IMP

Process View

Mus musculus

15 genes annotated in mouse

Multi-species View

positive regulation of isotype switching

GO:0045830

Any process that activates or increases the frequency, rate or extent of isotype switching.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of isotype switching"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of isotype switching" (in gray)

Name	Description	Probability	Func Analog Organism
Tcra	T-cell receptor alpha chain	0.925
Tnf	tumor necrosis factor	0.855
Foxp3	forkhead box P3	0.792
Il10	interleukin 10	0.746
Lyz2	lysozyme 2	0.512
Cd19	CD19 antigen	0.484
Il2	interleukin 2	0.435
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.423
Stat6	signal transducer and activator of transcription 6	0.378
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.361
Stat5b	signal transducer and activator of transcription 5B	0.343	Mouse
Pitx1	paired-like homeodomain transcription factor 1	0.329
Ikzf1	IKAROS family zinc finger 1	0.309
Tbx3	T-box 3	0.299	Mouse
Rag1	recombination activating gene 1	0.264
Prf1	perforin 1 (pore forming protein)	0.252
Fyn	Fyn proto-oncogene	0.246
Inpp5d	inositol polyphosphate-5-phosphatase D	0.220
Fas	Fas (TNF receptor superfamily member 6)	0.211
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.197
Socs1	suppressor of cytokine signaling 1	0.194
Il4ra	interleukin 4 receptor, alpha	0.189
Stat3	signal transducer and activator of transcription 3	0.169	Mouse
Il6	interleukin 6	0.168
Il4	interleukin 4	0.159
Irf9	interferon regulatory factor 9	0.148
Myd88	myeloid differentiation primary response gene 88	0.145
Stat5a	signal transducer and activator of transcription 5A	0.139	Mouse
Cd40	CD40 antigen	0.135
Hoxa1	homeobox A1	0.135
Ifng	interferon gamma	0.135
Fasl	Fas ligand (TNF superfamily, member 6)	0.129
Cd28	CD28 antigen	0.119
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.109
Rag2	recombination activating gene 2	0.099
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.098
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.096
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.072
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.071
Nos2	nitric oxide synthase 2, inducible	0.064
Lta	lymphotoxin A	0.061
Pitx2	paired-like homeodomain transcription factor 2	0.059
Tlr4	toll-like receptor 4	0.058
Esr2	estrogen receptor 2 (beta)	0.055
Pou5f1	POU domain, class 5, transcription factor 1	0.050
Il6st	interleukin 6 signal transducer	0.050
B2m	beta-2 microglobulin	0.050
Tbx5	T-box 5	0.046	Mouse
Runx2	runt related transcription factor 2	0.044
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.044
Mmp9	matrix metallopeptidase 9	0.041
Il1r1	interleukin 1 receptor, type I	0.041
Sh2d1a	SH2 domain protein 1A	0.041
Icos	inducible T-cell co-stimulator	0.039	Mouse
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.037
Il2rb	interleukin 2 receptor, beta chain	0.034
Ccr7	chemokine (C-C motif) receptor 7	0.030
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.029
Cd40lg	CD40 ligand	0.027
Csf1	colony stimulating factor 1 (macrophage)	0.025
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.025
Gja5	gap junction protein, alpha 5	0.025
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.025
Traf2	TNF receptor-associated factor 2	0.024
Tbx4	T-box 4	0.024	Mouse
Stat1	signal transducer and activator of transcription 1	0.024	Mouse
Prkcd	protein kinase C, delta	0.023
Ccr6	chemokine (C-C motif) receptor 6	0.021
Il2rg	interleukin 2 receptor, gamma chain	0.021
Il21r	interleukin 21 receptor	0.021
Foxg1	forkhead box G1	0.020
Ifnar2	interferon (alpha and beta) receptor 2	0.020
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.020
Lepr	leptin receptor	0.019
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.019
Ltb	lymphotoxin B	0.018
Traf3ip2	TRAF3 interacting protein 2	0.018
Alx1	ALX homeobox 1	0.018
Rxra	retinoid X receptor alpha	0.017
Gpr132	G protein-coupled receptor 132	0.017
Fgfr2	fibroblast growth factor receptor 2	0.017
Pax2	paired box gene 2	0.016
Pdcd1	programmed cell death 1	0.016
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.016
Lif	leukemia inhibitory factor	0.016
Slamf1	signaling lymphocytic activation molecule family member 1	0.016
Lag3	lymphocyte-activation gene 3	0.015
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.015
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.015
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.015	Mouse
Il27ra	interleukin 27 receptor, alpha	0.014
Ikbkg	inhibitor of kappaB kinase gamma	0.014
Noto	notochord homolog (Xenopus laevis)	0.014
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.014
Spna1	spectrin alpha 1	0.014
Bcl3	B-cell leukemia/lymphoma 3	0.014
Lef1	lymphoid enhancer binding factor 1	0.014
Runx3	runt related transcription factor 3	0.014
Igh	immunoglobulin heavy chain complex	0.014
Trim21	tripartite motif-containing 21	0.014
Lck	lymphocyte protein tyrosine kinase	0.013
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.013
Bmp5	bone morphogenetic protein 5	0.013
Ptgs2	prostaglandin-endoperoxide synthase 2	0.013
Ncoa3	nuclear receptor coactivator 3	0.013
Chd7	chromodomain helicase DNA binding protein 7	0.013
Hoxa10	homeobox A10	0.013
Cd4	CD4 antigen	0.013
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.013
Apoe	apolipoprotein E	0.012
Shh	sonic hedgehog	0.012
Dll4	delta-like 4 (Drosophila)	0.012
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.012
Npy1r	neuropeptide Y receptor Y1	0.012
Cd8a	CD8 antigen, alpha chain	0.011
Wt1	Wilms tumor 1 homolog	0.011
Traf6	TNF receptor-associated factor 6	0.011
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.011
Pdcd1lg2	programmed cell death 1 ligand 2	0.011
Nfil3	nuclear factor, interleukin 3, regulated	0.011
Sall4	sal-like 4 (Drosophila)	0.011
Trp63	transformation related protein 63	0.011
Cd96	CD96 antigen	0.011
Gzmk	granzyme K	0.011
Pag1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
Cd5	CD5 antigen	0.011
Gata3	GATA binding protein 3	0.011
Sh2d2a	SH2 domain protein 2A	0.010
Arid1b	AT rich interactive domain 1B (SWI-like)	0.010
Runx1	runt related transcription factor 1	0.010