IMP

Process View

Homo sapiens

24 genes annotated in human

negative regulation of cell substrate adhesion

Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of cell substrate adhesion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of cell substrate adhesion" (in gray)

Name	Description	Probability	Func Analog Organism
JAG1	jagged 1	0.953
ENG	endoglin	0.749
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.674
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.636
NOTCH1	notch 1	0.610
FKBP1A	FK506 binding protein 1A, 12kDa	0.578
BCAR1	breast cancer anti-estrogen resistance 1	0.453
PLAU	plasminogen activator, urokinase	0.421	Human
HOXB5	homeobox B5	0.411	Human
DLG1	discs, large homolog 1 (Drosophila)	0.358
IGFBP3	insulin-like growth factor binding protein 3	0.340
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.335
TEK	TEK tyrosine kinase, endothelial	0.322
TGFB3	transforming growth factor, beta 3	0.319
ABI2	abl-interactor 2	0.245
NCOA1	nuclear receptor coactivator 1	0.186
TGFB1	transforming growth factor, beta 1	0.144
FZD1	frizzled homolog 1 (Drosophila)	0.137	Human
NOTCH3	notch 3	0.116	Human
SMAD7	SMAD family member 7	0.103
HOXA5	homeobox A5	0.101	Human
PLAT	plasminogen activator, tissue	0.096	Human
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.095
HOXB7	homeobox B7	0.094	Human
HOXA7	homeobox A7	0.090
RXRA	retinoid X receptor, alpha	0.089
BBS10	Bardet-Biedl syndrome 10	0.089
THBS1	thrombospondin 1	0.088
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.087
NRP1	neuropilin 1	0.077
FN1	fibronectin 1	0.075
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.074
HOXC6	homeobox C6	0.073	Human
CXCR4	chemokine (C-X-C motif) receptor 4	0.073
SDC2	syndecan 2	0.070
HOXB6	homeobox B6	0.069	Human
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.068
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.067
GDF5	growth differentiation factor 5	0.063
INADL	InaD-like (Drosophila)	0.057
SH3PXD2A	SH3 and PX domains 2A	0.056
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.055
DLL1	delta-like 1 (Drosophila)	0.053
WNT5A	wingless-type MMTV integration site family, member 5A	0.053	Human
FAF1	Fas (TNFRSF6) associated factor 1	0.052
HOXB3	homeobox B3	0.051
BMPR1A	bone morphogenetic protein receptor, type IA	0.051	Human
HOXA11	homeobox A11	0.051
LIN7C	lin-7 homolog C (C. elegans)	0.050
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.049
PTK2	PTK2 protein tyrosine kinase 2	0.049
HOXA10	homeobox A10	0.049
COL1A2	collagen, type I, alpha 2	0.048
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.047
SNX33	sorting nexin 33	0.046
SFRP1	secreted frizzled-related protein 1	0.046
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.046
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.044
NCK1	NCK adaptor protein 1	0.043
TIMP2	TIMP metallopeptidase inhibitor 2	0.043
SH3D19	SH3 domain containing 19	0.043
HOXB9	homeobox B9	0.043
WNT3A	wingless-type MMTV integration site family, member 3A	0.042	Human
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.042
PDGFC	platelet derived growth factor C	0.041
NCOR2	nuclear receptor corepressor 2	0.040
HOXA4	homeobox A4	0.040	Human
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.039
COL1A1	collagen, type I, alpha 1	0.039	Mouse
WISP1	WNT1 inducible signaling pathway protein 1	0.038
ACVR1	activin A receptor, type I	0.038	Human
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.037	Human
GAST	gastrin	0.037
BMP4	bone morphogenetic protein 4	0.037
HOXA2	homeobox A2	0.036
ZMYND11	zinc finger, MYND-type containing 11	0.036
HOXC10	homeobox C10	0.036
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.036
FYN	FYN oncogene related to SRC, FGR, YES	0.036
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.035
MUC1	mucin 1, cell surface associated	0.034
SRCIN1	SRC kinase signaling inhibitor 1	0.034
CLDN1	claudin 1	0.034
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.033
SMAD1	SMAD family member 1	0.032
PRKG1	protein kinase, cGMP-dependent, type I	0.031
LRP6	low density lipoprotein receptor-related protein 6	0.031
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.030
COL5A1	collagen, type V, alpha 1	0.030
PLAUR	plasminogen activator, urokinase receptor	0.030
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.029
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.029
JAG2	jagged 2	0.029
SMAD6	SMAD family member 6	0.028
PTPRA	protein tyrosine phosphatase, receptor type, A	0.028
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.028
TNC	tenascin C	0.027
ELF5	E74-like factor 5 (ets domain transcription factor)	0.027
NOTCH2NL	notch 2 N-terminal like	0.027
FZD7	frizzled homolog 7 (Drosophila)	0.026
PLXDC1	plexin domain containing 1	0.026
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.026
MXRA5	matrix-remodelling associated 5	0.025
BMP1	bone morphogenetic protein 1	0.025
LIN7A	lin-7 homolog A (C. elegans)	0.024
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.024
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.023	Rat
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.023
NDP	Norrie disease (pseudoglioma)	0.023
CCND1	cyclin D1	0.023
ANGPT1	angiopoietin 1	0.023
EPS8	epidermal growth factor receptor pathway substrate 8	0.023
SFRP4	secreted frizzled-related protein 4	0.023	Human
PCDH9	protocadherin 9	0.023
EPHB2	EPH receptor B2	0.022
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.022
ALK	anaplastic lymphoma receptor tyrosine kinase	0.022
FGF18	fibroblast growth factor 18	0.022
HOXA6	homeobox A6	0.022	Human
ARHGAP5	Rho GTPase activating protein 5	0.021
BGN	biglycan	0.021
IGF2	insulin-like growth factor 2 (somatomedin A)	0.020
IGF1R	insulin-like growth factor 1 receptor	0.020
FZD8	frizzled homolog 8 (Drosophila)	0.020	Human
NRP2	neuropilin 2	0.019
INHBA	inhibin, beta A	0.019
WNT1	wingless-type MMTV integration site family, member 1	0.019
BMP2	bone morphogenetic protein 2	0.019
ADAM12	ADAM metallopeptidase domain 12	0.019	Human
MAML1	mastermind-like 1 (Drosophila)	0.018
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.018
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.018
GYPC	glycophorin C (Gerbich blood group)	0.018
HOXA3	homeobox A3	0.018
PRELP	proline/arginine-rich end leucine-rich repeat protein	0.017
HAP1	huntingtin-associated protein 1	0.017
COL6A3	collagen, type VI, alpha 3	0.017
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.017
WNT2	wingless-type MMTV integration site family member 2	0.017	Human
FBLN1	fibulin 1	0.017
VEGFC	vascular endothelial growth factor C	0.017
CXCL14	chemokine (C-X-C motif) ligand 14	0.016
RARA	retinoic acid receptor, alpha	0.016
IGFBP5	insulin-like growth factor binding protein 5	0.016
STC2	stanniocalcin 2	0.016
NOTCH2	notch 2	0.016	Human
HOXC4	homeobox C4	0.016	Human
IGF1	insulin-like growth factor 1 (somatomedin C)	0.015
HOXC8	homeobox C8	0.015	Human
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.015
HOXB4	homeobox B4	0.015	Human
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.014
C16orf53	chromosome 16 open reading frame 53	0.014
XIAP	X-linked inhibitor of apoptosis	0.014
LNX1	ligand of numb-protein X 1	0.014
FSTL1	follistatin-like 1	0.014
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.014
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.014
COL11A1	collagen, type XI, alpha 1	0.014
COL6A1	collagen, type VI, alpha 1	0.014
HOXB2	homeobox B2	0.014
ANGPTL2	angiopoietin-like 2	0.014
A2M	alpha-2-macroglobulin	0.014
HOXD8	homeobox D8	0.014	Human
SPRED1	sprouty-related, EVH1 domain containing 1	0.013
F11R	F11 receptor	0.013
TJP3	tight junction protein 3 (zona occludens 3)	0.013
ANAPC1	anaphase promoting complex subunit 1	0.013
COL7A1	collagen, type VII, alpha 1	0.013
GDF10	growth differentiation factor 10	0.013
COL4A5	collagen, type IV, alpha 5	0.013
WIF1	WNT inhibitory factor 1	0.013
EFS	embryonal Fyn-associated substrate	0.013
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.013
FOXF2	forkhead box F2	0.013
PDGFA	platelet-derived growth factor alpha polypeptide	0.013
NID1	nidogen 1	0.013
EGFR	epidermal growth factor receptor	0.013
HOXC5	homeobox C5	0.013	Human
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.013
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.012
SMAD2	SMAD family member 2	0.012
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.012
HOXD10	homeobox D10	0.012
THBS2	thrombospondin 2	0.012	Human
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.012
LAMA5	laminin, alpha 5	0.012
PRRX1	paired related homeobox 1	0.012
FRZB	frizzled-related protein	0.012	Human
HOXC11	homeobox C11	0.012
COL10A1	collagen, type X, alpha 1	0.012
PPAP2B	phosphatidic acid phosphatase type 2B	0.012
HOXC9	homeobox C9	0.012
PGR	progesterone receptor	0.012
NPHP1	nephronophthisis 1 (juvenile)	0.012
TIMP3	TIMP metallopeptidase inhibitor 3	0.012
CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	0.012
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.012
PTHLH	parathyroid hormone-like hormone	0.012
POSTN	periostin, osteoblast specific factor	0.012
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.012
TWIST1	twist homolog 1 (Drosophila)	0.011
FNDC1	fibronectin type III domain containing 1	0.011
ECM1	extracellular matrix protein 1	0.011
KRT15	keratin 15	0.011
IHH	Indian hedgehog	0.011
CDC27	cell division cycle 27 homolog (S. cerevisiae)	0.011
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.011
HOXA1	homeobox A1	0.011
OSMR	oncostatin M receptor	0.011
WNT10A	wingless-type MMTV integration site family, member 10A	0.011	Human
LRP1	low density lipoprotein receptor-related protein 1	0.011
HOXB8	homeobox B8	0.011	Human
FZD2	frizzled homolog 2 (Drosophila)	0.011	Human
VWF	von Willebrand factor	0.011
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.011
CCND2	cyclin D2	0.011
EPB41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.011
GPR124	G protein-coupled receptor 124	0.011
MXRA8	matrix-remodelling associated 8	0.011
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.011
POU2F3	POU class 2 homeobox 3	0.011
AMOT	angiomotin	0.010
PPARA	peroxisome proliferator-activated receptor alpha	0.010
ITGA6	integrin, alpha 6	0.010
SFRP2	secreted frizzled-related protein 2	0.010
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.010
SPP1	secreted phosphoprotein 1	0.010
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.010
LTBP2	latent transforming growth factor beta binding protein 2	0.010
THY1	Thy-1 cell surface antigen	0.010
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.010
DDR2	discoidin domain receptor tyrosine kinase 2	0.010
CTGF	connective tissue growth factor	0.010
FURIN	furin (paired basic amino acid cleaving enzyme)	0.010