IMP

Process View

Homo sapiens

13 genes annotated in human

Multi-species View

regulation of alpha beta t cell activation

GO:0046634

Any process that modulates the frequency, rate or extent of alpha-beta T cell activation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of alpha beta t cell activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of alpha beta t cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
CD247	CD247 molecule	0.902
LCK	lymphocyte-specific protein tyrosine kinase	0.888
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.874
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.546
IL4R	interleukin 4 receptor	0.514	Mouse
TRAF1	TNF receptor-associated factor 1	0.492
CCR5	chemokine (C-C motif) receptor 5	0.467
LAT	linker for activation of T cells	0.415
CCL4	chemokine (C-C motif) ligand 4	0.401	Human
SYK	spleen tyrosine kinase	0.394	Mouse
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.375
RXRA	retinoid X receptor, alpha	0.366
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.338	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.268
LIN9	lin-9 homolog (C. elegans)	0.246
CD2	CD2 molecule	0.246
CXCL9	chemokine (C-X-C motif) ligand 9	0.242
IL1B	interleukin 1, beta	0.212
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.198
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.196
GRAP2	GRB2-related adaptor protein 2	0.192
CD86	CD86 molecule	0.174
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.167
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.155
NCOR2	nuclear receptor corepressor 2	0.150
HK3	hexokinase 3 (white cell)	0.150
SH3KBP1	SH3-domain kinase binding protein 1	0.141
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.141	Human
PILRA	paired immunoglobin-like type 2 receptor alpha	0.139
CCR1	chemokine (C-C motif) receptor 1	0.136
TFF1	trefoil factor 1	0.135
IDE	insulin-degrading enzyme	0.125
CXCL2	chemokine (C-X-C motif) ligand 2	0.118
RARA	retinoic acid receptor, alpha	0.101
IL2RG	interleukin 2 receptor, gamma	0.097	Mouse
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.096
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.087	Human
SIGLEC7	sialic acid binding Ig-like lectin 7	0.085
IL4	interleukin 4	0.064	Mouse
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.063	Human
CCR7	chemokine (C-C motif) receptor 7	0.058
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.058
DRD2	dopamine receptor D2	0.053
TGIF1	TGFB-induced factor homeobox 1	0.051
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.051
MED25	mediator complex subunit 25	0.048
ICAM1	intercellular adhesion molecule 1	0.048
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.048
IFNG	interferon, gamma	0.046
IL23A	interleukin 23, alpha subunit p19	0.044
CD40	CD40 molecule, TNF receptor superfamily member 5	0.044
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.042
IL8	interleukin 8	0.042
SH2D1A	SH2 domain containing 1A	0.041
CD48	CD48 molecule	0.039
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.037
CCL2	chemokine (C-C motif) ligand 2	0.035	Human
CCL13	chemokine (C-C motif) ligand 13	0.035	Human
CD163	CD163 molecule	0.035
NAMPT	nicotinamide phosphoribosyltransferase	0.034
IL2RB	interleukin 2 receptor, beta	0.033
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.033
CCL5	chemokine (C-C motif) ligand 5	0.033	Human
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.033
PTAFR	platelet-activating factor receptor	0.033
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.032
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.031
CXCL10	chemokine (C-X-C motif) ligand 10	0.030
SOCS3	suppressor of cytokine signaling 3	0.030
CREBBP	CREB binding protein	0.030
CD80	CD80 molecule	0.026	Mouse
PTPRC	protein tyrosine phosphatase, receptor type, C	0.026	Mouse
TRAF5	TNF receptor-associated factor 5	0.026
IL7R	interleukin 7 receptor	0.026
SH3BP2	SH3-domain binding protein 2	0.026
TYMP	thymidine phosphorylase	0.025
CCL8	chemokine (C-C motif) ligand 8	0.025	Human
PPARA	peroxisome proliferator-activated receptor alpha	0.025
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.025
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.024
ADAM15	ADAM metallopeptidase domain 15	0.024
NOD2	nucleotide-binding oligomerization domain containing 2	0.024
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.023
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.023
TGFB1	transforming growth factor, beta 1	0.022
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.022
SH2D2A	SH2 domain containing 2A	0.022
VAV1	vav 1 guanine nucleotide exchange factor	0.022
CD33	CD33 molecule	0.022
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.021
IL6R	interleukin 6 receptor	0.020
LIN54	lin-54 homolog (C. elegans)	0.020
PML	promyelocytic leukemia	0.020
CD28	CD28 molecule	0.019	Mouse
TGFB3	transforming growth factor, beta 3	0.018
CCL19	chemokine (C-C motif) ligand 19	0.018	Human Mouse
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.017
CCL22	chemokine (C-C motif) ligand 22	0.017	Human
IL1RN	interleukin 1 receptor antagonist	0.017
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.016
NLRP3	NLR family, pyrin domain containing 3	0.016
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.016
CSNK1G1	casein kinase 1, gamma 1	0.016
CXCL13	chemokine (C-X-C motif) ligand 13	0.015
BIRC3	baculoviral IAP repeat containing 3	0.015
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.015
SIRPB1	signal-regulatory protein beta 1	0.015
CCR4	chemokine (C-C motif) receptor 4	0.014
CXCL3	chemokine (C-X-C motif) ligand 3	0.014
RUNX1	runt-related transcription factor 1	0.014
CMKLR1	chemokine-like receptor 1	0.014
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.014
SELL	selectin L	0.014
KLHL24	kelch-like 24 (Drosophila)	0.014
E2F1	E2F transcription factor 1	0.014
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.013
NCOA1	nuclear receptor coactivator 1	0.013
PSMB9	proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)	0.013
CD37	CD37 molecule	0.013
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.013	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.013
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.013
SIGLEC9	sialic acid binding Ig-like lectin 9	0.013
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.012
IL10RA	interleukin 10 receptor, alpha	0.012
HCK	hemopoietic cell kinase	0.012
TREM1	triggering receptor expressed on myeloid cells 1	0.012
TOP3A	topoisomerase (DNA) III alpha	0.012
CCL3	chemokine (C-C motif) ligand 3	0.012	Human
CD274	CD274 molecule	0.012
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.012
DPP4	dipeptidyl-peptidase 4	0.012
FPR3	formyl peptide receptor 3	0.012
HLA-G	major histocompatibility complex, class I, G	0.011
CCR3	chemokine (C-C motif) receptor 3	0.011
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.011
CD22	CD22 molecule	0.011
CD2AP	CD2-associated protein	0.011
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.010
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.010
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.010
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.010
HLA-F	major histocompatibility complex, class I, F	0.010