IMP

Process View

Mus musculus

22 genes annotated in mouse

dendritic spine morphogenesis

The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dendritic spine morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dendritic spine morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Ephb2	Eph receptor B2	1.000
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	1.000
Dab1	disabled homolog 1 (Drosophila)	0.998
Dlg4	discs, large homolog 4 (Drosophila)	0.997
Efnb2	ephrin B2	0.984	Mouse
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.963
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.952
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.921
Epha4	Eph receptor A4	0.898
Nsf	N-ethylmaleimide sensitive fusion protein	0.638
Ephb3	Eph receptor B3	0.550
Reln	reelin	0.495
Efnb1	ephrin B1	0.487	Mouse
Onecut1	one cut domain, family member 1	0.448	Mouse
Bsn	bassoon	0.405
Grip1	glutamate receptor interacting protein 1	0.403
Nos1	nitric oxide synthase 1, neuronal	0.376
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.365
Src	Rous sarcoma oncogene	0.354
Lrp8	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	0.335
Grm1	glutamate receptor, metabotropic 1	0.327
Ret	ret proto-oncogene	0.327
Ina	internexin neuronal intermediate filament protein, alpha	0.308
Emx1	empty spiracles homolog 1 (Drosophila)	0.286
Ctnnb1	catenin (cadherin associated protein), beta 1	0.265
Cit	citron	0.243
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.228
Trp53	transformation related protein 53	0.226
Mtap2	microtubule-associated protein 2	0.224
Gata4	GATA binding protein 4	0.208
Mdm2	transformed mouse 3T3 cell double minute 2	0.203
Gria2	glutamate receptor, ionotropic, AMPA2 (alpha 2)	0.201
Wdr1	WD repeat domain 1	0.177
Psen1	presenilin 1	0.176
Zfpm2	zinc finger protein, multitype 2	0.174
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.148
Dlg3	discs, large homolog 3 (Drosophila)	0.140	Mouse
Gata5	GATA binding protein 5	0.132
Nrcam	neuron-glia-CAM-related cell adhesion molecule	0.131
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.124
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.118
Plcg1	phospholipase C, gamma 1	0.111
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.103
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.100
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.097
Cux2	cut-like homeobox 2	0.094
Fzd7	frizzled homolog 7 (Drosophila)	0.094
Kalrn	kalirin, RhoGEF kinase	0.093
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.092
Cnih2	cornichon homolog 2 (Drosophila)	0.092
Onecut2	one cut domain, family member 2	0.085	Mouse
Arc	activity regulated cytoskeletal-associated protein	0.084
Flt1	FMS-like tyrosine kinase 1	0.083
Epha5	Eph receptor A5	0.081	Mouse Rat
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.081
BC018242	cDNA sequence BC018242	0.076
Nf1	neurofibromatosis 1	0.075
Dock1	dedicator of cytokinesis 1	0.073
Prox1	prospero-related homeobox 1	0.072
Prkce	protein kinase C, epsilon	0.071
Jag1	jagged 1	0.070
Neurod6	neurogenic differentiation 6	0.069
Krt8	keratin 8	0.069
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.068
Adam11	a disintegrin and metallopeptidase domain 11	0.067
Dnm1	dynamin 1	0.063
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.061
Sema4g	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	0.059
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.058
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.058
Grik5	glutamate receptor, ionotropic, kainate 5 (gamma 2)	0.057
Fbn2	fibrillin 2	0.057
App	amyloid beta (A4) precursor protein	0.056
Efna5	ephrin A5	0.056	Mouse
Tgfb2	transforming growth factor, beta 2	0.055
Neurod1	neurogenic differentiation 1	0.052
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.052
Pten	phosphatase and tensin homolog	0.051
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.049
Gli3	GLI-Kruppel family member GLI3	0.048
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.048
Ntf3	neurotrophin 3	0.045
Dcx	doublecortin	0.044
Dll4	delta-like 4 (Drosophila)	0.043
Apc2	adenomatosis polyposis coli 2	0.042
Msi1	Musashi homolog 1(Drosophila)	0.041
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.040
Efna1	ephrin A1	0.040
Tceal1	transcription elongation factor A (SII)-like 1	0.039
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.039
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.039
Ctnnd2	catenin (cadherin associated protein), delta 2	0.039
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.039
Tnks1bp1	tankyrase 1 binding protein 1	0.038
Pvrl1	poliovirus receptor-related 1	0.038
Auts2	autism susceptibility candidate 2	0.038
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.038
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.037
Sh3rf1	SH3 domain containing ring finger 1	0.037
Syn2	synapsin II	0.037
Adam17	a disintegrin and metallopeptidase domain 17	0.036
Hapln1	hyaluronan and proteoglycan link protein 1	0.036
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.034
Tbx3	T-box 3	0.034
Plxna3	plexin A3	0.034
Homer1	homer homolog 1 (Drosophila)	0.034
Fgfr2	fibroblast growth factor receptor 2	0.033
Kif1a	kinesin family member 1A	0.033
Nynrin	NYN domain and retroviral integrase containing	0.033
Gak	cyclin G associated kinase	0.033
Shc1	src homology 2 domain-containing transforming protein C1	0.032
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.032
Lrp5	low density lipoprotein receptor-related protein 5	0.032
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.031
Cdh2	cadherin 2	0.031
Nrg3	neuregulin 3	0.031
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.030
Wwc1	WW, C2 and coiled-coil domain containing 1	0.030
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.030
Nkx6-1	NK6 homeobox 1	0.030
Celf4	CUGBP, Elav-like family member 4	0.030
Dlx1	distal-less homeobox 1	0.030
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.030
L1cam	L1 cell adhesion molecule	0.029
Prkar2b	protein kinase, cAMP dependent regulatory, type II beta	0.029
Hif1a	hypoxia inducible factor 1, alpha subunit	0.029
Rnf208	ring finger protein 208	0.028
Tuba1a	tubulin, alpha 1A	0.028
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.028
Grik4	glutamate receptor, ionotropic, kainate 4	0.028
Odz4	odd Oz/ten-m homolog 4 (Drosophila)	0.028
Arhgef15	Rho guanine nucleotide exchange factor (GEF) 15	0.028	Mouse
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.028
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.028
C77080	expressed sequence C77080	0.027
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.027
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.027
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.027
Fzd3	frizzled homolog 3 (Drosophila)	0.026
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.026
Gnao1	guanine nucleotide binding protein, alpha O	0.026
Tro	trophinin	0.026
Gpr12	G-protein coupled receptor 12	0.026
Mmp16	matrix metallopeptidase 16	0.026
Dpysl4	dihydropyrimidinase-like 4	0.026
Mmp15	matrix metallopeptidase 15	0.026
Plxna2	plexin A2	0.026
Mapt	microtubule-associated protein tau	0.025
Il1r1	interleukin 1 receptor, type I	0.025
Mark1	MAP/microtubule affinity-regulating kinase 1	0.025
Efna3	ephrin A3	0.025	Mouse
Cplx2	complexin 2	0.025
Rora	RAR-related orphan receptor alpha	0.025
Foxc1	forkhead box C1	0.025
Pvrl2	poliovirus receptor-related 2	0.025
Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.024
Myh10	myosin, heavy polypeptide 10, non-muscle	0.024
Meis2	Meis homeobox 2	0.024
Lhx1	LIM homeobox protein 1	0.023
Pax6	paired box gene 6	0.023
Wnt7b	wingless-related MMTV integration site 7B	0.023
Mdm4	transformed mouse 3T3 cell double minute 4	0.023
Cdh4	cadherin 4	0.023
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.023
Lhx5	LIM homeobox protein 5	0.023
Arhgef40	Rho guanine nucleotide exchange factor (GEF) 40	0.022
Dsg1a	desmoglein 1 alpha	0.022
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.022
Pbx1	pre B-cell leukemia transcription factor 1	0.022
C77370	expressed sequence C77370	0.022
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.022
Vldlr	very low density lipoprotein receptor	0.022	Mouse
Tubb4	tubulin, beta 4	0.021
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.021
Klf3	Kruppel-like factor 3 (basic)	0.021
Tead2	TEA domain family member 2	0.021
Actg1	actin, gamma, cytoplasmic 1	0.021
Mgat3	mannoside acetylglucosaminyltransferase 3	0.020
Sox9	SRY-box containing gene 9	0.020
Stx1a	syntaxin 1A (brain)	0.020
Cttn	cortactin	0.020
Adamts7	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7	0.020
Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	0.020
Grb2	growth factor receptor bound protein 2	0.020
Dnm1l	dynamin 1-like	0.020
Adrb1	adrenergic receptor, beta 1	0.020
Appl1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.020
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.020
Ephb4	Eph receptor B4	0.019	Mouse
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.019
Adcy1	adenylate cyclase 1	0.019
Syt5	synaptotagmin V	0.018
Shank3	SH3/ankyrin domain gene 3	0.018
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.018
Pcdh1	protocadherin 1	0.018
Foxq1	forkhead box Q1	0.017
Cxadr	coxsackie virus and adenovirus receptor	0.017
Gm4836	predicted gene 4836	0.017
Apoe	apolipoprotein E	0.017
Kifc2	kinesin family member C2	0.017
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.017
Dlg1	discs, large homolog 1 (Drosophila)	0.017	Mouse
Bai1	brain-specific angiogenesis inhibitor 1	0.017
Nfib	nuclear factor I/B	0.016
Fam84a	family with sequence similarity 84, member A	0.016
Clcn2	chloride channel 2	0.016
Fam171a1	family with sequence similarity 171, member A1	0.016
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.016
Unc5c	unc-5 homolog C (C. elegans)	0.016
Jup	junction plakoglobin	0.016
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.016
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.015
Sox18	SRY-box containing gene 18	0.015
Syt1	synaptotagmin I	0.015
Nefm	neurofilament, medium polypeptide	0.015
Klc2	kinesin light chain 2	0.015
Tuba1b	tubulin, alpha 1B	0.015
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.015	Rat
Pou3f3	POU domain, class 3, transcription factor 3	0.015
Neurod2	neurogenic differentiation 2	0.015
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.015
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.015
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.015
Smad6	MAD homolog 6 (Drosophila)	0.015
Rimklb	ribosomal modification protein rimK-like family member B	0.015
Epha7	Eph receptor A7	0.015	Mouse
Rgl3	ral guanine nucleotide dissociation stimulator-like 3	0.015
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.015
Efna2	ephrin A2	0.014	Mouse
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.014
Col9a3	collagen, type IX, alpha 3	0.014
Spnb3	spectrin beta 3	0.014
Plcb1	phospholipase C, beta 1	0.014
Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	0.014
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.014
Foxg1	forkhead box G1	0.014
Notch1	Notch gene homolog 1 (Drosophila)	0.014
Sox5	SRY-box containing gene 5	0.014
Shisa7	shisa homolog 7 (Xenopus laevis)	0.014
Notch2	Notch gene homolog 2 (Drosophila)	0.014
Frs2	fibroblast growth factor receptor substrate 2	0.013
Eno1	enolase 1, alpha non-neuron	0.013
Prkcb	protein kinase C, beta	0.013
Wnk2	WNK lysine deficient protein kinase 2	0.013
Scd1	stearoyl-Coenzyme A desaturase 1	0.013
Zfp28	zinc finger protein 28	0.013
Tead1	TEA domain family member 1	0.013
Dcc	deleted in colorectal carcinoma	0.013
Fzd4	frizzled homolog 4 (Drosophila)	0.013
Fjx1	four jointed box 1 (Drosophila)	0.013
Agap1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	0.013
Rtkn	rhotekin	0.013
Lama5	laminin, alpha 5	0.013
Pdx1	pancreatic and duodenal homeobox 1	0.013
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.013
Npas2	neuronal PAS domain protein 2	0.013
Ptpn13	protein tyrosine phosphatase, non-receptor type 13	0.013
Caskin2	CASK-interacting protein 2	0.013
Sstr3	somatostatin receptor 3	0.013
Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	0.013
Gm5934	predicted gene 5934	0.013
Ptprf	protein tyrosine phosphatase, receptor type, F	0.013
Epb4.1l1	erythrocyte protein band 4.1-like 1	0.013
BC024139	cDNA sequence BC024139	0.013
Fzd1	frizzled homolog 1 (Drosophila)	0.013
Sall2	sal-like 2 (Drosophila)	0.013
Rtn4r	reticulon 4 receptor	0.012
Dab2ip	disabled homolog 2 (Drosophila) interacting protein	0.012
Arx	aristaless related homeobox	0.012
Nos3	nitric oxide synthase 3, endothelial cell	0.012
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.012
Trp53bp1	transformation related protein 53 binding protein 1	0.012
Cachd1	cache domain containing 1	0.012
Lrp1	low density lipoprotein receptor-related protein 1	0.012
Efnb3	ephrin B3	0.012	Mouse
Gm4297	predicted gene 4297	0.012
Grid2	glutamate receptor, ionotropic, delta 2	0.012
Kcnma1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	0.012
Tcfap2c	transcription factor AP-2, gamma	0.012
Tshz3	teashirt zinc finger family member 3	0.012
Tbx2	T-box 2	0.012
Ldb2	LIM domain binding 2	0.012
Lcat	lecithin cholesterol acyltransferase	0.012
Astn1	astrotactin 1	0.012
Efna4	ephrin A4	0.012
Plxna4	plexin A4	0.012
Ptk7	PTK7 protein tyrosine kinase 7	0.012
Col9a2	collagen, type IX, alpha 2	0.012
Shd	src homology 2 domain-containing transforming protein D	0.012
Elavl2	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)	0.012
Cdk18	cyclin-dependent kinase 18	0.012
Fmr1	fragile X mental retardation syndrome 1 homolog	0.012
Gnaz	guanine nucleotide binding protein, alpha z subunit	0.012
Gm6121	predicted gene 6121	0.011
Sh3gl2	SH3-domain GRB2-like 2	0.011
Epha2	Eph receptor A2	0.011	Mouse
Tbr1	T-box brain gene 1	0.011
Phox2a	paired-like homeobox 2a	0.011
Myt1l	myelin transcription factor 1-like	0.011
Syt3	synaptotagmin III	0.011
Bcar1	breast cancer anti-estrogen resistance 1	0.011
Srcin1	SRC kinase signaling inhibitor 1	0.011	Human
Slx	Sycp3 like X-linked	0.011	Mouse
Ncan	neurocan	0.011
Nfia	nuclear factor I/A	0.011
Gm10230	predicted gene 10230	0.011
Nlgn3	neuroligin 3	0.011
Gata6	GATA binding protein 6	0.011
Hap1	huntingtin-associated protein 1	0.011
Ctnna2	catenin (cadherin associated protein), alpha 2	0.011
Zfp618	zinc fingerprotein 618	0.011
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.011
Gdpd5	glycerophosphodiester phosphodiesterase domain containing 5	0.011
Shank2	SH3/ankyrin domain gene 2	0.011	Mouse
Wnt5b	wingless-related MMTV integration site 5B	0.011
Unc5b	unc-5 homolog B (C. elegans)	0.011
Epha3	Eph receptor A3	0.011	Mouse
Grm4	glutamate receptor, metabotropic 4	0.011
Lhx6	LIM homeobox protein 6	0.011
Gabrb1	gamma-aminobutyric acid (GABA) A receptor, subunit beta 1	0.011
Sox11	SRY-box containing gene 11	0.010
Edar	ectodysplasin-A receptor	0.010
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.010
Zfp532	zinc finger protein 532	0.010
Gm10058	predicted gene 10058	0.010
1700008P20Rik	RIKEN cDNA 1700008P20 gene	0.010
Dsg4	desmoglein 4	0.010
St6galnac5	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	0.010
Hes5	hairy and enhancer of split 5 (Drosophila)	0.010
Tubb2a	tubulin, beta 2A	0.010
Napb	N-ethylmaleimide sensitive fusion protein attachment protein beta	0.010
Epb4.1l4b	erythrocyte protein band 4.1-like 4b	0.010
Cys1	cystin 1	0.010
Fzd8	frizzled homolog 8 (Drosophila)	0.010
Vcl	vinculin	0.010
Actb	actin, beta	0.010
Actn1	actinin, alpha 1	0.010