The network for 'regulation of epidermis development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of epidermis development

Any process that modulates the frequency, rate or extent of epidermis development.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.990
Notch1 Notch gene homolog 1 (Drosophila) 0.986
Otx2 orthodenticle homolog 2 (Drosophila) 0.966
Fgf8 fibroblast growth factor 8 0.925
Foxc1 forkhead box C1 0.907
Gli3 GLI-Kruppel family member GLI3 0.895
Fgfr1 fibroblast growth factor receptor 1 0.851
Wnt3a wingless-related MMTV integration site 3A 0.842
Hes1 hairy and enhancer of split 1 (Drosophila) 0.793
Krt27 keratin 27 0.734
Dlx3 distal-less homeobox 3 0.722
Hand2 heart and neural crest derivatives expressed transcript 2 0.708
Smad4 MAD homolog 4 (Drosophila) 0.702
Trp63 transformation related protein 63 0.699
Emx1 empty spiracles homolog 1 (Drosophila) 0.672
Ptf1a pancreas specific transcription factor, 1a 0.664
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.661
En1 engrailed 1 0.656
Krt17 keratin 17 0.643
Gata4 GATA binding protein 4 0.633
Foxn1 forkhead box N1 0.624
Pten phosphatase and tensin homolog 0.622
Krt8 keratin 8 0.613
Efnb2 ephrin B2 0.611
Psen1 presenilin 1 0.587
Hes5 hairy and enhancer of split 5 (Drosophila) 0.566
Twist2 twist homolog 2 (Drosophila) 0.548
Dll1 delta-like 1 (Drosophila) 0.520
Hand1 heart and neural crest derivatives expressed transcript 1 0.493
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.486
Egr2 early growth response 2 0.475
Pax6 paired box gene 6 0.453
Krt5 keratin 5 0.449
Nog noggin 0.439
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.431
Hoxa1 homeobox A1 0.426
Krt14 keratin 14 0.425
Smad3 MAD homolog 3 (Drosophila) 0.409
Krt6a keratin 6A 0.380
Egfr epidermal growth factor receptor 0.380
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.366
Krtdap keratinocyte differentiation associated protein 0.355
Tlx3 T-cell leukemia, homeobox 3 0.334
Isl1 ISL1 transcription factor, LIM/homeodomain 0.313
Ctnnb1 catenin (cadherin associated protein), beta 1 0.308
Tnf tumor necrosis factor 0.306
Fgf5 fibroblast growth factor 5 0.305
Efna2 ephrin A2 0.299
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.298
Foxc2 forkhead box C2 0.296
Krt33b keratin 33B 0.289
Lhx5 LIM homeobox protein 5 0.286
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.278
Krtap8-1 keratin associated protein 8-1 0.277
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.274
Nhlh1 nescient helix loop helix 1 0.272
Padi3 peptidyl arginine deiminase, type III 0.272
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.270
Ntf3 neurotrophin 3 0.268
Krt36 keratin 36 0.263
Pitx2 paired-like homeodomain transcription factor 2 0.258
Wnt6 wingless-related MMTV integration site 6 0.249
Fgfr2 fibroblast growth factor receptor 2 0.245
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.245
Ldb3 LIM domain binding 3 0.245
Krt71 keratin 71 0.223
Wnt1 wingless-related MMTV integration site 1 0.215
Irf6 interferon regulatory factor 6 0.213
Hoxd13 homeobox D13 0.212
Gli2 GLI-Kruppel family member GLI2 0.212
Dlx5 distal-less homeobox 5 0.209
Wnt4 wingless-related MMTV integration site 4 0.203
Tcf3 transcription factor 3 0.198
Snai1 snail homolog 1 (Drosophila) 0.196
Msx2 homeobox, msh-like 2 0.195
Dlx2 distal-less homeobox 2 0.195
Lhx3 LIM homeobox protein 3 0.186
Psapl1 prosaposin-like 1 0.186
Lgals7 lectin, galactose binding, soluble 7 0.186
Hoxa13 homeobox A13 0.181
Fgf15 fibroblast growth factor 15 0.177
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.172
Pax3 paired box gene 3 0.171
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.169
Smad1 MAD homolog 1 (Drosophila) 0.169
Etv4 ets variant gene 4 (E1A enhancer binding protein, E1AF) 0.167
Krt18 keratin 18 0.164
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.164
Ltb lymphotoxin B 0.163
Emx2 empty spiracles homolog 2 (Drosophila) 0.162
Klk6 kallikrein related-peptidase 6 0.162
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.161
Bnc1 basonuclin 1 0.159
Krt35 keratin 35 0.159
Dlx1 distal-less homeobox 1 0.158
Fosl2 fos-like antigen 2 0.157
Col22a1 collagen, type XXII, alpha 1 0.156
Krt15 keratin 15 0.154
Cldn3 claudin 3 0.153
Rxra retinoid X receptor alpha 0.148
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.855
cdh1 cadherin 1, epithelial 0.643
fgf24 fibroblast growth factor 24 0.302
slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 0.269
tbx20 T-box 20 0.234
pitx3 paired-like homeodomain transcription factor 3 0.151
notch1a notch homolog 1a 0.130
dlc deltaC 0.115
celsr1a cadherin EGF LAG seven-pass G-type receptor 1a 0.104
tp63 tumor protein p63 0.101
tfap2a transcription factor AP-2 alpha 0.101
foxi1 forkhead box I1 0.085
zgc:92533 zgc:92533 0.075
ptf1a pancreas specific transcription factor, 1a 0.073
dlb deltaB 0.072
atoh1b atonal homolog 1b 0.071
krt4 keratin 4 0.067
notch3 notch homolog 3 0.066
mib mind bomb 0.065
hapln3 hyaluronan and proteoglycan link protein 3 0.063
llgl2 lethal giant larvae homolog 2 (Drosophila) 0.062
hoxb1a homeo box B1a 0.062
pax2a paired box gene 2a 0.061
slc24a5 solute carrier family 24, member 5 0.061
disp1 dispatched homolog 1 (Drosophila) 0.059
eng2b engrailed 2b 0.057
atoh1a atonal homolog 1a 0.056
gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.055
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.052
atoh1c atonal homolog 1c 0.052
krt5 keratin 5 0.050
id3 inhibitor of DNA binding 3 0.048
dlx3b distal-less homeobox gene 3b 0.047
anxa1a annexin A1a 0.047
cav1 caveolin 1 0.047
six4b sine oculis homeobox homolog 4b 0.046
xbp1 X-box binding protein 1 0.046
gata2a GATA-binding protein 2a 0.046
szl sizzled 0.045
perp PERP, TP53 apoptosis effector 0.045
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.042
hnrnpa0 heterogeneous nuclear ribonucleoprotein A0 0.039
fstl1b follistatin-like 1b 0.039
cdh23 cadherin-like 23 0.039
vgll4l vestigial like 4 like 0.039
rasl11b RAS-like, family 11, member B 0.039
crabp2a cellular retinoic acid binding protein 2, a 0.038
foxi3a forkhead box I3a 0.038
slc1a3b solute carrier family 1 (glial high affinity glutamate transporter), member 3b 0.037
tm9sf2 transmembrane 9 superfamily member 2 0.037
anxa2a annexin A2a 0.036
znf703 zinc finger protein 703 0.036
cxcr4a chemokine (C-X-C motif) receptor 4a 0.036
dlx4a distal-less homeobox gene 4a 0.036
cldnb claudin b 0.035
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.035
esrra estrogen-related receptor alpha 0.034
pcf11 cleavage and polyadenylation factor subunit, homolog (S. cerevisiae) 0.034
pitx2 paired-like homeodomain transcription factor 2 0.034
hoxd3a homeo box D3a 0.034
irx4b iroquois homeobox protein 4b 0.034
lama5 laminin, alpha 5 0.033
six1b sine oculis homeobox homolog 1b 0.033
irx1b iroquois homeobox protein 1, b 0.033
crb2a crumbs homolog 2a 0.033
tbx5a T-box 5a 0.032
ctsl1b cathepsin L, 1 b 0.032
creb3l3l cAMP responsive element binding protein 3-like 3 like 0.031
lamc1 laminin, gamma 1 0.030
cldna claudin a 0.030
dld deltaD 0.029
supt6h suppressor of Ty 6 homolog 0.029
epcam epithelial cell adhesion molecule 0.029
tagln2 transgelin 2 0.028
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.028
leo1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.028
egr2b early growth response 2b 0.028
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.028
cldni claudin i 0.028
klf2b Kruppel-like factor 2b 0.027
hnrpl heterogeneous nuclear ribonucleoprotein L 0.027
arrdc3a arrestin domain containing 3a 0.027
dmd dystrophin 0.027
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.027
neurog1 neurogenin 1 0.027
nppa natriuretic peptide precursor A 0.027
rest RE1-silencing transcription factor 0.026
gyltl1b glycosyltransferase-like 1b 0.026
aldob aldolase b, fructose-bisphosphate 0.025
kdrl kinase insert domain receptor like 0.025
rhoaa ras homolog gene family, member Aa 0.025
smarca5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.025
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.025
col14a1 collagen, type XIV, alpha 1 0.025
jup junction plakoglobin 0.025
cfl1 cofilin 1 (non-muscle) 0.024
eya1 eyes absent homolog 1 0.024
trim33 tripartite motif-containing 33 0.023
zgc:64161 zgc:64161 0.023
ppl periplakin 0.023
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Dl Delta 0.020
Mad Mothers against dpp 0.017
N Notch 0.014
ro rough 0.013
stg string 0.012
hh hedgehog 0.012
lqfR liquid facets-Related 0.011
dia diaphanous 0.011
Peb Protein ejaculatory bulb 0.011
dlt discs lost 0.011
baz bazooka 0.011
dib disembodied 0.011
E(spl) Enhancer of split 0.011
sens senseless 0.010
CycE Cyclin E 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.872
BMPR1A bone morphogenetic protein receptor, type IA 0.622
AR androgen receptor 0.591
CREBBP CREB binding protein 0.581
HOXB5 homeobox B5 0.551
NCOR2 nuclear receptor corepressor 2 0.499
ESR1 estrogen receptor 1 0.468
SFN stratifin 0.452
JAG1 jagged 1 0.444
NCOA1 nuclear receptor coactivator 1 0.440
HOXA5 homeobox A5 0.401
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.400
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.387
NCOR1 nuclear receptor corepressor 1 0.348
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.320
BBS10 Bardet-Biedl syndrome 10 0.319
HOXA10 homeobox A10 0.307
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.302
NOTCH3 notch 3 0.258
FSTL1 follistatin-like 1 0.254
HOXA7 homeobox A7 0.227
NME2 non-metastatic cells 2, protein (NM23B) expressed in 0.210
PKP3 plakophilin 3 0.185
CTNND1 catenin (cadherin-associated protein), delta 1 0.182
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.137
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.128
HOXB3 homeobox B3 0.125
HOXA11 homeobox A11 0.124
NCOA2 nuclear receptor coactivator 2 0.124
ZNF746 zinc finger protein 746 0.120
JUP junction plakoglobin 0.109
HOXB9 homeobox B9 0.108
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.103
RXRA retinoid X receptor, alpha 0.100
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.087
HOXB6 homeobox B6 0.087
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.086
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.085
KRT5 keratin 5 0.084
HOXA4 homeobox A4 0.084
HIPK2 homeodomain interacting protein kinase 2 0.083
MSX1 msh homeobox 1 0.076
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.074
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.074
TGFB1 transforming growth factor, beta 1 0.068
EPPK1 epiplakin 1 0.067
HOXC6 homeobox C6 0.065
TRAF1 TNF receptor-associated factor 1 0.065
HOXC10 homeobox C10 0.063
NCOA3 nuclear receptor coactivator 3 0.063
HOXB7 homeobox B7 0.062
NME1 non-metastatic cells 1, protein (NM23A) expressed in 0.060
NOTCH1 notch 1 0.057
RND3 Rho family GTPase 3 0.057
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.056
HOXA2 homeobox A2 0.055
ZNF775 zinc finger protein 775 0.053
JUB jub, ajuba homolog (Xenopus laevis) 0.051
WNT3A wingless-type MMTV integration site family, member 3A 0.050
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.050
LAD1 ladinin 1 0.049
RUNX1 runt-related transcription factor 1 0.049
NME3 non-metastatic cells 3, protein expressed in 0.048
HR hairless homolog (mouse) 0.046
PSEN1 presenilin 1 0.045
WNT5A wingless-type MMTV integration site family, member 5A 0.044
ZFYVE9 zinc finger, FYVE domain containing 9 0.043
HOXA6 homeobox A6 0.043
DDIT3 DNA-damage-inducible transcript 3 0.043
BHLHE40 basic helix-loop-helix family, member e40 0.041
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.041
STMN2 stathmin-like 2 0.038
TJP1 tight junction protein 1 (zona occludens 1) 0.038
PARD6G par-6 partitioning defective 6 homolog gamma (C. elegans) 0.038
NDP Norrie disease (pseudoglioma) 0.037
ESR2 estrogen receptor 2 (ER beta) 0.035
FOXO1 forkhead box O1 0.035
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.034
NFIL3 nuclear factor, interleukin 3 regulated 0.034
INHBA inhibin, beta A 0.033
EP300 E1A binding protein p300 0.033
ENG endoglin 0.032
NCOA6 nuclear receptor coactivator 6 0.032
NME4 non-metastatic cells 4, protein expressed in 0.031
EHF ets homologous factor 0.031
ELF5 E74-like factor 5 (ets domain transcription factor) 0.030
SFRP1 secreted frizzled-related protein 1 0.030
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.029
TNK2 tyrosine kinase, non-receptor, 2 0.029
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.029
KRT6C keratin 6C 0.029
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.028
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.028
CREB1 cAMP responsive element binding protein 1 0.028
HTT huntingtin 0.028
SKIL SKI-like oncogene 0.027
CABLES1 Cdk5 and Abl enzyme substrate 1 0.027
SATB2 SATB homeobox 2 0.027
TNS4 tensin 4 0.027
RBM39 RNA binding motif protein 39 0.026
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism