IMP

Process View

Homo sapiens

3 genes annotated in human

endocardial cushion development

The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endocardial cushion development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endocardial cushion development" (in gray)

Name	Description	Probability	Func Analog Organism
TGFB1	transforming growth factor, beta 1	1.000
NOTCH1	notch 1	1.000	Mouse
SKIL	SKI-like oncogene	0.999
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.999	Human
TAL1	T-cell acute lymphocytic leukemia 1	0.998
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.997
SMAD3	SMAD family member 3	0.997
ENG	endoglin	0.996	Mouse
BMPR1A	bone morphogenetic protein receptor, type IA	0.996	Human Mouse
BMP2	bone morphogenetic protein 2	0.992	Mouse
JAG1	jagged 1	0.988	Mouse
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.985	Human
FKBP1A	FK506 binding protein 1A, 12kDa	0.984
NOTCH3	notch 3	0.973
FSTL1	follistatin-like 1	0.955
TGFBR1	transforming growth factor, beta receptor 1	0.955	Human
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.920
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.917
SMAD1	SMAD family member 1	0.893
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.788
SMAD4	SMAD family member 4	0.747	Mouse
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.745	Mouse
XIAP	X-linked inhibitor of apoptosis	0.701
SMAD2	SMAD family member 2	0.692
ACVR1	activin A receptor, type I	0.654
MAML1	mastermind-like 1 (Drosophila)	0.628
CXXC5	CXXC finger protein 5	0.585
SETD8	SET domain containing (lysine methyltransferase) 8	0.572
TGFB3	transforming growth factor, beta 3	0.530
HIPK2	homeodomain interacting protein kinase 2	0.520
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.519
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.502
NOTCH2	notch 2	0.448
GATA4	GATA binding protein 4	0.394
PRKG1	protein kinase, cGMP-dependent, type I	0.337
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.325
MSX1	msh homeobox 1	0.314	Mouse
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.279
EGR1	early growth response 1	0.262
SMAD7	SMAD family member 7	0.245
GATA2	GATA binding protein 2	0.232	Human
ATXN1L	ataxin 1-like	0.221
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.182
TBX5	T-box 5	0.175	Mouse
PTK6	PTK6 protein tyrosine kinase 6	0.168
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.166	Mouse
SMAD9	SMAD family member 9	0.165
MSX2	msh homeobox 2	0.165	Mouse
NRP1	neuropilin 1	0.160
SPEN	spen homolog, transcriptional regulator (Drosophila)	0.151
FOXF1	forkhead box F1	0.146
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.125
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.114
TBX2	T-box 2	0.109
ANKRD13A	ankyrin repeat domain 13A	0.108
TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.104
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	0.104
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	0.099
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.094
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.094
EP300	E1A binding protein p300	0.081
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.078	Human
FOXF2	forkhead box F2	0.077	Human
RBPMS	RNA binding protein with multiple splicing	0.071
FGF2	fibroblast growth factor 2 (basic)	0.069
JAG2	jagged 2	0.065
DLL1	delta-like 1 (Drosophila)	0.064
RUNX1	runt-related transcription factor 1	0.064
BMP4	bone morphogenetic protein 4	0.064
FGFR1	fibroblast growth factor receptor 1	0.060
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.059
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.058
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.057
FZD7	frizzled homolog 7 (Drosophila)	0.055
MAPK8	mitogen-activated protein kinase 8	0.055
ZFPM1	zinc finger protein, multitype 1	0.054
SP1	Sp1 transcription factor	0.053
SMAD6	SMAD family member 6	0.053
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.050
TGFB2	transforming growth factor, beta 2	0.049
RXRA	retinoid X receptor, alpha	0.049
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.048
GRB7	growth factor receptor-bound protein 7	0.048
LAPTM5	lysosomal protein transmembrane 5	0.048
NCOR1	nuclear receptor corepressor 1	0.047
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.046
ARRDC3	arrestin domain containing 3	0.046
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.044
SOX17	SRY (sex determining region Y)-box 17	0.044
HEYL	hairy/enhancer-of-split related with YRPW motif-like	0.042	Mouse
NOG	noggin	0.042
INHBB	inhibin, beta B	0.040
NCOR2	nuclear receptor corepressor 2	0.039
TGFBR3	transforming growth factor, beta receptor III	0.039
HIPK1	homeodomain interacting protein kinase 1	0.038
SOX7	SRY (sex determining region Y)-box 7	0.036
BMPR1B	bone morphogenetic protein receptor, type IB	0.035	Human
ACVRL1	activin A receptor type II-like 1	0.035	Human
APP	amyloid beta (A4) precursor protein	0.035
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.034
HAND2	heart and neural crest derivatives expressed 2	0.034
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.033
EPAS1	endothelial PAS domain protein 1	0.033
FGF1	fibroblast growth factor 1 (acidic)	0.033
ZMYND11	zinc finger, MYND-type containing 11	0.033
RNF168	ring finger protein 168	0.032
PDGFC	platelet derived growth factor C	0.032
EVC2	Ellis van Creveld syndrome 2	0.032
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.030
KLF13	Kruppel-like factor 13	0.030
NLK	nemo-like kinase	0.029
ZFYVE9	zinc finger, FYVE domain containing 9	0.028
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.028
FOXC1	forkhead box C1	0.028
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.027
EFNB2	ephrin-B2	0.027
KLF5	Kruppel-like factor 5 (intestinal)	0.026
DHH	desert hedgehog	0.026
HOXB13	homeobox B13	0.026
HIPK3	homeodomain interacting protein kinase 3	0.026
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.025
ID4	inhibitor of DNA binding 4, dominant negative helix-loop-helix protein	0.025
COL4A2	collagen, type IV, alpha 2	0.025
USP15	ubiquitin specific peptidase 15	0.024
GATA5	GATA binding protein 5	0.023	Human
NID1	nidogen 1	0.023
PROX1	prospero homeobox 1	0.023
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.023
VAV3	vav 3 guanine nucleotide exchange factor	0.023
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.022
NCOA1	nuclear receptor coactivator 1	0.022
CIR1	corepressor interacting with RBPJ, 1	0.021
CAMSAP1	calmodulin regulated spectrin-associated protein 1	0.021
ASB2	ankyrin repeat and SOCS box containing 2	0.021
FZD10	frizzled homolog 10 (Drosophila)	0.021
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.021
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.021
F3	coagulation factor III (thromboplastin, tissue factor)	0.020
STC1	stanniocalcin 1	0.020
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.020
LOXL4	lysyl oxidase-like 4	0.020
MTMR10	myotubularin related protein 10	0.020
WT1	Wilms tumor 1	0.019
SFRP5	secreted frizzled-related protein 5	0.019
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.019
EFNA5	ephrin-A5	0.019
FOXQ1	forkhead box Q1	0.019
COL2A1	collagen, type II, alpha 1	0.019
TCF12	transcription factor 12	0.019
GDF5	growth differentiation factor 5	0.019
TBX3	T-box 3	0.019
FBLN1	fibulin 1	0.019
INHBA	inhibin, beta A	0.018
CALD1	caldesmon 1	0.018
TFPI2	tissue factor pathway inhibitor 2	0.018
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.018
LHX2	LIM homeobox 2	0.018
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.018
ALX4	ALX homeobox 4	0.018
ABTB1	ankyrin repeat and BTB (POZ) domain containing 1	0.018
HOXA5	homeobox A5	0.018
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.017
NKX3-2	NK3 homeobox 2	0.017
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.017
HIC1	hypermethylated in cancer 1	0.017
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.017
SCARB2	scavenger receptor class B, member 2	0.017
ZBED5	zinc finger, BED-type containing 5	0.017
EGFL7	EGF-like-domain, multiple 7	0.017
RPS6KA6	ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.017
ZZEF1	zinc finger, ZZ-type with EF-hand domain 1	0.016
EPHA7	EPH receptor A7	0.016
FLI1	Friend leukemia virus integration 1	0.016
RHAG	Rh-associated glycoprotein	0.016
ACVR2A	activin A receptor, type IIA	0.016
ARNT	aryl hydrocarbon receptor nuclear translocator	0.016
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.016
PLK2	polo-like kinase 2	0.016
HOXD11	homeobox D11	0.016
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.016	Mouse
TWIST2	twist homolog 2 (Drosophila)	0.016
ZBTB16	zinc finger and BTB domain containing 16	0.015
NRG1	neuregulin 1	0.015
FOXO3	forkhead box O3	0.015
JUN	jun proto-oncogene	0.015
AMHR2	anti-Mullerian hormone receptor, type II	0.015	Human
RAMP2	receptor (G protein-coupled) activity modifying protein 2	0.015
DACH1	dachshund homolog 1 (Drosophila)	0.015
PDGFA	platelet-derived growth factor alpha polypeptide	0.015
LAMB1	laminin, beta 1	0.015
ACVR2B	activin A receptor, type IIB	0.015
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.015
SYDE1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)	0.015
HOXA11	homeobox A11	0.015
EPHB1	EPH receptor B1	0.015
MKL2	MKL/myocardin-like 2	0.014
SLIT2	slit homolog 2 (Drosophila)	0.014
SLCO2A1	solute carrier organic anion transporter family, member 2A1	0.014
LMO2	LIM domain only 2 (rhombotin-like 1)	0.014
GLI2	GLI family zinc finger 2	0.014
CYR61	cysteine-rich, angiogenic inducer, 61	0.014
TBX1	T-box 1	0.014
BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	0.014
DCP1B	DCP1 decapping enzyme homolog B (S. cerevisiae)	0.014
SOX18	SRY (sex determining region Y)-box 18	0.014
EDN1	endothelin 1	0.014
PPARD	peroxisome proliferator-activated receptor delta	0.014
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.014
MTMR4	myotubularin related protein 4	0.014
FZD1	frizzled homolog 1 (Drosophila)	0.014
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.014
HOXB9	homeobox B9	0.014
GDNF	glial cell derived neurotrophic factor	0.014
GATA3	GATA binding protein 3	0.014	Human
IL11	interleukin 11	0.014
RUNX3	runt-related transcription factor 3	0.014
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.014
MEX3B	mex-3 homolog B (C. elegans)	0.014
GMEB1	glucocorticoid modulatory element binding protein 1	0.014
HNF4A	hepatocyte nuclear factor 4, alpha	0.014
SAMD3	sterile alpha motif domain containing 3	0.014
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.014
PIAS4	protein inhibitor of activated STAT, 4	0.014
PGR	progesterone receptor	0.013
NR2F1	nuclear receptor subfamily 2, group F, member 1	0.013
TNS3	tensin 3	0.013
FOXD1	forkhead box D1	0.013
CHN2	chimerin (chimaerin) 2	0.013
FGF18	fibroblast growth factor 18	0.013
TPST1	tyrosylprotein sulfotransferase 1	0.013
DUSP4	dual specificity phosphatase 4	0.013
BMP6	bone morphogenetic protein 6	0.013
FNDC3B	fibronectin type III domain containing 3B	0.013
ITGA8	integrin, alpha 8	0.013
HOXD9	homeobox D9	0.013
FST	follistatin	0.013
HOXD1	homeobox D1	0.013
SIX2	SIX homeobox 2	0.013
ANTXR2	anthrax toxin receptor 2	0.013
DLC1	deleted in liver cancer 1	0.013
EYA2	eyes absent homolog 2 (Drosophila)	0.012
PNMT	phenylethanolamine N-methyltransferase	0.012
ZEB2	zinc finger E-box binding homeobox 2	0.012
QRICH2	glutamine rich 2	0.012
TENC1	tensin like C1 domain containing phosphatase (tensin 2)	0.012
UBE2H	ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)	0.012
CD248	CD248 molecule, endosialin	0.012
KLF1	Kruppel-like factor 1 (erythroid)	0.012
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.012
