IMP

Process View

Mus musculus

7 genes annotated in mouse

Multi-species View

negative regulation of erbb signaling pathway

GO:1901185

Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of erbb signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of erbb signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Inpp5d	inositol polyphosphate-5-phosphatase D	0.811
Grb2	growth factor receptor bound protein 2	0.711	Fly
Cbl	Casitas B-lineage lymphoma	0.614	Fly
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.376
Blnk	B-cell linker	0.369
Egfr	epidermal growth factor receptor	0.359
Shc1	src homology 2 domain-containing transforming protein C1	0.286
Psen1	presenilin 1	0.269
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.246
Notch2	Notch gene homolog 2 (Drosophila)	0.192
Btk	Bruton agammaglobulinemia tyrosine kinase	0.168
Gab2	growth factor receptor bound protein 2-associated protein 2	0.132
Usp8	ubiquitin specific peptidase 8	0.102
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.096
Fgfr2	fibroblast growth factor receptor 2	0.092
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.080
App	amyloid beta (A4) precursor protein	0.077
Prnp	prion protein	0.075
Notch1	Notch gene homolog 1 (Drosophila)	0.068
Ncstn	nicastrin	0.067
Src	Rous sarcoma oncogene	0.050
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.049
Vegfa	vascular endothelial growth factor A	0.049
Vav2	vav 2 oncogene	0.041
Itgb3	integrin beta 3	0.041
Stam2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.037	Fly
Sh3kbp1	SH3-domain kinase binding protein 1	0.035
Dab1	disabled homolog 1 (Drosophila)	0.034
Fyn	Fyn proto-oncogene	0.032
Dnm2	dynamin 2	0.030
Sos1	son of sevenless homolog 1 (Drosophila)	0.029
Rasal3	RAS protein activator like 3	0.029
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.028
Chuk	conserved helix-loop-helix ubiquitous kinase	0.028
Dok1	docking protein 1	0.026
Flt1	FMS-like tyrosine kinase 1	0.024
Gng12	guanine nucleotide binding protein (G protein), gamma 12	0.024
Fgfr3	fibroblast growth factor receptor 3	0.023
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.021
Sykb	spleen tyrosine kinase	0.021
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.020
Prkcd	protein kinase C, delta	0.019
Zbtb7b	zinc finger and BTB domain containing 7B	0.019
Ptpra	protein tyrosine phosphatase, receptor type, A	0.018
Cd22	CD22 antigen	0.018
Ctsb	cathepsin B	0.018
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.018
L1cam	L1 cell adhesion molecule	0.018
Tgfbr2	transforming growth factor, beta receptor II	0.017
Rasgrp1	RAS guanyl releasing protein 1	0.017
Frs2	fibroblast growth factor receptor substrate 2	0.017
Nckap1l	NCK associated protein 1 like	0.016
Rdh10	retinol dehydrogenase 10 (all-trans)	0.016
Vav1	vav 1 oncogene	0.016
Aph1a	anterior pharynx defective 1a homolog (C. elegans)	0.016
Cd37	CD37 antigen	0.015
Itgal	integrin alpha L	0.015	Mouse
Dok2	docking protein 2	0.015
Parvg	parvin, gamma	0.015
Col12a1	collagen, type XII, alpha 1	0.015
Acvr1	activin A receptor, type 1	0.015
Vangl2	vang-like 2 (van gogh, Drosophila)	0.014
Apaf1	apoptotic peptidase activating factor 1	0.014
Gab1	growth factor receptor bound protein 2-associated protein 1	0.013
Efnb2	ephrin B2	0.013
Ctnnb1	catenin (cadherin associated protein), beta 1	0.013
Myo1f	myosin IF	0.013
Dll1	delta-like 1 (Drosophila)	0.013
Jak2	Janus kinase 2	0.013
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.013
Numb	numb gene homolog (Drosophila)	0.013
Sulf1	sulfatase 1	0.013	Fly
Lcp2	lymphocyte cytosolic protein 2	0.013
Plcg2	phospholipase C, gamma 2	0.013	Fly
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.012
Aplp2	amyloid beta (A4) precursor-like protein 2	0.012
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Psen2	presenilin 2	0.012
Erlin2	ER lipid raft associated 2	0.012
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.012
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.011
Braf	Braf transforming gene	0.011
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.011	Fly
Psenen	presenilin enhancer 2 homolog (C. elegans)	0.011
Eng	endoglin	0.011
Pdcd6	programmed cell death 6	0.011
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.011
Fmnl1	formin-like 1	0.011
Tbcb	tubulin folding cofactor B	0.011
Ehf	ets homologous factor	0.011
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.011
Sulf2	sulfatase 2	0.011	Fly
Brd4	bromodomain containing 4	0.010
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.010
Hmha1	histocompatibility (minor) HA-1	0.010
Rac1	RAS-related C3 botulinum substrate 1	0.010
Adam8	a disintegrin and metallopeptidase domain 8	0.010
Itga4	integrin alpha 4	0.010	Mouse
Sdc3	syndecan 3	0.010
Lrp6	low density lipoprotein receptor-related protein 6	0.010