The network for 'chondrocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

chondrocyte differentiation

The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Fgfr3 fibroblast growth factor receptor 3 1.000
Sox9 SRY-box containing gene 9 1.000
Fgf8 fibroblast growth factor 8 1.000
Bmp4 bone morphogenetic protein 4 1.000
Prrx1 paired related homeobox 1 0.999
Col1a1 collagen, type I, alpha 1 0.999
Fgfr1 fibroblast growth factor receptor 1 0.998
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.997
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.997
Foxc1 forkhead box C1 0.996
Nodal nodal 0.995
Pten phosphatase and tensin homolog 0.995
Rarg retinoic acid receptor, gamma 0.994
Prrx2 paired related homeobox 2 0.994
Pax3 paired box gene 3 0.994
Tgfbr2 transforming growth factor, beta receptor II 0.994
Nog noggin 0.993
Tgfb2 transforming growth factor, beta 2 0.991
Otx2 orthodenticle homolog 2 (Drosophila) 0.990
Pthlh parathyroid hormone-like peptide 0.989
Mapk14 mitogen-activated protein kinase 14 0.987
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.985
En1 engrailed 1 0.983
Runx2 runt related transcription factor 2 0.981
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.981
Bmp7 bone morphogenetic protein 7 0.981
Dlx5 distal-less homeobox 5 0.980
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.980
Hoxd11 homeobox D11 0.978
Msx1 homeobox, msh-like 1 0.973
Pax2 paired box gene 2 0.972
Hoxd13 homeobox D13 0.970
Amhr2 anti-Mullerian hormone type 2 receptor 0.958
Smo smoothened homolog (Drosophila) 0.957
Col2a1 collagen, type II, alpha 1 0.956
Twist2 twist homolog 2 (Drosophila) 0.955
Neurod1 neurogenic differentiation 1 0.952
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.951
Gata4 GATA binding protein 4 0.948
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.947
Lhx1 LIM homeobox protein 1 0.942
Sfrp2 secreted frizzled-related protein 2 0.941
Col5a1 collagen, type V, alpha 1 0.938
Fbn1 fibrillin 1 0.935
Smad6 MAD homolog 6 (Drosophila) 0.933
Fgf18 fibroblast growth factor 18 0.928
Snai1 snail homolog 1 (Drosophila) 0.927
Hoxa1 homeobox A1 0.927
Hoxa13 homeobox A13 0.922
Ptch1 patched homolog 1 0.921
Sox2 SRY-box containing gene 2 0.917
Eya1 eyes absent 1 homolog (Drosophila) 0.912
Wnt5a wingless-related MMTV integration site 5A 0.911
Col1a2 collagen, type I, alpha 2 0.910
Apc adenomatosis polyposis coli 0.910
Meox2 mesenchyme homeobox 2 0.907
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.906
Fgf10 fibroblast growth factor 10 0.903
Pax9 paired box gene 9 0.898
Alx4 aristaless-like homeobox 4 0.889
Foxc2 forkhead box C2 0.872
Hand1 heart and neural crest derivatives expressed transcript 1 0.868
Msx2 homeobox, msh-like 2 0.864
Neurog3 neurogenin 3 0.860
Col11a1 collagen, type XI, alpha 1 0.853
Tcfap2a transcription factor AP-2, alpha 0.849
Bmp5 bone morphogenetic protein 5 0.840
Pitx2 paired-like homeodomain transcription factor 2 0.837
Smad3 MAD homolog 3 (Drosophila) 0.834
Foxa2 forkhead box A2 0.833
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.833
Fgf9 fibroblast growth factor 9 0.831
Twist1 twist homolog 1 (Drosophila) 0.827
Gas1 growth arrest specific 1 0.827
Bmpr1a bone morphogenetic protein receptor, type 1A 0.825
Hand2 heart and neural crest derivatives expressed transcript 2 0.823
Col5a2 collagen, type V, alpha 2 0.816
Rara retinoic acid receptor, alpha 0.814
Lox lysyl oxidase 0.810
Wnt3a wingless-related MMTV integration site 3A 0.803
Gpc3 glypican 3 0.797
Alx3 aristaless-like homeobox 3 0.797
Ret ret proto-oncogene 0.795
Eln elastin 0.789
Smad4 MAD homolog 4 (Drosophila) 0.785
Acvr1 activin A receptor, type 1 0.778
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.768
Fstl1 follistatin-like 1 0.762
Mrc2 mannose receptor, C type 2 0.756
Fzd2 frizzled homolog 2 (Drosophila) 0.754
Tbx15 T-box 15 0.748
Kiss1 KiSS-1 metastasis-suppressor 0.737
Col6a2 collagen, type VI, alpha 2 0.735
Lef1 lymphoid enhancer binding factor 1 0.734
Tbx1 T-box 1 0.732
Tcf21 transcription factor 21 0.727
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
wnt5b wingless-type MMTV integration site family, member 5b 0.466
col11a2 collagen type XI alpha-2 0.276
tbx1 T-box 1 0.175
twist3 twist3 0.156
shha sonic hedgehog a 0.074
hoxa13b homeo box A13b 0.063
