IMP

Process View

Homo sapiens

22 genes annotated in human

Multi-species View

positive regulation of chemokine production

GO:0032722

Any process that activates or increases the frequency, rate, or extent of chemokine production.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of chemokine production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of chemokine production" (in gray)

Name	Description	Probability	Func Analog Organism
MYD88	myeloid differentiation primary response gene (88)	0.995	Mouse
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.978	Mouse
IL1R1	interleukin 1 receptor, type I	0.868
TLR4	toll-like receptor 4	0.827
ABI2	abl-interactor 2	0.798
IRAK2	interleukin-1 receptor-associated kinase 2	0.723
TICAM2	toll-like receptor adaptor molecule 2	0.680
LAT	linker for activation of T cells	0.672
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.480	Human
IRAK1	interleukin-1 receptor-associated kinase 1	0.408
IL4R	interleukin 4 receptor	0.300	Mouse
C1QA	complement component 1, q subcomponent, A chain	0.291	Human
TLR2	toll-like receptor 2	0.278
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.270
C1QC	complement component 1, q subcomponent, C chain	0.248	Human
IL1RAP	interleukin 1 receptor accessory protein	0.220
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.212
NLRC4	NLR family, CARD domain containing 4	0.207
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.191
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.170
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.145
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.144
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.122
HDAC2	histone deacetylase 2	0.120
MAP2K4	mitogen-activated protein kinase kinase 4	0.109
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.103
NRP1	neuropilin 1	0.099
TMEM173	transmembrane protein 173	0.098
TRAF6	TNF receptor-associated factor 6	0.095
COTL1	coactosin-like 1 (Dictyostelium)	0.088
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.076
APOE	apolipoprotein E	0.070
PGF	placental growth factor	0.067
SETD8	SET domain containing (lysine methyltransferase) 8	0.066
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.065
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.064
SNX33	sorting nexin 33	0.062
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.062
IRAK3	interleukin-1 receptor-associated kinase 3	0.057
IRAK4	interleukin-1 receptor-associated kinase 4	0.053
BIRC3	baculoviral IAP repeat containing 3	0.052
DLG1	discs, large homolog 1 (Drosophila)	0.051
CFH	complement factor H	0.051
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.050
IL4	interleukin 4	0.044	Mouse
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.043
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.043
CDH5	cadherin 5, type 2 (vascular endothelium)	0.043
IL1RN	interleukin 1 receptor antagonist	0.042	Human
MEFV	Mediterranean fever	0.039
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.038
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.037	Human
PTPRB	protein tyrosine phosphatase, receptor type, B	0.037
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.036
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.036
SH3D19	SH3 domain containing 19	0.033
GAB1	GRB2-associated binding protein 1	0.033
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.033
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.031
NOD2	nucleotide-binding oligomerization domain containing 2	0.030
CFI	complement factor I	0.030
JAK1	Janus kinase 1	0.028
CD14	CD14 molecule	0.027
SOD2	superoxide dismutase 2, mitochondrial	0.026
TRAF1	TNF receptor-associated factor 1	0.026
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.026	Human
FZD1	frizzled homolog 1 (Drosophila)	0.025
RUNX1	runt-related transcription factor 1	0.025
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.024
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.024
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.024
TRAF2	TNF receptor-associated factor 2	0.024
TRAF3	TNF receptor-associated factor 3	0.024
GATA2	GATA binding protein 2	0.024
IL6	interleukin 6 (interferon, beta 2)	0.023
IL1B	interleukin 1, beta	0.022
STC2	stanniocalcin 2	0.022
CD40	CD40 molecule, TNF receptor superfamily member 5	0.022
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.021
ALOX12B	arachidonate 12-lipoxygenase, 12R type	0.021	Human
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.020
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.020
C1QB	complement component 1, q subcomponent, B chain	0.018	Human
EGFR	epidermal growth factor receptor	0.018
LY96	lymphocyte antigen 96	0.018
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.018
IL6R	interleukin 6 receptor	0.017
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.017
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.017
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.017
MSR1	macrophage scavenger receptor 1	0.017
HCK	hemopoietic cell kinase	0.017
HP	haptoglobin	0.017
CCL8	chemokine (C-C motif) ligand 8	0.017
PDGFA	platelet-derived growth factor alpha polypeptide	0.017
IL2RG	interleukin 2 receptor, gamma	0.016
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.016
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.016
KITLG	KIT ligand	0.016
VSIG4	V-set and immunoglobulin domain containing 4	0.015
MPO	myeloperoxidase	0.015
C1S	complement component 1, s subcomponent	0.015
SYK	spleen tyrosine kinase	0.015
ZC3H12A	zinc finger CCCH-type containing 12A	0.015
FGFR1	fibroblast growth factor receptor 1	0.015
NOD1	nucleotide-binding oligomerization domain containing 1	0.015
SPRR2A	small proline-rich protein 2A	0.014
PTAFR	platelet-activating factor receptor	0.014
CLEC7A	C-type lectin domain family 7, member A	0.014
LDLR	low density lipoprotein receptor	0.014
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.014
XPO7	exportin 7	0.014
LMO2	LIM domain only 2 (rhombotin-like 1)	0.014
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.014
VEGFA	vascular endothelial growth factor A	0.014
IRF5	interferon regulatory factor 5	0.014
SAMHD1	SAM domain and HD domain 1	0.014
IL1R2	interleukin 1 receptor, type II	0.014
BCAR1	breast cancer anti-estrogen resistance 1	0.014
IL8	interleukin 8	0.014
CMIP	c-Maf-inducing protein	0.013
IFIH1	interferon induced with helicase C domain 1	0.013
CXCR4	chemokine (C-X-C motif) receptor 4	0.013
STAP2	signal transducing adaptor family member 2	0.013
IRS1	insulin receptor substrate 1	0.013
TAL1	T-cell acute lymphocytic leukemia 1	0.012	Human
TLR7	toll-like receptor 7	0.012
IGFBP3	insulin-like growth factor binding protein 3	0.012
ALOXE3	arachidonate lipoxygenase 3	0.012	Human
TXN	thioredoxin	0.012
SLC15A3	solute carrier family 15, member 3	0.012
IRF8	interferon regulatory factor 8	0.012
PLAUR	plasminogen activator, urokinase receptor	0.012
CTSG	cathepsin G	0.012
GAB2	GRB2-associated binding protein 2	0.012
PILRA	paired immunoglobin-like type 2 receptor alpha	0.012
C1R	complement component 1, r subcomponent	0.012
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.011
MPEG1	macrophage expressed 1	0.011
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.011
SOCS3	suppressor of cytokine signaling 3	0.011
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.011	Human
KRT5	keratin 5	0.011
CCL20	chemokine (C-C motif) ligand 20	0.011
IRF7	interferon regulatory factor 7	0.010
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.010