The network for 'interferon gamma mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interferon gamma mediated signaling pathway

A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.

Homo sapiens
Name Description Probability Func Analog Organism
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.851
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.826
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.818
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.504
STAT1 signal transducer and activator of transcription 1, 91kDa 0.367
EGFR epidermal growth factor receptor 0.364
FYN FYN oncogene related to SRC, FGR, YES 0.348
HCK hemopoietic cell kinase 0.326
JAK2 Janus kinase 2 0.302
HNF4A hepatocyte nuclear factor 4, alpha 0.275
NCOR2 nuclear receptor corepressor 2 0.225
IRF9 interferon regulatory factor 9 0.195
NMI N-myc (and STAT) interactor 0.171
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.167
RXRA retinoid X receptor, alpha 0.163
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.157
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.156
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.153
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.130
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.122
STAP2 signal transducing adaptor family member 2 0.107
INSR insulin receptor 0.083
RIPK2 receptor-interacting serine-threonine kinase 2 0.080
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.076
ESR1 estrogen receptor 1 0.062
GHR growth hormone receptor 0.057
IL4R interleukin 4 receptor 0.055
SPRR2A small proline-rich protein 2A 0.055
PLCG1 phospholipase C, gamma 1 0.050
SYK spleen tyrosine kinase 0.049
NCK1 NCK adaptor protein 1 0.046
BIRC3 baculoviral IAP repeat containing 3 0.045
STAT5A signal transducer and activator of transcription 5A 0.044
GRB2 growth factor receptor-bound protein 2 0.042
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.042
LCK lymphocyte-specific protein tyrosine kinase 0.040
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.039
IL2RB interleukin 2 receptor, beta 0.038
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.035
IL12RB2 interleukin 12 receptor, beta 2 0.031
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.030
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.028
ITK IL2-inducible T-cell kinase 0.025
BCAR1 breast cancer anti-estrogen resistance 1 0.025
WIPF1 WAS/WASL interacting protein family, member 1 0.024
IFNGR1 interferon gamma receptor 1 0.024
STAT2 signal transducer and activator of transcription 2, 113kDa 0.020
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.019
NCOA1 nuclear receptor coactivator 1 0.019
COMMD1 copper metabolism (Murr1) domain containing 1 0.017
MAVS mitochondrial antiviral signaling protein 0.017
SP1 Sp1 transcription factor 0.016
BTN3A1 butyrophilin, subfamily 3, member A1 0.016
BCL3 B-cell CLL/lymphoma 3 0.016
GAS7 growth arrest-specific 7 0.015
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.014
MET met proto-oncogene (hepatocyte growth factor receptor) 0.014
MED10 mediator complex subunit 10 0.014
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.013
DTX3L deltex 3-like (Drosophila) 0.013
JAK1 Janus kinase 1 0.012
PGR progesterone receptor 0.012
TNS4 tensin 4 0.012
GRB7 growth factor receptor-bound protein 7 0.012
SH2B1 SH2B adaptor protein 1 0.011
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.011
MED28 mediator complex subunit 28 0.011
GBP5 guanylate binding protein 5 0.011
SOCS3 suppressor of cytokine signaling 3 0.010
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
atf3 activating transcription factor 3 0.566
socs3a suppressor of cytokine signaling 3a 0.417
junb jun B proto-oncogene 0.325
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.105
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.102
junbl jun B proto-oncogene, like 0.077
fosl2 fos-like antigen 2 0.077
jun jun proto-oncogene 0.047
LOC100000332 e3 ubiquitin-protein ligase RNF182-like 0.044
zgc:153997 zgc:153997 0.043
copeb core promoter element binding protein 0.036
stat3 signal transduction and activation of transcription 3 0.033
mmp9 matrix metalloproteinase 9 0.032
socs3b suppressor of cytokine signaling 3b 0.031
zgc:92851 zgc:92851 0.030
cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.029
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.027
fabp11a fatty acid binding protein 11a 0.025
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.024
mcl1a myeloid cell leukemia sequence 1a 0.023
vtg1 vitellogenin 1 0.023
dusp2 dual specificity phosphatase 2 0.020
LOC100331484 hypothetical protein LOC100331484 0.020
zgc:110340 zgc:110340 0.017
si:dkey-228g21.4 si:dkey-228g21.4 0.017
cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.016
irf11 interferon regulatory factor 11 0.015
kiss1 KiSS-1 metastasis-suppressor 0.015
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.013
gadd45bb growth arrest and DNA-damage-inducible, beta b 0.013
sgk1 serum/glucocorticoid regulated kinase 1 0.012
igfbp1a insulin-like growth factor binding protein 1a 0.012
gadd45g growth arrest and DNA-damage-inducible, gamma 0.012
dusp5 dual specificity phosphatase 5 0.011
sat1a spermidine/spermine N1-acetyltransferase 1a 0.011
card14 caspase recruitment domain family, member 14 0.010
zgc:100919 zgc:100919 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Stat3 signal transducer and activator of transcription 3 0.966
Irf9 interferon regulatory factor 9 0.416
Lepr leptin receptor 0.397
Fas Fas (TNF receptor superfamily member 6) 0.328
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.312
Uba7 ubiquitin-like modifier activating enzyme 7 0.288
Foxp3 forkhead box P3 0.251
Stat2 signal transducer and activator of transcription 2 0.233
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.207
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.196
Jak2 Janus kinase 2 0.178
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.169
Il6st interleukin 6 signal transducer 0.154
Myd88 myeloid differentiation primary response gene 88 0.148
Socs3 suppressor of cytokine signaling 3 0.142
Il4ra interleukin 4 receptor, alpha 0.132
Socs1 suppressor of cytokine signaling 1 0.082
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.078
Irgm1 immunity-related GTPase family M member 1 0.064
Trim21 tripartite motif-containing 21 0.055
Il1r1 interleukin 1 receptor, type I 0.051
Igtp interferon gamma induced GTPase 0.049
Tgfb1 transforming growth factor, beta 1 0.049
Kit kit oncogene 0.049
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.046
Stat6 signal transducer and activator of transcription 6 0.044
Tapbp TAP binding protein 0.040
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.038
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.037
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.033
Stat1 signal transducer and activator of transcription 1 0.031
Jak1 Janus kinase 1 0.031
Trp53 transformation related protein 53 0.029
Ncoa3 nuclear receptor coactivator 3 0.029
Ncoa6 nuclear receptor coactivator 6 0.029
Csf1 colony stimulating factor 1 (macrophage) 0.028
Irgm2 immunity-related GTPase family M member 2 0.027
Ifnar2 interferon (alpha and beta) receptor 2 0.027
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.025
Lyz2 lysozyme 2 0.025
Junb Jun-B oncogene 0.024
Mx2 myxovirus (influenza virus) resistance 2 0.023
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.022
Parp14 poly (ADP-ribose) polymerase family, member 14 0.021
Ikzf1 IKAROS family zinc finger 1 0.021
Nckap1l NCK associated protein 1 like 0.020
Tbk1 TANK-binding kinase 1 0.019
Il17ra interleukin 17 receptor A 0.019
Adar adenosine deaminase, RNA-specific 0.019
Bcl3 B-cell leukemia/lymphoma 3 0.019
Znfx1 zinc finger, NFX1-type containing 1 0.019
H2-K1 histocompatibility 2, K1, K region 0.019
Stat5b signal transducer and activator of transcription 5B 0.018
Smad4 MAD homolog 4 (Drosophila) 0.018
Gbp7 guanylate binding protein 7 0.018
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.017
Ifnar1 interferon (alpha and beta) receptor 1 0.017
Birc3 baculoviral IAP repeat-containing 3 0.016
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.016
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.016
Nfil3 nuclear factor, interleukin 3, regulated 0.015
Cd19 CD19 antigen 0.015
Gbp2 guanylate binding protein 2 0.015
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.014
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.014
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.014
Usp18 ubiquitin specific peptidase 18 0.014
Gbp3 guanylate binding protein 3 0.014
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.014
Ifit1 interferon-induced protein with tetratricopeptide repeats 1 0.013
Zfp36 zinc finger protein 36 0.013
Adam17 a disintegrin and metallopeptidase domain 17 0.013
Pim1 proviral integration site 1 0.013
Irf8 interferon regulatory factor 8 0.013
Tgtp2 T-cell specific GTPase 2 0.012
Ghr growth hormone receptor 0.012
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.012
Icos inducible T-cell co-stimulator 0.012
H2-D1 histocompatibility 2, D region locus 1 0.012
Dock2 dedicator of cyto-kinesis 2 0.012
1810019J16Rik RIKEN cDNA 1810019J16 gene 0.012
Irf7 interferon regulatory factor 7 0.011
Ahr aryl-hydrocarbon receptor 0.011
Jak3 Janus kinase 3 0.011
Irf1 interferon regulatory factor 1 0.011
Traf6 TNF receptor-associated factor 6 0.011
Tnip1 TNFAIP3 interacting protein 1 0.011
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.011
Cd28 CD28 antigen 0.011
BC006779 cDNA sequence BC006779 0.011
Icam1 intercellular adhesion molecule 1 0.010
Il6 interleukin 6 0.010
Sp100 nuclear antigen Sp100 0.010
Arid1b AT rich interactive domain 1B (SWI-like) 0.010
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism