The network for 'angiogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Pax2 paired box gene 2 0.998
Gli3 GLI-Kruppel family member GLI3 0.995
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.995
Efnb2 ephrin B2 0.994
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.993
Pten phosphatase and tensin homolog 0.993
Nos3 nitric oxide synthase 3, endothelial cell 0.987
Otx2 orthodenticle homolog 2 (Drosophila) 0.985
Fgfr1 fibroblast growth factor receptor 1 0.984
Nog noggin 0.983
Vegfa vascular endothelial growth factor A 0.982
Ptgs2 prostaglandin-endoperoxide synthase 2 0.981
Gdnf glial cell line derived neurotrophic factor 0.978
Csf1 colony stimulating factor 1 (macrophage) 0.977
Fgf8 fibroblast growth factor 8 0.974
Tgfbr2 transforming growth factor, beta receptor II 0.970
Foxc1 forkhead box C1 0.968
Fgfr3 fibroblast growth factor receptor 3 0.968
Epha4 Eph receptor A4 0.966
Wt1 Wilms tumor 1 homolog 0.965
Shh sonic hedgehog 0.954
Pax3 paired box gene 3 0.951
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.951
Smad3 MAD homolog 3 (Drosophila) 0.950
Rarg retinoic acid receptor, gamma 0.950
Tcf21 transcription factor 21 0.947
Bmp4 bone morphogenetic protein 4 0.938
Sox7 SRY-box containing gene 7 0.938
Apc adenomatosis polyposis coli 0.937
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.936
Hoxa13 homeobox A13 0.934
Gli2 GLI-Kruppel family member GLI2 0.933
Pitx2 paired-like homeodomain transcription factor 2 0.932
Tgfb2 transforming growth factor, beta 2 0.927
Foxc2 forkhead box C2 0.926
Nodal nodal 0.924
Cav1 caveolin 1, caveolae protein 0.923
Lef1 lymphoid enhancer binding factor 1 0.923
Twist2 twist homolog 2 (Drosophila) 0.918
Eya1 eyes absent 1 homolog (Drosophila) 0.915
Ccl2 chemokine (C-C motif) ligand 2 0.913
Sox9 SRY-box containing gene 9 0.904
Ntf3 neurotrophin 3 0.902
Ar androgen receptor 0.901
Ptch1 patched homolog 1 0.900
Epas1 endothelial PAS domain protein 1 0.899
Acvrl1 activin A receptor, type II-like 1 0.886
Dab1 disabled homolog 1 (Drosophila) 0.884
Pbx1 pre B-cell leukemia transcription factor 1 0.882
Tbx3 T-box 3 0.878
Mapk14 mitogen-activated protein kinase 14 0.875
Sox3 SRY-box containing gene 3 0.874
Lepr leptin receptor 0.872
Smad6 MAD homolog 6 (Drosophila) 0.869
Pgr progesterone receptor 0.861
Kdr kinase insert domain protein receptor 0.861
Hand1 heart and neural crest derivatives expressed transcript 1 0.858
Mgat3 mannoside acetylglucosaminyltransferase 3 0.857
Hif1a hypoxia inducible factor 1, alpha subunit 0.855
Dll4 delta-like 4 (Drosophila) 0.852
Nos2 nitric oxide synthase 2, inducible 0.850
Rb1 retinoblastoma 1 0.849
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.846
Pax8 paired box gene 8 0.843
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.840
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.834
Hoxd13 homeobox D13 0.832
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.831
Gpc3 glypican 3 0.831
Pax6 paired box gene 6 0.830
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.823
Dll1 delta-like 1 (Drosophila) 0.822
Foxf1a forkhead box F1a 0.815
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.815
Fgf10 fibroblast growth factor 10 0.814
Ccr2 chemokine (C-C motif) receptor 2 0.813
Ephb2 Eph receptor B2 0.809
Cdh5 cadherin 5 0.807
Timp3 tissue inhibitor of metalloproteinase 3 0.806
Bmp5 bone morphogenetic protein 5 0.805
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.804
Sox2 SRY-box containing gene 2 0.803
Il6st interleukin 6 signal transducer 0.800
Emx2 empty spiracles homolog 2 (Drosophila) 0.796
Efna1 ephrin A1 0.792
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.786
Hes1 hairy and enhancer of split 1 (Drosophila) 0.781
Prrx2 paired related homeobox 2 0.777
Pthlh parathyroid hormone-like peptide 0.771
Sall4 sal-like 4 (Drosophila) 0.771
Foxa2 forkhead box A2 0.767
Hif3a hypoxia inducible factor 3, alpha subunit 0.766
Hand2 heart and neural crest derivatives expressed transcript 2 0.761
Ctnnb1 catenin (cadherin associated protein), beta 1 0.761
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.760
Adra2b adrenergic receptor, alpha 2b 0.756
Hoxa10 homeobox A10 0.756
Bmpr1a bone morphogenetic protein receptor, type 1A 0.755
Zic3 zinc finger protein of the cerebellum 3 0.752
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.958
cxcr4a chemokine (C-X-C motif) receptor 4a 0.957
wu:fv91b12 wu:fv91b12 0.938
fgfrl1b fibroblast growth factor receptor-like 1b 0.923
cdh5 cadherin 5 0.921
notch3 notch homolog 3 0.918
kdrl kinase insert domain receptor like 0.909
pitx3 paired-like homeodomain transcription factor 3 0.905
fli1a friend leukemia integration 1a 0.903
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.900
cxcr4b chemokine (C-X-C motif), receptor 4b 0.852
pea3 ETS-domain transcription factor pea3 0.850
alcama activated leukocyte cell adhesion molecule a 0.835
gata2a GATA-binding protein 2a 0.826
runx1 runt-related transcription factor 1 0.808
hapln3 hyaluronan and proteoglycan link protein 3 0.803
edn1 endothelin 1 0.802
fn1 fibronectin 1 0.792
tp53 tumor protein p53 0.786
jag2 jagged 2 0.777
efnb2a ephrin B2a 0.767
sema3fa semaphorin 3fa 0.762
dll4 delta-like 4 (Drosophila) 0.758
lef1 lymphocyte enhancer binding factor 1 0.751
grna granulin a 0.746
eng2a engrailed 2a 0.741
pcdh18b protocadherin 18b 0.740
wnt9b wingless-type MMTV integration site family, member 9B 0.739
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.725
tie2 endothelium-specific receptor tyrosine kinase 2 0.722
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.717
gro2 groucho 2 0.705
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.693
dld deltaD 0.670
tbx16 T-box gene 16 0.661
wnt11r wingless-type MMTV integration site family, member 11, related 0.656
gli2a GLI-Kruppel family member GLI2a 0.655
wnt9a wingless-type MMTV integration site family, member 9A 0.638
col12a1 collagen, type XII, alpha 1 0.638
her11 hairy-related 11 0.634
mmp2 matrix metalloproteinase 2 0.629
traf4a tnf receptor-associated factor 4a 0.627
myf5 myogenic factor 5 0.604
osr2 odd-skipped related 2 (Drosophila) 0.598
fbn2b fibrillin 2b 0.589
sema3aa semaphorin 3aa 0.584
twist1a twist1a 0.567
mpx myeloid-specific peroxidase 0.567
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.566
tbx2a T-box gene 2a 0.560
nrarpa notch-regulated ankyrin repeat protein a 0.560
ndr2 nodal-related 2 0.560
nrp1a neuropilin 1a 0.559
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.545
vegfc vascular endothelial growth factor c 0.531
shhb sonic hedgehog b 0.528
ephb4b eph receptor B4b 0.520
pax8 paired box gene 8 0.511
sox2 SRY-box containing gene 2 0.508
sox9a SRY-box containing gene 9a 0.501
tgfb3 transforming growth factor, beta 3 0.496
her9 hairy-related 9 0.493
alcamb activated leukocyte cell adhesion molecule b 0.480
zfyve26 zinc finger, FYVE domain containing 26 0.479
notch1b notch homolog 1b 0.478
tp63 tumor protein p63 0.478
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.477
birc2 baculoviral IAP repeat-containing 2 0.474
ilk integrin linked kinase 0.469
twist1b twist1b 0.467
sulf1 sulfatase 1 0.465
ednra endothelin receptor type A 0.459
itgb1b integrin, beta 1b 0.459
wnt5b wingless-type MMTV integration site family, member 5b 0.458
sim1a single-minded homolog 1a (Drosophila) 0.454
grem2 gremlin 2, cysteine knot superfamily 0.454
si:ch211-235f6.2 si:ch211-235f6.2 0.443
dlc deltaC 0.440
wnt3 wingless-type MMTV integration site family, member 3 0.439
runx2b runt-related transcription factor 2b 0.433
lama5 laminin, alpha 5 0.432
si:ch73-60e21.1 si:ch73-60e21.1 0.417
pcdh8 protocadherin 8 0.412
tagln2 transgelin 2 0.411
rargb retinoic acid receptor, gamma b 0.409
tgfbi transforming growth factor, beta-induced 0.406
coro1a coronin, actin binding protein, 1A 0.401
sox7 SRY-box containing gene 7 0.398
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.398
tagln transgelin 0.398
ttna titin a 0.397
tal1 T-cell acute lymphocytic leukemia 1 0.394
unc5b unc-5 homolog B (C. elegans) 0.392
hoxa9b homeo box A9b 0.392
rtn4b reticulon 4b 0.387
notch2 notch homolog 2 0.386
flot1 flotillin 1 0.385
gng2 guanine nucleotide binding protein (G protein), gamma 2 0.380
plcg1 phospholipase C, gamma 1 0.380
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.378
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CREBBP CREB binding protein 0.998
ENG endoglin 0.988
JAG1 jagged 1 0.985
NOTCH1 notch 1 0.984
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.982
FGFR2 fibroblast growth factor receptor 2 0.980
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.975
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.974
EP300 E1A binding protein p300 0.973
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.971
FN1 fibronectin 1 0.968
COL4A2 collagen, type IV, alpha 2 0.968
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.966
IQGAP1 IQ motif containing GTPase activating protein 1 0.964
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.963
EGFR epidermal growth factor receptor 0.957
THBS1 thrombospondin 1 0.956
CDH5 cadherin 5, type 2 (vascular endothelium) 0.956
SMAD2 SMAD family member 2 0.955
TEK TEK tyrosine kinase, endothelial 0.955
VEGFA vascular endothelial growth factor A 0.946
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.941
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.930
PAX3 paired box 3 0.924
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.919
MET met proto-oncogene (hepatocyte growth factor receptor) 0.914
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.901
ANXA1 annexin A1 0.899
FGFR1 fibroblast growth factor receptor 1 0.898
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.894
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.871
CD34 CD34 molecule 0.867
CAV2 caveolin 2 0.861
NOTCH3 notch 3 0.860
NRP1 neuropilin 1 0.846
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.829
FGF1 fibroblast growth factor 1 (acidic) 0.817
TIMP3 TIMP metallopeptidase inhibitor 3 0.817
PRKCA protein kinase C, alpha 0.816
TGFB1 transforming growth factor, beta 1 0.807
HOXB5 homeobox B5 0.790
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.790
YAP1 Yes-associated protein 1 0.789
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.776
COL4A1 collagen, type IV, alpha 1 0.776
COL1A1 collagen, type I, alpha 1 0.763
CAV1 caveolin 1, caveolae protein, 22kDa 0.762
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.762
TCF4 transcription factor 4 0.756
CCR2 chemokine (C-C motif) receptor 2 0.747
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.742
CYR61 cysteine-rich, angiogenic inducer, 61 0.740
RAMP3 receptor (G protein-coupled) activity modifying protein 3 0.735
SKIL SKI-like oncogene 0.730
COL6A2 collagen, type VI, alpha 2 0.728
LTBP2 latent transforming growth factor beta binding protein 2 0.722
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.716
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.711
CTGF connective tissue growth factor 0.693
BCAR1 breast cancer anti-estrogen resistance 1 0.681
PLCG1 phospholipase C, gamma 1 0.672
PML promyelocytic leukemia 0.666
COL5A1 collagen, type V, alpha 1 0.665
ANGPTL2 angiopoietin-like 2 0.655
AR androgen receptor 0.648
COL1A2 collagen, type I, alpha 2 0.639
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.635
E2F7 E2F transcription factor 7 0.634
PECAM1 platelet/endothelial cell adhesion molecule 0.632
ITGB5 integrin, beta 5 0.629
BMP2 bone morphogenetic protein 2 0.617
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.604
COL6A1 collagen, type VI, alpha 1 0.600
SMAD7 SMAD family member 7 0.598
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.575
TJP1 tight junction protein 1 (zona occludens 1) 0.569
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.564
CXCL2 chemokine (C-X-C motif) ligand 2 0.560
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.545
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.534
ILK integrin-linked kinase 0.523
PTEN phosphatase and tensin homolog 0.520
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.516
CRYAB crystallin, alpha B 0.500
HOXA10 homeobox A10 0.486
ANXA5 annexin A5 0.477
MEF2C myocyte enhancer factor 2C 0.475
EPHA2 EPH receptor A2 0.474
SMAD3 SMAD family member 3 0.473
IL2RB interleukin 2 receptor, beta 0.470
CD44 CD44 molecule (Indian blood group) 0.470
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.470
POU5F1 POU class 5 homeobox 1 0.468
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.461
SFN stratifin 0.459
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.453
FHL2 four and a half LIM domains 2 0.450
EGR3 early growth response 3 0.441
BCL6 B-cell CLL/lymphoma 6 0.430
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.425
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Rattus norvegicus
Name Description Probability Func Analog Organism
Met met proto-oncogene 0.639
Alb albumin 0.558
Ccr2 chemokine (C-C motif) receptor 2 0.526
Fgfr2 fibroblast growth factor receptor 2 0.513
Edn1 endothelin 1 0.455
Egr2 early growth response 2 0.437
Flt1 FMS-related tyrosine kinase 1 0.421
Id3 inhibitor of DNA binding 3 0.402
Pecam1 platelet/endothelial cell adhesion molecule 1 0.369
Ccl2 chemokine (C-C motif) ligand 2 0.369
Il9r interleukin 9 receptor 0.356
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.352
Il8rb interleukin 8 receptor, beta 0.345
Itgam integrin, alpha M 0.322
Tacr1 tachykinin receptor 1 0.313
Csf1 colony stimulating factor 1 (macrophage) 0.310
Mmp3 matrix metallopeptidase 3 0.303
Tek TEK tyrosine kinase, endothelial 0.292
Utrn utrophin 0.278
Mmp10 matrix metallopeptidase 10 0.267
Ccl4 chemokine (C-C motif) ligand 4 0.266
Cxcl2 chemokine (C-X-C motif) ligand 2 0.262
Cdh5 cadherin 5 0.243
Cd4 Cd4 molecule 0.242
Egr1 early growth response 1 0.229
Trim47 tripartite motif-containing 47 0.209
Plxnd1 plexin D1 0.200
Ptafr platelet-activating factor receptor 0.194
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.188
Cmklr1 chemokine-like receptor 1 0.186
Emcn endomucin 0.182
Il1r1 interleukin 1 receptor, type I 0.180
Hpx hemopexin 0.174
Cpa3 carboxypeptidase A3, mast cell 0.170
Otx1 orthodenticle homeobox 1 0.170
Hspa1a heat shock 70kD protein 1A 0.166
Kdr kinase insert domain receptor 0.165
Gzmk granzyme K 0.159
Ngf nerve growth factor (beta polypeptide) 0.157
Gper G protein-coupled estrogen receptor 1 0.156
Slc6a18 solute carrier family 6, member 18 0.156
Il4 interleukin 4 0.154
Elk3 ELK3, ETS-domain protein 0.150
LOC60591 calcium-activated potassium channel beta subunit 0.150
Cxcr5 chemokine (C-X-C motif) receptor 5 0.149
Dusp1 dual specificity phosphatase 1 0.148
Msn moesin 0.146
Arl5c ADP-ribosylation factor-like 5C 0.142
Egr3 early growth response 3 0.142
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.141
Gal galanin prepropeptide 0.140
Il6 interleukin 6 0.137
Pfn1 profilin 1 0.135
Cd200r1 CD200 receptor 1 0.132
Mbl1 mannose-binding lectin (protein A) 1 0.128
Epas1 endothelial PAS domain protein 1 0.128
Twist2 twist homolog 2 (Drosophila) 0.127
Igfbp5 insulin-like growth factor binding protein 5 0.127
Orm1 orosomucoid 1 0.125
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.124
Ahsg alpha-2-HS-glycoprotein 0.123
Adora2a adenosine A2a receptor 0.122
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.121
Smgb neonatal submandibular gland protein B 0.121
Plekhg2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.120
Meox2 mesenchyme homeobox 2 0.120
Mmp12 matrix metallopeptidase 12 0.118
Egfl7 EGF-like-domain, multiple 7 0.115
Rhob ras homolog gene family, member B 0.115
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.115
Apoa2 apolipoprotein A-II 0.114
Reg1a regenerating islet-derived 1 alpha 0.113
Prrx1 paired related homeobox 1 0.113
Socs3 suppressor of cytokine signaling 3 0.110
Grasp GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.110
Calcrl calcitonin receptor-like 0.109
Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.108
Adam7 ADAM metallopeptidase domain 7 0.107
Has2 hyaluronan synthase 2 0.106
Itga6 integrin, alpha 6 0.106
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.105
Sell selectin L 0.104
Stc1 stanniocalcin 1 0.103
Ccl3 chemokine (C-C motif) ligand 3 0.102
Tas2r126 taste receptor, type 2, member 126 0.101
Smad1 SMAD family member 1 0.100
Cd80 Cd80 molecule 0.100
Gata2 GATA binding protein 2 0.099
Il1rl1 interleukin 1 receptor-like 1 0.098
Iapp islet amyloid polypeptide 0.098
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.097
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.096
Cyyr1 cysteine/tyrosine-rich 1 0.094
Col12a1 collagen, type XII, alpha 1 0.094
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.092
Ccr5 chemokine (C-C motif) receptor 5 0.092
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.092
Gucy2d guanylate cyclase 2d 0.091
Mmp13 matrix metallopeptidase 13 0.090
Jun Jun oncogene 0.089
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism