The network for 'lateral inhibition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lateral inhibition

Signaling between cells of equivalent developmental potential that results in these cells adopting different developmental fates. An example is the suppression by cells with a particular fate of the adoption of the same fate by surrounding cells.

Mus musculus
Name Description Probability Func Analog Organism
Psen1 presenilin 1 1.000
Notch1 Notch gene homolog 1 (Drosophila) 1.000
Pten phosphatase and tensin homolog 0.995
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.995
Hes1 hairy and enhancer of split 1 (Drosophila) 0.990
Notch2 Notch gene homolog 2 (Drosophila) 0.989
Ctnnb1 catenin (cadherin associated protein), beta 1 0.988
Dll1 delta-like 1 (Drosophila) 0.985
Id3 inhibitor of DNA binding 3 0.972
Id1 inhibitor of DNA binding 1 0.933
Emx1 empty spiracles homolog 1 (Drosophila) 0.920
Psen2 presenilin 2 0.919
Robo1 roundabout homolog 1 (Drosophila) 0.911
Fyn Fyn proto-oncogene 0.893
Chd7 chromodomain helicase DNA binding protein 7 0.885
Cbl Casitas B-lineage lymphoma 0.834
Sox2 SRY-box containing gene 2 0.830
Cdc25b cell division cycle 25 homolog B (S. pombe) 0.813
Cdc25a cell division cycle 25 homolog A (S. pombe) 0.775
Grb2 growth factor receptor bound protein 2 0.757
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.713
Emx2 empty spiracles homolog 2 (Drosophila) 0.706
Tcf4 transcription factor 4 0.666
Tsc1 tuberous sclerosis 1 0.635
Pax2 paired box gene 2 0.624
Aph1a anterior pharynx defective 1a homolog (C. elegans) 0.622
Foxg1 forkhead box G1 0.583
Mapk14 mitogen-activated protein kinase 14 0.563
Jag1 jagged 1 0.554
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.551
Lmnb1 lamin B1 0.548
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.512
Cops6 COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana) 0.500
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.493
Rb1 retinoblastoma 1 0.491
Nf2 neurofibromatosis 2 0.490
Tcf3 transcription factor 3 0.440
Wiz widely-interspaced zinc finger motifs 0.428
Prkg1 protein kinase, cGMP-dependent, type I 0.425
Ncstn nicastrin 0.400
Uncx UNC homeobox 0.399
Cops3 COP9 (constitutive photomorphogenic) homolog, subunit 3 (Arabidopsis thaliana) 0.393
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.376
Ptk7 PTK7 protein tyrosine kinase 7 0.373
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.358
Otx1 orthodenticle homolog 1 (Drosophila) 0.357
Lmnb2 lamin B2 0.357
Slit3 slit homolog 3 (Drosophila) 0.355
Otx2 orthodenticle homolog 2 (Drosophila) 0.354
Efnb2 ephrin B2 0.344
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.329
Smad1 MAD homolog 1 (Drosophila) 0.324
Dll4 delta-like 4 (Drosophila) 0.321
Mib1 mindbomb homolog 1 (Drosophila) 0.318
Skor1 SKI family transcriptional corepressor 1 0.318
Kpna3 karyopherin (importin) alpha 3 0.313
Egfl7 EGF-like domain 7 0.309
Ikzf1 IKAROS family zinc finger 1 0.308
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.293
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.271
Slit2 slit homolog 2 (Drosophila) 0.270
Foxc1 forkhead box C1 0.265
Ptf1a pancreas specific transcription factor, 1a 0.263
Polr2k polymerase (RNA) II (DNA directed) polypeptide K 0.263
Jag2 jagged 2 0.263
Ptp4a2 protein tyrosine phosphatase 4a2 0.260
Ncapg non-SMC condensin I complex, subunit G 0.259
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.259
Brd4 bromodomain containing 4 0.258
Arhgap1 Rho GTPase activating protein 1 0.257
Efnb1 ephrin B1 0.253
App amyloid beta (A4) precursor protein 0.245
Pofut1 protein O-fucosyltransferase 1 0.242
Ddah2 dimethylarginine dimethylaminohydrolase 2 0.242
Prkcd protein kinase C, delta 0.239
Atp11c ATPase, class VI, type 11C 0.238
Cpeb3 cytoplasmic polyadenylation element binding protein 3 0.234
Lrrc40 leucine rich repeat containing 40 0.231
Cops5 COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana) 0.230
Lig1 ligase I, DNA, ATP-dependent 0.229
Ube2c ubiquitin-conjugating enzyme E2C 0.228
Syvn1 synovial apoptosis inhibitor 1, synoviolin 0.228
Gsk3b glycogen synthase kinase 3 beta 0.228
Lhx9 LIM homeobox protein 9 0.227
Lin7c lin-7 homolog C (C. elegans) 0.225
Fgfr1 fibroblast growth factor receptor 1 0.225
Kitl kit ligand 0.223
Nrarp Notch-regulated ankyrin repeat protein 0.222
Cdt1 chromatin licensing and DNA replication factor 1 0.221
Wnt4 wingless-related MMTV integration site 4 0.217
Dlg1 discs, large homolog 1 (Drosophila) 0.215
Fzd2 frizzled homolog 2 (Drosophila) 0.212
Gps1 G protein pathway suppressor 1 0.208
Cox5a cytochrome c oxidase, subunit Va 0.206
Rrm2 ribonucleotide reductase M2 0.206
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.204
Rrm1 ribonucleotide reductase M1 0.199
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.196
Ptrf polymerase I and transcript release factor 0.196
Usp9x ubiquitin specific peptidase 9, X chromosome 0.192
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
ttm-4 Protein TTM-4 0.014
unc-73 Protein UNC-73 0.014
C05C10.2 Protein C05C10.2 0.013
cdl-1 Protein CDL-1 0.013
ccdc-47 Protein CCDC-47 0.013
Y42H9B.3 Protein Y42H9B.3 0.013
grl-4 Protein GRL-4 0.013
sel-10 Protein SEL-10 0.012
lin-40 Protein LIN-40 0.012
F11E6.7 Protein F11E6.7 0.012
mex-5 Protein MEX-5 0.012
ifa-1 Protein IFA-1 0.012
kin-10 Protein KIN-10 0.012
sas-4 Protein SAS-4 0.012
mig-2 Protein MIG-2 0.012
zyg-8 Protein ZYG-8 0.012
smg-7 Protein SMG-7 0.012
npp-2 Protein NPP-2 0.011
mdf-2 Protein MDF-2 0.011
smu-2 Protein SMU-2 0.011
tag-315 Protein TAG-315 0.011
rfc-2 Protein RFC-2 0.011
syg-2 Protein SYG-2 0.011
ifb-2 Protein IFB-2 0.011
nhr-31 Protein NHR-31 0.011
sas-5 Protein SAS-5 0.011
cam-1 Protein CAM-1 0.011
F12F6.1 Protein F12F6.1 0.011
rnr-1 Protein RNR-1 0.011
taf-6.1 Protein TAF-6.1 0.011
pqn-51 Protein PQN-51 0.011
rpa-1 Protein RPA-1 0.011
sel-8 Protein SEL-8 0.011
mcm-4 Protein MCM-4 0.011
par-5 Protein PAR-5 0.011
nhr-55 Protein NHR-55 0.011
pxf-1 Protein PXF-1 0.011
ttll-4 Protein TTLL-4 0.011
trr-1 Protein TRR-1 0.011
cco-1 Protein CCO-1 0.011
B0205.9 Protein B0205.9 0.011
cas-2 Protein CAS-2 0.010
CELE_C12D8.1 Protein C12D8.1 0.010
F25B5.2 Protein F25B5.2 0.010
pct-1 Protein PCT-1 0.010
zfp-3 Protein ZFP-3 0.010
C16B8.3 Protein C16B8.3 0.010
H06I04.1 Protein H06I04.1 0.010
ocam-1 Protein OCAM-1 0.010
toe-4 Protein TOE-4 0.010
F22D3.2 Protein F22D3.2 0.010
lag-1 Protein LAG-1 0.010
csn-3 Protein CSN-3 0.010
dpy-26 Protein DPY-26 0.010
CELE_Y41D4B.6 Protein Y41D4B.6 0.010
F38E9.5 Protein F38E9.5 0.010
vps-36 Protein VPS-36 0.010
F13B12.1 Protein F13B12.1 0.010
lag-2 Protein LAG-2 0.010
ubc-3 Protein UBC-3 0.010
mls-2 Protein MLS-2 0.010
kin-19 Protein KIN-19 0.010
F17B5.6 Protein F17B5.6 0.010
CELE_F46F2.3 Protein F46F2.3 0.010
san-1 Protein SAN-1 0.010
pos-1 Protein POS-1 0.010
ant-1.1 Protein ANT-1.1 0.010
T19H12.2 Protein T19H12.2 0.010
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Danio rerio
Name Description Probability Func Analog Organism
jag1b jagged 1b 0.748
jag2 jagged 2 0.715
hlxb9la homeo box HB9 like a 0.635
kdrl kinase insert domain receptor like 0.632
twist1a twist1a 0.620
emx3 empty spiracles homeobox 3 0.578
dlc deltaC 0.569
gro1 groucho 1 0.547
dla deltaA 0.492
etv2 ets variant gene 2 0.487
notch3 notch homolog 3 0.432
notch2 notch homolog 2 0.413
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.400
tbx2b T-box 2b 0.381
lhx1a LIM homeobox 1a 0.374
dld deltaD 0.369
akt2 v-akt murine thymoma viral oncogene homolog 2 0.358
hgfa hepatocyte growth factor a 0.354
notch1a notch homolog 1a 0.349
inka1a induced in neural crest by AP2, 1a 0.330
kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.313
tp53 tumor protein p53 0.313
ascl1a achaete-scute complex-like 1a (Drosophila) 0.306
sox3 SRY-box containing gene 3 0.296
ephb4b eph receptor B4b 0.295
snai1a snail homolog 1a (Drosophila) 0.291
pou3f1 POU class 3 homeobox 1 0.287
alcamb activated leukocyte cell adhesion molecule b 0.281
coe2 coe2 0.278
sema3aa semaphorin 3aa 0.270
sema3fb semaphorin 3fb 0.269
her6 hairy-related 6 0.267
ccm2 cerebral cavernous malformation 2 0.267
wu:fv91b12 wu:fv91b12 0.261
barhl1.2 BarH-like 1.2 0.254
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.253
foxp2 forkhead box P2 0.249
hlxb9lb homeo box HB9 like b 0.249
cdh1 cadherin 1, epithelial 0.248
sox19a SRY-box containing gene 19a 0.247
wtip Wilms tumor 1 interacting protein 0.242
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.241
efnb2a ephrin B2a 0.239
grina glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 0.238
fzd5 frizzled homolog 5 0.237
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.236
gdf6a growth differentiation factor 6a 0.233
tal1 T-cell acute lymphocytic leukemia 1 0.224
wnt5b wingless-type MMTV integration site family, member 5b 0.223
dzip1 DAZ interacting protein 1 0.217
zgc:55573 zgc:55573 0.213
stmn1b stathmin 1b 0.208
olig2 oligodendrocyte lineage transcription factor 2 0.207
gpia glucose phosphate isomerase a 0.203
her1 hairy-related 1 0.202
ubl7 ubiquitin-like 7 0.201
gpc4 glypican 4 0.195
cops3 COP9 constitutive photomorphogenic homolog subunit 3 0.192
plcg1 phospholipase C, gamma 1 0.190
ptp4a1 protein tyrosine phosphatase type IVA, member 1 0.184
mfn2 mitofusin 2 0.180
ebf3 early B-cell factor 3 0.178
cap1 Cap1 CAP, adenylate cyclase-associated protein 1 0.177
pdzrn3 PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3 0.174
foxn1 forkhead box N1 0.168
vasp vasodilator-stimulated phosphoprotein 0.166
mapk14a mitogen-activated protein kinase 14a 0.165
dlb deltaB 0.165
chpf chondroitin polymerizing factor 0.162
LOC565459 tight junction protein ZO-1-like 0.155
fn1 fibronectin 1 0.154
hsp47 heat shock protein 47 0.154
racgap1 Rac GTPase-activating protein 1 0.154
wls wntless homolog (Drosophila) 0.153
vegfab vascular endothelial growth factor Ab 0.153
dab1b disabled homolog 1b (Drosophila) 0.151
ptpreb protein tyrosine phosphatase, receptor type, E, b 0.150
nrarpa notch-regulated ankyrin repeat protein a 0.150
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.143
pgk1 phosphoglycerate kinase 1 0.142
spon1b spondin 1b 0.137
ube4b ubiquitination factor E4B, UFD2 homolog (S. cerevisiae) 0.136
mllt11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.135
rbl1 retinoblastoma-like 1 (p107) 0.132
bmp4 bone morphogenetic protein 4 0.130
pitx3 paired-like homeodomain transcription factor 3 0.130
tjp1 tight junction protein 1 (zona occludens 1) 0.130
col11a1b collagen type XI alpha-1b and collagen, type XI, alpha 1b 0.126
hoxa13b homeo box A13b 0.126
gyltl1b glycosyltransferase-like 1b 0.125
ednra endothelin receptor type A 0.124
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.122
slit2 slit (Drosophila) homolog 2 0.121
smarcb1a SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a 0.120
cdk8 cyclin-dependent kinase 8 0.117
ptprea protein tyrosine phosphatase, receptor type, E, a 0.115
ripply1 ripply1 0.113
hnf1bb HNF1 homeobox Bb 0.113
wt1b wilms tumor 1b 0.112
ncl1 nicalin 0.111
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Drosophila melanogaster
Name Description Probability Func Analog Organism
dlt discs lost 0.978
stg string 0.970
Mad Mothers against dpp 0.966
Su(H) Suppressor of Hairless 0.953
Dl Delta 0.952
Ras85D Ras oncogene at 85D 0.902
Tab2 TAK1-associated binding protein 2 0.878
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.872
kuz kuzbanian 0.866
Sema-2a CG4700 gene product from transcript CG4700-RC 0.850
Det Deterin 0.842
spdo sanpodo 0.819
RfC4 Replication factor C subunit 4 0.808
ed echinoid 0.798
Dsor1 Downstream of raf1 0.796
slou slouch 0.795
esg escargot 0.776
Pde11 Phosphodiesterase 11 0.760
trio CG18214 gene product from transcript CG18214-RA 0.730
CG34345 CG34345 gene product from transcript CG34345-RA 0.722
Gnf1 Germ line transcription factor 1 0.693
Prosap CG30483 gene product from transcript CG30483-RA 0.689
Lam Lamin 0.685
ham hamlet 0.679
E(spl) Enhancer of split 0.662
mam mastermind 0.658
S6k RPS6-p70-protein kinase 0.658
CG31343 CG31343 gene product from transcript CG31343-RA 0.651
Fas2 Fasciclin 2 0.650
Psf3 CG2222 gene product from transcript CG2222-RA 0.612
slp1 sloppy paired 1 0.604
Lerp lysosomal enzyme receptor protein 0.600
Psf1 CG9187 gene product from transcript CG9187-RA 0.579
plexA plexin A 0.573
CG42404 CG42404 gene product from transcript CG42404-RC 0.572
CG2183 CG2183 gene product from transcript CG2183-RA 0.567
mid midline 0.561
CG5362 CG5362 gene product from transcript CG5362-RA 0.549
dap dacapo 0.541
proPO-A1 prophenol oxidase A1 0.541
larp La related protein 0.540
B-H2 BarH2 0.535
CG42369 CG42369 gene product from transcript CG42369-RA 0.532
CG8021 CG8021 gene product from transcript CG8021-RA 0.532
amos absent MD neurons and olfactory sensilla 0.519
kirre kin of irre 0.519
spen split ends 0.514
Rab10 Rab-protein 10 0.511
msk moleskin 0.507
Top1 Topoisomerase 1 0.501
fas faint sausage 0.497
lace CG4162 gene product from transcript CG4162-RA 0.478
zfh1 Zn finger homeodomain 1 0.474
klu klumpfuss 0.459
Mcm2 Minichromosome maintenance 2 0.458
RfC3 Replication factor C subunit 3 0.449
CG31198 CG31198 gene product from transcript CG31198-RA 0.444
babo baboon 0.434
scrib scribbled 0.427
tara taranis 0.424
Psn Presenilin 0.423
CG13983 CG13983 gene product from transcript CG13983-RA 0.420
eIF-4E Eukaryotic initiation factor 4E 0.415
CG8142 CG8142 gene product from transcript CG8142-RA 0.403
CtBP C-terminal Binding Protein 0.403
drl derailed 0.395
Taf1 TBP-associated factor 1 0.394
bib big brain 0.391
dsh dishevelled 0.385
CG16704 CG16704 gene product from transcript CG16704-RA 0.384
sing singles bar 0.379
hang hangover 0.378
sns sticks and stones 0.371
hipk homeodomain interacting protein kinase 0.367
CG7470 CG7470 gene product from transcript CG7470-RA 0.366
Tak1 TGF-beta activated kinase 1 0.364
sty sprouty 0.360
hbs hibris 0.356
WASp CG1520 gene product from transcript CG1520-RA 0.355
gig gigas 0.351
N Notch 0.343
vav CG7893 gene product from transcript CG7893-RB 0.343
bs blistered 0.338
ths thisbe 0.337
CG4612 CG4612 gene product from transcript CG4612-RA 0.333
KLHL18 CG3571 gene product from transcript CG3571-RA 0.330
egr eiger 0.324
sda slamdance 0.323
sbr small bristles 0.323
crol crooked legs 0.319
ewg erect wing 0.314
Hsc70-4 Heat shock protein cognate 4 0.309
dj don juan 0.300
l(2)k16918 lethal (2) k16918 0.298
sd scalloped 0.297
MtnA Metallothionein A 0.297
sna snail 0.297
CSN3 COP9 complex homolog subunit 3 0.296
ik2 IkappaB kinase-like 2 0.294
CG9772 CG9772 gene product from transcript CG9772-RB 0.294
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism