IMP

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Homo sapiens

4 genes annotated in human

cardiac muscle cell fate commitment

The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cardiac muscle cell fate commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cardiac muscle cell fate commitment" (in gray)

Name	Description	Probability	Func Analog Organism
FKBP1A	FK506 binding protein 1A, 12kDa	0.999
TGFB1	transforming growth factor, beta 1	0.998
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.995	Human
TGFB3	transforming growth factor, beta 3	0.990
BMP2	bone morphogenetic protein 2	0.988
ENG	endoglin	0.964
TBX5	T-box 5	0.956
NOTCH1	notch 1	0.946
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.853
FSTL1	follistatin-like 1	0.839
ACVR1	activin A receptor, type I	0.822
LRP6	low density lipoprotein receptor-related protein 6	0.819
PRKG1	protein kinase, cGMP-dependent, type I	0.694
NRP1	neuropilin 1	0.691
TGFBR1	transforming growth factor, beta receptor 1	0.682	Human
SMAD7	SMAD family member 7	0.664
ATXN1L	ataxin 1-like	0.639
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.619	Human
GDF5	growth differentiation factor 5	0.576
SMAD2	SMAD family member 2	0.561
BMPR1A	bone morphogenetic protein receptor, type IA	0.555	Human
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.516
FZD1	frizzled homolog 1 (Drosophila)	0.366
JAG1	jagged 1	0.357
ZMYND11	zinc finger, MYND-type containing 11	0.330
MAML1	mastermind-like 1 (Drosophila)	0.262
MAPK8	mitogen-activated protein kinase 8	0.261
NCOR2	nuclear receptor corepressor 2	0.260
PDGFC	platelet derived growth factor C	0.259
GATA4	GATA binding protein 4	0.242
FGF18	fibroblast growth factor 18	0.208
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.200
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.200
BMP4	bone morphogenetic protein 4	0.173
IQGAP1	IQ motif containing GTPase activating protein 1	0.086
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.086
SMAD6	SMAD family member 6	0.072
VEGFA	vascular endothelial growth factor A	0.065
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.060
SNIP1	Smad nuclear interacting protein 1	0.059
WNT1	wingless-type MMTV integration site family, member 1	0.054	Human
SNW1	SNW domain containing 1	0.051
FZD8	frizzled homolog 8 (Drosophila)	0.049
CIR1	corepressor interacting with RBPJ, 1	0.049
RXRA	retinoid X receptor, alpha	0.048
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.047
XIAP	X-linked inhibitor of apoptosis	0.046
IHH	Indian hedgehog	0.046
NOTCH3	notch 3	0.043
TGFBR3	transforming growth factor, beta receptor III	0.042
NOTCH2	notch 2	0.041
SFRP1	secreted frizzled-related protein 1	0.041
AQP5	aquaporin 5	0.040
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.040
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.039
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.039
LBX1	ladybird homeobox 1	0.037
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.035
PGR	progesterone receptor	0.033
WNT10A	wingless-type MMTV integration site family, member 10A	0.033	Human
FNDC3B	fibronectin type III domain containing 3B	0.033
WIF1	WNT inhibitory factor 1	0.032
FGF4	fibroblast growth factor 4	0.032
TGFB2	transforming growth factor, beta 2	0.031
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.030
GDNF	glial cell derived neurotrophic factor	0.030
GATA5	GATA binding protein 5	0.029
ANTXR2	anthrax toxin receptor 2	0.028
HS3ST6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	0.028
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.027
FGF8	fibroblast growth factor 8 (androgen-induced)	0.026
FOXF2	forkhead box F2	0.026
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.026
THBS1	thrombospondin 1	0.025
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.025
HMX1	H6 family homeobox 1	0.024
FGF3	fibroblast growth factor 3	0.024
LRRK2	leucine-rich repeat kinase 2	0.023
FZD7	frizzled homolog 7 (Drosophila)	0.023
APP	amyloid beta (A4) precursor protein	0.023
PAX7	paired box 7	0.023
SART1	squamous cell carcinoma antigen recognized by T cells	0.023
SHH	sonic hedgehog	0.023
MED25	mediator complex subunit 25	0.022
CTNNBL1	catenin, beta like 1	0.022
TLX3	T-cell leukemia homeobox 3	0.022
SOX21	SRY (sex determining region Y)-box 21	0.021
HOXB13	homeobox B13	0.021
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.021	Mouse
BHLHE23	basic helix-loop-helix family, member e23	0.021
FOXL1	forkhead box L1	0.021
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.020
CDX1	caudal type homeobox 1	0.020
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.020
HES2	hairy and enhancer of split 2 (Drosophila)	0.020
DLL1	delta-like 1 (Drosophila)	0.019
ACVR2B	activin A receptor, type IIB	0.019
SOX1	SRY (sex determining region Y)-box 1	0.019
ACVR2A	activin A receptor, type IIA	0.019
SPRED1	sprouty-related, EVH1 domain containing 1	0.019
VEGFC	vascular endothelial growth factor C	0.019
BMPR1B	bone morphogenetic protein receptor, type IB	0.019	Human
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.019
TACC1	transforming, acidic coiled-coil containing protein 1	0.018
PDGFA	platelet-derived growth factor alpha polypeptide	0.018
WNT3A	wingless-type MMTV integration site family, member 3A	0.018
PAX8	paired box 8	0.018
SOX7	SRY (sex determining region Y)-box 7	0.018
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.018
WNT11	wingless-type MMTV integration site family, member 11	0.018	Human
SIX2	SIX homeobox 2	0.018
SCARB2	scavenger receptor class B, member 2	0.018
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.018
RAX	retina and anterior neural fold homeobox	0.018
WNT3	wingless-type MMTV integration site family, member 3	0.018	Human
ZNF830	zinc finger protein 830	0.018
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.018
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.018
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.017
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.017
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.017
HOXA11	homeobox A11	0.017
SRI	sorcin	0.017
FOXF1	forkhead box F1	0.017
HOXB1	homeobox B1	0.016
HIC1	hypermethylated in cancer 1	0.016
NPM3	nucleophosmin/nucleoplasmin 3	0.016
PPARA	peroxisome proliferator-activated receptor alpha	0.016
DHH	desert hedgehog	0.016
TLX1	T-cell leukemia homeobox 1	0.016
INHBB	inhibin, beta B	0.016
ARRDC3	arrestin domain containing 3	0.016
AHR	aryl hydrocarbon receptor	0.016
NKX3-2	NK3 homeobox 2	0.016
HOXC8	homeobox C8	0.016
SOCS5	suppressor of cytokine signaling 5	0.016
FIBCD1	fibrinogen C domain containing 1	0.015
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.015
COL2A1	collagen, type II, alpha 1	0.015
DLX4	distal-less homeobox 4	0.015
EXOC3L2	exocyst complex component 3-like 2	0.015
WNT7A	wingless-type MMTV integration site family, member 7A	0.015	Human
C1QL1	complement component 1, q subcomponent-like 1	0.015
MBNL2	muscleblind-like 2 (Drosophila)	0.015
TBX2	T-box 2	0.014
KNDC1	kinase non-catalytic C-lobe domain (KIND) containing 1	0.014
HOXD13	homeobox D13	0.014
PYY	peptide YY	0.014
FOXD3	forkhead box D3	0.014
NRP2	neuropilin 2	0.014
FZD2	frizzled homolog 2 (Drosophila)	0.014
BMP6	bone morphogenetic protein 6	0.014
WNT9B	wingless-type MMTV integration site family, member 9B	0.014	Human
LMX1A	LIM homeobox transcription factor 1, alpha	0.014
CDX2	caudal type homeobox 2	0.014
EPHB3	EPH receptor B3	0.014
MDFI	MyoD family inhibitor	0.014
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.014
PITX1	paired-like homeodomain 1	0.014
MIXL1	Mix1 homeobox-like 1 (Xenopus laevis)	0.014
BMP8A	bone morphogenetic protein 8a	0.014
GSX2	GS homeobox 2	0.014
PAX2	paired box 2	0.014
GUCA2A	guanylate cyclase activator 2A (guanylin)	0.014
COL4A6	collagen, type IV, alpha 6	0.013
NKD1	naked cuticle homolog 1 (Drosophila)	0.013
RARG	retinoic acid receptor, gamma	0.013
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	0.013
EPHA8	EPH receptor A8	0.013
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.013
PTH2	parathyroid hormone 2	0.013
NEUROG2	neurogenin 2	0.013
NOG	noggin	0.013
SIX5	SIX homeobox 5	0.013
TBX3	T-box 3	0.013	Mouse
CALD1	caldesmon 1	0.013
HOXB8	homeobox B8	0.013
SFRP5	secreted frizzled-related protein 5	0.013
MMP19	matrix metallopeptidase 19	0.013
PKP1	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	0.013
QKI	quaking homolog, KH domain RNA binding (mouse)	0.013
JAG2	jagged 2	0.013
NKD2	naked cuticle homolog 2 (Drosophila)	0.013
MSX2	msh homeobox 2	0.013
CEP164	centrosomal protein 164kDa	0.013
BMP7	bone morphogenetic protein 7	0.013
DLL4	delta-like 4 (Drosophila)	0.013
LAMB1	laminin, beta 1	0.013
PTHLH	parathyroid hormone-like hormone	0.013
PRRX2	paired related homeobox 2	0.013
ATP2B4	ATPase, Ca++ transporting, plasma membrane 4	0.013
GATA2	GATA binding protein 2	0.013
CRLF1	cytokine receptor-like factor 1	0.012
PITX2	paired-like homeodomain 2	0.012
KIAA0174	KIAA0174	0.012
F3	coagulation factor III (thromboplastin, tissue factor)	0.012
EN1	engrailed homeobox 1	0.012
GDF6	growth differentiation factor 6	0.012
TBX1	T-box 1	0.012
MYO6	myosin VI	0.012
WISP1	WNT1 inducible signaling pathway protein 1	0.012
FOXN4	forkhead box N4	0.012
WNT7B	wingless-type MMTV integration site family, member 7B	0.012	Human
BNC1	basonuclin 1	0.012
PAX3	paired box 3	0.012
VSTM2L	V-set and transmembrane domain containing 2 like	0.012
RBMS1	RNA binding motif, single stranded interacting protein 1	0.012
INHBA	inhibin, beta A	0.012
OTP	orthopedia homeobox	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
COL6A1	collagen, type VI, alpha 1	0.012
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.012
PAWR	PRKC, apoptosis, WT1, regulator	0.012
LTK	leukocyte receptor tyrosine kinase	0.012
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.012
HOXC12	homeobox C12	0.012
FZD10	frizzled homolog 10 (Drosophila)	0.012
FOXL2	forkhead box L2	0.012
GATAD2B	GATA zinc finger domain containing 2B	0.012
HOXD11	homeobox D11	0.012
IL11	interleukin 11	0.012
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.012
WDFY3	WD repeat and FYVE domain containing 3	0.012
GAS1	growth arrest-specific 1	0.012
HOXD1	homeobox D1	0.012
POU3F3	POU class 3 homeobox 3	0.012
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.012
FST	follistatin	0.012
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.011
SIM2	single-minded homolog 2 (Drosophila)	0.011
SKIL	SKI-like oncogene	0.011
WNT10B	wingless-type MMTV integration site family, member 10B	0.011	Human
SLC30A2	solute carrier family 30 (zinc transporter), member 2	0.011
UTRN	utrophin	0.011
NKPD1	NTPase, KAP family P-loop domain containing 1	0.011
RBMS3	RNA binding motif, single stranded interacting protein 3	0.011
INSL3	insulin-like 3 (Leydig cell)	0.011
PEG10	paternally expressed 10	0.011
GUCY1A2	guanylate cyclase 1, soluble, alpha 2	0.011
WNT6	wingless-type MMTV integration site family, member 6	0.011	Human
FAM43B	family with sequence similarity 43, member B	0.011
NKX2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.011
WNT4	wingless-type MMTV integration site family, member 4	0.011	Human
WNT5B	wingless-type MMTV integration site family, member 5B	0.011	Human
ROR2	receptor tyrosine kinase-like orphan receptor 2	0.011
HOXD9	homeobox D9	0.011
ALX4	ALX homeobox 4	0.011
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.011
HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	0.011
USH1G	Usher syndrome 1G (autosomal recessive)	0.011
HYAL1	hyaluronoglucosaminidase 1	0.011
WNT2	wingless-type MMTV integration site family member 2	0.011	Human
KCNC3	potassium voltage-gated channel, Shaw-related subfamily, member 3	0.011
HOXD4	homeobox D4	0.011
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.011
AVPR1B	arginine vasopressin receptor 1B	0.011
HOXA2	homeobox A2	0.011
EFNB2	ephrin-B2	0.011
RHBG	Rh family, B glycoprotein (gene/pseudogene)	0.011
FOXB1	forkhead box B1	0.011
SMTNL2	smoothelin-like 2	0.011
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.011
FGF19	fibroblast growth factor 19	0.011
SOX18	SRY (sex determining region Y)-box 18	0.011
POU3F1	POU class 3 homeobox 1	0.011
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.011
PRPH	peripherin	0.011
PTPRG	protein tyrosine phosphatase, receptor type, G	0.011
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.011
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.011
NKX6-2	NK6 homeobox 2	0.011
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.011
ADRB3	adrenergic, beta-3-, receptor	0.010
EPHB2	EPH receptor B2	0.010
GSC	goosecoid homeobox	0.010
SDC2	syndecan 2	0.010
HEG1	HEG homolog 1 (zebrafish)	0.010
SMAD4	SMAD family member 4	0.010
C1orf94	chromosome 1 open reading frame 94	0.010
LEPROT	leptin receptor overlapping transcript	0.010
SCARF2	scavenger receptor class F, member 2	0.010
NLK	nemo-like kinase	0.010
FEZF2	FEZ family zinc finger 2	0.010
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.010
GGN	gametogenetin	0.010
ATP10D	ATPase, class V, type 10D	0.010
RGS9BP	regulator of G protein signaling 9 binding protein	0.010
HOXC6	homeobox C6	0.010
CXorf56	chromosome X open reading frame 56	0.010
KCNK9	potassium channel, subfamily K, member 9	0.010
HES5	hairy and enhancer of split 5 (Drosophila)	0.010
HCRTR1	hypocretin (orexin) receptor 1	0.010
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.010
COL4A4	collagen, type IV, alpha 4	0.010
BDNF	brain-derived neurotrophic factor	0.010
NPPC	natriuretic peptide C	0.010
AXIN1	axin 1	0.010
SIX3	SIX homeobox 3	0.010
WNT2B	wingless-type MMTV integration site family, member 2B	0.010	Human
GPC4	glypican 4	0.010
MNX1	motor neuron and pancreas homeobox 1	0.010
TG	thyroglobulin	0.010
FLRT2	fibronectin leucine rich transmembrane protein 2	0.010
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.010
JPH3	junctophilin 3	0.010
HIVEP1	human immunodeficiency virus type I enhancer binding protein 1	0.010
PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	0.010
VSX1	visual system homeobox 1	0.010
ZFYVE9	zinc finger, FYVE domain containing 9	0.010