IMP

Process View

Homo sapiens

18 genes annotated in human

Multi-species View

negative regulation of t cell activation

GO:0050868

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of t cell activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of t cell activation" (in gray)

Name	Description	Probability	Func Analog Organism
HLA-B	major histocompatibility complex, class I, B	0.908
B2M	beta-2-microglobulin	0.879
CD80	CD80 molecule	0.548
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.505
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.494
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.353	Mouse
HLA-F	major histocompatibility complex, class I, F	0.338	Human
HLA-DMB	major histocompatibility complex, class II, DM beta	0.263
HLA-G	major histocompatibility complex, class I, G	0.249
PILRA	paired immunoglobin-like type 2 receptor alpha	0.165
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.157
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.136
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.121
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.114
HLA-E	major histocompatibility complex, class I, E	0.109	Human
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.100
BMPR1A	bone morphogenetic protein receptor, type IA	0.100
CCL4	chemokine (C-C motif) ligand 4	0.085	Human
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.079	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.078
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.077	Mouse
IL4R	interleukin 4 receptor	0.075	Mouse
CCR5	chemokine (C-C motif) receptor 5	0.068
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.065
IL2RG	interleukin 2 receptor, gamma	0.064
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.064
CXCL9	chemokine (C-X-C motif) ligand 9	0.063
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.062
ICAM1	intercellular adhesion molecule 1	0.060
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.059
FSTL1	follistatin-like 1	0.053
CD86	CD86 molecule	0.052
HLA-C	major histocompatibility complex, class I, C	0.045	Human
XIAP	X-linked inhibitor of apoptosis	0.043
HK3	hexokinase 3 (white cell)	0.041
HLA-A	major histocompatibility complex, class I, A	0.040	Human
LAT	linker for activation of T cells	0.038
CD247	CD247 molecule	0.038
RNF11	ring finger protein 11	0.037
ADAM17	ADAM metallopeptidase domain 17	0.036
SIGLEC7	sialic acid binding Ig-like lectin 7	0.036
CXCL10	chemokine (C-X-C motif) ligand 10	0.035
TRAF1	TNF receptor-associated factor 1	0.035
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.035
CCR7	chemokine (C-C motif) receptor 7	0.034
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.033	Human
CD40	CD40 molecule, TNF receptor superfamily member 5	0.032
CCL8	chemokine (C-C motif) ligand 8	0.032	Human
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.030
CCL13	chemokine (C-C motif) ligand 13	0.030	Human
IL10	interleukin 10	0.029
CCL5	chemokine (C-C motif) ligand 5	0.029	Human
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.027
EGFR	epidermal growth factor receptor	0.027
BTN3A1	butyrophilin, subfamily 3, member A1	0.027
APAF1	apoptotic peptidase activating factor 1	0.026
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.026	Human
CCR1	chemokine (C-C motif) receptor 1	0.025
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.025
DPP4	dipeptidyl-peptidase 4	0.024
TFF1	trefoil factor 1	0.024
BIRC3	baculoviral IAP repeat containing 3	0.024
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.023
IFNG	interferon, gamma	0.022
TAPBP	TAP binding protein (tapasin)	0.022
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.022	Mouse
IL4	interleukin 4	0.022	Mouse
GRAP2	GRB2-related adaptor protein 2	0.021
IDE	insulin-degrading enzyme	0.021
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.021	Human
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.020
MICA	MHC class I polypeptide-related sequence A	0.020
VAV1	vav 1 guanine nucleotide exchange factor	0.020
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.019
NCOR2	nuclear receptor corepressor 2	0.019
CD300C	CD300c molecule	0.018	Human
CCR4	chemokine (C-C motif) receptor 4	0.018
DRD2	dopamine receptor D2	0.018
CCL2	chemokine (C-C motif) ligand 2	0.017	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.017
NAMPT	nicotinamide phosphoribosyltransferase	0.017
CMKLR1	chemokine-like receptor 1	0.016
CFLAR	CASP8 and FADD-like apoptosis regulator	0.016
CD163	CD163 molecule	0.016
BTN2A2	butyrophilin, subfamily 2, member A2	0.016	Mouse
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.015
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.015
CD2	CD2 molecule	0.015
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.015	Human Rat
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.015
APP	amyloid beta (A4) precursor protein	0.015
C1QB	complement component 1, q subcomponent, B chain	0.014
IL2RA	interleukin 2 receptor, alpha	0.014	Mouse
CCL7	chemokine (C-C motif) ligand 7	0.013	Human
BTN3A3	butyrophilin, subfamily 3, member A3	0.013
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.013	Human
HDAC9	histone deacetylase 9	0.013
INSR	insulin receptor	0.013
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.013
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.013
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.012
THAP2	THAP domain containing, apoptosis associated protein 2	0.012
PLK3	polo-like kinase 3	0.012
FPR3	formyl peptide receptor 3	0.012
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.012
PBK	PDZ binding kinase	0.012
IL15RA	interleukin 15 receptor, alpha	0.012
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.011
IL10RA	interleukin 10 receptor, alpha	0.011
RARRES3	retinoic acid receptor responder (tazarotene induced) 3	0.011
SIGLEC9	sialic acid binding Ig-like lectin 9	0.011
MARCO	macrophage receptor with collagenous structure	0.011
GRN	granulin	0.011
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.011
PCDH9	protocadherin 9	0.011
HCP5	HLA complex P5	0.011
CD320	CD320 molecule	0.010
IL32	interleukin 32	0.010
EBI3	Epstein-Barr virus induced 3	0.010
SLAMF1	signaling lymphocytic activation molecule family member 1	0.010
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.010
APOL3	apolipoprotein L, 3	0.010
CXCL13	chemokine (C-X-C motif) ligand 13	0.010
CDK6	cyclin-dependent kinase 6	0.010