The network for 'regulation of phosphatase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of phosphatase activity

Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.

Homo sapiens
Name Description Probability Func Analog Organism
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.908
FHL2 four and a half LIM domains 2 0.843
ANKRD28 ankyrin repeat domain 28 0.750
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.674
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.624
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.596
PTPRC protein tyrosine phosphatase, receptor type, C 0.528
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.525
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.487
ACTB actin, beta 0.468
BIRC2 baculoviral IAP repeat containing 2 0.389
RIPK3 receptor-interacting serine-threonine kinase 3 0.363
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.342
ANKRD52 ankyrin repeat domain 52 0.321
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.276
ENG endoglin 0.276
PFN1 profilin 1 0.274
AFF4 AF4/FMR2 family, member 4 0.266
TSC2 tuberous sclerosis 2 0.235
BIRC3 baculoviral IAP repeat containing 3 0.228
TSSK2 testis-specific serine kinase 2 0.213
TP53BP2 tumor protein p53 binding protein, 2 0.202
PPP6C protein phosphatase 6, catalytic subunit 0.199
GDA guanine deaminase 0.192
CASC5 cancer susceptibility candidate 5 0.174
BMPR1A bone morphogenetic protein receptor, type IA 0.157
MPRIP myosin phosphatase Rho interacting protein 0.150
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.149
CDH5 cadherin 5, type 2 (vascular endothelium) 0.145
KLHL3 kelch-like 3 (Drosophila) 0.144
NRP1 neuropilin 1 0.144
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.143
TCTEX1D4 Tctex1 domain containing 4 0.141
KIAA1683 KIAA1683 0.136
PTEN phosphatase and tensin homolog 0.133
ZFYVE9 zinc finger, FYVE domain containing 9 0.127
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.123
ADRB1 adrenergic, beta-1-, receptor 0.123
FSTL1 follistatin-like 1 0.121
EAF1 ELL associated factor 1 0.118
TFF1 trefoil factor 1 0.116
ACVR1B activin A receptor, type IB 0.113
LAT linker for activation of T cells 0.110
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.102
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.101
CFL1 cofilin 1 (non-muscle) 0.099
KIAA1949 KIAA1949 0.096
PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8 0.095
PXN paxillin 0.094
BCL2L1 BCL2-like 1 0.093
MOBKL1A MOB1, Mps One Binder kinase activator-like 1A (yeast) 0.088
ADORA2A adenosine A2a receptor 0.087
CDK1 cyclin-dependent kinase 1 0.086
MYO10 myosin X 0.086
CDHR2 cadherin-related family member 2 0.084
PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10 0.077
TGFBR1 transforming growth factor, beta receptor 1 0.074
PBK PDZ binding kinase 0.073
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.073
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.072
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.070
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.068
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.067
SORBS1 sorbin and SH3 domain containing 1 0.066
PPP4C protein phosphatase 4, catalytic subunit 0.065
PLXND1 plexin D1 0.065
TBC1D17 TBC1 domain family, member 17 0.062
PKM2 pyruvate kinase, muscle 0.062
PGF placental growth factor 0.060
RANBP9 RAN binding protein 9 0.060
RLN3 relaxin 3 0.059
TRAF1 TNF receptor-associated factor 1 0.059
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.059
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.059
CCND3 cyclin D3 0.059
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.058
VEGFA vascular endothelial growth factor A 0.058
PPP1R15B protein phosphatase 1, regulatory (inhibitor) subunit 15B 0.058
ZBTB16 zinc finger and BTB domain containing 16 0.057
GAS7 growth arrest-specific 7 0.057
SKA3 spindle and kinetochore associated complex subunit 3 0.056
FAT1 FAT tumor suppressor homolog 1 (Drosophila) 0.055
SPTBN1 spectrin, beta, non-erythrocytic 1 0.055
C11orf66 chromosome 11 open reading frame 66 0.054
STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.053
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.051
LDLR low density lipoprotein receptor 0.051
CAPZB capping protein (actin filament) muscle Z-line, beta 0.050
FANCC Fanconi anemia, complementation group C 0.049
PPP1R13B protein phosphatase 1, regulatory (inhibitor) subunit 13B 0.048
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.048
TANK TRAF family member-associated NFKB activator 0.047
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.046
CD33 CD33 molecule 0.046
INSR insulin receptor 0.046
BAI1 brain-specific angiogenesis inhibitor 1 0.046
PDIA6 protein disulfide isomerase family A, member 6 0.046
LCK lymphocyte-specific protein tyrosine kinase 0.046
MAPK1 mitogen-activated protein kinase 1 0.046
KITLG KIT ligand 0.045
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Tor Target of rapamycin 0.317
ena enabled 0.203
didum dilute class unconventional myosin 0.166
lola longitudinals lacking 0.130
Lis-1 Lissencephaly-1 0.108
stan starry night 0.105
Src64B Src oncogene at 64B 0.102
mei-P26 CG12218 gene product from transcript CG12218-RA 0.081
W Wrinkled 0.078
fz frizzled 0.076
jumu jumeau 0.072
mRpL49 mitochondrial ribosomal protein L49 0.072
Fmr1 CG6203 gene product from transcript CG6203-RC 0.071
Atpalpha Na pump alpha subunit 0.071
BicD Bicaudal D 0.069
pum pumilio 0.063
slik Sterile20-like kinase 0.061
psq pipsqueak 0.059
JIL-1 CG6297 gene product from transcript CG6297-RA 0.058
BEAF-32 Boundary element-associated factor of 32kD 0.058
dp dumpy 0.056
mts microtubule star 0.056
lea leak 0.053
Rm62 CG10279 gene product from transcript CG10279-RD 0.052
Mhc Myosin heavy chain 0.052
sesB stress-sensitive B 0.051
chic chickadee 0.051
robo roundabout 0.050
bon bonus 0.049
fz2 frizzled 2 0.048
chico CG5686 gene product from transcript CG5686-RB 0.047
Arf51F ADP ribosylation factor 51F 0.046
Dscam Down syndrome cell adhesion molecule 0.045
CG11699 CG11699 gene product from transcript CG11699-RA 0.045
CG3731 CG3731 gene product from transcript CG3731-RA 0.044
phl pole hole 0.044
flfl falafel 0.043
fw furrowed 0.043
gwl greatwall 0.042
su(f) suppressor of forked 0.042
Rho1 CG8416 gene product from transcript CG8416-RB 0.042
CG8680 CG8680 gene product from transcript CG8680-RA 0.041
ftz-f1 ftz transcription factor 1 0.041
Bx42 CG8264 gene product from transcript CG8264-RA 0.041
tral trailer hitch 0.040
shi shibire 0.039
Syx7 Syntaxin 7 0.038
gl glass 0.038
wg wingless 0.038
Pp1-87B Protein phosphatase 1 at 87B 0.037
nej nejire 0.037
ecd ecdysoneless 0.037
Abl Abl tyrosine kinase 0.037
Pc Polycomb 0.036
crc cryptocephal 0.036
Tsc1 CG6147 gene product from transcript CG6147-RA 0.036
spin spinster 0.036
Pink1 PTEN-induced putative kinase 1 0.036
Hsf Heat shock factor 0.036
Vang Van Gogh 0.035
CG14818 CG14818 gene product from transcript CG14818-RA 0.035
Caf1 Chromatin assembly factor 1 subunit 0.035
C3G CG42328 gene product from transcript CG42328-RC 0.035
Pep Protein on ecdysone puffs 0.035
mmy mummy 0.035
Gem3 Gemin3 0.034
Pka-R1 cAMP-dependent protein kinase R1 0.033
fru fruitless 0.033
csw corkscrew 0.033
Csp Cysteine string protein 0.033
CG1074 CG1074 gene product from transcript CG1074-RA 0.032
dnc dunce 0.032
E2f2 E2F transcription factor 2 0.032
bcd bicoid 0.032
CG6843 CG6843 gene product from transcript CG6843-RA 0.032
CG2116 CG2116 gene product from transcript CG2116-RA 0.032
CG3689 CG3689 gene product from transcript CG3689-RB 0.032
nos nanos 0.031
RpS17 Ribosomal protein S17 0.031
ben bendless 0.031
pds5 CG17509 gene product from transcript CG17509-RA 0.031
L Lobe 0.031
g garnet 0.030
par-6 CG5884 gene product from transcript CG5884-RA 0.030
rl rolled 0.030
Khc Kinesin heavy chain 0.030
ck crinkled 0.029
fl(2)d female lethal d 0.029
Myt1 CG32417 gene product from transcript CG32417-RA 0.029
comm commissureless 0.029
cg combgap 0.029
Ubx Ultrabithorax 0.029
wge winged eye 0.029
PpD3 Protein phosphatase D3 0.029
Lam Lamin 0.029
salm spalt major 0.029
dpp decapentaplegic 0.029
Dl Delta 0.029
msk moleskin 0.028
nmo nemo 0.028
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Mus musculus
Name Description Probability Func Analog Organism
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.452
Tnf tumor necrosis factor 0.292
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.204
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.184
Fas Fas (TNF receptor superfamily member 6) 0.175
Ifng interferon gamma 0.135
Dlg4 discs, large homolog 4 (Drosophila) 0.124
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.105
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.097
Nos3 nitric oxide synthase 3, endothelial cell 0.094
Hand2 heart and neural crest derivatives expressed transcript 2 0.084
Hdac4 histone deacetylase 4 0.080
Acvr1 activin A receptor, type 1 0.079
Lepr leptin receptor 0.078
Apc adenomatosis polyposis coli 0.077
Il7 interleukin 7 0.075
Hspa5 heat shock protein 5 0.075
Tox thymocyte selection-associated high mobility group box 0.074
Ltb lymphotoxin B 0.074
Lrp1 low density lipoprotein receptor-related protein 1 0.067
Il2rg interleukin 2 receptor, gamma chain 0.065
Lyz2 lysozyme 2 0.058
Cxcr5 chemokine (C-X-C motif) receptor 5 0.055
Il10 interleukin 10 0.054
Lta lymphotoxin A 0.049
Cxcl13 chemokine (C-X-C motif) ligand 13 0.044
Bmp4 bone morphogenetic protein 4 0.041
Mef2d myocyte enhancer factor 2D 0.038
Tgfbr2 transforming growth factor, beta receptor II 0.036
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.034
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.033
Nf2 neurofibromatosis 2 0.032
Ikzf1 IKAROS family zinc finger 1 0.031
Prrx1 paired related homeobox 1 0.027
Mef2c myocyte enhancer factor 2C 0.027
Cd40 CD40 antigen 0.026
Manf mesencephalic astrocyte-derived neurotrophic factor 0.023
Zeb2 zinc finger E-box binding homeobox 2 0.023
Agtr2 angiotensin II receptor, type 2 0.023
Rab25 RAB25, member RAS oncogene family 0.023
Il2 interleukin 2 0.023
Tsc2 tuberous sclerosis 2 0.022
Dnajb11 DnaJ (Hsp40) homolog, subfamily B, member 11 0.021
Creld2 cysteine-rich with EGF-like domains 2 0.021
Snap25 synaptosomal-associated protein 25 0.021
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.020
Plxna4 plexin A4 0.020
Hdac5 histone deacetylase 5 0.020
Col4a3 collagen, type IV, alpha 3 0.020
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.019
Fyn Fyn proto-oncogene 0.019
Trp53 transformation related protein 53 0.019
Csf1 colony stimulating factor 1 (macrophage) 0.018
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.017
Nrcam neuron-glia-CAM-related cell adhesion molecule 0.016
Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 0.016
Bcl3 B-cell leukemia/lymphoma 3 0.016
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.015
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.015
Pten phosphatase and tensin homolog 0.015
Casp8 caspase 8 0.015
Tlr2 toll-like receptor 2 0.014
Nf1 neurofibromatosis 1 0.014
Rag1 recombination activating gene 1 0.013
Hspa1a heat shock protein 1A 0.013
Hand1 heart and neural crest derivatives expressed transcript 1 0.013
Il6st interleukin 6 signal transducer 0.013
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.013
Cd19 CD19 antigen 0.013
Tcra T-cell receptor alpha chain 0.013
Gucy1a3 guanylate cyclase 1, soluble, alpha 3 0.012
Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta 0.012
Il4 interleukin 4 0.012
Ptgs2 prostaglandin-endoperoxide synthase 2 0.012
Esr1 estrogen receptor 1 (alpha) 0.012
Gja1 gap junction protein, alpha 1 0.012
Dnajc3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.012
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.012
Ret ret proto-oncogene 0.012
Id2 inhibitor of DNA binding 2 0.012
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.011
Adam17 a disintegrin and metallopeptidase domain 17 0.011
Cd44 CD44 antigen 0.011
Ptprc protein tyrosine phosphatase, receptor type, C 0.011
Gucy1b3 guanylate cyclase 1, soluble, beta 3 0.011
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.011
Igbp1 immunoglobulin (CD79A) binding protein 1 0.011
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.011
Cntn1 contactin 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TFG2 Tfg2p 0.014