IMP

Process View

Mus musculus

9 genes annotated in mouse

tight junction assembly

The aggregation, arrangement and bonding together of a set of components to form a tight junction, an occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "tight junction assembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "tight junction assembly" (in gray)

Name	Description	Probability	Func Analog Organism
Ctnnb1	catenin (cadherin associated protein), beta 1	0.995
Wnt3a	wingless-related MMTV integration site 3A	0.640	Mouse
Gopc	golgi associated PDZ and coiled-coil motif containing	0.508
Tjp1	tight junction protein 1	0.490
Lhx1	LIM homeobox protein 1	0.487
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.404
Rac1	RAS-related C3 botulinum substrate 1	0.363
Fzd1	frizzled homolog 1 (Drosophila)	0.342	Mouse
Wnt5a	wingless-related MMTV integration site 5A	0.335	Mouse
Krt15	keratin 15	0.293
Smad6	MAD homolog 6 (Drosophila)	0.292
Ldb3	LIM domain binding 3	0.204
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.203
Trp63	transformation related protein 63	0.183
Gli3	GLI-Kruppel family member GLI3	0.177
Ilk	integrin linked kinase	0.165
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.158
Hif1a	hypoxia inducible factor 1, alpha subunit	0.153
Dlg1	discs, large homolog 1 (Drosophila)	0.145	Human
Zfp185	zinc finger protein 185	0.144
Wnt4	wingless-related MMTV integration site 4	0.129	Mouse
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.126
Fgfr2	fibroblast growth factor receptor 2	0.125
T	brachyury	0.114
Pvrl3	poliovirus receptor-related 3	0.110
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.105
Actn4	actinin alpha 4	0.105
Kitl	kit ligand	0.096
Lrp6	low density lipoprotein receptor-related protein 6	0.094
Dsg2	desmoglein 2	0.090
Grb10	growth factor receptor bound protein 10	0.090
Fzd8	frizzled homolog 8 (Drosophila)	0.090	Mouse
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.088
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.085
Dlg4	discs, large homolog 4 (Drosophila)	0.076
Fzd7	frizzled homolog 7 (Drosophila)	0.073	Mouse
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.070
Ptk2	PTK2 protein tyrosine kinase 2	0.068
Lmna	lamin A	0.063
Adrb1	adrenergic receptor, beta 1	0.062
Dlg2	discs, large homolog 2 (Drosophila)	0.062
Hes1	hairy and enhancer of split 1 (Drosophila)	0.060
Scn5a	sodium channel, voltage-gated, type V, alpha	0.059
Srebf2	sterol regulatory element binding factor 2	0.059
Traf6	TNF receptor-associated factor 6	0.057
Foxc1	forkhead box C1	0.055
Hrc	histidine rich calcium binding protein	0.051
Ctnnd1	catenin (cadherin associated protein), delta 1	0.049
Krtdap	keratinocyte differentiation associated protein	0.047
Ocln	occludin	0.047	Human
Col22a1	collagen, type XXII, alpha 1	0.046
Wnt11	wingless-related MMTV integration site 11	0.045
Plcd1	phospholipase C, delta 1	0.044
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.042
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.041
Tnni2	troponin I, skeletal, fast 2	0.040
Hoxa13	homeobox A13	0.039
Lef1	lymphoid enhancer binding factor 1	0.039
Pou3f3	POU domain, class 3, transcription factor 3	0.038
Dlg3	discs, large homolog 3 (Drosophila)	0.038
Wnt6	wingless-related MMTV integration site 6	0.037	Mouse
Prkcz	protein kinase C, zeta	0.037
Prkar2b	protein kinase, cAMP dependent regulatory, type II beta	0.036
Trp73	transformation related protein 73	0.036
Il6st	interleukin 6 signal transducer	0.036
Efna4	ephrin A4	0.036
Tcfap2c	transcription factor AP-2, gamma	0.035
Rnf11	ring finger protein 11	0.034
Irf6	interferon regulatory factor 6	0.033
Smad7	MAD homolog 7 (Drosophila)	0.033
Hoxd9	homeobox D9	0.033
Sox9	SRY-box containing gene 9	0.033
Lgals7	lectin, galactose binding, soluble 7	0.033
Emp2	epithelial membrane protein 2	0.032
Twist2	twist homolog 2 (Drosophila)	0.032
Cd151	CD151 antigen	0.032
Tbx3	T-box 3	0.031
Fgf8	fibroblast growth factor 8	0.030
Fzd4	frizzled homolog 4 (Drosophila)	0.030	Mouse
Gas1	growth arrest specific 1	0.030
Crabp2	cellular retinoic acid binding protein II	0.029
Psen1	presenilin 1	0.029
Myl3	myosin, light polypeptide 3	0.028
Fzd2	frizzled homolog 2 (Drosophila)	0.028	Mouse
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.027
Wnt7b	wingless-related MMTV integration site 7B	0.027	Mouse
Prkci	protein kinase C, iota	0.027
Sfn	stratifin	0.027
Tspan12	tetraspanin 12	0.026
Efs	embryonal Fyn-associated substrate	0.026
Wnt1	wingless-related MMTV integration site 1	0.026	Mouse
Lama5	laminin, alpha 5	0.026
Vax1	ventral anterior homeobox containing gene 1	0.025
Tnnt3	troponin T3, skeletal, fast	0.025
Cldn4	claudin 4	0.025
Actn2	actinin alpha 2	0.025	Mouse
Krt14	keratin 14	0.024
Pou3f1	POU domain, class 3, transcription factor 1	0.024
Col4a5	collagen, type IV, alpha 5	0.024
Pdlim5	PDZ and LIM domain 5	0.024
Nog	noggin	0.024
Efnb2	ephrin B2	0.023
Pcdh12	protocadherin 12	0.023
Gpc3	glypican 3	0.022
Phkb	phosphorylase kinase beta	0.022
Rarg	retinoic acid receptor, gamma	0.022
Barx2	BarH-like homeobox 2	0.022
Xirp1	xin actin-binding repeat containing 1	0.022
Tbx15	T-box 15	0.022
Jup	junction plakoglobin	0.022
Des	desmin	0.022
Fjx1	four jointed box 1 (Drosophila)	0.022
Porcn	porcupine homolog (Drosophila)	0.022
Myh10	myosin, heavy polypeptide 10, non-muscle	0.022
Acvr1	activin A receptor, type 1	0.022
Wnt5b	wingless-related MMTV integration site 5B	0.022	Mouse
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.022
Hoxa2	homeobox A2	0.022
Sox1	SRY-box containing gene 1	0.021
Esrp2	epithelial splicing regulatory protein 2	0.021
Nkd1	naked cuticle 1 homolog (Drosophila)	0.021
Gli1	GLI-Kruppel family member GLI1	0.021
Mpzl2	myelin protein zero-like 2	0.021
Padi3	peptidyl arginine deiminase, type III	0.021
Fgf18	fibroblast growth factor 18	0.020
Lamc2	laminin, gamma 2	0.020
Shh	sonic hedgehog	0.020
Foxd1	forkhead box D1	0.020
Nfe2l3	nuclear factor, erythroid derived 2, like 3	0.020
Smo	smoothened homolog (Drosophila)	0.020
Cyld	cylindromatosis (turban tumor syndrome)	0.020
Ctnna1	catenin (cadherin associated protein), alpha 1	0.020
Irs1	insulin receptor substrate 1	0.020
Myh9	myosin, heavy polypeptide 9, non-muscle	0.020
Meox2	mesenchyme homeobox 2	0.020
Npas1	neuronal PAS domain protein 1	0.019
Dvl1	dishevelled, dsh homolog 1 (Drosophila)	0.019
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.019
Emx2	empty spiracles homolog 2 (Drosophila)	0.019
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.019
Fgf2	fibroblast growth factor 2	0.019
Mapkapk2	MAP kinase-activated protein kinase 2	0.019
Fgfr1	fibroblast growth factor receptor 1	0.019
Grid1	glutamate receptor, ionotropic, delta 1	0.018
Eya4	eyes absent 4 homolog (Drosophila)	0.018
Wnt10b	wingless related MMTV integration site 10b	0.018	Mouse
Cxadr	coxsackie virus and adenovirus receptor	0.018
Tcap	titin-cap	0.018
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.018
Dlx3	distal-less homeobox 3	0.018
Emid2	EMI domain containing 2	0.018
Wdr1	WD repeat domain 1	0.018
Actc1	actin, alpha, cardiac muscle 1	0.018
Gdnf	glial cell line derived neurotrophic factor	0.018
Stat3	signal transducer and activator of transcription 3	0.018
Smoc2	SPARC related modular calcium binding 2	0.018
Hoxa10	homeobox A10	0.017
Tmem64	transmembrane protein 64	0.017
Foxq1	forkhead box Q1	0.017
Stra6	stimulated by retinoic acid gene 6	0.017
Numb	numb gene homolog (Drosophila)	0.017
Tead2	TEA domain family member 2	0.017
Igfbp2	insulin-like growth factor binding protein 2	0.016
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.016
Smad4	MAD homolog 4 (Drosophila)	0.016
Gli2	GLI-Kruppel family member GLI2	0.016
Myo1b	myosin IB	0.016
Esyt3	extended synaptotagmin-like protein 3	0.015
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.015
Fgf17	fibroblast growth factor 17	0.015
Homer1	homer homolog 1 (Drosophila)	0.015
Acan	aggrecan	0.015
Smad3	MAD homolog 3 (Drosophila)	0.015
Gsk3b	glycogen synthase kinase 3 beta	0.015
Mtap2	microtubule-associated protein 2	0.015
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.015
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.015
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.015
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.014
Adm	adrenomedullin	0.014
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.014
Bmp7	bone morphogenetic protein 7	0.014
Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	0.014
Nr2f2	nuclear receptor subfamily 2, group F, member 2	0.014
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.014
Bmp8b	bone morphogenetic protein 8b	0.014
Mpdz	multiple PDZ domain protein	0.014
Krt25	keratin 25	0.014
Vcl	vinculin	0.014
Src	Rous sarcoma oncogene	0.014
Nkd2	naked cuticle 2 homolog (Drosophila)	0.014
Wwtr1	WW domain containing transcription regulator 1	0.014
Trp53bp1	transformation related protein 53 binding protein 1	0.013
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.013
Adam17	a disintegrin and metallopeptidase domain 17	0.013
Tnni1	troponin I, skeletal, slow 1	0.013
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.013
Smtn	smoothelin	0.013
Irx4	Iroquois related homeobox 4 (Drosophila)	0.013
Gja5	gap junction protein, alpha 5	0.013
Fermt2	fermitin family homolog 2 (Drosophila)	0.013
Itga3	integrin alpha 3	0.013
Rarb	retinoic acid receptor, beta	0.013
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.013
Bnc1	basonuclin 1	0.013
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.013
Axin1	axin 1	0.013
Sh3d19	SH3 domain protein D19	0.013
Vstm2b	V-set and transmembrane domain containing 2B	0.013
Cdh1	cadherin 1	0.013
Prkce	protein kinase C, epsilon	0.012
Otx1	orthodenticle homolog 1 (Drosophila)	0.012
Foxa1	forkhead box A1	0.012
Fgf5	fibroblast growth factor 5	0.012
Efna2	ephrin A2	0.012
Ptprk	protein tyrosine phosphatase, receptor type, K	0.012
Yap1	yes-associated protein 1	0.012
Apcdd1	adenomatosis polyposis coli down-regulated 1	0.012
Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.012
Ptprf	protein tyrosine phosphatase, receptor type, F	0.012
Notch2	Notch gene homolog 2 (Drosophila)	0.012
Hist1h1t	histone cluster 1, H1t	0.012
Rapsn	receptor-associated protein of the synapse	0.012
Apc	adenomatosis polyposis coli	0.012
Dlx4	distal-less homeobox 4	0.012
Bcam	basal cell adhesion molecule	0.012
Hoxb9	homeobox B9	0.012
Arc	activity regulated cytoskeletal-associated protein	0.012
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.011
Efna3	ephrin A3	0.011
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.011
Alx4	aristaless-like homeobox 4	0.011
Tnfrsf8	tumor necrosis factor receptor superfamily, member 8	0.011
Usp43	ubiquitin specific peptidase 43	0.011
Nf1	neurofibromatosis 1	0.011
Btbd17	BTB (POZ) domain containing 17	0.011
Tcf15	transcription factor 15	0.011
Ephb3	Eph receptor B3	0.011
Hoxd8	homeobox D8	0.011
Wnt9a	wingless-type MMTV integration site 9A	0.011	Mouse
Cldn6	claudin 6	0.011
Actn3	actinin alpha 3	0.011	Mouse
Wls	wntless homolog (Drosophila)	0.011
Cox6a2	cytochrome c oxidase, subunit VI a, polypeptide 2	0.011
Cldn8	claudin 8	0.011
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.010
Hoxb6	homeobox B6	0.010
Gja1	gap junction protein, alpha 1	0.010	Rat
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.010	Mouse
Sh3pxd2a	SH3 and PX domains 2A	0.010
Lrp5	low density lipoprotein receptor-related protein 5	0.010
Cflar	CASP8 and FADD-like apoptosis regulator	0.010
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.010
Foxa2	forkhead box A2	0.010
Hspb1	heat shock protein 1	0.010
Pax8	paired box gene 8	0.010
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.010
Pgam2	phosphoglycerate mutase 2	0.010