The network for 'histone acetylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histone acetylation

The modification of a histone by the addition of an acetyl group.

Mus musculus
Name Description Probability Func Analog Organism
Kat2a K(lysine) acetyltransferase 2A 1.000
Trrap transformation/transcription domain-associated protein 0.999
Rnf2 ring finger protein 2 0.999
Rybp RING1 and YY1 binding protein 0.996
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.995
Per2 period homolog 2 (Drosophila) 0.994
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.993
Arid1a AT rich interactive domain 1A (SWI-like) 0.991
Otx2 orthodenticle homolog 2 (Drosophila) 0.985
Tal1 T-cell acute lymphocytic leukemia 1 0.979
Wdr5 WD repeat domain 5 0.978
Cry2 cryptochrome 2 (photolyase-like) 0.974
Clock circadian locomotor output cycles kaput 0.964
Ep300 E1A binding protein p300 0.963
Pax3 paired box gene 3 0.957
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.954
Pou5f1 POU domain, class 5, transcription factor 1 0.947
Brca1 breast cancer 1 0.937
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.905
Dmap1 DNA methyltransferase 1-associated protein 1 0.903
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.894
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.890
Sin3a transcriptional regulator, SIN3A (yeast) 0.883
Pitx2 paired-like homeodomain transcription factor 2 0.861
Tbx1 T-box 1 0.851
Tcfcp2l1 transcription factor CP2-like 1 0.840
Kat5 K(lysine) acetyltransferase 5 0.831
Neurod1 neurogenic differentiation 1 0.828
Ep400 E1A binding protein p400 0.824
Tcf3 transcription factor 3 0.822
Gata4 GATA binding protein 4 0.814
Runx1 runt related transcription factor 1 0.795
Rbbp7 retinoblastoma binding protein 7 0.784
Foxc1 forkhead box C1 0.763
Gli2 GLI-Kruppel family member GLI2 0.743
Trp53 transformation related protein 53 0.726
Cry1 cryptochrome 1 (photolyase-like) 0.724
Crebbp CREB binding protein 0.723
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.676
Isl1 ISL1 transcription factor, LIM/homeodomain 0.647
Zeb1 zinc finger E-box binding homeobox 1 0.631
Ptf1a pancreas specific transcription factor, 1a 0.566
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.562
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.557
Pax7 paired box gene 7 0.505
Esr1 estrogen receptor 1 (alpha) 0.503
Pax9 paired box gene 9 0.495
Nos2 nitric oxide synthase 2, inducible 0.480
Lep leptin 0.475
Brd2 bromodomain containing 2 0.460
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.460
Mecom MDS1 and EVI1 complex locus 0.456
Arid1b AT rich interactive domain 1B (SWI-like) 0.439
Hdac2 histone deacetylase 2 0.433
Mga MAX gene associated 0.424
Prrx1 paired related homeobox 1 0.424
Smarcc2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.417
Hoxd13 homeobox D13 0.412
Hoxa1 homeobox A1 0.410
Chd4 chromodomain helicase DNA binding protein 4 0.407
Vegfa vascular endothelial growth factor A 0.406
Mecp2 methyl CpG binding protein 2 0.402
Atg12 autophagy-related 12 (yeast) 0.399
Myog myogenin 0.378
Kdm2b lysine (K)-specific demethylase 2B 0.374
Dlx2 distal-less homeobox 2 0.374
Myf5 myogenic factor 5 0.368
Zfpm2 zinc finger protein, multitype 2 0.365
Rxra retinoid X receptor alpha 0.361
Eya1 eyes absent 1 homolog (Drosophila) 0.353
Tada3 transcriptional adaptor 3 0.353
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.352
Rara retinoic acid receptor, alpha 0.338
Gata6 GATA binding protein 6 0.338
Hand2 heart and neural crest derivatives expressed transcript 2 0.337
Kdm5b lysine (K)-specific demethylase 5B 0.335
Irs2 insulin receptor substrate 2 0.329
Cic capicua homolog (Drosophila) 0.329
Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.319
Ssbp2 single-stranded DNA binding protein 2 0.318
Morf4l1 mortality factor 4 like 1 0.307
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.299
H2afz H2A histone family, member Z 0.295
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.287
Kiss1 KiSS-1 metastasis-suppressor 0.283
Hdac1 histone deacetylase 1 0.277
Bap1 Brca1 associated protein 1 0.275
Neurog2 neurogenin 2 0.273
Neurog3 neurogenin 3 0.268
Ldb1 LIM domain binding 1 0.264
Msx1 homeobox, msh-like 1 0.258
Gsc goosecoid homeobox 0.253
Stat1 signal transducer and activator of transcription 1 0.246
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.243
Mta1 metastasis associated 1 0.243
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.241
Myod1 myogenic differentiation 1 0.237
Atxn7l3 ataxin 7-like 3 0.235
Mapk1 mitogen-activated protein kinase 1 0.233
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.230
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
F33H1.4 Protein F33H1.4 0.012
hda-2 Protein HDA-2 0.011
apr-1 Protein APR-1 0.011
F59G1.8 Protein F59G1.8 0.010
attf-2 Protein ATTF-2 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
CG10414 CG10414 gene product from transcript CG10414-RA 0.993
Pcaf CG4107 gene product from transcript CG4107-RA 0.992
Hcf Host cell factor 0.990
dik diskette 0.968
D12 CG13400 gene product from transcript CG13400-RA 0.968
Sir2 CG5216 gene product from transcript CG5216-RA 0.928
Atac1 ATAC component 1 0.909
Mocs2 Molybdopterin synthase 2 0.909
Snr1 Snf5-related 1 0.867
Saf6 SAGA factor-like TAF6 0.848
His2Av Histone H2A variant 0.841
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.807
Bap55 Brahma associated protein 55kD 0.803
Sgf29 CG30390 gene product from transcript CG30390-RA 0.782
mod(mdg4) modifier of mdg4 0.755
egg eggless 0.736
wds will die slowly 0.685
SuUR Suppressor of Under-Replication 0.572
Nipped-A CG33554 gene product from transcript CG33554-RE 0.569
msl-3 male-specific lethal 3 0.549
Nf-YB Nuclear factor Y-box B 0.478
Rga Regena 0.415
wapl wings apart-like 0.408
Ino80 CG31212 gene product from transcript CG31212-RA 0.407
ash1 absent, small, or homeotic discs 1 0.398
MRG15 CG6363 gene product from transcript CG6363-RA 0.396
e(y)3 enhancer of yellow 3 0.396
B52 CG10851 gene product from transcript CG10851-RB 0.389
defl deflated 0.365
Rpd3 CG7471 gene product from transcript CG7471-RA 0.351
SmD3 Small ribonucleoprotein particle protein SmD3 0.333
pr-set7 CG3307 gene product from transcript CG3307-RC 0.324
pan pangolin 0.316
cg combgap 0.302
lwr lesswright 0.296
Su(var)3-3 Suppressor of variegation 3-3 0.289
MED16 Mediator complex subunit 16 0.233
dbe dribble 0.229
Tao-1 CG14217 gene product from transcript CG14217-RF 0.228
Scm Sex comb on midleg 0.222
ph-d polyhomeotic distal 0.222
Hel25E Helicase at 25E 0.194
O-fut1 O-fucosyltransferase 1 0.184
Trn-SR Transportin-Serine/Arginine rich 0.177
Rpb4 CG33520 gene product from transcript CG33520-RF 0.176
brm brahma 0.176
noi noisette 0.173
glo glorund 0.171
Cul-4 Cullin-4 0.162
l(3)mbt lethal (3) malignant brain tumor 0.156
dco discs overgrown 0.155
msl-1 male-specific lethal 1 0.151
Mad Mothers against dpp 0.151
CG3995 CG3995 gene product from transcript CG3995-RA 0.150
dalao CG7055 gene product from transcript CG7055-RA 0.148
pzg putzig 0.147
Su(H) Suppressor of Hairless 0.141
hpo hippo 0.141
Aut1 CG6877 gene product from transcript CG6877-RA 0.140
Su(var)3-7 Suppressor of variegation 3-7 0.140
SRm160 CG11274 gene product from transcript CG11274-RA 0.137
BRWD3 CG31132 gene product from transcript CG31132-RA 0.132
Gmd GDP-mannose 4,6-dehydratase 0.131
cyc cycle 0.129
Ote Otefin 0.124
CG3363 CG3363 gene product from transcript CG3363-RB 0.124
Pc Polycomb 0.117
NC2beta CG4185 gene product from transcript CG4185-RA 0.112
pic piccolo 0.112
key kenny 0.103
Akt1 CG4006 gene product from transcript CG4006-RA 0.102
ksr kinase suppressor of ras 0.101
Taf5 TBP-associated factor 5 0.101
wdn wings down 0.100
CTCF CG8591 gene product from transcript CG8591-RA 0.097
Taf6 TBP-associated factor 6 0.097
not non-stop 0.096
CG32343 CG32343 gene product from transcript CG32343-RB 0.094
Su(var)205 Suppressor of variegation 205 0.093
Kr Kruppel 0.086
Traf6 TNF-receptor-associated factor 6 0.084
Snap Soluble NSF attachment protein 0.084
Iswi Imitation SWI 0.082
CSN6 COP9 complex homolog subunit 6 0.081
mof males absent on the first 0.080
kni knirps 0.079
bon bonus 0.077
CSN5 COP9 complex homolog subunit 5 0.077
tsu tsunagi 0.075
RhoGAP100F CG1976 gene product from transcript CG1976-RB 0.074
Es2 CG1474 gene product from transcript CG1474-RA 0.073
CG10107 CG10107 gene product from transcript CG10107-RA 0.073
Chro Chromator 0.073
lt light 0.066
Taf1 TBP-associated factor 1 0.066
CG32418 CG32418 gene product from transcript CG32418-RA 0.066
byn brachyenteron 0.064
Su(var)2-10 Suppressor of variegation 2-10 0.064
Top2 Topoisomerase 2 0.063
CG11242 CG11242 gene product from transcript CG11242-RA 0.063
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Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
C20orf20 chromosome 20 open reading frame 20 1.000
TRRAP transformation/transcription domain-associated protein 1.000
KAT2B K(lysine) acetyltransferase 2B 1.000
WDR5 WD repeat domain 5 1.000
BRCA1 breast cancer 1, early onset 1.000
CREBBP CREB binding protein 1.000
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.999
KAT2A K(lysine) acetyltransferase 2A 0.999
SIRT1 sirtuin 1 0.997
USP22 ubiquitin specific peptidase 22 0.995
TBP TATA box binding protein 0.995
RUVBL1 RuvB-like 1 (E. coli) 0.987
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.985
JUN jun proto-oncogene 0.980
ACTL6A actin-like 6A 0.976
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.969
TADA3 transcriptional adaptor 3 0.958
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.954
RB1 retinoblastoma 1 0.952
CFL1 cofilin 1 (non-muscle) 0.951
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.940
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa 0.937
EP300 E1A binding protein p300 0.928
ARID1A AT rich interactive domain 1A (SWI-like) 0.926
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.916
RUNX1 runt-related transcription factor 1 0.901
SMN1 survival of motor neuron 1, telomeric 0.900
NCOA3 nuclear receptor coactivator 3 0.893
NCOR1 nuclear receptor corepressor 1 0.889
YY1 YY1 transcription factor 0.888
MAPK14 mitogen-activated protein kinase 14 0.883
NCOA1 nuclear receptor coactivator 1 0.879
TAL1 T-cell acute lymphocytic leukemia 1 0.873
DOT1L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.861
ESR1 estrogen receptor 1 0.850
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.847
NCOA2 nuclear receptor coactivator 2 0.832
RBBP5 retinoblastoma binding protein 5 0.831
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.824
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.824
HTT huntingtin 0.823
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.820
AR androgen receptor 0.820
ING3 inhibitor of growth family, member 3 0.819
SMAD3 SMAD family member 3 0.799
CREB1 cAMP responsive element binding protein 1 0.799
MBIP MAP3K12 binding inhibitory protein 1 0.797
GSK3B glycogen synthase kinase 3 beta 0.797
DAXX death-domain associated protein 0.778
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.766
HIST1H3B histone cluster 1, H3b 0.759
NCOA6 nuclear receptor coactivator 6 0.706
HCFC1 host cell factor C1 (VP16-accessory protein) 0.699
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.693
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.686
ATXN7 ataxin 7 0.662
RBBP7 retinoblastoma binding protein 7 0.660
FOS FBJ murine osteosarcoma viral oncogene homolog 0.657
HIST2H3C histone cluster 2, H3c 0.646
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.631
UBE3A ubiquitin protein ligase E3A 0.630
HDAC1 histone deacetylase 1 0.628
WRN Werner syndrome, RecQ helicase-like 0.623
RBBP4 retinoblastoma binding protein 4 0.620
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 0.615
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa 0.609
MRFAP1 Morf4 family associated protein 1 0.606
CCDC101 coiled-coil domain containing 101 0.571
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.551
SETD8 SET domain containing (lysine methyltransferase) 8 0.539
MTA1 metastasis associated 1 0.538
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.538
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.513
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.508
MORF4L2 mortality factor 4 like 2 0.503
INO80 INO80 homolog (S. cerevisiae) 0.498
DUSP1 dual specificity phosphatase 1 0.496
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.489
ZNF148 zinc finger protein 148 0.487
ZNF512B zinc finger protein 512B 0.467
INO80E INO80 complex subunit E 0.466
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 0.442
MECP2 methyl CpG binding protein 2 (Rett syndrome) 0.431
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.428
SKI v-ski sarcoma viral oncogene homolog (avian) 0.420
ZNF496 zinc finger protein 496 0.412
ATG3 ATG3 autophagy related 3 homolog (S. cerevisiae) 0.412
ATF3 activating transcription factor 3 0.403
CSNK1E casein kinase 1, epsilon 0.395
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.385
KAT5 K(lysine) acetyltransferase 5 0.380
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 0.371
EPC1 enhancer of polycomb homolog 1 (Drosophila) 0.367
GATAD2B GATA zinc finger domain containing 2B 0.360
CBX5 chromobox homolog 5 0.357
ELP2 elongation protein 2 homolog (S. cerevisiae) 0.349
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.347
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.344
EP400 E1A binding protein p400 0.342
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.094
Tuba1c tubulin, alpha 1C 0.029
Actb actin, beta 0.029
Casp2 caspase 2 0.019
Actg1 actin, gamma 1 0.015
Hspa8 heat shock protein 8 0.011
Ash1l ash1 (absent, small, or homeotic)-like (Drosophila) 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
TRA1 Tra1p 1.000
NGG1 Ngg1p 0.997
TAF6 Taf6p 0.991
GCN5 Gcn5p 0.991
ADA2 Ada2p 0.987
SPT8 Spt8p 0.977
HHT1 Hht1p 0.973
EPL1 Epl1p 0.933
TAF12 Taf12p 0.925
ARP4 Arp4p 0.911
SGF29 Sgf29p 0.909
HFI1 Hfi1p 0.907
TAF5 Taf5p 0.897
SPT7 Spt7p 0.868
SPT20 Spt20p 0.855
BDF1 Bdf1p 0.849
EAF1 Eaf1p 0.842
EAF3 Eaf3p 0.828
TAF10 Taf10p 0.821
EAF6 Eaf6p 0.814
EAF5 Eaf5p 0.805
YAF9 Yaf9p 0.782
ASF1 Asf1p 0.767
YNG1 Yng1p 0.662
ESA1 Esa1p 0.582
SWC4 Swc4p 0.512
HAT2 Hat2p 0.493
YNG2 Yng2p 0.484
RCO1 Rco1p 0.389
SGF73 Sgf73p 0.375
SDC1 Sdc1p 0.369
SPT15 Spt15p 0.360
UBP8 Ubp8p 0.298
SPT3 Spt3p 0.259
TAF9 Taf9p 0.234
RSC4 Rsc4p 0.232
SGF11 Sgf11p 0.224
HIF1 Hif1p 0.213
ISW1 Isw1p 0.211
SUS1 Sus1p 0.210
EAF7 Eaf7p 0.181
HAT1 Hat1p 0.179
ELP6 Elp6p 0.178
CAC2 Cac2p 0.165
TEC1 Tec1p 0.158
YTA7 Yta7p 0.157
RTT106 Rtt106p 0.153
FUS3 Fus3p 0.144
SWI1 Swi1p 0.144
TAF3 Taf3p 0.140
SAS3 Sas3p 0.140
NAT1 Nat1p 0.137
RSC1 Rsc1p 0.120
SNF5 Snf5p 0.117
SAS5 Sas5p 0.104
NTO1 Nto1p 0.093
PSH1 Psh1p 0.090
IKI1 Iki1p 0.089
MDM20 Mdm20p 0.083
VPS75 Vps75p 0.082
HIR1 Hir1p 0.078
HHO1 Hho1p 0.076
SET2 Set2p 0.073
CKB1 Ckb1p 0.071
SAP185 Sap185p 0.070
ORC4 Orc4p 0.068
NSA1 Nsa1p 0.067
HIR2 Hir2p 0.064
HMO1 Hmo1p 0.061
ELP4 Elp4p 0.061
RSC8 Rsc8p 0.061
SWD3 Swd3p 0.056
POL2 Pol2p 0.056
DPB3 Dpb3p 0.056
RSC30 Rsc30p 0.054
TAF14 Taf14p 0.051
SIN3 Sin3p 0.051
RPD3 Rpd3p 0.049
DLS1 Dls1p 0.046
HDA2 Hda2p 0.045
HOS2 Hos2p 0.044
ESF1 Esf1p 0.042
NOP10 Nop10p 0.040
SAM2 Sam2p 0.040
LEO1 Leo1p 0.039
NRG2 Nrg2p 0.038
RLF2 Rlf2p 0.038
SWR1 Swr1p 0.037
NPL6 Npl6p 0.036
IES2 Ies2p 0.036
GCN20 Gcn20p 0.036
SEN1 Sen1p 0.035
SPT10 Spt10p 0.035
SPP1 Spp1p 0.034
HPC2 Hpc2p 0.034
RSC6 Rsc6p 0.033
VMA7 Vma7p 0.032
YHB1 Yhb1p 0.032
SRD1 Srd1p 0.031
HST3 Hst3p 0.031