SALL1	sal-like 1 (Drosophila)	0.012
HAND1	heart and neural crest derivatives expressed 1	0.012
SHOX2	short stature homeobox 2	0.012
ESAM	endothelial cell adhesion molecule	0.012
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.012
MBNL2	muscleblind-like 2 (Drosophila)	0.012
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.012
COL5A1	collagen, type V, alpha 1	0.012
PITX2	paired-like homeodomain 2	0.012
DAB1	disabled homolog 1 (Drosophila)	0.012
DLX5	distal-less homeobox 5	0.012
DLX2	distal-less homeobox 2	0.012
FOXL2	forkhead box L2	0.012
YY1	YY1 transcription factor	0.012
DLK1	delta-like 1 homolog (Drosophila)	0.012
POU2F1	POU class 2 homeobox 1	0.012
PCDH17	protocadherin 17	0.012
F2RL1	coagulation factor II (thrombin) receptor-like 1	0.012
BCL6B	B-cell CLL/lymphoma 6, member B	0.012
KCNE4	potassium voltage-gated channel, Isk-related family, member 4	0.012
TMEM2	transmembrane protein 2	0.012
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.012
OSMR	oncostatin M receptor	0.011
PF4	platelet factor 4	0.011
WNT5A	wingless-type MMTV integration site family, member 5A	0.011
PELP1	proline, glutamate and leucine rich protein 1	0.011
CALCR	calcitonin receptor	0.011
PTHLH	parathyroid hormone-like hormone	0.011
UNC5B	unc-5 homolog B (C. elegans)	0.011
EGR3	early growth response 3	0.011
GSK3B	glycogen synthase kinase 3 beta	0.011
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	0.011
TLX1	T-cell leukemia homeobox 1	0.011
MAST4	microtubule associated serine/threonine kinase family member 4	0.011
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.011
BCAR3	breast cancer anti-estrogen resistance 3	0.011
ZFAND5	zinc finger, AN1-type domain 5	0.011
PDE3A	phosphodiesterase 3A, cGMP-inhibited	0.011
SCG2	secretogranin II	0.011
NDFIP1	Nedd4 family interacting protein 1	0.011
KDM2A	lysine (K)-specific demethylase 2A	0.011
EDNRA	endothelin receptor type A	0.011
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.011
SREBF2	sterol regulatory element binding transcription factor 2	0.011
APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.011
ACVR1B	activin A receptor, type IB	0.011	Human
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.011
DLL4	delta-like 4 (Drosophila)	0.011
GPR124	G protein-coupled receptor 124	0.011
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	0.011
PIAS1	protein inhibitor of activated STAT, 1	0.011
LEF1	lymphoid enhancer-binding factor 1	0.011
ZFPM2	zinc finger protein, multitype 2	0.011
COL5A3	collagen, type V, alpha 3	0.011
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif, 1	0.011
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.011
SOX13	SRY (sex determining region Y)-box 13	0.011
PLCD3	phospholipase C, delta 3	0.011
NID2	nidogen 2 (osteonidogen)	0.011
RFX1	regulatory factor X, 1 (influences HLA class II expression)	0.011
MCM3AP	minichromosome maintenance complex component 3 associated protein	0.011
SOX8	SRY (sex determining region Y)-box 8	0.011
TM4SF1	transmembrane 4 L six family member 1	0.011
COL13A1	collagen, type XIII, alpha 1	0.010
MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	0.010
GPRC5A	G protein-coupled receptor, family C, group 5, member A	0.010
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.010
SFRP2	secreted frizzled-related protein 2	0.010
PLXDC1	plexin domain containing 1	0.010
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.010
LMO4	LIM domain only 4	0.010
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.010
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.010
TINAGL1	tubulointerstitial nephritis antigen-like 1	0.010
CLDN11	claudin 11	0.010
MAN1C1	mannosidase, alpha, class 1C, member 1	0.010
MNX1	motor neuron and pancreas homeobox 1	0.010
HRH1	histamine receptor H1	0.010
LTBP1	latent transforming growth factor beta binding protein 1	0.010