The network for 'regulation of peptide secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of peptide secretion

Any process that modulates the frequency, rate, or extent of peptide secretion.

Homo sapiens
Name Description Probability Func Analog Organism
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.901
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.757
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.707
TEK TEK tyrosine kinase, endothelial 0.571
CCR5 chemokine (C-C motif) receptor 5 0.566
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.511
EGFR epidermal growth factor receptor 0.468
IGF1R insulin-like growth factor 1 receptor 0.436
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.430
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.416
FGB fibrinogen beta chain 0.377
FGA fibrinogen alpha chain 0.364
ZFYVE9 zinc finger, FYVE domain containing 9 0.319
S100A8 S100 calcium binding protein A8 0.289
INSR insulin receptor 0.284
HLA-DRA major histocompatibility complex, class II, DR alpha 0.260
S100A9 S100 calcium binding protein A9 0.246
CRHR1 corticotropin releasing hormone receptor 1 0.229
CCNY cyclin Y 0.226
IL1R1 interleukin 1 receptor, type I 0.224
CCL4 chemokine (C-C motif) ligand 4 0.213
SNAP23 synaptosomal-associated protein, 23kDa 0.192
LIN7B lin-7 homolog B (C. elegans) 0.164
PDX1 pancreatic and duodenal homeobox 1 0.159
KCNE1 potassium voltage-gated channel, Isk-related family, member 1 0.145
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.134
MT1A metallothionein 1A 0.132
SNAP25 synaptosomal-associated protein, 25kDa 0.132
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.127
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.126
CRP C-reactive protein, pentraxin-related 0.123
NOSTRIN nitric oxide synthase trafficker 0.122
ADORA2A adenosine A2a receptor 0.121
CHD8 chromodomain helicase DNA binding protein 8 0.118
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.116
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.112
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.107
PPARA peroxisome proliferator-activated receptor alpha 0.106
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.104
DRD2 dopamine receptor D2 0.102
SH2B1 SH2B adaptor protein 1 0.100
FGG fibrinogen gamma chain 0.099
HCK hemopoietic cell kinase 0.096
NKX2-1 NK2 homeobox 1 0.090
CLASP1 cytoplasmic linker associated protein 1 0.089
GRB10 growth factor receptor-bound protein 10 0.088
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.083
CHD7 chromodomain helicase DNA binding protein 7 0.074
CAPNS1 calpain, small subunit 1 0.072
HNF1B HNF1 homeobox B 0.072
ONECUT1 one cut homeobox 1 0.068
CCL8 chemokine (C-C motif) ligand 8 0.067
PTK2 PTK2 protein tyrosine kinase 2 0.066
IL1B interleukin 1, beta 0.065
CCL2 chemokine (C-C motif) ligand 2 0.065
TNF tumor necrosis factor 0.065
IL1R2 interleukin 1 receptor, type II 0.064
NSF N-ethylmaleimide-sensitive factor 0.064
MPDZ multiple PDZ domain protein 0.063
CCK cholecystokinin 0.063
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.062
IRS1 insulin receptor substrate 1 0.059
PSEN1 presenilin 1 0.059
CXCL9 chemokine (C-X-C motif) ligand 9 0.058
IDE insulin-degrading enzyme 0.058
MEOX1 mesenchyme homeobox 1 0.057
NCK1 NCK adaptor protein 1 0.054
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.053
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.052
CDX2 caudal type homeobox 2 0.052
VAC14 Vac14 homolog (S. cerevisiae) 0.051
TTR transthyretin 0.051
LAT linker for activation of T cells 0.050
GJD2 gap junction protein, delta 2, 36kDa 0.050
CCR1 chemokine (C-C motif) receptor 1 0.050
IL1RN interleukin 1 receptor antagonist 0.049
BMPR1B bone morphogenetic protein receptor, type IB 0.047
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.046
GRB2 growth factor receptor-bound protein 2 0.046
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 0.046
CCL7 chemokine (C-C motif) ligand 7 0.045
HLA-DMB major histocompatibility complex, class II, DM beta 0.045
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.044
GOLGA2 golgin A2 0.044
MTNR1A melatonin receptor 1A 0.043
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.042
RGS20 regulator of G-protein signaling 20 0.042
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.041
GPR50 G protein-coupled receptor 50 0.041
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.041
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.040
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.040
SREBF2 sterol regulatory element binding transcription factor 2 0.040
SPRR2A small proline-rich protein 2A 0.039
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.038
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.036
MED15 mediator complex subunit 15 0.035
MARCO macrophage receptor with collagenous structure 0.035
TOM1L1 target of myb1 (chicken)-like 1 0.034
PYY peptide YY 0.034
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
myoglianin CG1838 gene product from transcript CG1838-RD 0.227
Pk61C Protein kinase 61C 0.181
shn schnurri 0.143
Atg9 Autophagy-specific gene 9 0.120
unc-104 CG8566 gene product from transcript CG8566-RB 0.107
disco disconnected 0.092
Actbeta Activin-beta 0.087
Pp2B-14D Protein phosphatase 2B at 14D 0.085
SNF4Agamma SNF4/AMP-activated protein kinase gamma subunit 0.085
Plc21C Phospholipase C at 21C 0.077
Eip63F-1 Ecdysone-induced protein 63F 1 0.071
hth homothorax 0.063
dnc dunce 0.052
tim timeless 0.050
CaMKII Calcium/calmodulin-dependent protein kinase II 0.049
unc-13 CG2999 gene product from transcript CG2999-RA 0.048
mav maverick 0.047
Shaw Shaker cognate w 0.045
Mmp2 Matrix metalloproteinase 2 0.043
Atf-2 Activating transcription factor-2 0.041
Ric Ras which interacts with Calmodulin 0.041
CadN Cadherin-N 0.039
Pde8 Phosphodiesterase 8 0.035
Irk3 Inwardly rectifying potassium channel 3 0.035
HDAC6 CG6170 gene product from transcript CG6170-RA 0.032
GABA-B-R2 metabotropic GABA-B receptor subtype 2 0.030
Dat Dopamine N acetyltransferase 0.028
Rab7 Rab-protein 7 0.027
Unc-76 CG3981 gene product from transcript CG3981-RB 0.025
Gadd45 CG11086 gene product from transcript CG11086-RA 0.022
Tequila CG4821 gene product from transcript CG4821-RE 0.021
CG34139 CG34139 gene product from transcript CG34139-RD 0.020
kay kayak 0.018
CycJ Cyclin J 0.016
CG42574 CG42574 gene product from transcript CG42574-RE 0.016
Mad Mothers against dpp 0.014
grp grapes 0.014
wit wishful thinking 0.014
Bre1 CG10542 gene product from transcript CG10542-RA 0.013
Ssdp Sequence-specific single-stranded DNA-binding protein 0.013
SoxN SoxNeuro 0.013
norpA no receptor potential A 0.013
AdoR Adenosine receptor 0.012
Pka-R2 cAMP-dependent protein kinase R2 0.012
daw dawdle 0.012
Med Medea 0.012
CG34400 CG34400 gene product from transcript CG34400-RD 0.012
stai stathmin 0.012
E23 Early gene at 23 0.011
Ork1 Open rectifier K[+] channel 1 0.011
boi brother of iHog 0.011
ERR estrogen-related receptor 0.011
LIMK1 LIM-kinase1 0.011
Akt1 CG4006 gene product from transcript CG4006-RA 0.010
Mekk1 CG7717 gene product from transcript CG7717-RB 0.010
kibra kibra ortholog 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Gata4 GATA binding protein 4 0.999
Lep leptin 0.951
Nos3 nitric oxide synthase 3, endothelial cell 0.935
Kl klotho 0.869
Drd2 dopamine receptor D2 0.852
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.838
Tgfb2 transforming growth factor, beta 2 0.832
Cry2 cryptochrome 2 (photolyase-like) 0.786
Cckbr cholecystokinin B receptor 0.783
Thrb thyroid hormone receptor beta 0.770
Bglap bone gamma carboxyglutamate protein 0.752
Nf1 neurofibromatosis 1 0.744
Esr1 estrogen receptor 1 (alpha) 0.744
S100a6 S100 calcium binding protein A6 (calcyclin) 0.727
Fgf8 fibroblast growth factor 8 0.700
Lepr leptin receptor 0.670
Per2 period homolog 2 (Drosophila) 0.651
Clock circadian locomotor output cycles kaput 0.634
Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 0.608
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.608
Rarg retinoic acid receptor, gamma 0.608
Ephb2 Eph receptor B2 0.585
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.577
Ahr aryl-hydrocarbon receptor 0.565
Pparg peroxisome proliferator activated receptor gamma 0.559
Pnpla2 patatin-like phospholipase domain containing 2 0.539
Fgfr3 fibroblast growth factor receptor 3 0.516
Pim3 proviral integration site 3 0.508
Ghr growth hormone receptor 0.505
Thra thyroid hormone receptor alpha 0.503
Fshr follicle stimulating hormone receptor 0.497
Nos2 nitric oxide synthase 2, inducible 0.497
Sox11 SRY-box containing gene 11 0.492
Nrxn1 neurexin I 0.482
Epha4 Eph receptor A4 0.472
Foxc1 forkhead box C1 0.469
Runx2 runt related transcription factor 2 0.458
Insr insulin receptor 0.444
Ctnnb1 catenin (cadherin associated protein), beta 1 0.442
Vegfa vascular endothelial growth factor A 0.439
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.435
Prox1 prospero-related homeobox 1 0.413
Vipr1 vasoactive intestinal peptide receptor 1 0.405
Pax3 paired box gene 3 0.392
Fst follistatin 0.376
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.369
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.363
Ern2 endoplasmic reticulum (ER) to nucleus signalling 2 0.363
Otp orthopedia homolog (Drosophila) 0.362
Pdx1 pancreatic and duodenal homeobox 1 0.356
Esr2 estrogen receptor 2 (beta) 0.355
Pax2 paired box gene 2 0.352
Nkx2-2 NK2 transcription factor related, locus 2 (Drosophila) 0.345
Tnf tumor necrosis factor 0.343
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.341
Tgfbr2 transforming growth factor, beta receptor II 0.333
Vdr vitamin D receptor 0.324
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.324
Hoxd13 homeobox D13 0.323
Jag1 jagged 1 0.320
Lmx1b LIM homeobox transcription factor 1 beta 0.318
Shc3 src homology 2 domain-containing transforming protein C3 0.308
Rdh10 retinol dehydrogenase 10 (all-trans) 0.302
Ltb lymphotoxin B 0.301
Eya1 eyes absent 1 homolog (Drosophila) 0.296
Smad6 MAD homolog 6 (Drosophila) 0.294
Efnb2 ephrin B2 0.294
Adrb1 adrenergic receptor, beta 1 0.288
Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 0.273
Ar androgen receptor 0.272
Wwox WW domain-containing oxidoreductase 0.265
Cav1 caveolin 1, caveolae protein 0.263
Lef1 lymphoid enhancer binding factor 1 0.263
Prlr prolactin receptor 0.260
Mgat3 mannoside acetylglucosaminyltransferase 3 0.250
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.248
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.248
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.245
Grid2 glutamate receptor, ionotropic, delta 2 0.243
Nrxn3 neurexin III 0.241
Alx4 aristaless-like homeobox 4 0.239
Sstr3 somatostatin receptor 3 0.239
Hnf4a hepatic nuclear factor 4, alpha 0.238
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.237
Rxra retinoid X receptor alpha 0.237
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.232
Foxg1 forkhead box G1 0.224
Kcnk3 potassium channel, subfamily K, member 3 0.223
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.220
Sox4 SRY-box containing gene 4 0.220
Irs2 insulin receptor substrate 2 0.215
Anxa2 annexin A2 0.215
Ret ret proto-oncogene 0.214
Irs1 insulin receptor substrate 1 0.210
H2-Eb1 histocompatibility 2, class II antigen E beta 0.206
Insm1 insulinoma-associated 1 0.205
Snap23 synaptosomal-associated protein 23 0.204
Adra2a adrenergic receptor, alpha 2a 0.198
Gast gastrin 0.197
Galr1 galanin receptor 1 0.197
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.302
Neurod2 neurogenic differentiation 2 0.295
Apoa4 apolipoprotein A-IV 0.282
Hrh3 histamine receptor H3 0.273
Nfasc neurofascin 0.227
Pnoc prepronociceptin 0.203
Egr3 early growth response 3 0.182
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.167
Abcc8 ATP-binding cassette, subfamily C (CFTR/MRP), member 8 0.167
Syt4 synaptotagmin IV 0.161
Notch4 Notch homolog 4 (Drosophila) 0.135
Rxrg retinoid X receptor gamma 0.132
Dnase1 deoxyribonuclease I 0.131
Camk2g calcium/calmodulin-dependent protein kinase II gamma 0.123
Iapp islet amyloid polypeptide 0.122
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.121
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.121
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.120
Glp1r glucagon-like peptide 1 receptor 0.119
Bsn bassoon 0.113
RT1-Ba RT1 class II, locus Ba 0.112
Adam5 a disintegrin and metallopeptidase domain 5 0.112
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.111
Ins2 insulin 2 0.109
Casp3 caspase 3 0.109
Dbp D site of albumin promoter (albumin D-box) binding protein 0.109
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.106
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.103
Faim2 Fas apoptotic inhibitory molecule 2 0.099
Reg3g regenerating islet-derived 3 gamma 0.098
Ppara peroxisome proliferator activated receptor alpha 0.097
Prph2 peripherin 2 0.097
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.095
Phkg1 phosphorylase kinase, gamma 1 0.095
Camk1g calcium/calmodulin-dependent protein kinase IG 0.094
Gast gastrin 0.093
Grm7 glutamate receptor, metabotropic 7 0.093
Ush1c Usher syndrome 1C homolog (human) 0.092
Rp9 retinitis pigmentosa 9 (human) 0.092
Sstr2 somatostatin receptor 2 0.091
Rims1 regulating synaptic membrane exocytosis 1 0.090
Pnliprp2 pancreatic lipase-related protein 2 0.089
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.089
Rab3b RAB3B, member RAS oncogene family 0.088
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.088
Scn10a sodium channel, voltage-gated, type X, alpha subunit 0.084
Necab2 N-terminal EF-hand calcium binding protein 2 0.084
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.083
Syn1 synapsin I 0.083
Cga glycoprotein hormones, alpha polypeptide 0.080
Pde3a phosphodiesterase 3A, cGMP inhibited 0.080
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.079
Ecel1 endothelin converting enzyme-like 1 0.079
Lifr leukemia inhibitory factor receptor alpha 0.079
Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 0.079
Ppyr1 pancreatic polypeptide receptor 1 0.078
Mtmr7 myotubularin related protein 7 0.077
Acaa1b acetyl-Coenzyme A acyltransferase 1B 0.076
Tshb thyroid stimulating hormone, beta 0.076
Acot12 acyl-CoA thioesterase 12 0.076
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.075
Adam1a a disintegrin and metallopeptidase domain 1a 0.075
Nell2 NEL-like 2 (chicken) 0.074
Pecam1 platelet/endothelial cell adhesion molecule 1 0.073
Mamdc4 MAM domain containing 4 0.073
Gjd2 gap junction protein, delta 2 0.072
Cds2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 0.072
Tmod2 tropomodulin 2 0.072
Grm5 glutamate receptor, metabotropic 5 0.071
Mertk c-mer proto-oncogene tyrosine kinase 0.071
Chrnb2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.071
Cxcr5 chemokine (C-X-C motif) receptor 5 0.070
Ptgfr prostaglandin F receptor 0.069
Grk4 G protein-coupled receptor kinase 4 0.069
Fbp1 fructose-1,6-bisphosphatase 1 0.069
Cdh22 cadherin 22 0.069
Olr414 olfactory receptor 414 0.069
Slc28a1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 0.068
Sftpd surfactant protein D 0.068
Crhr1 corticotropin releasing hormone receptor 1 0.068
Smad3 SMAD family member 3 0.068
Fam168b family with sequence similarity 168, member B 0.068
Pcsk4 proprotein convertase subtilisin/kexin type 4 0.067
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.067
Sebox SEBOX homeobox 0.067
Aqp2 aquaporin 2 (collecting duct) 0.066
Igf2 insulin-like growth factor 2 0.066
Dmrta1 DMRT-like family A1 0.065
Gata4 GATA binding protein 4 0.065
Csn2 casein beta 0.064
Insr insulin receptor 0.064
Gpr173 G-protein coupled receptor 173 0.063
Plin perilipin 0.063
Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.062
Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 0.062
Mef2d myocyte enhancer factor 2D 0.062
Olr1654 olfactory receptor 1654 0.061
Ptprh protein tyrosine phosphatase, receptor type, H 0.061
Pdx1 pancreatic and duodenal homeobox 1 0.061
Idi1 isopentenyl-diphosphate delta isomerase 1 0.061
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism