The network for 'interaction with host' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interaction with host

An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.

Homo sapiens
Name Description Probability Func Analog Organism
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.997
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.995
BCL2 B-cell CLL/lymphoma 2 0.993
SMAD3 SMAD family member 3 0.974
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.959
RNF11 ring finger protein 11 0.937
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.918
SMAD1 SMAD family member 1 0.913
BCL2L1 BCL2-like 1 0.863
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.850
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.850
SMAD2 SMAD family member 2 0.821
ENG endoglin 0.820
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.788
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.754
MED25 mediator complex subunit 25 0.736
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.702
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.702
SMAD5 SMAD family member 5 0.693
FHL2 four and a half LIM domains 2 0.681
BAX BCL2-associated X protein 0.601
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.597
RRAGC Ras-related GTP binding C 0.596
TAPBP TAP binding protein (tapasin) 0.584
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 0.544
ISG15 ISG15 ubiquitin-like modifier 0.529
SMAD4 SMAD family member 4 0.455
RNF5 ring finger protein 5 0.450
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.440
AXL AXL receptor tyrosine kinase 0.422
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.417
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.392
RARA retinoic acid receptor, alpha 0.392
TRIM39 tripartite motif containing 39 0.364
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.359
BAK1 BCL2-antagonist/killer 1 0.354
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.314
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.294
PDIA3 protein disulfide isomerase family A, member 3 0.273
TGFB1 transforming growth factor, beta 1 0.266
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.242
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.226
B2M beta-2-microglobulin 0.205
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.202
TGFBR1 transforming growth factor, beta receptor 1 0.170
SMAD6 SMAD family member 6 0.169
ZNFX1 zinc finger, NFX1-type containing 1 0.168
MED15 mediator complex subunit 15 0.168
SKIL SKI-like oncogene 0.160
TLN1 talin 1 0.159
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.155
FBXL15 F-box and leucine-rich repeat protein 15 0.144
THBS1 thrombospondin 1 0.144
PVRL3 poliovirus receptor-related 3 0.140
PVRL4 poliovirus receptor-related 4 0.139
DAXX death-domain associated protein 0.130
ZFYVE9 zinc finger, FYVE domain containing 9 0.129
INSR insulin receptor 0.127
UTRN utrophin 0.125
DMD dystrophin 0.125
TRIM21 tripartite motif containing 21 0.123
CYLD cylindromatosis (turban tumor syndrome) 0.121
SP110 SP110 nuclear body protein 0.119
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.118
GCC1 GRIP and coiled-coil domain containing 1 0.114
ITGB4 integrin, beta 4 0.113
XIAP X-linked inhibitor of apoptosis 0.110
IRF9 interferon regulatory factor 9 0.107
CXXC5 CXXC finger protein 5 0.104
TRIM43 tripartite motif containing 43 0.104
EFCAB4B EF-hand calcium binding domain 4B 0.101
TP53 tumor protein p53 0.099
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.095
ANKRD13A ankyrin repeat domain 13A 0.091
HLA-A major histocompatibility complex, class I, A 0.090
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.089
BAD BCL2-associated agonist of cell death 0.089
SPOP speckle-type POZ protein 0.088
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.087
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.087
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.086
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.084
IGF1R insulin-like growth factor 1 receptor 0.082
FN1 fibronectin 1 0.077
CD63 CD63 molecule 0.076
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.074
RHOA ras homolog gene family, member A 0.073
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.073
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.071
FAM46A family with sequence similarity 46, member A 0.068
MOV10 Mov10, Moloney leukemia virus 10, homolog (mouse) 0.068
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.067
ZNF263 zinc finger protein 263 0.065
DYNLL1 dynein, light chain, LC8-type 1 0.065
VDAC1 voltage-dependent anion channel 1 0.063
UBE2U ubiquitin-conjugating enzyme E2U (putative) 0.061
TRIM5 tripartite motif containing 5 0.060
RRAGD Ras-related GTP binding D 0.058
STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.057
