IMP

Process View

Mus musculus

20 genes annotated in mouse

negative regulation of hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of hormone secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of hormone secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.985
Clock	circadian locomotor output cycles kaput	0.978
Lep	leptin	0.909
Insr	insulin receptor	0.896
Esr1	estrogen receptor 1 (alpha)	0.810
Nos3	nitric oxide synthase 3, endothelial cell	0.781
Per2	period homolog 2 (Drosophila)	0.729
Nos2	nitric oxide synthase 2, inducible	0.678
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.594
Esr2	estrogen receptor 2 (beta)	0.561
Apc	adenomatosis polyposis coli	0.388
Cry1	cryptochrome 1 (photolyase-like)	0.368
Cry2	cryptochrome 2 (photolyase-like)	0.331
Lepr	leptin receptor	0.266
LOC100048884	novel member of the major urinary protein (Mup) gene family	0.260	Mouse
Ghr	growth hormone receptor	0.229
Fst	follistatin	0.221
Fshr	follicle stimulating hormone receptor	0.219
Pomc	pro-opiomelanocortin-alpha	0.215
Mup19	major urinary protein 19	0.212	Mouse
Mup10	major urinary protein 10	0.181	Mouse
Ptgs2	prostaglandin-endoperoxide synthase 2	0.169
Tnf	tumor necrosis factor	0.168
Mup1	major urinary protein 1	0.152
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.149
Ccl2	chemokine (C-C motif) ligand 2	0.143
Mup12	major urinary protein 12	0.139	Mouse
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.121
Nos1	nitric oxide synthase 1, neuronal	0.112	Rat
Mup8	major urinary protein 8	0.102	Mouse
Pparg	peroxisome proliferator activated receptor gamma	0.100
Bglap	bone gamma carboxyglutamate protein	0.099
Pim3	proviral integration site 3	0.096
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.092
Fgf8	fibroblast growth factor 8	0.089
Mup4	major urinary protein 4	0.089	Mouse
Ctnnb1	catenin (cadherin associated protein), beta 1	0.087
Mup11	major urinary protein 11	0.086	Mouse
Mup5	major urinary protein 5	0.083	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.081
Mup9	major urinary protein 9	0.081	Mouse
Gata4	GATA binding protein 4	0.081
Mup14	major urinary protein 14	0.076	Mouse
Mup17	major urinary protein 17	0.072
Mup13	major urinary protein 13	0.072
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.069	Mouse
Htt	huntingtin	0.066
Plin1	perilipin 1	0.066
Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	0.066
Mup7	major urinary protein 7	0.065	Mouse
Gnrh1	gonadotropin releasing hormone 1	0.063
Il1a	interleukin 1 alpha	0.062	Mouse
Tgfbr2	transforming growth factor, beta receptor II	0.062	Mouse
Col1a1	collagen, type I, alpha 1	0.060
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.060
Stat3	signal transducer and activator of transcription 3	0.059
Prlr	prolactin receptor	0.058
Mup15	major urinary protein 15	0.057	Mouse
Per1	period homolog 1 (Drosophila)	0.056
LOC100048885	major urinary protein LOC100048885	0.056	Mouse
Mup2	major urinary protein 2	0.054	Mouse
Mup3	major urinary protein 3	0.053	Mouse
Tlr2	toll-like receptor 2	0.052
Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	0.052
Il1r1	interleukin 1 receptor, type I	0.050
Thra	thyroid hormone receptor alpha	0.050
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.049
Plcg1	phospholipase C, gamma 1	0.047
Vegfa	vascular endothelial growth factor A	0.047
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.044
Kiss1	KiSS-1 metastasis-suppressor	0.044
Crh	corticotropin releasing hormone	0.043	Rat
Ar	androgen receptor	0.042
Prkg1	protein kinase, cGMP-dependent, type I	0.042
Svs5	seminal vesicle secretory protein 5	0.042
Pten	phosphatase and tensin homolog	0.041
Nf1	neurofibromatosis 1	0.041
Cav1	caveolin 1, caveolae protein	0.039
Mstn	myostatin	0.039
Socs1	suppressor of cytokine signaling 1	0.039
Sfrp2	secreted frizzled-related protein 2	0.038
Cidec	cell death-inducing DFFA-like effector c	0.038
Igh	immunoglobulin heavy chain complex	0.036
Cd70	CD70 antigen	0.035
Inhba	inhibin beta-A	0.035	Mouse
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.034
Adipoq	adiponectin, C1Q and collagen domain containing	0.034
Tgfb1	transforming growth factor, beta 1	0.034
Irs2	insulin receptor substrate 2	0.033
Il1b	interleukin 1 beta	0.033
Pnpla2	patatin-like phospholipase domain containing 2	0.033
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.032
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.032
Casr	calcium-sensing receptor	0.032
Apoe	apolipoprotein E	0.031
Sstr3	somatostatin receptor 3	0.031
Csf1	colony stimulating factor 1 (macrophage)	0.030
Cd80	CD80 antigen	0.029
Cps1	carbamoyl-phosphate synthetase 1	0.027
Orm2	orosomucoid 2	0.027
Vdr	vitamin D receptor	0.026	Mouse
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.026
Ifnb1	interferon beta 1, fibroblast	0.026
Pcsk4	proprotein convertase subtilisin/kexin type 4	0.026
Smad4	MAD homolog 4 (Drosophila)	0.025
Syt2	synaptotagmin II	0.025
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.025
Il6st	interleukin 6 signal transducer	0.025
Sin3a	transcriptional regulator, SIN3A (yeast)	0.025
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.024
Usp2	ubiquitin specific peptidase 2	0.024
Sox9	SRY-box containing gene 9	0.023
Ngf	nerve growth factor	0.023
Inha	inhibin alpha	0.023	Rat
Gja1	gap junction protein, alpha 1	0.023
Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	0.023
Tlr4	toll-like receptor 4	0.022
Pkm2	pyruvate kinase, muscle	0.022
Mas1	MAS1 oncogene	0.022
Nodal	nodal	0.021
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.021
Pim1	proviral integration site 1	0.021	Mouse
Ldlr	low density lipoprotein receptor	0.020
Srf	serum response factor	0.020
Acvr1	activin A receptor, type 1	0.019	Mouse
Hr	hairless	0.019
Agrp	agouti related protein	0.019
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.019
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.019
Sult1b1	sulfotransferase family 1B, member 1	0.019
Shc1	src homology 2 domain-containing transforming protein C1	0.019
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.018
Aldoa	aldolase A, fructose-bisphosphate	0.018
Mmp9	matrix metallopeptidase 9	0.018
Gdf15	growth differentiation factor 15	0.018
Accn5	amiloride-sensitive cation channel 5, intestinal	0.018
Klk1b26	kallikrein 1-related petidase b26	0.017
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.017
Egfr	epidermal growth factor receptor	0.017
Pdx1	pancreatic and duodenal homeobox 1	0.017
Il10	interleukin 10	0.017
Atp4b	ATPase, H+/K+ exchanging, beta polypeptide	0.017
Tdo2	tryptophan 2,3-dioxygenase	0.017
Hoxd13	homeobox D13	0.017
Gabrr1	gamma-aminobutyric acid (GABA) C receptor, subunit rho 1	0.017
Btg4	B-cell translocation gene 4	0.016
Apoa4	apolipoprotein A-IV	0.016
Eng	endoglin	0.016
Fam83f	family with sequence similarity 83, member F	0.016
Nr5a2	nuclear receptor subfamily 5, group A, member 2	0.016
Hdac2	histone deacetylase 2	0.015
Agtr2	angiotensin II receptor, type 2	0.015
Kl	klotho	0.015
Rag1	recombination activating gene 1	0.015
Art1	ADP-ribosyltransferase 1	0.015
Igf1	insulin-like growth factor 1	0.015
Tph2	tryptophan hydroxylase 2	0.015
Utf1	undifferentiated embryonic cell transcription factor 1	0.015
Tph1	tryptophan hydroxylase 1	0.015
Npas2	neuronal PAS domain protein 2	0.014
U46068	cDNA sequence U46068	0.014
Lif	leukemia inhibitory factor	0.014	Human
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.014
2310002J15Rik	RIKEN cDNA 2310002J15 gene	0.014
Gab1	growth factor receptor bound protein 2-associated protein 1	0.014
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.014
Vav2	vav 2 oncogene	0.014
Ifng	interferon gamma	0.013
Foxc1	forkhead box C1	0.013
Klf3	Kruppel-like factor 3 (basic)	0.013
Rgs11	regulator of G-protein signaling 11	0.013
Adam17	a disintegrin and metallopeptidase domain 17	0.013
Irak4	interleukin-1 receptor-associated kinase 4	0.013
Bik	BCL2-interacting killer	0.013
Tgfbr3	transforming growth factor, beta receptor III	0.013
Hamp	hepcidin antimicrobial peptide	0.013
Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	0.013
Cyp11b1	cytochrome P450, family 11, subfamily b, polypeptide 1	0.013
Npy1r	neuropeptide Y receptor Y1	0.013	Rat
Prodh2	proline dehydrogenase (oxidase) 2	0.012
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.012
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.012
Gab2	growth factor receptor bound protein 2-associated protein 2	0.012
Grm1	glutamate receptor, metabotropic 1	0.012
Gata6	GATA binding protein 6	0.012
Ryr2	ryanodine receptor 2, cardiac	0.012
Rxra	retinoid X receptor alpha	0.012
Mbl1	mannose-binding lectin (protein A) 1	0.012
Slc27a1	solute carrier family 27 (fatty acid transporter), member 1	0.012
Mc2r	melanocortin 2 receptor	0.012
Mmp7	matrix metallopeptidase 7	0.012
Gng4	guanine nucleotide binding protein (G protein), gamma 4	0.012
Kit	kit oncogene	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Sult1d1	sulfotransferase family 1D, member 1	0.012
Cyp2c39	cytochrome P450, family 2, subfamily c, polypeptide 39	0.012
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.011
Adig	adipogenin	0.011
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.011
Rxrg	retinoid X receptor gamma	0.011
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.011
Ctnnd1	catenin (cadherin associated protein), delta 1	0.011
Ang2	angiogenin, ribonuclease A family, member 2	0.011
Sel1l2	sel-1 suppressor of lin-12-like 2 (C. elegans)	0.011
Bmp4	bone morphogenetic protein 4	0.011
Cyp3a16	cytochrome P450, family 3, subfamily a, polypeptide 16	0.011
Sry	sex determining region of Chr Y	0.011
Stx4a	syntaxin 4A (placental)	0.011
Cxcl2	chemokine (C-X-C motif) ligand 2	0.011
Trpc4	transient receptor potential cation channel, subfamily C, member 4	0.011
Pim2	proviral integration site 2	0.011	Mouse
Fabp1	fatty acid binding protein 1, liver	0.011
Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	0.011
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.011
Obp1a	odorant binding protein Ia	0.011	Mouse
Alox8	arachidonate 8-lipoxygenase	0.011
Csnk1e	casein kinase 1, epsilon	0.010
Il13	interleukin 13	0.010
Rab25	RAB25, member RAS oncogene family	0.010
Spock2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2	0.010
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.010
Il4ra	interleukin 4 receptor, alpha	0.010
F12	coagulation factor XII (Hageman factor)	0.010