The network for 'cardiac muscle tissue morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle tissue morphogenesis

The process in which the anatomical structures of cardiac muscle tissue are generated and organized.

Mus musculus
Name Description Probability Func Analog Organism
Pitx2 paired-like homeodomain transcription factor 2 1.000
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Gata4 GATA binding protein 4 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Bmp4 bone morphogenetic protein 4 0.999
Fgfr2 fibroblast growth factor receptor 2 0.998
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.998
Pax2 paired box gene 2 0.998
Isl1 ISL1 transcription factor, LIM/homeodomain 0.997
Fgf8 fibroblast growth factor 8 0.996
Tbx3 T-box 3 0.995
Otx2 orthodenticle homolog 2 (Drosophila) 0.995
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.992
Lhx3 LIM homeobox protein 3 0.992
Jag1 jagged 1 0.990
Ctnnb1 catenin (cadherin associated protein), beta 1 0.989
Foxc1 forkhead box C1 0.988
Pax3 paired box gene 3 0.980
Notch1 Notch gene homolog 1 (Drosophila) 0.979
Foxc2 forkhead box C2 0.975
Foxh1 forkhead box H1 0.974
Hoxd13 homeobox D13 0.971
Hoxa13 homeobox A13 0.970
Nodal nodal 0.969
Nog noggin 0.955
Actc1 actin, alpha, cardiac muscle 1 0.950
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.948
Col1a1 collagen, type I, alpha 1 0.942
Pax6 paired box gene 6 0.941
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.938
Kcnq1 potassium voltage-gated channel, subfamily Q, member 1 0.930
Pitx1 paired-like homeodomain transcription factor 1 0.929
Gata6 GATA binding protein 6 0.924
Zic3 zinc finger protein of the cerebellum 3 0.918
Smad6 MAD homolog 6 (Drosophila) 0.918
Lhx1 LIM homeobox protein 1 0.914
Fgfr1 fibroblast growth factor receptor 1 0.907
Tbx1 T-box 1 0.906
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.898
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.886
Col2a1 collagen, type II, alpha 1 0.882
Pou3f3 POU domain, class 3, transcription factor 3 0.868
Scn5a sodium channel, voltage-gated, type V, alpha 0.861
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.854
Gdf3 growth differentiation factor 3 0.854
Cox6a2 cytochrome c oxidase, subunit VI a, polypeptide 2 0.847
Foxg1 forkhead box G1 0.834
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.829
Wnt3a wingless-related MMTV integration site 3A 0.828
Dll1 delta-like 1 (Drosophila) 0.825
Wnt4 wingless-related MMTV integration site 4 0.824
Tgfb2 transforming growth factor, beta 2 0.823
Hand1 heart and neural crest derivatives expressed transcript 1 0.823
Ttn titin 0.813
Hoxd11 homeobox D11 0.798
Meox2 mesenchyme homeobox 2 0.794
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.793
Gbx2 gastrulation brain homeobox 2 0.773
Sox2 SRY-box containing gene 2 0.773
Psen1 presenilin 1 0.763
Neurod4 neurogenic differentiation 4 0.751
Rxra retinoid X receptor alpha 0.751
Pax8 paired box gene 8 0.747
Foxf1a forkhead box F1a 0.743
Lmx1b LIM homeobox transcription factor 1 beta 0.723
Efnb2 ephrin B2 0.720
Notch2 Notch gene homolog 2 (Drosophila) 0.717
Gja1 gap junction protein, alpha 1 0.715
Cdx1 caudal type homeobox 1 0.714
Col3a1 collagen, type III, alpha 1 0.702
Tbx5 T-box 5 0.699
Pax1 paired box gene 1 0.695
Bmp7 bone morphogenetic protein 7 0.695
Fgfr3 fibroblast growth factor receptor 3 0.685
Bmpr1a bone morphogenetic protein receptor, type 1A 0.680
Smad3 MAD homolog 3 (Drosophila) 0.675
Ldb3 LIM domain binding 3 0.662
Mesp1 mesoderm posterior 1 0.658
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.654
Axin1 axin 1 0.654
Ntf3 neurotrophin 3 0.636
Sox9 SRY-box containing gene 9 0.626
Foxa2 forkhead box A2 0.626
Nos3 nitric oxide synthase 3, endothelial cell 0.616
T brachyury 0.610
Atoh1 atonal homolog 1 (Drosophila) 0.610
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.609
Insm1 insulinoma-associated 1 0.593
Lrp6 low density lipoprotein receptor-related protein 6 0.591
Tlx3 T-cell leukemia, homeobox 3 0.587
Gli2 GLI-Kruppel family member GLI2 0.582
Chd7 chromodomain helicase DNA binding protein 7 0.581
Grxcr1 glutaredoxin, cysteine rich 1 0.567
Hoxa1 homeobox A1 0.566
Sox11 SRY-box containing gene 11 0.562
Smad4 MAD homolog 4 (Drosophila) 0.555
Zeb1 zinc finger E-box binding homeobox 1 0.551
Tal2 T-cell acute lymphocytic leukemia 2 0.540
Alx3 aristaless-like homeobox 3 0.534
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.997
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.867
bmp4 bone morphogenetic protein 4 0.779
myod1 myogenic differentiation 1 0.771
tnnc1b troponin C type 1b (slow) 0.739
cdh2 cadherin 2, neuronal 0.714
ttna titin a 0.709
fgf8a fibroblast growth factor 8 a 0.591
tal1 T-cell acute lymphocytic leukemia 1 0.515
smyhc2 slow myosin heavy chain 2 0.484
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.439
gata2a GATA-binding protein 2a 0.367
smyd1b SET and MYND domain containing 1b 0.279
tbx5a T-box 5a 0.277
alcama activated leukocyte cell adhesion molecule a 0.220
wnt11r wingless-type MMTV integration site family, member 11, related 0.217
actc1b actin, alpha, cardiac muscle 1b 0.212
smyhc1l slow myosin heavy chain 1, like 0.188
pax2a paired box gene 2a 0.187
tnni1al troponin I, skeletal, slow like 0.180
nkx2.5 NK2 transcription factor related 5 0.175
actc1a actin, alpha, cardiac muscle 1a 0.168
unc45b unc-45 homolog B (C. elegans) 0.164
hhex hematopoietically expressed homeobox 0.152
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.140
tnni2a.4 troponin I, skeletal, fast 2a.4 0.137
cmlc1 cardiac myosin light chain-1 0.126
tbx18 T-box 18 0.108
tnnt3b troponin T3b, skeletal, fast 0.103
shha sonic hedgehog a 0.102
etv2 ets variant gene 2 0.100
tnnt3a troponin T3a, skeletal, fast 0.098
aplnrb apelin receptor b 0.089
hand2 heart and neural crest derivatives expressed transcript 2 0.084
mef2ca myocyte enhancer factor 2ca 0.082
fn1 fibronectin 1 0.078
tnnc2 troponin C type 2 (fast) 0.074
gata3 GATA-binding protein 3 0.065
myl7 myosin, light polypeptide 7, regulatory 0.062
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.061
myl1 myosin, light chain 1, alkali; skeletal, fast 0.060
foxc1a forkhead box C1a 0.059
hsp90a.1 heat shock protein 90-alpha 1 0.058
zgc:66286 zgc:66286 0.058
dlc deltaC 0.055
actn3b actinin alpha 3b 0.053
myog myogenin 0.050
mef2cb myocyte enhancer factor 2cb 0.049
gata5 GATA-binding protein 5 0.049
spaw southpaw 0.048
smyhc1 slow myosin heavy chain 1 0.048
tnnt2a troponin T2a, cardiac 0.046
hnf1ba HNF1 homeobox Ba 0.045
tpma alpha-tropomyosin 0.044
notch3 notch homolog 3 0.043
runx1 runt-related transcription factor 1 0.043
kdrl kinase insert domain receptor like 0.043
isl1 islet1 0.043
gata4 GATA-binding protein 4 0.042
prdm1a PR domain containing 1a, with ZNF domain 0.041
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.038
col11a1b collagen type XI alpha-1b and collagen, type XI, alpha 1b 0.037
plcg1 phospholipase C, gamma 1 0.036
ccm2 cerebral cavernous malformation 2 0.036
actn2 actinin, alpha 2 0.035
myf5 myogenic factor 5 0.035
nppa natriuretic peptide precursor A 0.035
hoxb5b homeo box B5b 0.034
rbm24a RNA binding motif protein 24a 0.033
flncb filamin C, gamma b (actin binding protein 280) 0.031
wif1 wnt inhibitory factor 1 0.031
six1b sine oculis homeobox homolog 1b 0.030
mef2d myocyte enhancer factor 2d 0.030
cast calpastatin 0.029
tcea1 transcription elongation factor A (SII), 1 0.029
alcamb activated leukocyte cell adhesion molecule b 0.028
pdlim7 PDZ and LIM domain 7 0.027
desma desmin a 0.026
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.026
tbx2b T-box 2b 0.025
ttnb titin b 0.024
bmp10 bone morphogenetic protein 10 0.024
stac3 SH3 and cysteine rich domain 3 0.024
ogg1 8-oxoguanine DNA glycosylase 0.023
bmp2b bone morphogenetic protein 2b 0.023
lamc1 laminin, gamma 1 0.023
fgf24 fibroblast growth factor 24 0.022
pld1a phospholipase D1a 0.022
atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.021
tnnt1 troponin T1, skeletal, slow 0.021
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.021
tnni1b troponin I, skeletal, slow b 0.020
antxr1 anthrax toxin receptor 1 0.020
serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 0.020
kbtbd10b kelch repeat and BTB (POZ) domain containing 10b 0.020
vmhc ventricular myosin heavy chain 0.019
s1pr2 sphingosine-1-phosphate receptor 2 0.019
wnt5b wingless-type MMTV integration site family, member 5b 0.018
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.018
pcdh10b protocadherin 10b 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TRIM63 tripartite motif containing 63 1.000
TNNI1 troponin I type 1 (skeletal, slow) 0.999
TNNC1 troponin C type 1 (slow) 0.997
TTN titin 0.985
TPM1 tropomyosin 1 (alpha) 0.973
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.895
ACTA1 actin, alpha 1, skeletal muscle 0.812
TNNI2 troponin I type 2 (skeletal, fast) 0.787
TCAP titin-cap (telethonin) 0.781
RARA retinoic acid receptor, alpha 0.772
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.726
TNNT2 troponin T type 2 (cardiac) 0.673
CKM creatine kinase, muscle 0.629
SMYD1 SET and MYND domain containing 1 0.625
DSP desmoplakin 0.623
ESR2 estrogen receptor 2 (ER beta) 0.613
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.594
ACTN2 actinin, alpha 2 0.594
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.558
DES desmin 0.512
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 0.511
TBX5 T-box 5 0.506
TNNT3 troponin T type 3 (skeletal, fast) 0.495
TPM2 tropomyosin 2 (beta) 0.489
TNNT1 troponin T type 1 (skeletal, slow) 0.453
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.446
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.433
MYOD1 myogenic differentiation 1 0.413
MYOZ1 myozenin 1 0.382
MYH9 myosin, heavy chain 9, non-muscle 0.374
LDB3 LIM domain binding 3 0.358
NOTCH1 notch 1 0.333
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.316
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.312
NEB nebulin 0.302
JAG1 jagged 1 0.297
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.267
BMPR1A bone morphogenetic protein receptor, type IA 0.261
TNNC2 troponin C type 2 (fast) 0.246
MYL1 myosin, light chain 1, alkali; skeletal, fast 0.236
MYBPC2 myosin binding protein C, fast type 0.213
ACVR1B activin A receptor, type IB 0.206
INADL InaD-like (Drosophila) 0.201
HAP1 huntingtin-associated protein 1 0.181
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.179
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 0.170
SFN stratifin 0.170
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.154
EP300 E1A binding protein p300 0.151
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.150
PKP2 plakophilin 2 0.148
GSK3B glycogen synthase kinase 3 beta 0.133
FGF10 fibroblast growth factor 10 0.133
EPAS1 endothelial PAS domain protein 1 0.132
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.130
FSTL1 follistatin-like 1 0.108
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.103
ACTC1 actin, alpha, cardiac muscle 1 0.101
SMAD3 SMAD family member 3 0.096
KRT14 keratin 14 0.094
FLNC filamin C, gamma 0.091
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.091
ACTN3 actinin, alpha 3 0.088
PDLIM7 PDZ and LIM domain 7 (enigma) 0.087
ANK1 ankyrin 1, erythrocytic 0.085
MYBPC1 myosin binding protein C, slow type 0.083
MYOG myogenin (myogenic factor 4) 0.081
CXXC5 CXXC finger protein 5 0.078
SETD8 SET domain containing (lysine methyltransferase) 8 0.076
CTGF connective tissue growth factor 0.070
PSEN1 presenilin 1 0.069
MYBPH myosin binding protein H 0.069
CALD1 caldesmon 1 0.068
ESR1 estrogen receptor 1 0.067
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.060
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.060
TCF4 transcription factor 4 0.058
JUP junction plakoglobin 0.053
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 0.050
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.048
TNNI3 troponin I type 3 (cardiac) 0.048
MYL4 myosin, light chain 4, alkali; atrial, embryonic 0.046
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.046
TPM4 tropomyosin 4 0.045
CREBBP CREB binding protein 0.045
TGFBR1 transforming growth factor, beta receptor 1 0.045
PAX8 paired box 8 0.042
NOTCH3 notch 3 0.042
CAPN3 calpain 3, (p94) 0.040
GATA4 GATA binding protein 4 0.039
MYLK myosin light chain kinase 0.038
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 0.037
GATA2 GATA binding protein 2 0.037
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.036
HNF4A hepatocyte nuclear factor 4, alpha 0.035
PDX1 pancreatic and duodenal homeobox 1 0.035
TGFB1 transforming growth factor, beta 1 0.033
TAGLN transgelin 0.033
OBSL1 obscurin-like 1 0.033
PTPRJ protein tyrosine phosphatase, receptor type, J 0.033
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Rattus norvegicus
Name Description Probability Func Analog Organism
Actc1 actin, alpha, cardiac muscle 1 0.971
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.927
Casq2 calsequestrin 2 (cardiac muscle) 0.716
Myh6 myosin, heavy chain 6, cardiac muscle, alpha 0.620
Myl3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.471
Des desmin 0.422
Myh7 myosin, heavy chain 7, cardiac muscle, beta 0.363
Actn2 actinin alpha 2 0.322
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.320
Csrp3 cysteine and glycine-rich protein 3 0.291
Hand2 heart and neural crest derivatives expressed 2 0.224
Cox6a2 cytochrome c oxidase, subunit VIa, polypeptide 2 0.223
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.201
Myoz2 myozenin 2 0.168
Ckm creatine kinase, muscle 0.158
Tnni3 troponin I type 3 (cardiac) 0.156
Pgam2 phosphoglycerate mutase 2 (muscle) 0.151
Cox8b cytochrome c oxidase, subunit VIIIb 0.123
Ckmt2 creatine kinase, mitochondrial 2, sarcomeric 0.113
Mb myoglobin 0.089
Ldb3 LIM domain binding 3 0.088
Klk1l kallikrein 1-like peptidase 0.081
Acta1 actin, alpha 1, skeletal muscle 0.067
Myom1 myomesin 1 0.063
Dnahc6 dynein, axonemal, heavy chain 6 0.061
Mybpc1 myosin binding protein C, slow type 0.055
Myl7 myosin, light chain 7, regulatory 0.053
Lama5 laminin, alpha 5 0.049
Smpx small muscle protein, X-linked 0.048
Dmd dystrophin 0.044
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.043
Dchs1 dachsous 1 (Drosophila) 0.043
Trim54 tripartite motif-containing 54 0.042
Amelx amelogenin X chromosome 0.042
Myh8 myosin, heavy chain 8, skeletal muscle, perinatal 0.042
Nrap nebulin-related anchoring protein 0.042
Alx1 ALX homeobox 1 0.041
Gja3 gap junction protein, alpha 3 0.039
Klk1c10 T-kininogenase 0.038
Nexn nexilin (F actin binding protein) 0.037
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.037
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.037
Creb1 cAMP responsive element binding protein 1 0.036
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.036
Pou2f2 POU class 2 homeobox 2 0.036
Unc45b unc-45 homolog B (C. elegans) 0.035
Mr1 major histocompatibility complex, class I-related 0.035
Itgb1bp2 integrin beta 1 binding protein 2 0.035
Tnnt2 troponin T type 2 (cardiac) 0.034
Myh2 myosin, heavy chain 2, skeletal muscle, adult 0.034
Acan aggrecan 0.033
Rest RE1-silencing transcription factor 0.033
Hspb7 heat shock protein family, member 7 (cardiovascular) 0.031
Cav3 caveolin 3 0.031
Bdkrb2 bradykinin receptor B2 0.030
Mybph myosin binding protein H 0.030
Neurog1 neurogenin 1 0.030
Tnni1 troponin I type 1 (skeletal, slow) 0.028
Snai2 snail homolog 2 (Drosophila) 0.028
Tnnc1 troponin C type 1 (slow) 0.027
Dhrs7c dehydrogenase/reductase (SDR family) member 7C 0.027
Klk1c10l2 kallikrein 1-related peptidase c10-like 2 0.027
Sox17 SRY (sex determining region Y)-box 17 0.026
Kcne1 potassium voltage-gated channel, Isk-related family, member 1 0.026
Bmp7 bone morphogenetic protein 7 0.026
Sdc3 syndecan 3 0.025
Myog myogenin 0.025
Tgfbr2 transforming growth factor, beta receptor II 0.025
Dcc deleted in colorectal carcinoma 0.025
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.024
Tpm1 tropomyosin 1, alpha 0.023
Fabp3 fatty acid binding protein 3, muscle and heart 0.023
Nfic nuclear factor I/C 0.023
Kcnq1 potassium voltage-gated channel, KQT-like subfamily, member 1 0.023
Slc20a2 solute carrier family 20 (phosphate transporter), member 2 0.022
Hhatl hedgehog acyltransferase-like 0.022
Ahr aryl hydrocarbon receptor 0.021
Lims1 LIM and senescent cell antigen-like domains 1 0.021
RGD1564327 similar to integrin alpha 8 0.021
Il1r1 interleukin 1 receptor, type I 0.021
Klks3 kallikrein, submaxillary gland S3 0.020
Hspb2 heat shock protein beta 2 0.020
Slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.020
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.020
Hoxd3 homeo box D3 0.020
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.020
Nfya nuclear transcription factor-Y alpha 0.020
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.020
Capn3 calpain 3 0.019
Myl1 myosin, light chain 1 0.019
Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 0.019
Cdh16 cadherin 16 0.019
Sult1e1 sulfotransferase family 1E, estrogen-preferring, member 1 0.019
Tceb3 transcription elongation factor B (SIII), polypeptide 3 0.019
Dspp dentin sialophosphoprotein 0.019
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.018
Xirp1 xin actin-binding repeat containing 1 0.018
Vipr1 vasoactive intestinal peptide receptor 1 0.018
Homer3 homer homolog 3 (Drosophila) 0.018
Cyb5r1 cytochrome b5 reductase 1 0.018
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism