The network for 'cellular response to retinoic acid' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to retinoic acid

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.

Mus musculus
Name Description Probability Func Analog Organism
Pax2 paired box gene 2 0.999
Hoxa1 homeobox A1 0.987
Pten phosphatase and tensin homolog 0.944
Rxra retinoid X receptor alpha 0.923
Prrx1 paired related homeobox 1 0.886
Pax3 paired box gene 3 0.877
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.867
Yap1 yes-associated protein 1 0.853
Rarg retinoic acid receptor, gamma 0.853
Vangl2 vang-like 2 (van gogh, Drosophila) 0.848
Pitx2 paired-like homeodomain transcription factor 2 0.801
Eya1 eyes absent 1 homolog (Drosophila) 0.788
Pitx1 paired-like homeodomain transcription factor 1 0.768
Fgfr2 fibroblast growth factor receptor 2 0.754
Fgf8 fibroblast growth factor 8 0.737
Foxc2 forkhead box C2 0.728
Rnf2 ring finger protein 2 0.697
Shh sonic hedgehog 0.677
Vegfa vascular endothelial growth factor A 0.633
Hoxa3 homeobox A3 0.628
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.627
Chd7 chromodomain helicase DNA binding protein 7 0.625
Sox2 SRY-box containing gene 2 0.616
Lhx1 LIM homeobox protein 1 0.613
Otx2 orthodenticle homolog 2 (Drosophila) 0.611
Sox4 SRY-box containing gene 4 0.564
Tbx1 T-box 1 0.505
Emx2 empty spiracles homolog 2 (Drosophila) 0.443
Rarb retinoic acid receptor, beta 0.442
Isl1 ISL1 transcription factor, LIM/homeodomain 0.397
Hoxa2 homeobox A2 0.389
Foxg1 forkhead box G1 0.389
Bdnf brain derived neurotrophic factor 0.367
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.363
Apoe apolipoprotein E 0.360
Gata3 GATA binding protein 3 0.358
Ntf3 neurotrophin 3 0.332
Fgf10 fibroblast growth factor 10 0.301
Fgfr1 fibroblast growth factor receptor 1 0.294
Phc2 polyhomeotic-like 2 (Drosophila) 0.269
Jag1 jagged 1 0.263
Gata4 GATA binding protein 4 0.252
Otx1 orthodenticle homolog 1 (Drosophila) 0.249
Tbx3 T-box 3 0.249
Hand1 heart and neural crest derivatives expressed transcript 1 0.225
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.223
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.217
Zic3 zinc finger protein of the cerebellum 3 0.215
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.213
Gbx2 gastrulation brain homeobox 2 0.210
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.205
Hoxb2 homeobox B2 0.195
Pax8 paired box gene 8 0.190
Wt1 Wilms tumor 1 homolog 0.189
Tcfap2a transcription factor AP-2, alpha 0.184
Lef1 lymphoid enhancer binding factor 1 0.184
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.180
T brachyury 0.166
Tead1 TEA domain family member 1 0.161
Rara retinoic acid receptor, alpha 0.160
Nog noggin 0.156
Fgf3 fibroblast growth factor 3 0.148
Pcgf2 polycomb group ring finger 2 0.136
Ghr growth hormone receptor 0.135
Gja5 gap junction protein, alpha 5 0.125
Lmx1a LIM homeobox transcription factor 1 alpha 0.119
Tead2 TEA domain family member 2 0.119
Wwtr1 WW domain containing transcription regulator 1 0.114
Phox2b paired-like homeobox 2b 0.109
Alx3 aristaless-like homeobox 3 0.108
Pou4f3 POU domain, class 4, transcription factor 3 0.107
Fyn Fyn proto-oncogene 0.105
Six2 sine oculis-related homeobox 2 homolog (Drosophila) 0.103
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.103
Igh immunoglobulin heavy chain complex 0.100
Emx1 empty spiracles homolog 1 (Drosophila) 0.099
Zeb1 zinc finger E-box binding homeobox 1 0.096
Hand2 heart and neural crest derivatives expressed transcript 2 0.086
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.085
Ednra endothelin receptor type A 0.085
Ptk2 PTK2 protein tyrosine kinase 2 0.085
Smad6 MAD homolog 6 (Drosophila) 0.084
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.083
Nf1 neurofibromatosis 1 0.082
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.082
Ece1 endothelin converting enzyme 1 0.081
Sox11 SRY-box containing gene 11 0.079
Pou4f2 POU domain, class 4, transcription factor 2 0.075
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.071
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.071
Nodal nodal 0.069
Nrg1 neuregulin 1 0.069
Inpp5d inositol polyphosphate-5-phosphatase D 0.069
Foxc1 forkhead box C1 0.067
Myo6 myosin VI 0.067
Col13a1 collagen, type XIII, alpha 1 0.066
Sykb spleen tyrosine kinase 0.065
Wnt5a wingless-related MMTV integration site 5A 0.064
Zfp503 zinc finger protein 503 0.062
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.061
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
col1a2 collagen, type I, alpha 2 0.873
col5a1 procollagen, type V, alpha 1 0.817
raraa retinoic acid receptor, alpha a 0.594
shha sonic hedgehog a 0.561
jag2 jagged 2 0.493
fgf8a fibroblast growth factor 8 a 0.393
col1a1a collagen, type I, alpha 1a 0.314
sparc secreted acidic cysteine rich glycoprotein 0.296
egr2b early growth response 2b 0.248
col5a2l collagen, type V, alpha 2-like 0.221
hoxb2a homeo box B2a 0.204
pax2a paired box gene 2a 0.194
sema3d semaphorin 3d 0.177
epha4a eph receptor A4a 0.167
col19a1 collagen, type XIX, alpha 1 0.166
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.161
postn periostin, osteoblast specific factor 0.158
pcdh18b protocadherin 18b 0.158
dcn decorin 0.145
rxrga retinoid x receptor, gamma a 0.136
sox9b SRY-box containing gene 9b 0.132
crabp2a cellular retinoic acid binding protein 2, a 0.127
sox11a SRY-box containing gene 11a 0.124
spry1 sprouty homolog 1 (Drosophila) 0.122
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.121
gsc goosecoid 0.115
acvr1b activin A receptor, type IB 0.114
prdm1a PR domain containing 1a, with ZNF domain 0.106
fzd7b frizzled homolog 7b 0.106
rargb retinoic acid receptor, gamma b 0.104
bmp4 bone morphogenetic protein 4 0.101
etv5b ets variant 5b 0.100
rarab retinoic acid receptor, alpha b 0.096
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.095
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.095
six1b sine oculis homeobox homolog 1b 0.094
rxraa retinoid X receptor, alpha a 0.093
prdm5 PR domain containing 5 0.093
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.087
hoxa3a homeo box A3a 0.085
cdx4 caudal type homeo box transcription factor 4 0.084
dusp6 dual specificity phosphatase 6 0.083
tgfbi transforming growth factor, beta-induced 0.077
sox3 SRY-box containing gene 3 0.076
bmper BMP binding endothelial regulator 0.073
lfng lunatic fringe homolog 0.073
col6a3 collagen, type VI, alpha 3 0.073
zgc:171553 zgc:171553 0.071
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.071
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.070
pdgfrl platelet-derived growth factor receptor-like 0.068
hoxb3a homeo box B3a 0.068
cdx1b caudal type homeobox 1 b 0.066
b2m beta-2-microglobulin 0.064
hand2 heart and neural crest derivatives expressed transcript 2 0.064
axin2 axin 2 (conductin, axil) 0.064
edn1 endothelin 1 0.063
neurog1 neurogenin 1 0.063
gltscr1 glioma tumor suppressor candidate region gene 1 0.063
vcanb versican b 0.063
fgfr1b fibroblast growth factor receptor 1b 0.060
si:ch1073-459j12.1 si:ch1073-459j12.1 0.059
flrt3 fibronectin leucine rich transmembrane 3 0.059
runx2a runt-related transcription factor 2a 0.058
nog2 noggin 2 0.057
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.057
neurod4 neurogenic differentiation 4 0.057
tfap2a transcription factor AP-2 alpha 0.053
zgc:64114 zgc:64114 0.053
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.053
dlx2a distal-less homeobox gene 2a 0.053
sox10 SRY-box containing gene 10 0.052
barx1 BarH-like homeobox 1 0.051
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.048
snai1a snail homolog 1a (Drosophila) 0.047
boc brother of CDO 0.047
fsta follistatin a 0.047
ext1a exostoses (multiple) 1a 0.046
irx3a iroquois homeobox protein 3a 0.046
dusp1 dual specificity phosphatase 1 0.046
tcf12 transcription factor 12 0.045
col1a1b collagen, type I, alpha 1b 0.045
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.045
cyp1b1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.045
mmp2 matrix metalloproteinase 2 0.044
col10a1 collagen, type X, alpha 1 0.044
pmp22a peripheral myelin protein 22a 0.043
satb2 SATB homeobox 2 0.043
wls wntless homolog (Drosophila) 0.043
lmo4a LIM domain only 4a 0.042
rgl2 ral guanine nucleotide dissociation stimulator-like 2 0.042
mgp matrix Gla protein 0.041
nr2f2 nuclear receptor subfamily 2, group F, member 2 0.040
col6a2 collagen, type VI, alpha 2 0.040
cltca clathrin, heavy polypeptide a (Hc) 0.040
irx3b iroquois homeobox protein 3b 0.040
pax3a paired box gene 3a 0.040
ctnnb1 catenin (cadherin-associated protein), beta 1 0.040
rxrba retinoid x receptor, beta a 0.039
fas Fas (TNF receptor superfamily, member 6) 0.038
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.993
EGFR epidermal growth factor receptor 0.618
BCAR1 breast cancer anti-estrogen resistance 1 0.562
FYN FYN oncogene related to SRC, FGR, YES 0.551
GRB2 growth factor receptor-bound protein 2 0.309
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.256
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.121
GRB10 growth factor receptor-bound protein 10 0.103
RARA retinoic acid receptor, alpha 0.098
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.092
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.081
PTK2 PTK2 protein tyrosine kinase 2 0.081
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.080
HCK hemopoietic cell kinase 0.080
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.077
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.074
YAP1 Yes-associated protein 1 0.063
GRB7 growth factor receptor-bound protein 7 0.062
SPRR2A small proline-rich protein 2A 0.057
SYK spleen tyrosine kinase 0.052
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.051
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.044
SPOP speckle-type POZ protein 0.039
NCK1 NCK adaptor protein 1 0.038
MET met proto-oncogene (hepatocyte growth factor receptor) 0.037
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.037
PAX3 paired box 3 0.035
PLCG1 phospholipase C, gamma 1 0.032
XIAP X-linked inhibitor of apoptosis 0.031
POU3F2 POU class 3 homeobox 2 0.030
COL3A1 collagen, type III, alpha 1 0.027
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.027
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.026
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.024
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.020
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.020
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.019
JAK2 Janus kinase 2 0.019
SRCIN1 SRC kinase signaling inhibitor 1 0.018
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.018
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.018
LCK lymphocyte-specific protein tyrosine kinase 0.018
TICAM2 toll-like receptor adaptor molecule 2 0.017
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.017
SMAD7 SMAD family member 7 0.017
FBXW11 F-box and WD repeat domain containing 11 0.017
EFNA1 ephrin-A1 0.017
IGFBP3 insulin-like growth factor binding protein 3 0.016
COL2A1 collagen, type II, alpha 1 0.016
SMAD5 SMAD family member 5 0.016
ZNF746 zinc finger protein 746 0.016
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.016
NCOR2 nuclear receptor corepressor 2 0.015
APAF1 apoptotic peptidase activating factor 1 0.015
MED28 mediator complex subunit 28 0.015
EFNA5 ephrin-A5 0.015
MEOX2 mesenchyme homeobox 2 0.014
KLHL24 kelch-like 24 (Drosophila) 0.014
ESR1 estrogen receptor 1 0.014
DIABLO diablo, IAP-binding mitochondrial protein 0.014
PDCD6IP programmed cell death 6 interacting protein 0.014
PPARA peroxisome proliferator-activated receptor alpha 0.014
BTRC beta-transducin repeat containing 0.014
HR hairless homolog (mouse) 0.012
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.012
FGF18 fibroblast growth factor 18 0.012
LOX lysyl oxidase 0.012
PCGF2 polycomb group ring finger 2 0.012
AMOTL1 angiomotin like 1 0.012
GAS7 growth arrest-specific 7 0.012
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.012
COL1A1 collagen, type I, alpha 1 0.011
RIN1 Ras and Rab interactor 1 0.011
WIPF1 WAS/WASL interacting protein family, member 1 0.011
RXRA retinoid X receptor, alpha 0.011
SALL2 sal-like 2 (Drosophila) 0.011
SFN stratifin 0.011
ADAM15 ADAM metallopeptidase domain 15 0.011
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.010
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.010
COL6A1 collagen, type VI, alpha 1 0.010
KLF6 Kruppel-like factor 6 0.010
WNT1 wingless-type MMTV integration site family, member 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a2 collagen, type I, alpha 2 0.565
Col12a1 collagen, type XII, alpha 1 0.197
Col5a1 collagen, type V, alpha 1 0.179
Dbp D site of albumin promoter (albumin D-box) binding protein 0.157
Col1a1 collagen, type I, alpha 1 0.154
Postn periostin, osteoblast specific factor 0.136
Eln elastin 0.102
Epn1 Epsin 1 0.090
Col14a1 collagen, type XIV, alpha 1 0.089
Nr1d2 nuclear receptor subfamily 1, group D, member 2 0.079
Col3a1 collagen, type III, alpha 1 0.073
Epor erythropoietin receptor 0.066
LOC498222 similar to specifically androgen-regulated protein 0.053
Scnn1g sodium channel, nonvoltage-gated 1, gamma 0.053
Fndc1 fibronectin type III domain containing 1 0.051
Ifitm3 interferon induced transmembrane protein 3 0.046
Ltb4r2 leukotriene B4 receptor 2 0.045
Foxo3 forkhead box O3 0.045
Fos FBJ osteosarcoma oncogene 0.044
Pitx3 paired-like homeodomain 3 0.043
LOC100365106 rCG32755-like 0.041
Loxl1 lysyl oxidase-like 1 0.037
Uts2r urotensin 2 receptor 0.037
Nid2 nidogen 2 0.036
Cpz carboxypeptidase Z 0.035
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.035
Icam1 intercellular adhesion molecule 1 0.035
RT1-S3 RT1 class Ib, locus S3 0.034
Mettl7b methyltransferase like 7B 0.034
Dab2 disabled homolog 2 (Drosophila) 0.034
Ccdc80 coiled-coil domain containing 80 0.033
Tert telomerase reverse transcriptase 0.033
Aqp4 aquaporin 4 0.033
Ltbp2 latent transforming growth factor beta binding protein 2 0.033
Evpl envoplakin 0.032
Cybrd1 cytochrome b reductase 1 0.031
Tacstd2 tumor-associated calcium signal transducer 2 0.031
Bmp1 bone morphogenetic protein 1 0.030
Chat choline acetyltransferase 0.030
Igfals insulin-like growth factor binding protein, acid labile subunit 0.028
Mrgprf MAS-related GPR, member F 0.028
Gabrr1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.028
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.027
Ttc36 tetratricopeptide repeat domain 36 0.027
Atp4b ATPase, H+/K+ exchanging, beta polypeptide 0.027
Gata4 GATA binding protein 4 0.026
Gbp2 guanylate binding protein 2 0.026
Acr acrosin 0.026
Dlg4 discs, large homolog 4 (Drosophila) 0.025
Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 0.025
Prss1 protease, serine, 1 (trypsin 1) 0.025
Bgn biglycan 0.024
Tef thyrotrophic embryonic factor 0.024
Dmkn dermokine 0.024
RGD1359529 similar to chromosome 1 open reading frame 63 0.023
Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.023
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.023
Fbn1 fibrillin 1 0.023
Haao 3-hydroxyanthranilate 3,4-dioxygenase 0.022
Taf6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.022
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.022
Ctsk cathepsin K 0.022
C1s complement component 1, s subcomponent 0.022
Fn1 fibronectin 1 0.022
Ptprh protein tyrosine phosphatase, receptor type, H 0.022
Espn espin 0.021
Fmod fibromodulin 0.021
Cxcl10 chemokine (C-X-C motif) ligand 10 0.021
Ccl7 chemokine (C-C motif) ligand 7 0.021
Fblim1 filamin binding LIM protein 1 0.021
Cpxm2 carboxypeptidase X (M14 family), member 2 0.021
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.020
Bmp7 bone morphogenetic protein 7 0.020
Anxa8 annexin A8 0.020
Epx eosinophil peroxidase 0.020
Pyy peptide YY (mapped) 0.020
Klk8 kallikrein related-peptidase 8 0.020
Omp olfactory marker protein 0.020
Fstl1 follistatin-like 1 0.019
Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 0.019
Fgfr2 fibroblast growth factor receptor 2 0.019
Hcrtr1 hypocretin (orexin) receptor 1 0.019
Drd2 dopamine receptor D2 0.019
Kcnt1 potassium channel, subfamily T, member 1 0.019
Acot12 acyl-CoA thioesterase 12 0.018
Gna15 guanine nucleotide binding protein, alpha 15 0.018
Slurp1 secreted Ly6/Plaur domain containing 1 0.018
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.018
Atp2c2 ATPase, Ca++ transporting, type 2C, member 2 0.018
Hal histidine ammonia lyase 0.018
Nradd neurotrophin receptor associated death domain 0.018
Smgb neonatal submandibular gland protein B 0.017
Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.017
Oasl 2'-5'-oligoadenylate synthetase-like 0.017
Ugt8 UDP glycosyltransferase 8 0.017
Slc26a1 solute carrier family 26 (sulfate transporter), member 1 0.017
Cox4i2 cytochrome c oxidase subunit IV isoform 2 0.017
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.017
Itgb4 integrin, beta 4 0.017
Col5a3 collagen, type V, alpha 3 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism