IMP

Process View

Mus musculus

11 genes annotated in mouse

cellular response to ionizing radiation

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to ionizing radiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to ionizing radiation" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	1.000
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.994
Brca1	breast cancer 1	0.964
Brca2	breast cancer 2	0.937
Pten	phosphatase and tensin homolog	0.887
Stat5a	signal transducer and activator of transcription 5A	0.850	Fly
Rb1	retinoblastoma 1	0.608
Kit	kit oncogene	0.591
Sfrp2	secreted frizzled-related protein 2	0.422
Mdm4	transformed mouse 3T3 cell double minute 4	0.420
Notch2	Notch gene homolog 2 (Drosophila)	0.396
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.362
Nos3	nitric oxide synthase 3, endothelial cell	0.278
Bax	BCL2-associated X protein	0.258	Mouse
Vhl	von Hippel-Lindau tumor suppressor	0.257
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.224
Bcl2	B-cell leukemia/lymphoma 2	0.214	Mouse
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.193
Nbn	nibrin	0.180
Nab2	Ngfi-A binding protein 2	0.171
Rxra	retinoid X receptor alpha	0.145
Flt4	FMS-like tyrosine kinase 4	0.136
Stat5b	signal transducer and activator of transcription 5B	0.131	Fly
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.129	Rat
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.121
Tbx1	T-box 1	0.120
Trp73	transformation related protein 73	0.117	Mouse Fly
Esr1	estrogen receptor 1 (alpha)	0.116
Mdm2	transformed mouse 3T3 cell double minute 2	0.107
Sfrp1	secreted frizzled-related protein 1	0.097
Wwtr1	WW domain containing transcription regulator 1	0.086
Mapkapk2	MAP kinase-activated protein kinase 2	0.083
Stat3	signal transducer and activator of transcription 3	0.083
Atm	ataxia telangiectasia mutated homolog (human)	0.081	Human
Rbl1	retinoblastoma-like 1 (p107)	0.080
Fos	FBJ osteosarcoma oncogene	0.079
Plk4	polo-like kinase 4 (Drosophila)	0.077
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.076
Egr2	early growth response 2	0.071	Mouse
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.068
Mlh1	mutL homolog 1 (E. coli)	0.068
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.064
Bak1	BCL2-antagonist/killer 1	0.061	Mouse
Ar	androgen receptor	0.060
Ahr	aryl-hydrocarbon receptor	0.059
Notch1	Notch gene homolog 1 (Drosophila)	0.058
Rad51ap1	RAD51 associated protein 1	0.055	Human
Lin9	lin-9 homolog (C. elegans)	0.054
Jun	Jun oncogene	0.053
Ptgs2	prostaglandin-endoperoxide synthase 2	0.050
Pola1	polymerase (DNA directed), alpha 1	0.049
Bcl2l1	BCL2-like 1	0.047
Pparg	peroxisome proliferator activated receptor gamma	0.045
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.043
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.041
Meox2	mesenchyme homeobox 2	0.038
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.035
Egr1	early growth response 1	0.034
Rad51	RAD51 homolog (S. cerevisiae)	0.034	Human
Msh2	mutS homolog 2 (E. coli)	0.033
Smad4	MAD homolog 4 (Drosophila)	0.031
Cdc6	cell division cycle 6 homolog (S. cerevisiae)	0.031
Pold3	polymerase (DNA-directed), delta 3, accessory subunit	0.031
Tgfb1	transforming growth factor, beta 1	0.031
Cav1	caveolin 1, caveolae protein	0.030
Vegfa	vascular endothelial growth factor A	0.030	Fly
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.030
Kdr	kinase insert domain protein receptor	0.029
Dok1	docking protein 1	0.029
Eri2	exoribonuclease 2	0.028
Kitl	kit ligand	0.028
Dusp1	dual specificity phosphatase 1	0.027
Terf1	telomeric repeat binding factor 1	0.027
Kiss1	KiSS-1 metastasis-suppressor	0.027
Cry1	cryptochrome 1 (photolyase-like)	0.027
Apc	adenomatosis polyposis coli	0.027
Snai2	snail homolog 2 (Drosophila)	0.027
Twist1	twist homolog 1 (Drosophila)	0.026
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.026
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.026
Runx1	runt related transcription factor 1	0.025
Chek2	CHK2 checkpoint homolog (S. pombe)	0.025	Fly
Smn1	survival motor neuron 1	0.025
Lepr	leptin receptor	0.024
Skil	SKI-like	0.023
Atad5	ATPase family, AAA domain containing 5	0.022
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.021
Cd151	CD151 antigen	0.021
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.021
Junb	Jun-B oncogene	0.020
Yap1	yes-associated protein 1	0.020	Human
Sp1	trans-acting transcription factor 1	0.020
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.020	Mouse
Stil	Scl/Tal1 interrupting locus	0.019
E2f1	E2F transcription factor 1	0.018
Bbc3	BCL2 binding component 3	0.018
Gdnf	glial cell line derived neurotrophic factor	0.018
Hif1a	hypoxia inducible factor 1, alpha subunit	0.018
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.018
Tmpo	thymopoietin	0.018
Mapk8	mitogen-activated protein kinase 8	0.017
Ep300	E1A binding protein p300	0.016
Rara	retinoic acid receptor, alpha	0.016
Il4ra	interleukin 4 receptor, alpha	0.016
Shc1	src homology 2 domain-containing transforming protein C1	0.015
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.015
Mis18bp1	MIS18 binding protein 1	0.015
Mapk11	mitogen-activated protein kinase 11	0.015
Klf6	Kruppel-like factor 6	0.014
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.014
Ccnd1	cyclin D1	0.013
Cdca7l	cell division cycle associated 7 like	0.013
S1pr2	sphingosine-1-phosphate receptor 2	0.013
Ptk2	PTK2 protein tyrosine kinase 2	0.013
Nxph4	neurexophilin 4	0.013
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.012
Raf1	v-raf-leukemia viral oncogene 1	0.012
Snai1	snail homolog 1 (Drosophila)	0.012	Mouse
Atr	ataxia telangiectasia and Rad3 related	0.012	Human
Shh	sonic hedgehog	0.012
Prkci	protein kinase C, iota	0.012
Ttk	Ttk protein kinase	0.012
Adam17	a disintegrin and metallopeptidase domain 17	0.012
Hells	helicase, lymphoid specific	0.012
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.012
Il6st	interleukin 6 signal transducer	0.012
Exosc8	exosome component 8	0.012
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.012
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.012
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.011
Ccna2	cyclin A2	0.011
Cdk2	cyclin-dependent kinase 2	0.011
Sass6	spindle assembly 6 homolog (C. elegans)	0.011
Haus6	HAUS augmin-like complex, subunit 6	0.011
Cdc7	cell division cycle 7 (S. cerevisiae)	0.011
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.011
Psen1	presenilin 1	0.011
Mcm8	minichromosome maintenance deficient 8 (S. cerevisiae)	0.011
Hoxb2	homeobox B2	0.011
Xpa	xeroderma pigmentosum, complementation group A	0.010
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.010
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.010
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.010
Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)	0.010
Nedd1	neural precursor cell expressed, developmentally down-regulated gene 1	0.010
Per2	period homolog 2 (Drosophila)	0.010
Recql	RecQ protein-like	0.010
Mndal	myeloid nuclear differentiation antigen like	0.010