PROX1 prospero homeobox 1 0.057
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
itgb3b integrin beta 3b 0.292
dmd dystrophin 0.154
mcl1a myeloid cell leukemia sequence 1a 0.108
eif4a1a eukaryotic translation initiation factor 4A, isoform 1A 0.103
ripk2 receptor-interacting serine-threonine kinase 2 0.098
lamc1 laminin, gamma 1 0.092
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.089
LOC566020 Gig2-like protein DreO 0.081
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.075
xbp1 X-box binding protein 1 0.073
mxi1 max interacting protein 0.071
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.068
rspo1 R-spondin homolog (Xenopus laevis) 0.065
map2k4a mitogen-activated protein kinase kinase 4a 0.061
igf1rb insulin-like growth factor 1b receptor 0.058
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.058
mych myelocytomatosis oncogene homolog 0.058
cflar CASP8 and FADD-like apoptosis regulator 0.057
ca8 carbonic anhydrase VIII 0.057
pkz protein kinase containing Z-DNA binding domains 0.056
tead3a TEA domain family member 3 a 0.056
LOC567131 calcitonin gene-related peptide type 1 receptor-like 0.056
lass2 LAG1 homolog, ceramide synthase 2 (S. cerevisiae) 0.055
greb1 growth regulation by estrogen in breast cancer 1 0.054
jag2 jagged 2 0.051
shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.051
ptpra protein tyrosine phosphatase, receptor type, A 0.051
myca myelocytomatosis oncogene a 0.049
rargb retinoic acid receptor, gamma b 0.047
furinb furin (paired basic amino acid cleaving enzyme) b 0.047
alcama activated leukocyte cell adhesion molecule a 0.047
ube2l3a ubiquitin-conjugating enzyme E2L 3a 0.046
bcl2l1 bcl2-like 1 0.046
ef1a elongation factor 1-alpha 0.046
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.045
insrb insulin receptor b 0.045
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.044
tfe3a transcription factor binding to IGHM enhancer 3a 0.044
eef2b eukaryotic translation elongation factor 2b 0.043
tp53bp2 tumor protein p53 binding protein, 2 0.043
dusp1 dual specificity phosphatase 1 0.042
slc2a11l solute carrier family 2 (facilitated glucose transporter), member 11-like 0.041
ifnphi1 interferon phi 1 0.040
zgc:63962 zgc:63962 0.040
isg15 ISG15 ubiquitin-like modifier 0.040
robo4 roundabout homolog 4 0.040
trim13 tripartite motif-containing 13 0.039
lef1 lymphocyte enhancer binding factor 1 0.039
cecr1a cat eye syndrome chromosome region, candidate 1a 0.039
vdra vitamin D receptor a 0.039
spry4 sprouty (Drosophila) homolog 4 0.038
lama2 laminin, alpha 2 0.037
ism1 isthmin 1 0.036
baxa bcl2-associated X protein, a 0.036
stat1a signal transduction and activation of transcription 1a 0.035
mycl1b v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b 0.034
gnb1a guanine nucleotide binding protein (G protein), beta polypeptide 1a 0.034
arf5 ADP-ribosylation factor 5 0.034
furina furin (paired basic amino acid cleaving enzyme) a 0.034
unc5b unc-5 homolog B (C. elegans) 0.033
glulb glutamate-ammonia ligase (glutamine synthase) b 0.033
tia1l cytotoxic granule-associated RNA binding protein 1, like 0.032
casp8 caspase 8, apoptosis-related cysteine peptidase 0.032
bmf1 Bcl2 modifying factor 1 0.032
sdf4 stromal cell derived factor 4 0.030
cct2 chaperonin containing TCP1, subunit 2 (beta) 0.030
cyp3c1 cytochrome P450, family 3, subfamily c, polypeptide 1 0.030
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.030
zgc:56306 zgc:56306 0.029
jam3b junctional adhesion molecule 3b 0.029
stat3 signal transduction and activation of transcription 3 0.029
optn optineurin 0.029
junbl jun B proto-oncogene, like 0.029
zgc:56382 zgc:56382 0.029
prdm5 PR domain containing 5 0.028
eprs glutamyl-prolyl-tRNA synthetase 0.028
abcb3l1 ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 1 0.028
eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.028
kiss1 KiSS-1 metastasis-suppressor 0.027
cry3 cryptochrome 3 0.027
sec61al2 Sec61 alpha like 2 0.027
zgc:112079 zgc:112079 0.027
slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 0.027
wu:fc18c07 wu:fc18c07 0.026
mknk2b MAP kinase-interacting serine/threonine kinase 2b 0.026
LOC560602 novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6) 0.026
irgq1 immunity-related GTPase family, q1 0.026
rln3a relaxin 3a 0.025
rnd1l Rho family GTPase 1 like 0.025
il17rd interleukin 17 receptor D 0.025
ldb1a LIM-domain binding factor 1a 0.025
trim3a tripartite motif-containing 3a 0.025
bmp7b bone morphogenetic protein 7b 0.025
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.025
mbtps1 membrane-bound transcription factor protease, site 1 0.025
rxfp1 relaxin/insulin-like family peptide receptor 1 0.025
zgc:112018 zgc:112018 0.024
sat1b spermidine/spermine N1-acetyl transferase 1b 0.024
nos2a nitric oxide synthase 2a, inducible 0.024
vps4b vacuolar protein sorting 4b (yeast) 0.024
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Tapbp TAP binding protein 0.875
Trim30d tripartite motif-containing 30D 0.472
Trim30a tripartite motif-containing 30A 0.460
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.395
Ifitm3 interferon induced transmembrane protein 3 0.371
Ccr2 chemokine (C-C motif) receptor 2 0.358
Traf3ip2 TRAF3 interacting protein 2 0.210
Cd44 CD44 antigen 0.210
Irf9 interferon regulatory factor 9 0.206
Irgm2 immunity-related GTPase family M member 2 0.183
Irgm1 immunity-related GTPase family M member 1 0.182
Stat1 signal transducer and activator of transcription 1 0.180
Gbp7 guanylate binding protein 7 0.178
Tgfb1 transforming growth factor, beta 1 0.176
Il10 interleukin 10 0.172
Kit kit oncogene 0.172
Parp14 poly (ADP-ribose) polymerase family, member 14 0.151
Tlr4 toll-like receptor 4 0.145
Ifi44 interferon-induced protein 44 0.143
Nos2 nitric oxide synthase 2, inducible 0.128
Trim21 tripartite motif-containing 21 0.122
Ifih1 interferon induced with helicase C domain 1 0.116
Trim12a tripartite motif-containing 12A 0.100
Spp1 secreted phosphoprotein 1 0.096
Ddx60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.094
Myd88 myeloid differentiation primary response gene 88 0.089
Ptprc protein tyrosine phosphatase, receptor type, C 0.086
Ifitm2 interferon induced transmembrane protein 2 0.085
Bcl2 B-cell leukemia/lymphoma 2 0.085
Oasl2 2'-5' oligoadenylate synthetase-like 2 0.085
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.084
Usp18 ubiquitin specific peptidase 18 0.083
Grb10 growth factor receptor bound protein 10 0.079
Dtx3l deltex 3-like (Drosophila) 0.073
Icam1 intercellular adhesion molecule 1 0.072
Tgfbr2 transforming growth factor, beta receptor II 0.072
Vdr vitamin D receptor 0.071
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.068
Gbp3 guanylate binding protein 3 0.067
Cct5 chaperonin containing Tcp1, subunit 5 (epsilon) 0.064
Foxp3 forkhead box P3 0.064
Trim55 tripartite motif-containing 55 0.062
Nos1 nitric oxide synthase 1, neuronal 0.060
Lepr leptin receptor 0.058
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.058
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.056
Slfn4 schlafen 4 0.055
Csf1 colony stimulating factor 1 (macrophage) 0.051
Isg15 ISG15 ubiquitin-like modifier 0.051
B2m beta-2 microglobulin 0.050
Rag1 recombination activating gene 1 0.050
Gm12185 predicted gene 12185 0.049
Cd19 CD19 antigen 0.049
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.047
Uba7 ubiquitin-like modifier activating enzyme 7 0.046
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.046
Ikzf1 IKAROS family zinc finger 1 0.046
Parp10 poly (ADP-ribose) polymerase family, member 10 0.045
Socs1 suppressor of cytokine signaling 1 0.045
Fcgr2b Fc receptor, IgG, low affinity IIb 0.042
Rtp4 receptor transporter protein 4 0.040
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.039
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.038
Tmem176a transmembrane protein 176A 0.038
Ifnab interferon alpha B 0.037
Igh immunoglobulin heavy chain complex 0.035
Plau plasminogen activator, urokinase 0.034
Rsad2 radical S-adenosyl methionine domain containing 2 0.034
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.032
Esr1 estrogen receptor 1 (alpha) 0.032
Pyhin1 pyrin and HIN domain family, member 1 0.032
Vhl von Hippel-Lindau tumor suppressor 0.032
Ifi35 interferon-induced protein 35 0.032
Stat3 signal transducer and activator of transcription 3 0.031
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.031
Hr hairless 0.031
Tor3a torsin family 3, member A 0.031
Pparg peroxisome proliferator activated receptor gamma 0.031
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.029
Il2 interleukin 2 0.029
Ifng interferon gamma 0.029
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.029
Ifi47 interferon gamma inducible protein 47 0.029
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.028
Samhd1 SAM domain and HD domain, 1 0.028
Il6st interleukin 6 signal transducer 0.028
Stx6 syntaxin 6 0.028
Cd14 CD14 antigen 0.027
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.027
Ticam1 toll-like receptor adaptor molecule 1 0.027
Acvr1 activin A receptor, type 1 0.027
Gck glucokinase 0.027
Herc6 hect domain and RLD 6 0.026
Samd9l sterile alpha motif domain containing 9-like 0.026
Lgals9 lectin, galactose binding, soluble 9 0.026
Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) 0.025
Dmd dystrophin, muscular dystrophy 0.025
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.024
Iigp1 interferon inducible GTPase 1 0.024
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.024
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism