IMP

Process View

Homo sapiens

2 genes annotated in human

osteoclast development

The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "osteoclast development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "osteoclast development" (in gray)

Name	Description	Probability	Func Analog Organism
PILRA	paired immunoglobin-like type 2 receptor alpha	0.964
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.960
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.877
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.875
SMN1	survival of motor neuron 1, telomeric	0.832
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.731	Human
ANXA1	annexin A1	0.558	Human
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.550	Human
S100A10	S100 calcium binding protein A10	0.437
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.291	Human
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.240
FYN	FYN oncogene related to SRC, FGR, YES	0.214
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.151
PTAFR	platelet-activating factor receptor	0.146
PDCD6	programmed cell death 6	0.142
ANXA5	annexin A5	0.129	Human
SIGLEC7	sialic acid binding Ig-like lectin 7	0.129
HCK	hemopoietic cell kinase	0.127
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.124
LCK	lymphocyte-specific protein tyrosine kinase	0.120
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.120
NMT2	N-myristoyltransferase 2	0.104
S100A11	S100 calcium binding protein A11	0.102
VIM	vimentin	0.096
HK3	hexokinase 3 (white cell)	0.084
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.068
CD33	CD33 molecule	0.062
DOCK7	dedicator of cytokinesis 7	0.061
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.055
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.054
PTK2	PTK2 protein tyrosine kinase 2	0.053
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.048
GRB7	growth factor receptor-bound protein 7	0.044
CD163	CD163 molecule	0.042
LGALS1	lectin, galactoside-binding, soluble, 1	0.041
EXT2	exostosin 2	0.041
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.040	Human
C1orf93	chromosome 1 open reading frame 93	0.039
TMSB4X	thymosin beta 4, X-linked	0.036
BBS10	Bardet-Biedl syndrome 10	0.033
TSC22D1	TSC22 domain family, member 1	0.033
BIN2	bridging integrator 2	0.031
CYTH4	cytohesin 4	0.030
ANXA2	annexin A2	0.029
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.029
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.028
SIGLEC9	sialic acid binding Ig-like lectin 9	0.027
NLRP3	NLR family, pyrin domain containing 3	0.027
CCR1	chemokine (C-C motif) receptor 1	0.027
TK1	thymidine kinase 1, soluble	0.026
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.025
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.025
TMSB10	thymosin beta 10	0.024
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.024	Human
LGALS3	lectin, galactoside-binding, soluble, 3	0.024
CD63	CD63 molecule	0.024
TREM1	triggering receptor expressed on myeloid cells 1	0.024
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.023
FPR2	formyl peptide receptor 2	0.023
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	0.022
GDI1	GDP dissociation inhibitor 1	0.022
LMO4	LIM domain only 4	0.022
ALG2	asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)	0.022
ITGB5	integrin, beta 5	0.022
CYBB	cytochrome b-245, beta polypeptide	0.022
PSAP	prosaposin	0.022
ANXA4	annexin A4	0.022	Human
ARF4	ADP-ribosylation factor 4	0.021
SNX9	sorting nexin 9	0.021
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.021
CMKLR1	chemokine-like receptor 1	0.021
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.021
ZNF431	zinc finger protein 431	0.020
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.020
VSIG4	V-set and immunoglobulin domain containing 4	0.020
FPR1	formyl peptide receptor 1	0.020
APLP2	amyloid beta (A4) precursor-like protein 2	0.020
TYMP	thymidine phosphorylase	0.020
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.020
NPC2	Niemann-Pick disease, type C2	0.020
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.020
CTSB	cathepsin B	0.020
C7orf64	chromosome 7 open reading frame 64	0.019
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.019
CD86	CD86 molecule	0.019
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.018
FN1	fibronectin 1	0.018
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.018
NOD2	nucleotide-binding oligomerization domain containing 2	0.017
HEXB	hexosaminidase B (beta polypeptide)	0.017
ANXA3	annexin A3	0.017
AOAH	acyloxyacyl hydrolase (neutrophil)	0.017
SIGLEC10	sialic acid binding Ig-like lectin 10	0.017
EMP1	epithelial membrane protein 1	0.017
VCAN	versican	0.017
GRAP2	GRB2-related adaptor protein 2	0.017
CFP	complement factor properdin	0.017
ATP6V0B	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b	0.017
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.016
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.016
PDCD6IP	programmed cell death 6 interacting protein	0.016
MAP2K4	mitogen-activated protein kinase kinase 4	0.016
DPEP2	dipeptidase 2	0.016
MBTPS1	membrane-bound transcription factor peptidase, site 1	0.016
APOBR	apolipoprotein B receptor	0.016
ZMYND11	zinc finger, MYND-type containing 11	0.016
NKG7	natural killer cell group 7 sequence	0.016
PLD3	phospholipase D family, member 3	0.016
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	0.016
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.016
CAV1	caveolin 1, caveolae protein, 22kDa	0.016
DAPK1	death-associated protein kinase 1	0.015
SIGLEC5	sialic acid binding Ig-like lectin 5	0.015
TLR8	toll-like receptor 8	0.015
CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	0.015
SNRNP35	small nuclear ribonucleoprotein 35kDa (U11/U12)	0.015
PECAM1	platelet/endothelial cell adhesion molecule	0.015
MARCO	macrophage receptor with collagenous structure	0.015
ASGR2	asialoglycoprotein receptor 2	0.015
TGFBI	transforming growth factor, beta-induced, 68kDa	0.014
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.014
IQGAP1	IQ motif containing GTPase activating protein 1	0.014
C3AR1	complement component 3a receptor 1	0.014
ACTG1	actin, gamma 1	0.014
CD59	CD59 molecule, complement regulatory protein	0.014
MATK	megakaryocyte-associated tyrosine kinase	0.014
OSTF1	osteoclast stimulating factor 1	0.014
S100A4	S100 calcium binding protein A4	0.014
SIRPB1	signal-regulatory protein beta 1	0.014
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.014
TM9SF2	transmembrane 9 superfamily member 2	0.014
ACOT9	acyl-CoA thioesterase 9	0.014
CD22	CD22 molecule	0.014
AHNAK	AHNAK nucleoprotein	0.014
FOLR2	folate receptor 2 (fetal)	0.014
LILRA5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	0.013	Human
SOCS1	suppressor of cytokine signaling 1	0.013
S100A6	S100 calcium binding protein A6	0.013
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.013
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.013
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.013
AP1G1	adaptor-related protein complex 1, gamma 1 subunit	0.013
FOLR3	folate receptor 3 (gamma)	0.013
SIRPA	signal-regulatory protein alpha	0.013
FAM127A	family with sequence similarity 127, member A	0.013
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.013
SLC15A3	solute carrier family 15, member 3	0.012
GRB2	growth factor receptor-bound protein 2	0.012
ADAM9	ADAM metallopeptidase domain 9	0.012
FCAR	Fc fragment of IgA, receptor for	0.012	Human
TRIOBP	TRIO and F-actin binding protein	0.012
CD68	CD68 molecule	0.012
MYOF	myoferlin	0.012
CD300C	CD300c molecule	0.012
ADAM15	ADAM metallopeptidase domain 15	0.012
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.012
CD14	CD14 molecule	0.012
AQP9	aquaporin 9	0.012
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.012
IGSF6	immunoglobulin superfamily, member 6	0.011
DSTN	destrin (actin depolymerizing factor)	0.011
NPEPPS	aminopeptidase puromycin sensitive	0.011
KIR3DL2	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	0.011
MAPT	microtubule-associated protein tau	0.011
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.011
PARP4	poly (ADP-ribose) polymerase family, member 4	0.011
LAPTM4A	lysosomal protein transmembrane 4 alpha	0.011
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.011
KLHL23	kelch-like 23 (Drosophila)	0.011
AMICA1	adhesion molecule, interacts with CXADR antigen 1	0.011
POU2F2	POU class 2 homeobox 2	0.011
AIF1	allograft inflammatory factor 1	0.011
TLR6	toll-like receptor 6	0.011
YIPF3	Yip1 domain family, member 3	0.011
CCR2	chemokine (C-C motif) receptor 2	0.011
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.011
PAPSS1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	0.011
PTTG1IP	pituitary tumor-transforming 1 interacting protein	0.011
GLB1	galactosidase, beta 1	0.011
CAST	calpastatin	0.011
RGS2	regulator of G-protein signaling 2, 24kDa	0.011
ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	0.011
LAMP2	lysosomal-associated membrane protein 2	0.011
SDCBP	syndecan binding protein (syntenin)	0.011
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.011
RABAC1	Rab acceptor 1 (prenylated)	0.011
JAK3	Janus kinase 3	0.011
BEST1	bestrophin 1	0.010
BICD2	bicaudal D homolog 2 (Drosophila)	0.010
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.010
SH3RF3	SH3 domain containing ring finger 3	0.010
LAIR2	leukocyte-associated immunoglobulin-like receptor 2	0.010	Human
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.010
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	0.010
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.010
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.010