IMP
Process View
The network for 'negative regulation of t cell receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
negative regulation of t cell receptor signaling pathway
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| LAT | linker for activation of T cells | 0.946 | |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa | 0.906 | |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.905 | |
| LCK | lymphocyte-specific protein tyrosine kinase | 0.850 | |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.808 | |
| GHR | growth hormone receptor | 0.794 | |
| CD2 | CD2 molecule | 0.750 | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.750 | |
| PSTPIP1 | proline-serine-threonine phosphatase interacting protein 1 | 0.549 | |
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.469 | |
| CD247 | CD247 molecule | 0.438 | |
| MAPK1 | mitogen-activated protein kinase 1 | 0.307 | |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 0.262 | |
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.247 | |
| THAP2 | THAP domain containing, apoptosis associated protein 2 | 0.229 | |
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.170 | |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.139 | |
| SYK | spleen tyrosine kinase | 0.134 | |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.119 | |
| CD33 | CD33 molecule | 0.099 | |
| MAPK3 | mitogen-activated protein kinase 3 | 0.092 | |
| SH3BP2 | SH3-domain binding protein 2 | 0.087 | |
| PEA15 | phosphoprotein enriched in astrocytes 15 | 0.082 | |
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.080 | |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.078 | |
| UTRN | utrophin | 0.074 | |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.067 | |
| DNM1 | dynamin 1 | 0.061 | |
| MICA | MHC class I polypeptide-related sequence A | 0.061 | |
| PTPRC | protein tyrosine phosphatase, receptor type, C | 0.054 | |
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.054 | |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.051 | |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.050 | |
| DUSP7 | dual specificity phosphatase 7 | 0.047 | |
| PLCG1 | phospholipase C, gamma 1 | 0.047 | |
| GAB1 | GRB2-associated binding protein 1 | 0.043 | |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.041 | |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.041 | |
| LYN | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 0.040 | |
| PILRA | paired immunoglobin-like type 2 receptor alpha | 0.040 | |
| MAPK14 | mitogen-activated protein kinase 14 | 0.040 | |
| SOCS2 | suppressor of cytokine signaling 2 | 0.039 | |
| LAIR1 | leukocyte-associated immunoglobulin-like receptor 1 | 0.038 | |
| BLNK | B-cell linker | 0.037 | |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.036 | |
| PTPN3 | protein tyrosine phosphatase, non-receptor type 3 | 0.035 | |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.034 | |
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.034 | |
| CD2AP | CD2-associated protein | 0.032 | |
| GRB2 | growth factor receptor-bound protein 2 | 0.029 | |
| PLK3 | polo-like kinase 3 | 0.028 | |
| MAP4K1 | mitogen-activated protein kinase kinase kinase kinase 1 | 0.028 | |
| BTN3A1 | butyrophilin, subfamily 3, member A1 | 0.027 | |
| DUSP1 | dual specificity phosphatase 1 | 0.026 | |
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.025 | |
| SH3GL3 | SH3-domain GRB2-like 3 | 0.024 | |
| BTN2A1 | butyrophilin, subfamily 2, member A1 | 0.024 | |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.023 | |
| BTN2A2 | butyrophilin, subfamily 2, member A2 | 0.022 | |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.021 | |
| DPYSL4 | dihydropyrimidinase-like 4 | 0.021 | |
| PTPN9 | protein tyrosine phosphatase, non-receptor type 9 | 0.021 | |
| FHL1 | four and a half LIM domains 1 | 0.020 | |
| BTN3A3 | butyrophilin, subfamily 3, member A3 | 0.020 | |
| DBNL | drebrin-like | 0.020 | |
| GAB2 | GRB2-associated binding protein 2 | 0.019 | |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.019 | |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.019 | |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.018 | |
| HOXA1 | homeobox A1 | 0.018 | |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | 0.018 | |
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 0.017 | |
| ITGA1 | integrin, alpha 1 | 0.017 | |
| RHOU | ras homolog gene family, member U | 0.017 | |
| LY6G6F | lymphocyte antigen 6 complex, locus G6F | 0.016 | |
| CRY1 | cryptochrome 1 (photolyase-like) | 0.016 | |
| DUSP3 | dual specificity phosphatase 3 | 0.016 | |
| SIRPA | signal-regulatory protein alpha | 0.015 | |
| SH2D2A | SH2 domain containing 2A | 0.015 | |
| CD22 | CD22 molecule | 0.015 | |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.015 | |
| PTPN7 | protein tyrosine phosphatase, non-receptor type 7 | 0.015 | |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.015 | |
| NCK2 | NCK adaptor protein 2 | 0.014 | |
| PTPN2 | protein tyrosine phosphatase, non-receptor type 2 | 0.014 | |
| REPS2 | RALBP1 associated Eps domain containing 2 | 0.014 | |
| PXN | paxillin | 0.014 | |
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.014 | |
| TNK2 | tyrosine kinase, non-receptor, 2 | 0.014 | |
| TRIM38 | tripartite motif containing 38 | 0.014 | |
| APP | amyloid beta (A4) precursor protein | 0.014 | |
| FTL | ferritin, light polypeptide | 0.013 | |
| DUSP5 | dual specificity phosphatase 5 | 0.013 | |
| GIT1 | G protein-coupled receptor kinase interacting ArfGAP 1 | 0.013 | |
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.013 | |
| CCDC85B | coiled-coil domain containing 85B | 0.013 | |
| CDC42 | cell division cycle 42 (GTP binding protein, 25kDa) | 0.013 | |
| SCNM1 | sodium channel modifier 1 | 0.013 | |
| PRKCQ | protein kinase C, theta | 0.012 | |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.012 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Cd80 | CD80 antigen | 0.094 | |
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.064 | |
| Jak2 | Janus kinase 2 | 0.050 | |
| Grb2 | growth factor receptor bound protein 2 | 0.041 | |
| Cdh5 | cadherin 5 | 0.031 | |
| Lyz2 | lysozyme 2 | 0.024 | |
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.016 | |
| S100a4 | S100 calcium binding protein A4 | 0.015 | |
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.015 | |
| Vav1 | vav 1 oncogene | 0.015 | |
| S100a6 | S100 calcium binding protein A6 (calcyclin) | 0.015 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.014 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.013 | |
| Grxcr1 | glutaredoxin, cysteine rich 1 | 0.012 | |
| 1600029D21Rik | RIKEN cDNA 1600029D21 gene | 0.012 | |
| Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.012 | |
| S100a11 | S100 calcium binding protein A11 (calgizzarin) | 0.011 | |
| Nfatc1 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | 0.011 | |
| Flt1 | FMS-like tyrosine kinase 1 | 0.011 | |
| Ehf | ets homologous factor | 0.011 | |
| Ncoa3 | nuclear receptor coactivator 3 | 0.010 | |
| Pax8 | paired box gene 8 | 0.010 |