The network for 'bone development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 0.999
Gli2 GLI-Kruppel family member GLI2 0.999
Col1a1 collagen, type I, alpha 1 0.999
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.998
Shh sonic hedgehog 0.996
Fgfr3 fibroblast growth factor receptor 3 0.995
Nos3 nitric oxide synthase 3, endothelial cell 0.995
Fbn1 fibrillin 1 0.993
Prrx1 paired related homeobox 1 0.993
Tgfbr2 transforming growth factor, beta receptor II 0.989
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.985
Hoxd11 homeobox D11 0.982
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.981
Fgf8 fibroblast growth factor 8 0.981
Prrx2 paired related homeobox 2 0.980
Tbx3 T-box 3 0.979
Smad3 MAD homolog 3 (Drosophila) 0.979
Pax3 paired box gene 3 0.975
Pitx2 paired-like homeodomain transcription factor 2 0.972
Twist2 twist homolog 2 (Drosophila) 0.966
Gli3 GLI-Kruppel family member GLI3 0.963
Col6a2 collagen, type VI, alpha 2 0.961
Hand1 heart and neural crest derivatives expressed transcript 1 0.961
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.956
Trp53 transformation related protein 53 0.955
Hand2 heart and neural crest derivatives expressed transcript 2 0.954
Pax2 paired box gene 2 0.948
Dlx5 distal-less homeobox 5 0.941
Mrc2 mannose receptor, C type 2 0.930
Hoxa11 homeobox A11 0.913
Pkd1 polycystic kidney disease 1 homolog 0.913
Msx1 homeobox, msh-like 1 0.913
Ltbp2 latent transforming growth factor beta binding protein 2 0.910
Eln elastin 0.902
Smad5 MAD homolog 5 (Drosophila) 0.897
Thra thyroid hormone receptor alpha 0.896
Fgfr1 fibroblast growth factor receptor 1 0.889
En1 engrailed 1 0.885
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.881
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.881
Wnt5a wingless-related MMTV integration site 5A 0.876
Tgfb2 transforming growth factor, beta 2 0.873
Hoxd13 homeobox D13 0.870
Pthlh parathyroid hormone-like peptide 0.867
Col2a1 collagen, type II, alpha 1 0.865
Pten phosphatase and tensin homolog 0.862
Gata4 GATA binding protein 4 0.856
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.845
Rarg retinoic acid receptor, gamma 0.838
Tbx2 T-box 2 0.837
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.828
Pitx1 paired-like homeodomain transcription factor 1 0.813
Pax9 paired box gene 9 0.811
Col1a2 collagen, type I, alpha 2 0.804
Zic3 zinc finger protein of the cerebellum 3 0.801
Nodal nodal 0.797
Twist1 twist homolog 1 (Drosophila) 0.796
Apc adenomatosis polyposis coli 0.793
Pbx1 pre B-cell leukemia transcription factor 1 0.788
Hoxc5 homeobox C5 0.785
Mmp2 matrix metallopeptidase 2 0.784
Wnt6 wingless-related MMTV integration site 6 0.773
Hoxa2 homeobox A2 0.771
Robo1 roundabout homolog 1 (Drosophila) 0.768
Bmp4 bone morphogenetic protein 4 0.752
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.741
Wt1 Wilms tumor 1 homolog 0.739
Hoxa1 homeobox A1 0.729
Col11a1 collagen, type XI, alpha 1 0.724
Col5a1 collagen, type V, alpha 1 0.721
Lox lysyl oxidase 0.720
Bglap bone gamma carboxyglutamate protein 0.716
Vdr vitamin D receptor 0.711
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.709
Neurog2 neurogenin 2 0.693
Runx2 runt related transcription factor 2 0.692
Ltbp1 latent transforming growth factor beta binding protein 1 0.680
Bmp7 bone morphogenetic protein 7 0.679
Sfrp2 secreted frizzled-related protein 2 0.675
Fgf18 fibroblast growth factor 18 0.670
Col3a1 collagen, type III, alpha 1 0.665
Tcfap2a transcription factor AP-2, alpha 0.662
Rara retinoic acid receptor, alpha 0.662
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.648
Alx3 aristaless-like homeobox 3 0.645
Col5a2 collagen, type V, alpha 2 0.634
Uncx UNC homeobox 0.633
Tgfb1 transforming growth factor, beta 1 0.628
Gas1 growth arrest specific 1 0.627
Smad7 MAD homolog 7 (Drosophila) 0.624
Hic1 hypermethylated in cancer 1 0.620
Tgfb1i1 transforming growth factor beta 1 induced transcript 1 0.614
Otx2 orthodenticle homolog 2 (Drosophila) 0.612
Fat4 FAT tumor suppressor homolog 4 (Drosophila) 0.611
Lef1 lymphoid enhancer binding factor 1 0.611
Chrd chordin 0.607
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.606
Neurog3 neurogenin 3 0.605
Hoxb4 homeobox B4 0.605
Sox9 SRY-box containing gene 9 0.602
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
gli2a GLI-Kruppel family member GLI2a 0.841
bmp2b bone morphogenetic protein 2b 0.817
foxi1 forkhead box I1 0.718
col5a1 procollagen, type V, alpha 1 0.698
pitx3 paired-like homeodomain transcription factor 3 0.680
bmp4 bone morphogenetic protein 4 0.649
wu:fv91b12 wu:fv91b12 0.552
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.494
bmp1a bone morphogenetic protein 1a 0.440
runx2b runt-related transcription factor 2b 0.430
jag1b jagged 1b 0.411
bglap bone gamma-carboxyglutamate (gla) protein 0.320
dld deltaD 0.319
il17rd interleukin 17 receptor D 0.299
ntla no tail a 0.279
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.264
efnb2a ephrin B2a 0.259
shha sonic hedgehog a 0.258
nkx3.2 NK3 homeobox 2 0.254
ripply1 ripply1 0.249
notch1a notch homolog 1a 0.246
col1a2 collagen, type I, alpha 2 0.230
prdm1a PR domain containing 1a, with ZNF domain 0.210
bmp2a bone morphogenetic protein 2a 0.167
sox9a SRY-box containing gene 9a 0.163
ctgf connective tissue growth factor 0.162
msxe muscle segment homeobox E 0.162
hoxa11a homeo box A11a 0.151
ihha Indian hedgehog homolog a 0.145
notch2 notch homolog 2 0.141
fgf17 fibroblast growth factor 17 0.131
prdm5 PR domain containing 5 0.126
fgfrl1a fibroblast growth factor receptor-like 1a 0.116
col9a3 collagen, type IX, alpha 3 0.116
gpr126 G protein-coupled receptor 126 0.114
msxc muscle segment homeobox C 0.108
myod1 myogenic differentiation 1 0.108
gbx2 gastrulation brain homeo box 2 0.107
angptl2 angiopoietin-like 2 0.103
mmp15b matrix metallopeptidase 15b 0.101
twist1b twist1b 0.101
neo1 neogenin 1 0.100
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.097
hapln1a hyaluronan and proteoglycan link protein 1a 0.096
sox2 SRY-box containing gene 2 0.094
msxb muscle segment homeobox B 0.092
msxd muscle segment homeobox D 0.087
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.085
hmx1 H6 homeo box 1 0.084
barx1 BarH-like homeobox 1 0.081
alcama activated leukocyte cell adhesion molecule a 0.079
her1 hairy-related 1 0.077
fgfr2 fibroblast growth factor receptor 2 0.077
dlx5a distal-less homeobox gene 5a 0.074
mmp2 matrix metalloproteinase 2 0.073
hmx4 H6 family homeobox 4 0.071
axin2 axin 2 (conductin, axil) 0.066
fgf3 fibroblast growth factor 3 0.065
eya1 eyes absent homolog 1 0.062
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.062
edar ectodysplasin A receptor 0.061
runx2a runt-related transcription factor 2a 0.060
wnt11 wingless-type MMTV integration site family, member 11 0.059
fgf20a fibroblast growth factor 20a 0.058
notch3 notch homolog 3 0.057
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.056
raraa retinoic acid receptor, alpha a 0.056
LOC100000687 signal peptide, CUB and EGF-like domain-containing protein 3-like 0.054
lmo4a LIM domain only 4a 0.054
ripply2 ripply2 0.052
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.050
tshb thyroid stimulating hormone, beta subunit 0.049
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.049
hoxb4a homeo box B4a 0.045
vwf von Willebrand factor 0.045
pdgfrl platelet-derived growth factor receptor-like 0.045
tgfbi transforming growth factor, beta-induced 0.045
mgp matrix Gla protein 0.044
fzd5 frizzled homolog 5 0.043
runx3 runt-related transcription factor 3 0.043
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.043
prrx1a paired related homeobox 1a 0.043
col5a2l collagen, type V, alpha 2-like 0.041
pkd2 polycystic kidney disease 2 0.040
crabp2a cellular retinoic acid binding protein 2, a 0.039
tbx2b T-box 2b 0.039
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.039
edn1 endothelin 1 0.039
LOC566708 FL cytokine receptor-like 0.038
epha4b eph receptor A4b 0.037
tbx16 T-box gene 16 0.037
col27a1a collagen, type XXVII, alpha 1a 0.037
foxa1 forkhead box A1 0.036
dlx4a distal-less homeobox gene 4a 0.036
col1a1a collagen, type I, alpha 1a 0.035
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.035
gli1 GLI-Kruppel family member 1 0.035
foxa2 forkhead box A2 0.033
fzd10 frizzled homolog 10 0.033
sox10 SRY-box containing gene 10 0.033
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
COL1A1 collagen, type I, alpha 1 0.962
SMAD4 SMAD family member 4 0.834
TGFB1 transforming growth factor, beta 1 0.813
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.655
COL5A1 collagen, type V, alpha 1 0.608
SMAD3 SMAD family member 3 0.604
FSTL1 follistatin-like 1 0.601
POU3F2 POU class 3 homeobox 2 0.489
NOSTRIN nitric oxide synthase trafficker 0.418
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.403
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.389
COL6A1 collagen, type VI, alpha 1 0.387
SMAD1 SMAD family member 1 0.321
POU5F1 POU class 5 homeobox 1 0.319
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.293
GH1 growth hormone 1 0.277
COL3A1 collagen, type III, alpha 1 0.259
PLXND1 plexin D1 0.241
FGF1 fibroblast growth factor 1 (acidic) 0.238
NOTCH1 notch 1 0.231
COL1A2 collagen, type I, alpha 2 0.230
NOTCH3 notch 3 0.200
BMPR1A bone morphogenetic protein receptor, type IA 0.198
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.194
COL6A2 collagen, type VI, alpha 2 0.169
SMAD7 SMAD family member 7 0.161
MSX2 msh homeobox 2 0.143
FZD1 frizzled homolog 1 (Drosophila) 0.134
SMAD5 SMAD family member 5 0.130
SETD8 SET domain containing (lysine methyltransferase) 8 0.127
PIAS1 protein inhibitor of activated STAT, 1 0.127
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.126
ADAM15 ADAM metallopeptidase domain 15 0.126
PAX3 paired box 3 0.120
NRP1 neuropilin 1 0.115
COL2A1 collagen, type II, alpha 1 0.113
APP amyloid beta (A4) precursor protein 0.108
CSH2 chorionic somatomammotropin hormone 2 0.106
NCF2 neutrophil cytosolic factor 2 0.101
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.101
ANGPT2 angiopoietin 2 0.100
ARRB1 arrestin, beta 1 0.099
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.097
FN1 fibronectin 1 0.095
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.095
BMP1 bone morphogenetic protein 1 0.090
WNT1 wingless-type MMTV integration site family, member 1 0.085
MEOX2 mesenchyme homeobox 2 0.084
JAG1 jagged 1 0.080
ANGPT1 angiopoietin 1 0.079
MEOX1 mesenchyme homeobox 1 0.073
IGFBP5 insulin-like growth factor binding protein 5 0.068
SKIL SKI-like oncogene 0.067
SMAD2 SMAD family member 2 0.066
GH2 growth hormone 2 0.066
COL18A1 collagen, type XVIII, alpha 1 0.066
RND1 Rho family GTPase 1 0.063
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.062
SORBS1 sorbin and SH3 domain containing 1 0.062
CXXC5 CXXC finger protein 5 0.062
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.061
TGFBR1 transforming growth factor, beta receptor 1 0.060
EP300 E1A binding protein p300 0.059
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.058
INHBA inhibin, beta A 0.058
FGFR2 fibroblast growth factor receptor 2 0.058
CSHL1 chorionic somatomammotropin hormone-like 1 0.057
PDIA6 protein disulfide isomerase family A, member 6 0.055
ANGPTL2 angiopoietin-like 2 0.053
BGN biglycan 0.053
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.051
SOS1 son of sevenless homolog 1 (Drosophila) 0.051
NCF4 neutrophil cytosolic factor 4, 40kDa 0.051
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.051
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) 0.050
SOCS3 suppressor of cytokine signaling 3 0.049
MSX1 msh homeobox 1 0.049
PTPRC protein tyrosine phosphatase, receptor type, C 0.048
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 0.048
WNT11 wingless-type MMTV integration site family, member 11 0.048
SMAD6 SMAD family member 6 0.048
CYBA cytochrome b-245, alpha polypeptide 0.048
ENG endoglin 0.046
TGFB3 transforming growth factor, beta 3 0.046
PTHLH parathyroid hormone-like hormone 0.045
NRP2 neuropilin 2 0.045
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.044
NCF1 neutrophil cytosolic factor 1 0.043
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.042
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.042
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.042
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.041
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.040
ADAM12 ADAM metallopeptidase domain 12 0.040
SORBS3 sorbin and SH3 domain containing 3 0.040
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.039
FGF3 fibroblast growth factor 3 0.038
PTPRB protein tyrosine phosphatase, receptor type, B 0.038
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.037
FGF18 fibroblast growth factor 18 0.037
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Rattus norvegicus
Name Description Probability Func Analog Organism
Col1a1 collagen, type I, alpha 1 0.918
Col3a1 collagen, type III, alpha 1 0.628
Col4a1 collagen, type IV, alpha 1 0.325
Col5a1 collagen, type V, alpha 1 0.316
Fstl1 follistatin-like 1 0.171
Col12a1 collagen, type XII, alpha 1 0.145
Dab2 disabled homolog 2 (Drosophila) 0.112
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.110
Fn1 fibronectin 1 0.107
Col5a2 collagen, type V, alpha 2 0.099
Sparc secreted protein, acidic, cysteine-rich (osteonectin) 0.092
Shox2 short stature homeobox 2 0.092
Pxdn peroxidasin homolog (Drosophila) 0.085
Col1a2 collagen, type I, alpha 2 0.081
Fgfr2 fibroblast growth factor receptor 2 0.075
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.075
Fbn1 fibrillin 1 0.070
Ctrc chymotrypsin C (caldecrin) 0.065
Pcolce procollagen C-endopeptidase enhancer 0.065
Gabre gamma-aminobutyric acid (GABA) A receptor, epsilon 0.062
Postn periostin, osteoblast specific factor 0.060
Cd97 CD97 molecule 0.060
Col9a1 collagen, type IX, alpha 1 0.060
Elk3 ELK3, ETS-domain protein 0.059
Vim vimentin 0.057
Adarb2 adenosine deaminase, RNA-specific, B2 0.051
Loxl1 lysyl oxidase-like 1 0.051
Emcn endomucin 0.049
Lox lysyl oxidase 0.048
Tnc tenascin C 0.045
Pecam1 platelet/endothelial cell adhesion molecule 1 0.045
Bgn biglycan 0.045
Bmp1 bone morphogenetic protein 1 0.044
Lum lumican 0.044
Drd3 dopamine receptor D3 0.042
Srpx sushi-repeat-containing protein, X-linked 0.042
Acan aggrecan 0.041
Sry sex determining region Y 0.040
Lect1 leukocyte cell derived chemotaxin 1 0.037
Slc6a5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 0.037
Lamc1 laminin, gamma 1 0.035
Scarf2 scavenger receptor class F, member 2 0.034
Col6a2 collagen, type VI, alpha 2 0.034
RY2G5 potential ligand-binding protein 0.033
Prl8a2 prolactin family 8, subfamily a, member 2 0.033
Igf2r insulin-like growth factor 2 receptor 0.032
Efna5 ephrin A5 0.032
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.032
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.031
Kdr kinase insert domain receptor 0.031
Cercam cerebral endothelial cell adhesion molecule 0.031
Cfp complement factor properdin 0.030
Lef1 lymphoid enhancer binding factor 1 0.029
Col14a1 collagen, type XIV, alpha 1 0.029
Apoa5 apolipoprotein A-V 0.029
Cga glycoprotein hormones, alpha polypeptide 0.028
LOC100362331 rCG59612-like 0.028
Edn2 endothelin 2 0.028
Sox17 SRY (sex determining region Y)-box 17 0.027
Leprel2 leprecan-like 2 0.027
Col4a2 collagen, type IV, alpha 2 0.027
Itgam integrin, alpha M 0.026
Lcp2 lymphocyte cytosolic protein 2 0.026
Pou1f1 POU class 1 homeobox 1 0.026
Ugt8 UDP glycosyltransferase 8 0.026
Mpz myelin protein zero 0.026
Twist2 twist homolog 2 (Drosophila) 0.025
Calu calumenin 0.025
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.025
Prm3 protamine 3 0.024
Gcm1 glial cells missing homolog 1 (Drosophila) 0.024
Aebp1 AE binding protein 1 0.024
Prrx1 paired related homeobox 1 0.024
Prss23 protease, serine, 23 0.024
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.023
Iqgap1 IQ motif containing GTPase activating protein 1 0.023
Adcy4 adenylate cyclase 4 0.023
Cast calpastatin 0.023
Crybb3 crystallin, beta B3 0.022
Pomc proopiomelanocortin 0.022
Adrb1 adrenergic, beta-1-, receptor 0.022
Pax6 paired box 6 0.022
Oaz3 ornithine decarboxylase antizyme 3 0.022
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.021
Irx4 iroquois homeobox 4 0.021
Plin perilipin 0.021
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.021
Enpep glutamyl aminopeptidase 0.021
Cdh5 cadherin 5 0.021
Cd9 CD9 molecule 0.021
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.021
Apom apolipoprotein M 0.020
Ccdc80 coiled-coil domain containing 80 0.020
Ggcx gamma-glutamyl carboxylase 0.020
Asgr1 asialoglycoprotein receptor 1 0.020
Fat2 FAT tumor suppressor homolog 2 (Drosophila) 0.020
Bdkrb2 bradykinin receptor B2 0.019
Lgals8 lectin, galactoside-binding, soluble, 8 0.019
Plod1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.019
Tacr1 tachykinin receptor 1 0.019
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism