IMP

Process View

Homo sapiens

23 genes annotated in human

regulation of steroid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of steroid biosynthetic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of steroid biosynthetic process" (in gray)

Name	Description	Probability	Func Analog Organism
FGFR2	fibroblast growth factor receptor 2	0.997	Human
FGF1	fibroblast growth factor 1 (acidic)	0.993
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.989
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.976	Yeast
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.890	Human
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.885	Human
FGFR1	fibroblast growth factor receptor 1	0.820	Human
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.808	Human
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.690	Human
IL1R1	interleukin 1 receptor, type I	0.559
BMPR1A	bone morphogenetic protein receptor, type IA	0.530
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.528
HNF4A	hepatocyte nuclear factor 4, alpha	0.522
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.520	Human
FGF10	fibroblast growth factor 10	0.408	Human
ZFYVE9	zinc finger, FYVE domain containing 9	0.394
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.365
CSHL1	chorionic somatomammotropin hormone-like 1	0.316	Rat
SREBF2	sterol regulatory element binding transcription factor 2	0.307
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.297
BCL3	B-cell CLL/lymphoma 3	0.288
BMPR1B	bone morphogenetic protein receptor, type IB	0.245
FGF4	fibroblast growth factor 4	0.187	Human
AR	androgen receptor	0.183
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.181	Yeast
INSR	insulin receptor	0.179
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.176	Human
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.164
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.161	Yeast
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.153
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.113	Yeast
NCOR2	nuclear receptor corepressor 2	0.111
NOG	noggin	0.107
CSH2	chorionic somatomammotropin hormone 2	0.106	Rat
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.090
GH1	growth hormone 1	0.087	Rat
IL1RAP	interleukin 1 receptor accessory protein	0.085
MYO6	myosin VI	0.075
FGF8	fibroblast growth factor 8 (androgen-induced)	0.074
APOC1	apolipoprotein C-I	0.073
PGRMC1	progesterone receptor membrane component 1	0.073
RARA	retinoic acid receptor, alpha	0.071
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	0.070
ZMYND11	zinc finger, MYND-type containing 11	0.070
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.068	Rat
CREBBP	CREB binding protein	0.068
LDLR	low density lipoprotein receptor	0.068
JUB	jub, ajuba homolog (Xenopus laevis)	0.066
MED15	mediator complex subunit 15	0.060
FGF2	fibroblast growth factor 2 (basic)	0.059	Human
HP	haptoglobin	0.059
RXRA	retinoid X receptor, alpha	0.056
HR	hairless homolog (mouse)	0.053
PEX19	peroxisomal biogenesis factor 19	0.053
ITGB1BP3	integrin beta 1 binding protein 3	0.052
FSTL1	follistatin-like 1	0.050
KLB	klotho beta	0.050
FRS2	fibroblast growth factor receptor substrate 2	0.049
IL1B	interleukin 1, beta	0.047
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.047
WNT1	wingless-type MMTV integration site family, member 1	0.045	Human
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.042
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.040
FGF7	fibroblast growth factor 7	0.038	Human
FGA	fibrinogen alpha chain	0.037
SF3A2	splicing factor 3a, subunit 2, 66kDa	0.036
PGR	progesterone receptor	0.036
FBXL15	F-box and leucine-rich repeat protein 15	0.035
IRS1	insulin receptor substrate 1	0.034
FGF18	fibroblast growth factor 18	0.033
LCAT	lecithin-cholesterol acyltransferase	0.033
GH2	growth hormone 2	0.032	Rat
SMAD7	SMAD family member 7	0.031
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.030
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.030
A2M	alpha-2-macroglobulin	0.030
BMP4	bone morphogenetic protein 4	0.029	Human
GEMIN4	gem (nuclear organelle) associated protein 4	0.029
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.029
FGF19	fibroblast growth factor 19	0.029
SMN1	survival of motor neuron 1, telomeric	0.028
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	0.027
ANKRD13A	ankyrin repeat domain 13A	0.027
FOXD3	forkhead box D3	0.027
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.027
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.026
SKIL	SKI-like oncogene	0.026
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.026
SMAD2	SMAD family member 2	0.025
TRADD	TNFRSF1A-associated via death domain	0.024
ING2	inhibitor of growth family, member 2	0.024
APOC2	apolipoprotein C-II	0.024
SFRP1	secreted frizzled-related protein 1	0.024
OPTN	optineurin	0.024
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.023
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.023
TMF1	TATA element modulatory factor 1	0.022
KAT2B	K(lysine) acetyltransferase 2B	0.022
APOC3	apolipoprotein C-III	0.022
IL1RN	interleukin 1 receptor antagonist	0.021	Human
SMAD4	SMAD family member 4	0.021
SQLE	squalene epoxidase	0.021
IL1R2	interleukin 1 receptor, type II	0.021
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.021	Human
DHCR7	7-dehydrocholesterol reductase	0.020
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.020
MMP11	matrix metallopeptidase 11 (stromelysin 3)	0.020
NR5A2	nuclear receptor subfamily 5, group A, member 2	0.020
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.020
NOTCH1	notch 1	0.020
FBLN1	fibulin 1	0.019
EPS15	epidermal growth factor receptor pathway substrate 15	0.019
LHX3	LIM homeobox 3	0.019
WNT11	wingless-type MMTV integration site family, member 11	0.019	Human
IHH	Indian hedgehog	0.019
ATN1	atrophin 1	0.018
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.018
TG	thyroglobulin	0.018
RBM4	RNA binding motif protein 4	0.017
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.017
RNF11	ring finger protein 11	0.017
NOSTRIN	nitric oxide synthase trafficker	0.017
HDAC3	histone deacetylase 3	0.017
FAF1	Fas (TNFRSF6) associated factor 1	0.017
GDNF	glial cell derived neurotrophic factor	0.017
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.017
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.017
SF3B4	splicing factor 3b, subunit 4, 49kDa	0.017
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.017
JAG2	jagged 2	0.017
NOV	nephroblastoma overexpressed gene	0.016
HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.016	Rat
DCN	decorin	0.016
TGFB3	transforming growth factor, beta 3	0.016
POU5F1	POU class 5 homeobox 1	0.016
RNF168	ring finger protein 168	0.015
NCOA1	nuclear receptor coactivator 1	0.015
WNT3	wingless-type MMTV integration site family, member 3	0.015	Human
CD83	CD83 molecule	0.015
SOX21	SRY (sex determining region Y)-box 21	0.015
NKD2	naked cuticle homolog 2 (Drosophila)	0.015
LOXL4	lysyl oxidase-like 4	0.015
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.015
NCOR1	nuclear receptor corepressor 1	0.015
CCL1	chemokine (C-C motif) ligand 1	0.015
CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	0.015
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.015
IVL	involucrin	0.015
TGFB1	transforming growth factor, beta 1	0.014
CXXC5	CXXC finger protein 5	0.014
SPG20	spastic paraplegia 20 (Troyer syndrome)	0.014
GHR	growth hormone receptor	0.014
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.014
KLF5	Kruppel-like factor 5 (intestinal)	0.014
SMAD3	SMAD family member 3	0.014
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.014
TNIP1	TNFAIP3 interacting protein 1	0.014
TRIM11	tripartite motif containing 11	0.014
CYP11A1	cytochrome P450, family 11, subfamily A, polypeptide 1	0.013	Human
LIPC	lipase, hepatic	0.013
PEX14	peroxisomal biogenesis factor 14	0.013
APOA1	apolipoprotein A-I	0.013	Human
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.013
COL2A1	collagen, type II, alpha 1	0.013
GSK3B	glycogen synthase kinase 3 beta	0.013
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.013	Yeast
FZD10	frizzled homolog 10 (Drosophila)	0.013
GAS1	growth arrest-specific 1	0.013
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.013
CCL20	chemokine (C-C motif) ligand 20	0.013
CTGF	connective tissue growth factor	0.013
KCNK9	potassium channel, subfamily K, member 9	0.013
C1D	C1D nuclear receptor corepressor	0.013
HAND1	heart and neural crest derivatives expressed 1	0.013
MED25	mediator complex subunit 25	0.012
PTH1R	parathyroid hormone 1 receptor	0.012
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.012
SOX1	SRY (sex determining region Y)-box 1	0.012
FOXF2	forkhead box F2	0.012
FGFBP1	fibroblast growth factor binding protein 1	0.012
CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	0.012
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.012
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.012
RNF31	ring finger protein 31	0.012
SUCLG2	succinate-CoA ligase, GDP-forming, beta subunit	0.012
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.012
NELL2	NEL-like 2 (chicken)	0.012
APOB	apolipoprotein B (including Ag(x) antigen)	0.012	Mouse
CTBP2	C-terminal binding protein 2	0.012
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.012
WIF1	WNT inhibitory factor 1	0.012
GLYAT	glycine-N-acyltransferase	0.012
LRP6	low density lipoprotein receptor-related protein 6	0.012
ZC3H12A	zinc finger CCCH-type containing 12A	0.011
FGFR3	fibroblast growth factor receptor 3	0.011	Human
AADAC	arylacetamide deacetylase (esterase)	0.011
RAB4A	RAB4A, member RAS oncogene family	0.011
EGFR	epidermal growth factor receptor	0.011
GNG13	guanine nucleotide binding protein (G protein), gamma 13	0.011
SRI	sorcin	0.011
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.011
RASGRF1	Ras protein-specific guanine nucleotide-releasing factor 1	0.011
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.011	Yeast
WNK1	WNK lysine deficient protein kinase 1	0.011
ABCD3	ATP-binding cassette, sub-family D (ALD), member 3	0.011
NTN1	netrin 1	0.011
LBP	lipopolysaccharide binding protein	0.011
SLC9A3	solute carrier family 9 (sodium/hydrogen exchanger), member 3	0.011
NGF	nerve growth factor (beta polypeptide)	0.011
WNT4	wingless-type MMTV integration site family, member 4	0.011
FST	follistatin	0.011
PRDM5	PR domain containing 5	0.011
LHX5	LIM homeobox 5	0.011
DLX4	distal-less homeobox 4	0.011
THPO	thrombopoietin	0.011
CUL1	cullin 1	0.011
HOXB1	homeobox B1	0.011
CAT	catalase	0.011
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
SMAD5	SMAD family member 5	0.010
GAB1	GRB2-associated binding protein 1	0.010
PPARA	peroxisome proliferator-activated receptor alpha	0.010	Human
HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	0.010
FGF21	fibroblast growth factor 21	0.010	Human
IRS2	insulin receptor substrate 2	0.010
TLX1	T-cell leukemia homeobox 1	0.010
IDI1	isopentenyl-diphosphate delta isomerase 1	0.010
C11orf2	chromosome 11 open reading frame 2	0.010
SOCS3	suppressor of cytokine signaling 3	0.010
WNT10A	wingless-type MMTV integration site family, member 10A	0.010	Human
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.010
CYP7B1	cytochrome P450, family 7, subfamily B, polypeptide 1	0.010	Human
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.010
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.010
ACAN	aggrecan	0.010
APOA2	apolipoprotein A-II	0.010
FOXO3	forkhead box O3	0.010
BHMT	betaine--homocysteine S-methyltransferase	0.010
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	0.010