gli1 GLI-Kruppel family member 1 0.062
bmp2a bone morphogenetic protein 2a 0.061
twist1a twist1a 0.056
sox9a SRY-box containing gene 9a 0.055
ptch2 patched 2 0.055
wnt9a wingless-type MMTV integration site family, member 9A 0.055
fgf3 fibroblast growth factor 3 0.051
hoxa11a homeo box A11a 0.045
tbx2a T-box gene 2a 0.034
fgf4 fibroblast growth factor 4 0.033
tbx18 T-box 18 0.033
gpc4 glypican 4 0.032
fgf10a fibroblast growth factor 10a 0.031
wnt1 wingless-type MMTV integration site family, member 1 0.031
wnt10a wingless-type MMTV integration site family, member 10a 0.031
sulf1 sulfatase 1 0.028
wnt3 wingless-type MMTV integration site family, member 3 0.028
wnt2 wingless-type MMTV integration site family member 2 0.027
runx2b runt-related transcription factor 2b 0.027
hoxd9a homeo box D9a 0.026
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.025
bmp2b bone morphogenetic protein 2b 0.025
col5a1 procollagen, type V, alpha 1 0.024
rarga retinoic acid receptor gamma a 0.023
hoxd13a homeo box D13a 0.023
fn1 fibronectin 1 0.022
zic3 zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila) 0.021
hoxa11b homeo box A11b 0.021
col10a1 collagen, type X, alpha 1 0.020
sparc secreted acidic cysteine rich glycoprotein 0.020
wnt11r wingless-type MMTV integration site family, member 11, related 0.020
msxd muscle segment homeobox D 0.020
barx1 BarH-like homeobox 1 0.019
alpi alkaline phosphatase, intestinal 0.019
zfyve26 zinc finger, FYVE domain containing 26 0.019
hoxd10a homeo box D10a 0.018
prrx1a paired related homeobox 1a 0.018
fgf17 fibroblast growth factor 17 0.018
bmp4 bone morphogenetic protein 4 0.018
myf6 myogenic factor 6 0.018
dlx5a distal-less homeobox gene 5a 0.018
hoxd4a homeo box D4a 0.017
col2a1a collagen type II, alpha-1a 0.017
hoxa9b homeo box A9b 0.017
wnt9b wingless-type MMTV integration site family, member 9B 0.016
foxd3 forkhead box D3 0.016
hand2 heart and neural crest derivatives expressed transcript 2 0.016
wu:fv91b12 wu:fv91b12 0.015
msxb muscle segment homeobox B 0.015
gngt2b guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b 0.015
myod1 myogenic differentiation 1 0.015
boc brother of CDO 0.015
osr2 odd-skipped related 2 (Drosophila) 0.014
bhlhe41 basic helix-loop-helix family, member e41 0.013
sdc2 syndecan 2 0.013
mef2ca myocyte enhancer factor 2ca 0.013
fgf6a fibroblast growth factor 6a 0.013
igfbp3 insulin-like growth factor binding protein 3 0.013
prdm1a PR domain containing 1a, with ZNF domain 0.013
dlx3b distal-less homeobox gene 3b 0.013
wnt4a wingless-type MMTV integration site family, member 4a 0.013
si:ch211-173b8.2 si:ch211-173b8.2 0.012
mef2d myocyte enhancer factor 2d 0.012
slit3 slit (Drosophila) homolog 3 0.012
prrx1b paired related homeobox 1b 0.012
dlx2a distal-less homeobox gene 2a 0.012
wnt3a wingless-type MMTV integration site family, member 3A 0.012
eng1a engrailed 1a 0.012
gpr126 G protein-coupled receptor 126 0.012
mical3 flavoprotein oxidoreductase MICAL3 0.012
ism1 isthmin 1 0.011
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.011
smad9 MAD homolog 9 (Drosophila) 0.011
smad3a MAD homolog 3a (Drosophila) 0.011
sema3aa semaphorin 3aa 0.011
dkk1b dickkopf 1b 0.010
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.010
tnfsf10l3 tumor necrosis factor (ligand) superfamily, member 10 like 3 0.010
fgfr2 fibroblast growth factor receptor 2 0.010
s1pr2 sphingosine-1-phosphate receptor 2 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SMAD7 SMAD family member 7 0.939
ENG endoglin 0.672
BMPR1A bone morphogenetic protein receptor, type IA 0.589
FBLN1 fibulin 1 0.446
FSTL1 follistatin-like 1 0.406
FKBP1A FK506 binding protein 1A, 12kDa 0.403
BMP2 bone morphogenetic protein 2 0.363
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.284
SMAD2 SMAD family member 2 0.277
ELN elastin 0.220
POU3F2 POU class 3 homeobox 2 0.211
FN1 fibronectin 1 0.183
COL6A2 collagen, type VI, alpha 2 0.183
PAX3 paired box 3 0.182
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.180
SMAD4 SMAD family member 4 0.165
ATN1 atrophin 1 0.150
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.096
TGFB1 transforming growth factor, beta 1 0.084
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.081
GDF5 growth differentiation factor 5 0.076
PCGF2 polycomb group ring finger 2 0.072
SORBS3 sorbin and SH3 domain containing 3 0.072
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.070
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.065
FBN1 fibrillin 1 0.061
BMPR1B bone morphogenetic protein receptor, type IB 0.060
TGFB3 transforming growth factor, beta 3 0.059
LTBP2 latent transforming growth factor beta binding protein 2 0.058
COL2A1 collagen, type II, alpha 1 0.053
LOXL1 lysyl oxidase-like 1 0.051
MEOX2 mesenchyme homeobox 2 0.046
COL1A1 collagen, type I, alpha 1 0.045
FZD1 frizzled homolog 1 (Drosophila) 0.042
SKI v-ski sarcoma viral oncogene homolog (avian) 0.042
ACVR1 activin A receptor, type I 0.042
FBLN5 fibulin 5 0.041
LTBP4 latent transforming growth factor beta binding protein 4 0.040
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.039
FGF1 fibroblast growth factor 1 (acidic) 0.036
COL5A1 collagen, type V, alpha 1 0.036
DDR2 discoidin domain receptor tyrosine kinase 2 0.035
ZFYVE9 zinc finger, FYVE domain containing 9 0.032
FGF18 fibroblast growth factor 18 0.031
MSX1 msh homeobox 1 0.030
BMP4 bone morphogenetic protein 4 0.030
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.029
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.027
COL6A1 collagen, type VI, alpha 1 0.027
CTGF connective tissue growth factor 0.026
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.026
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.025
SFRP1 secreted frizzled-related protein 1 0.025
FGF2 fibroblast growth factor 2 (basic) 0.024
BMP1 bone morphogenetic protein 1 0.024
HMGA2 high mobility group AT-hook 2 0.023
THBS1 thrombospondin 1 0.023
BMI1 BMI1 polycomb ring finger oncogene 0.023
AR androgen receptor 0.023
PCOLCE procollagen C-endopeptidase enhancer 0.023
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.023
BGN biglycan 0.022
LRP6 low density lipoprotein receptor-related protein 6 0.022
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.021
PRKG1 protein kinase, cGMP-dependent, type I 0.021
ACAN aggrecan 0.020
IGFBP5 insulin-like growth factor binding protein 5 0.020
INHBA inhibin, beta A 0.020
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.020
SMAD1 SMAD family member 1 0.020
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.019
CYR61 cysteine-rich, angiogenic inducer, 61 0.019
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.019
NFIA nuclear factor I/A 0.018
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.018
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.018
HOXB5 homeobox B5 0.018
LTBP1 latent transforming growth factor beta binding protein 1 0.018
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.018
CALD1 caldesmon 1 0.017
GDF6 growth differentiation factor 6 0.017
LOX lysyl oxidase 0.017
TGFBR1 transforming growth factor, beta receptor 1 0.017
COL13A1 collagen, type XIII, alpha 1 0.016
WNT4 wingless-type MMTV integration site family, member 4 0.016
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.016
FZD8 frizzled homolog 8 (Drosophila) 0.016
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.016
TNC tenascin C 0.016
INHBB inhibin, beta B 0.016
COMP cartilage oligomeric matrix protein 0.016
TRIP6 thyroid hormone receptor interactor 6 0.016
EP300 E1A binding protein p300 0.015
TGFB2 transforming growth factor, beta 2 0.015
SP1 Sp1 transcription factor 0.015
EPAS1 endothelial PAS domain protein 1 0.015
CBX8 chromobox homolog 8 0.015
EHD2 EH-domain containing 2 0.015
IGFBP3 insulin-like growth factor binding protein 3 0.015
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.014
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.524
Col5a2 collagen, type V, alpha 2 0.213
Col3a1 collagen, type III, alpha 1 0.142
Col1a2 collagen, type I, alpha 2 0.052
Fstl1 follistatin-like 1 0.043
Dbp D site of albumin promoter (albumin D-box) binding protein 0.041
Col12a1 collagen, type XII, alpha 1 0.038
Lox lysyl oxidase 0.034
Fbn1 fibrillin 1 0.031
Postn periostin, osteoblast specific factor 0.026
Col4a5 collagen, type IV, alpha 5 0.024
Dab2 disabled homolog 2 (Drosophila) 0.023
Vim vimentin 0.022
Lum lumican 0.020
Fn1 fibronectin 1 0.017
Col5a1 collagen, type V, alpha 1 0.017
Bgn biglycan 0.013
Loxl1 lysyl oxidase-like 1 0.013
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism