IMP

Process View

Homo sapiens

29 genes annotated in human

negative regulation of protein secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein secretion" (in gray)

Name	Description	Probability	Func Analog Organism
SMN1	survival of motor neuron 1, telomeric	0.998
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.891
PILRA	paired immunoglobin-like type 2 receptor alpha	0.622
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.603
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.534	Human
MED15	mediator complex subunit 15	0.485
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.447
S100A10	S100 calcium binding protein A10	0.413
TRIM39	tripartite motif containing 39	0.407	Human
SIGLEC7	sialic acid binding Ig-like lectin 7	0.406
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.404
HP	haptoglobin	0.365
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.358	Human
ANXA1	annexin A1	0.322
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.296
TEK	TEK tyrosine kinase, endothelial	0.225
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.218
TK1	thymidine kinase 1, soluble	0.204
ALB	albumin	0.189
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.189	Human
IL1B	interleukin 1, beta	0.181
APOC1	apolipoprotein C-I	0.133
C19orf50	chromosome 19 open reading frame 50	0.133
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.125
IL10RA	interleukin 10 receptor, alpha	0.123
IL22RA1	interleukin 22 receptor, alpha 1	0.117
ZNF263	zinc finger protein 263	0.115
AXL	AXL receptor tyrosine kinase	0.108
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.103
ITGB1BP3	integrin beta 1 binding protein 3	0.101
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.096
ADORA2A	adenosine A2a receptor	0.089
IL22RA2	interleukin 22 receptor, alpha 2	0.081
TYMP	thymidine phosphorylase	0.081
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.067
NMT2	N-myristoyltransferase 2	0.067
LCAT	lecithin-cholesterol acyltransferase	0.066
VCAN	versican	0.063
MPDZ	multiple PDZ domain protein	0.060
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.057
PTAFR	platelet-activating factor receptor	0.056
ANXA5	annexin A5	0.053	Human
FAF1	Fas (TNFRSF6) associated factor 1	0.052
SNAP23	synaptosomal-associated protein, 23kDa	0.051
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.051
TRIM26	tripartite motif containing 26	0.051
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.047
LGALS1	lectin, galactoside-binding, soluble, 1	0.043
HK3	hexokinase 3 (white cell)	0.043
S100A11	S100 calcium binding protein A11	0.042
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.042
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.036
LGALS3	lectin, galactoside-binding, soluble, 3	0.036
FCAR	Fc fragment of IgA, receptor for	0.035	Human
SSTR3	somatostatin receptor 3	0.034	Human
TRIM5	tripartite motif containing 5	0.034	Human
IL10	interleukin 10	0.034
SP100	SP100 nuclear antigen	0.033
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.033
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.032	Human
HLA-F	major histocompatibility complex, class I, F	0.032
BTN3A1	butyrophilin, subfamily 3, member A1	0.031
RNF11	ring finger protein 11	0.031
CCR1	chemokine (C-C motif) receptor 1	0.030
SSTR2	somatostatin receptor 2	0.030	Human
CCL1	chemokine (C-C motif) ligand 1	0.028
TRIM8	tripartite motif containing 8	0.028
CCL22	chemokine (C-C motif) ligand 22	0.028
BTN2A2	butyrophilin, subfamily 2, member A2	0.028	Mouse
IGF2R	insulin-like growth factor 2 receptor	0.028
CACNA1H	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.027
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.027
FPR2	formyl peptide receptor 2	0.027
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.026
ANXA4	annexin A4	0.025
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.025
TSC22D1	TSC22 domain family, member 1	0.024
S100A6	S100 calcium binding protein A6	0.024
TRIM17	tripartite motif containing 17	0.024	Human
TREM1	triggering receptor expressed on myeloid cells 1	0.023
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.023
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.023	Human
TMSB10	thymosin beta 10	0.023
GPR132	G protein-coupled receptor 132	0.023
ANGPT2	angiopoietin 2	0.023
ZNRF1	zinc and ring finger 1	0.023
NOD2	nucleotide-binding oligomerization domain containing 2	0.022	Human
PDCD6	programmed cell death 6	0.022
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.022
AOAH	acyloxyacyl hydrolase (neutrophil)	0.022
IFI16	interferon, gamma-inducible protein 16	0.021
TRAF1	TNF receptor-associated factor 1	0.021
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.021
SIRPB1	signal-regulatory protein beta 1	0.021
JAK3	Janus kinase 3	0.021
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.021
ASGR2	asialoglycoprotein receptor 2	0.020
TRIM21	tripartite motif containing 21	0.020	Human
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.020
NLRP3	NLR family, pyrin domain containing 3	0.020
HAMP	hepcidin antimicrobial peptide	0.019
SIGLEC9	sialic acid binding Ig-like lectin 9	0.019
CNGB1	cyclic nucleotide gated channel beta 1	0.019
AQP9	aquaporin 9	0.019
S100A12	S100 calcium binding protein A12	0.019
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.019
CD80	CD80 molecule	0.019
ANXA7	annexin A7	0.019	Human
MR1	major histocompatibility complex, class I-related	0.018
KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	0.018
CAV1	caveolin 1, caveolae protein, 22kDa	0.018
BTN2A1	butyrophilin, subfamily 2, member A1	0.018	Mouse
IL1R1	interleukin 1 receptor, type I	0.018
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.018
BTN3A3	butyrophilin, subfamily 3, member A3	0.018
PECAM1	platelet/endothelial cell adhesion molecule	0.017
TRIM22	tripartite motif containing 22	0.017	Human
EMP1	epithelial membrane protein 1	0.017
CHRNA4	cholinergic receptor, nicotinic, alpha 4	0.017
TRIM52	tripartite motif containing 52	0.017
ANXA2	annexin A2	0.017	Human
APOC3	apolipoprotein C-III	0.017
RNF5	ring finger protein 5	0.017
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.017
APOC2	apolipoprotein C-II	0.017
TRIM43	tripartite motif containing 43	0.017
CD300C	CD300c molecule	0.017
IRF8	interferon regulatory factor 8	0.017
ITGB5	integrin, beta 5	0.016
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.016
FFAR3	free fatty acid receptor 3	0.016	Human
CSK	c-src tyrosine kinase	0.016
ARIH2	ariadne homolog 2 (Drosophila)	0.016
TRIM32	tripartite motif containing 32	0.016
CD86	CD86 molecule	0.016
PYDC2	pyrin domain containing 2	0.016
TRIM34	tripartite motif containing 34	0.016
DEFB4A	defensin, beta 4A	0.016
IL1R2	interleukin 1 receptor, type II	0.016
APOA2	apolipoprotein A-II	0.016
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.016
LOXL4	lysyl oxidase-like 4	0.015
MEFV	Mediterranean fever	0.015
TLR8	toll-like receptor 8	0.015
FFAR2	free fatty acid receptor 2	0.015
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.015
MAPK12	mitogen-activated protein kinase 12	0.015
SIGLEC5	sialic acid binding Ig-like lectin 5	0.015
IFI44	interferon-induced protein 44	0.015
ZNF473	zinc finger protein 473	0.015
ARF4	ADP-ribosylation factor 4	0.014
MCOLN1	mucolipin 1	0.014
CD33	CD33 molecule	0.014
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.014
GBP5	guanylate binding protein 5	0.014
CCL7	chemokine (C-C motif) ligand 7	0.014
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.014
IL2RA	interleukin 2 receptor, alpha	0.014
GLIPR1	GLI pathogenesis-related 1	0.014
CCL11	chemokine (C-C motif) ligand 11	0.013
GPX5	glutathione peroxidase 5 (epididymal androgen-related protein)	0.013
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.013
FAM83C	family with sequence similarity 83, member C	0.013
CTSO	cathepsin O	0.013
PLSCR1	phospholipid scramblase 1	0.013
CMKLR1	chemokine-like receptor 1	0.013
HDAC9	histone deacetylase 9	0.013
EMR3	egf-like module containing, mucin-like, hormone receptor-like 3	0.013
SAMD9	sterile alpha motif domain containing 9	0.013
ARG1	arginase, liver	0.013
MARCO	macrophage receptor with collagenous structure	0.013
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.013
CCL4	chemokine (C-C motif) ligand 4	0.013
XAF1	XIAP associated factor 1	0.012
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.012
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.012
IFNA10	interferon, alpha 10	0.012	Human
SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	0.012
PML	promyelocytic leukemia	0.012
IFNA4	interferon, alpha 4	0.012
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.012
CAST	calpastatin	0.012
IFNA21	interferon, alpha 21	0.012	Human
MSTO1	misato homolog 1 (Drosophila)	0.012
FPR1	formyl peptide receptor 1	0.012
IL1RN	interleukin 1 receptor antagonist	0.012	Human
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.012
STX11	syntaxin 11	0.012
IFNA16	interferon, alpha 16	0.012	Human
IL20	interleukin 20	0.012	Human
BTN3A2	butyrophilin, subfamily 3, member A2	0.012
ZNF431	zinc finger protein 431	0.012
C2	complement component 2	0.012
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.012
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.012
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.011
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.011
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.011
TRIM35	tripartite motif containing 35	0.011
DCN	decorin	0.011
SLAMF7	SLAM family member 7	0.011
TMSB4X	thymosin beta 4, X-linked	0.011
CIDEA	cell death-inducing DFFA-like effector a	0.011
INADL	InaD-like (Drosophila)	0.011
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.011
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.011
PARP4	poly (ADP-ribose) polymerase family, member 4	0.011
ETV7	ets variant 7	0.011
CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.011
IFNG	interferon, gamma	0.011
APOBR	apolipoprotein B receptor	0.011
CAV2	caveolin 2	0.011
CLIC1	chloride intracellular channel 1	0.011
IGFBP7	insulin-like growth factor binding protein 7	0.011
AMBP	alpha-1-microglobulin/bikunin precursor	0.011
UBE2D2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.011
TRIM41	tripartite motif containing 41	0.011	Human
MYOF	myoferlin	0.011
SDS	serine dehydratase	0.011
EPOR	erythropoietin receptor	0.011
RNF130	ring finger protein 130	0.011
TRIM15	tripartite motif containing 15	0.010	Human
TRIM6-TRIM34	TRIM6-TRIM34 readthrough	0.010
VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	0.010
RETN	resistin	0.010
BPI	bactericidal/permeability-increasing protein	0.010
ADIPOR1	adiponectin receptor 1	0.010
IL21	interleukin 21	0.010
CD300A	CD300a molecule	0.010
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.010
C3AR1	complement component 3a receptor 1	0.010
SIRPA	signal-regulatory protein alpha	0.010