
H2AFX H2A histone family, member X 0.021
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.021
PLCG1 phospholipase C, gamma 1 0.021
BCL2L1 BCL2-like 1 0.020
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.020
TGFB1 transforming growth factor, beta 1 0.019
SKI v-ski sarcoma viral oncogene homolog (avian) 0.019
HDAC5 histone deacetylase 5 0.019
RBMX2 RNA binding motif protein, X-linked 2 0.019
TNIP1 TNFAIP3 interacting protein 1 0.018
RARA retinoic acid receptor, alpha 0.018
IRF4 interferon regulatory factor 4 0.017
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.017
E2F4 E2F transcription factor 4, p107/p130-binding 0.017
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.017
NLK nemo-like kinase 0.017
ESR1 estrogen receptor 1 0.017
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.016
PLXND1 plexin D1 0.016
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.015
RB1 retinoblastoma 1 0.015
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.015
E2F1 E2F transcription factor 1 0.015
TRAF3IP3 TRAF3 interacting protein 3 0.015
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.014
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.014
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.013
CD7 CD7 molecule 0.013
CD6 CD6 molecule 0.013
SLA Src-like-adaptor 0.013
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Ikzf1 IKAROS family zinc finger 1 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.997
Bcl2 B-cell leukemia/lymphoma 2 0.997
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.997
Gli2 GLI-Kruppel family member GLI2 0.996
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.995
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.992
Fgfr2 fibroblast growth factor receptor 2 0.992
Tnf tumor necrosis factor 0.991
Pitx1 paired-like homeodomain transcription factor 1 0.989
Igh immunoglobulin heavy chain complex 0.988
Tbx3 T-box 3 0.988
Stat3 signal transducer and activator of transcription 3 0.984
Fas Fas (TNF receptor superfamily member 6) 0.977
Cd19 CD19 antigen 0.974
Lef1 lymphoid enhancer binding factor 1 0.974
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.971
Socs1 suppressor of cytokine signaling 1 0.968
Lepr leptin receptor 0.948
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.942
Pten phosphatase and tensin homolog 0.936
Jak2 Janus kinase 2 0.934
Rag1 recombination activating gene 1 0.927
Rarg retinoic acid receptor, gamma 0.926
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.922
Apc adenomatosis polyposis coli 0.919
Stat5a signal transducer and activator of transcription 5A 0.910
Zeb1 zinc finger E-box binding homeobox 1 0.910
Sox9 SRY-box containing gene 9 0.907
Ptprc protein tyrosine phosphatase, receptor type, C 0.906
Rxra retinoid X receptor alpha 0.901
Pitx2 paired-like homeodomain transcription factor 2 0.897
Cd40 CD40 antigen 0.870
Stat5b signal transducer and activator of transcription 5B 0.860
Smad4 MAD homolog 4 (Drosophila) 0.834
Fgf10 fibroblast growth factor 10 0.834
Shh sonic hedgehog 0.833
Runx1 runt related transcription factor 1 0.826
Bcl6 B-cell leukemia/lymphoma 6 0.819
Sfpi1 SFFV proviral integration 1 0.818
Cd247 CD247 antigen 0.808
Stat6 signal transducer and activator of transcription 6 0.791
Trp53 transformation related protein 53 0.790
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.769
Gata4 GATA binding protein 4 0.751
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.746
Socs3 suppressor of cytokine signaling 3 0.741
Bcl3 B-cell leukemia/lymphoma 3 0.735
Il2rb interleukin 2 receptor, beta chain 0.730
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.727
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.726
Ccl2 chemokine (C-C motif) ligand 2 0.726
Kit kit oncogene 0.702
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.693
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.684
Il2rg interleukin 2 receptor, gamma chain 0.670
Gli3 GLI-Kruppel family member GLI3 0.664
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.658
Pgr progesterone receptor 0.647
Foxp3 forkhead box P3 0.635
Irf9 interferon regulatory factor 9 0.631
Lat linker for activation of T cells 0.623
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.621
Nf1 neurofibromatosis 1 0.606
Fyn Fyn proto-oncogene 0.604
Creb1 cAMP responsive element binding protein 1 0.582
Twist2 twist homolog 2 (Drosophila) 0.571
Irf8 interferon regulatory factor 8 0.562
Cd28 CD28 antigen 0.550
Pxn paxillin 0.549
Lta lymphotoxin A 0.534
Cish cytokine inducible SH2-containing protein 0.529
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.523
Dysf dysferlin 0.522
Tcra T-cell receptor alpha chain 0.521
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.517
Foxn1 forkhead box N1 0.516
Bmp4 bone morphogenetic protein 4 0.511
Hoxd13 homeobox D13 0.503
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.500
Csf1 colony stimulating factor 1 (macrophage) 0.499
Ptgs2 prostaglandin-endoperoxide synthase 2 0.493
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.484
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.481
Atxn1 ataxin 1 0.469
Nodal nodal 0.465
Stat2 signal transducer and activator of transcription 2 0.464
Hhex hematopoietically expressed homeobox 0.463
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.462
Pax2 paired box gene 2 0.461
Il1b interleukin 1 beta 0.459
Jak3 Janus kinase 3 0.456
Prdm1 PR domain containing 1, with ZNF domain 0.446
Bmp2 bone morphogenetic protein 2 0.444
Tgfbr3 transforming growth factor, beta receptor III 0.440
Col2a1 collagen, type II, alpha 1 0.433
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.430
Wt1 Wilms tumor 1 homolog 0.429
Batf basic leucine zipper transcription factor, ATF-like 0.427
Msx2 homeobox, msh-like 2 0.422
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Gimap4 GTPase, IMAP family member 4 0.133
Apol3 apolipoprotein L, 3 0.091
Ddr1 discoidin domain receptor tyrosine kinase 1 0.086
Gja4 gap junction protein, alpha 4 0.052
Hmha1 histocompatibility (minor) HA-1 0.050
Cd37 CD37 molecule 0.048
Efnb1 ephrin B1 0.047
Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.044
Cd5 Cd5 molecule 0.044
Itgb7 integrin, beta 7 0.043
Tgfbr3 transforming growth factor, beta receptor III 0.038
Stat6 signal transducer and activator of transcription 6 0.038
Hdac7 histone deacetylase 7 0.034
Arhgap25 Rho GTPase activating protein 25 0.032
Anpep alanyl (membrane) aminopeptidase 0.031
Cd2 Cd2 molecule 0.030
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.029
Pecam1 platelet/endothelial cell adhesion molecule 1 0.029
Tek TEK tyrosine kinase, endothelial 0.029
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.028
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.028
Rxra retinoid X receptor alpha 0.027
Il2rg interleukin 2 receptor, gamma 0.026
Spn sialophorin 0.025
Sh2d1a SH2 domain protein 1A 0.024
Map3k3 mitogen activated protein kinase kinase kinase 3 0.023
Rhoh ras homolog gene family, member H 0.023
Mapk7 mitogen-activated protein kinase 7 0.023
Psd4 pleckstrin and Sec7 domain containing 4 0.023
Ncr3 natural cytotoxicity triggering receptor 3 0.022
Gpr4 G protein-coupled receptor 4 0.022
Cd247 Cd247 molecule 0.020
Egfl7 EGF-like-domain, multiple 7 0.020
Tfeb transcription factor EB 0.020
Prkch protein kinase C, eta 0.019
Arhgap4 Rho GTPase activating protein 4 0.018
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.018
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.018
Nfic nuclear factor I/C 0.018
Hdac1l histone deacetylase 1-like 0.018
Socs3 suppressor of cytokine signaling 3 0.018
Psen1 presenilin 1 0.017
Olr1469 olfactory receptor Olr1469 0.017
Smad7 SMAD family member 7 0.016
Nos3 nitric oxide synthase 3, endothelial cell 0.016
LOC363326 hypothetical LOC363326 0.016
Csk c-src tyrosine kinase 0.015
Epn1 Epsin 1 0.015
Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.015
Serpinb6b serine (or cysteine) peptidase inhibitor, clade B, member 6b 0.015
Triobp TRIO and F-actin binding protein 0.015
Jund jun D proto-oncogene 0.015
Bin2 bridging integrator 2 0.015
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.015
Podxl podocalyxin-like 0.014
Bak1 BCL2-antagonist/killer 1 0.014
Btk Bruton agammaglobulinemia tyrosine kinase 0.014
Gata2 GATA binding protein 2 0.014
Sdc3 syndecan 3 0.014
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.014
Cd3g CD3 molecule, gamma 0.013
Ctla2a cytotoxic T lymphocyte-associated protein 2 alpha 0.013
Hcst hematopoietic cell signal transducer 0.013
Sept1 septin 1 0.013
Nr2f6 nuclear receptor subfamily 2, group F, member 6 0.013
Faim3 Fas apoptotic inhibitory molecule 3 0.013
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.013
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.013
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.013
Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 0.012
Cd4 Cd4 molecule 0.012
Cnr2 cannabinoid receptor 2 (macrophage) 0.012
Wasf2 WAS protein family, member 2 0.012
Gulo gulonolactone (L-) oxidase 0.012
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.012
Gpsm3 G-protein signaling modulator 3 (AGS3-like, C. elegans) 0.012
Trim25 tripartite motif-containing 25 0.012
Ltb lymphotoxin beta (TNF superfamily, member 3) 0.012
Zfp36 zinc finger protein 36 0.012
Cish cytokine inducible SH2-containing protein 0.012
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.012
Scarf2 scavenger receptor class F, member 2 0.011
Emcn endomucin 0.011
Ralgds ral guanine nucleotide dissociation stimulator 0.011
Ccl5 chemokine (C-C motif) ligand 5 0.011
Sbno2 strawberry notch homolog 2 (Drosophila) 0.011
Lck lymphocyte-specific protein tyrosine kinase 0.011
Lgals2 lectin, galactoside-binding, soluble, 2 0.011
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.011
Ccdc69 coiled-coil domain containing 69 0.011
Grap GRB2-related adaptor protein 0.011
Ccl21 chemokine (C-C motif) ligand 21 0.011
Cd69 Cd69 molecule 0.011
Prickle3 prickle homolog 3 (Drosophila) 0.011
Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein 0.011
Dll4 delta-like 4 (Drosophila) 0.011
RT1-N3 RT1 class Ib, locus N3 0.010
Klf13 Kruppel-like factor 13 0.010
Actn4 actinin alpha 4 0.010
Zap70 zeta-chain (TCR) associated protein kinase 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism