The network for 'positive regulation of angiogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of angiogenesis

Any process that activates or increases angiogenesis.

Mus musculus
Name Description Probability Func Analog Organism
Pax2 paired box gene 2 0.995
Foxc1 forkhead box C1 0.989
Tgfbr2 transforming growth factor, beta receptor II 0.985
Vegfa vascular endothelial growth factor A 0.974
Shh sonic hedgehog 0.963
Csf1 colony stimulating factor 1 (macrophage) 0.955
Bmp4 bone morphogenetic protein 4 0.953
Pitx2 paired-like homeodomain transcription factor 2 0.929
Hand2 heart and neural crest derivatives expressed transcript 2 0.926
Fgfr1 fibroblast growth factor receptor 1 0.924
Fgfr2 fibroblast growth factor receptor 2 0.899
Gli3 GLI-Kruppel family member GLI3 0.884
Jag1 jagged 1 0.866
Ccl2 chemokine (C-C motif) ligand 2 0.858
Pax3 paired box gene 3 0.847
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.816
Fgf8 fibroblast growth factor 8 0.799
Hoxd13 homeobox D13 0.780
Nos3 nitric oxide synthase 3, endothelial cell 0.772
Pbx1 pre B-cell leukemia transcription factor 1 0.744
Selp selectin, platelet 0.740
Fgf10 fibroblast growth factor 10 0.735
Flt4 FMS-like tyrosine kinase 4 0.720
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.686
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.685
Cxcl13 chemokine (C-X-C motif) ligand 13 0.668
Kdr kinase insert domain protein receptor 0.663
C3ar1 complement component 3a receptor 1 0.635
Gata4 GATA binding protein 4 0.628
Lhx1 LIM homeobox protein 1 0.625
Gata6 GATA binding protein 6 0.609
Otx2 orthodenticle homolog 2 (Drosophila) 0.606
Efnb2 ephrin B2 0.600
Emx1 empty spiracles homolog 1 (Drosophila) 0.589
Apc adenomatosis polyposis coli 0.585
Tgfb2 transforming growth factor, beta 2 0.569
Emx2 empty spiracles homolog 2 (Drosophila) 0.566
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.557
Egfr epidermal growth factor receptor 0.553
Snai1 snail homolog 1 (Drosophila) 0.528
Il1b interleukin 1 beta 0.515
Tbx1 T-box 1 0.510
Meox2 mesenchyme homeobox 2 0.507
Ntf3 neurotrophin 3 0.505
Adra2b adrenergic receptor, alpha 2b 0.501
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.501
Hoxa1 homeobox A1 0.482
Smad6 MAD homolog 6 (Drosophila) 0.481
Eya1 eyes absent 1 homolog (Drosophila) 0.467
Msx2 homeobox, msh-like 2 0.462
Slc26a4 solute carrier family 26, member 4 0.451
Hoxa11 homeobox A11 0.447
Tcf21 transcription factor 21 0.433
Fbn1 fibrillin 1 0.429
Il1a interleukin 1 alpha 0.416
Pax6 paired box gene 6 0.410
Gata3 GATA binding protein 3 0.405
Flt1 FMS-like tyrosine kinase 1 0.405
Sox7 SRY-box containing gene 7 0.405
Nodal nodal 0.397
Foxc2 forkhead box C2 0.389
Sox9 SRY-box containing gene 9 0.387
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.385
Ceacam11 carcinoembryonic antigen-related cell adhesion molecule 11 0.373
Wt1 Wilms tumor 1 homolog 0.370
Pax8 paired box gene 8 0.367
Phox2b paired-like homeobox 2b 0.350
Sod3 superoxide dismutase 3, extracellular 0.320
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.318
Htra3 HtrA serine peptidase 3 0.315
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.308
Thbd thrombomodulin 0.301
Hoxd11 homeobox D11 0.297
Amh anti-Mullerian hormone 0.297
Notch2 Notch gene homolog 2 (Drosophila) 0.297
Acvrl1 activin A receptor, type II-like 1 0.290
Hic1 hypermethylated in cancer 1 0.288
Rarg retinoic acid receptor, gamma 0.284
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.283
Foxf2 forkhead box F2 0.283
Prl2b1 prolactin family 2, subfamily b, member 1 0.281
Gbx2 gastrulation brain homeobox 2 0.280
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.279
Plat plasminogen activator, tissue 0.269
Hand1 heart and neural crest derivatives expressed transcript 1 0.268
C1qc complement component 1, q subcomponent, C chain 0.267
Nog noggin 0.261
Nkx2-1 NK2 homeobox 1 0.260
Prl6a1 prolactin family 6, subfamily a, member 1 0.259
Hoxa9 homeobox A9 0.256
Tcfap2a transcription factor AP-2, alpha 0.256
Ldb3 LIM domain binding 3 0.252
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.252
Pcdh12 protocadherin 12 0.249
Rb1 retinoblastoma 1 0.246
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.246
Lmx1a LIM homeobox transcription factor 1 alpha 0.243
Prl8a2 prolactin family 8, subfamily a, member 2 0.240
Foxb2 forkhead box B2 0.239
Adm adrenomedullin 0.237
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.973
FGFR2 fibroblast growth factor receptor 2 0.964
LAT linker for activation of T cells 0.956
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.943
EGFR epidermal growth factor receptor 0.939
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.876
FGFR1 fibroblast growth factor receptor 1 0.875
TAL1 T-cell acute lymphocytic leukemia 1 0.866
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.848
PRKCA protein kinase C, alpha 0.847
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.829
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.725
IL1R1 interleukin 1 receptor, type I 0.681
VEGFA vascular endothelial growth factor A 0.679
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.643
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.641
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.640
SKIL SKI-like oncogene 0.626
GRB7 growth factor receptor-bound protein 7 0.590
ENG endoglin 0.559
PLAUR plasminogen activator, urokinase receptor 0.497
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.476
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.474
TGFB1 transforming growth factor, beta 1 0.448
CRYAB crystallin, alpha B 0.436
PLAU plasminogen activator, urokinase 0.422
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.419
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.397
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.396
HDAC7 histone deacetylase 7 0.372
NRP1 neuropilin 1 0.368
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.351
FGA fibrinogen alpha chain 0.328
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.320
MEF2C myocyte enhancer factor 2C 0.316
CCR5 chemokine (C-C motif) receptor 5 0.313
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.309
TEK TEK tyrosine kinase, endothelial 0.298
PSEN2 presenilin 2 (Alzheimer disease 4) 0.294
FN1 fibronectin 1 0.249
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.241
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.240
THBS1 thrombospondin 1 0.225
SFN stratifin 0.222
FGF1 fibroblast growth factor 1 (acidic) 0.210
PBX1 pre-B-cell leukemia homeobox 1 0.209
PLCG1 phospholipase C, gamma 1 0.201
PPL periplakin 0.173
RUNX1 runt-related transcription factor 1 0.172
MET met proto-oncogene (hepatocyte growth factor receptor) 0.171
SLA Src-like-adaptor 0.166
DDR2 discoidin domain receptor tyrosine kinase 2 0.156
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.153
BCL6 B-cell CLL/lymphoma 6 0.149
CDH5 cadherin 5, type 2 (vascular endothelium) 0.148
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.146
FGG fibrinogen gamma chain 0.137
CXCR6 chemokine (C-X-C motif) receptor 6 0.135
PLDN pallidin homolog (mouse) 0.131
NCF1 neutrophil cytosolic factor 1 0.130
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.129
PKN2 protein kinase N2 0.128
FGB fibrinogen beta chain 0.124
PRKCD protein kinase C, delta 0.117
PRELP proline/arginine-rich end leucine-rich repeat protein 0.116
EP300 E1A binding protein p300 0.115
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.111
FGF2 fibroblast growth factor 2 (basic) 0.110
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 0.109
COL6A1 collagen, type VI, alpha 1 0.106
BAG3 BCL2-associated athanogene 3 0.104
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.104
ELN elastin 0.101
RALBP1 ralA binding protein 1 0.100
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.099
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.099
NCOR2 nuclear receptor corepressor 2 0.098
HSPB2 heat shock 27kDa protein 2 0.098
EFNA5 ephrin-A5 0.096
TIMP1 TIMP metallopeptidase inhibitor 1 0.091
FGF8 fibroblast growth factor 8 (androgen-induced) 0.088
HDAC4 histone deacetylase 4 0.087
TBX5 T-box 5 0.086
FZD1 frizzled homolog 1 (Drosophila) 0.086
TGFB3 transforming growth factor, beta 3 0.085
ITGB5 integrin, beta 5 0.085
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.084
RB1 retinoblastoma 1 0.083
PLAT plasminogen activator, tissue 0.082
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.082
PRRX1 paired related homeobox 1 0.081
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 0.080
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.080
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.079
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.079
CCR2 chemokine (C-C motif) receptor 2 0.078
ANXA1 annexin A1 0.078
NGF nerve growth factor (beta polypeptide) 0.078
PDCD6IP programmed cell death 6 interacting protein 0.077
CCL22 chemokine (C-C motif) ligand 22 0.076
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ccl2 chemokine (C-C motif) ligand 2 0.370
Il1b interleukin 1 beta 0.250
Met met proto-oncogene 0.199
Emcn endomucin 0.183
Ccl4 chemokine (C-C motif) ligand 4 0.164
Sell selectin L 0.155
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.155
Acvrl1 activin A receptor type II-like 1 0.154
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.146
Il8rb interleukin 8 receptor, beta 0.128
Il2rg interleukin 2 receptor, gamma 0.105
Mmp3 matrix metallopeptidase 3 0.094
Neurl3 neuralized homolog 3 (Drosophila) 0.092
Cpa3 carboxypeptidase A3, mast cell 0.086
Csf3r colony stimulating factor 3 receptor (granulocyte) 0.085
Cd86 CD86 molecule 0.083
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.083
LOC24906 RoBo-1 0.076
Bst1 bone marrow stromal cell antigen 1 0.075
Col4a1 collagen, type IV, alpha 1 0.075
Csf1 colony stimulating factor 1 (macrophage) 0.074
Hck hemopoietic cell kinase 0.066
Il2rb interleukin 2 receptor, beta 0.066
Tgm1 transglutaminase 1, K polypeptide 0.066
Icam1 intercellular adhesion molecule 1 0.065
Il1rl1 interleukin 1 receptor-like 1 0.063
Itgb7 integrin, beta 7 0.061
Fas Fas (TNF receptor superfamily, member 6) 0.061
Ccl3 chemokine (C-C motif) ligand 3 0.060
Il6 interleukin 6 0.058
Reg3g regenerating islet-derived 3 gamma 0.057
Hpx hemopexin 0.057
Dmbt1 deleted in malignant brain tumors 1 0.055
Ccr1 chemokine (C-C motif) receptor 1 0.055
Gja4 gap junction protein, alpha 4 0.054
Hspa1a heat shock 70kD protein 1A 0.053
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.052
Gper G protein-coupled estrogen receptor 1 0.052
Kif6 kinesin family member 6 0.052
Adora2a adenosine A2a receptor 0.051
Cd14 CD14 molecule 0.051
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.050
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.049
Cd80 Cd80 molecule 0.045
Calcrl calcitonin receptor-like 0.045
Dock8 dedicator of cytokinesis 8 0.042
Olfml2b olfactomedin-like 2B 0.042
Gzmk granzyme K 0.042
Ctsb cathepsin B 0.042
Hpgds hematopoietic prostaglandin D synthase 0.041
Cldn7 claudin 7 0.041
Stat5a signal transducer and activator of transcription 5A 0.041
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.041
Cybb cytochrome b-245, beta polypeptide 0.041
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.041
Fcgrt Fc fragment of IgG, receptor, transporter, alpha 0.040
Has2 hyaluronan synthase 2 0.040
Tpsab1 tryptase alpha/beta 1 0.039
Ccr2 chemokine (C-C motif) receptor 2 0.039
Mmp2 matrix metallopeptidase 2 0.039
Ccr5 chemokine (C-C motif) receptor 5 0.038
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.037
Apol3 apolipoprotein L, 3 0.037
Cdh5 cadherin 5 0.037
Fgfr2 fibroblast growth factor receptor 2 0.037
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.036
Cd2 Cd2 molecule 0.035
Cryba4 crystallin, beta A4 0.035
C5ar1 complement component 5a receptor 1 0.035
Napsa napsin A aspartic peptidase 0.035
Runx1 runt-related transcription factor 1 0.034
Tek TEK tyrosine kinase, endothelial 0.034
Il1r2 interleukin 1 receptor, type II 0.034
Selp selectin P 0.034
Cd8b CD8b molecule 0.033
Gna15 guanine nucleotide binding protein, alpha 15 0.033
Rhox5 reproductive homeobox 5 0.032
Bgn biglycan 0.032
Prkch protein kinase C, eta 0.032
Mpeg1 macrophage expressed 1 0.032
Chordc1 cysteine and histidine-rich domain (CHORD)-containing 1 0.032
Cftr cystic fibrosis transmembrane conductance regulator homolog (human) 0.032
Fosl1 fos-like antigen 1 0.031
Tfpi2 tissue factor pathway inhibitor 2 0.031
Crisp1 cysteine-rich secretory protein 1 0.031
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.031
Calcb calcitonin-related polypeptide, beta 0.030
Itgam integrin, alpha M 0.030
Sult2a1 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.030
Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 0.030
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.030
Mmp12 matrix metallopeptidase 12 0.029
Il7 interleukin 7 0.029
Il1a interleukin 1 alpha 0.029
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.029
Gata2 GATA binding protein 2 0.029
Alb albumin 0.029
Stc1 stanniocalcin 1 0.029
Il2ra interleukin 2 receptor, alpha 0.029
Fuca1 fucosidase, alpha-L- 1, tissue 0.029
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism