The network for 'regulation of heart morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of heart morphogenesis

Any process that modulates the frequency, rate or extent of heart morphogenesis.

Homo sapiens
Name Description Probability Func Analog Organism
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.928
LRP6 low density lipoprotein receptor-related protein 6 0.910
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.906
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.904
CSNK1E casein kinase 1, epsilon 0.899
BMPR1A bone morphogenetic protein receptor, type IA 0.812
NOTCH1 notch 1 0.799
LRRK2 leucine-rich repeat kinase 2 0.760
SP1 Sp1 transcription factor 0.727
FOXD3 forkhead box D3 0.726
JAG1 jagged 1 0.714
PAX3 paired box 3 0.662
SETD8 SET domain containing (lysine methyltransferase) 8 0.634
SOX10 SRY (sex determining region Y)-box 10 0.622
SPEN spen homolog, transcriptional regulator (Drosophila) 0.612
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.596
AXIN1 axin 1 0.545
SOX2 SRY (sex determining region Y)-box 2 0.507
SMAD3 SMAD family member 3 0.491
CTNNBIP1 catenin, beta interacting protein 1 0.450
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.416
FZD1 frizzled homolog 1 (Drosophila) 0.377
MAML1 mastermind-like 1 (Drosophila) 0.278
NOTCH3 notch 3 0.275
SNIP1 Smad nuclear interacting protein 1 0.240
FSTL1 follistatin-like 1 0.199
ATXN1L ataxin 1-like 0.197
BTRC beta-transducin repeat containing 0.182
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.178
SMAD1 SMAD family member 1 0.166
GSK3B glycogen synthase kinase 3 beta 0.165
GATA4 GATA binding protein 4 0.161
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.160
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.146
TCF4 transcription factor 4 0.135
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.133
ZFYVE9 zinc finger, FYVE domain containing 9 0.124
ZNF512B zinc finger protein 512B 0.123
CEP164 centrosomal protein 164kDa 0.122
SMAD7 SMAD family member 7 0.107
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.106
CTNND1 catenin (cadherin-associated protein), delta 1 0.103
MDFI MyoD family inhibitor 0.102
HMGA1 high mobility group AT-hook 1 0.101
SMAD2 SMAD family member 2 0.094
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.086
WT1 Wilms tumor 1 0.082
CSNK1D casein kinase 1, delta 0.072
SNW1 SNW domain containing 1 0.069
EP300 E1A binding protein p300 0.069
SOX11 SRY (sex determining region Y)-box 11 0.063
BTF3 basic transcription factor 3 0.061
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.060
TAOK1 TAO kinase 1 0.058
FZD8 frizzled homolog 8 (Drosophila) 0.053
XIAP X-linked inhibitor of apoptosis 0.048
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.048
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.046
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.044
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.044
FST follistatin 0.043
ATF7IP activating transcription factor 7 interacting protein 0.043
BBS10 Bardet-Biedl syndrome 10 0.042
CXXC5 CXXC finger protein 5 0.040
DSP desmoplakin 0.039
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.039
SKI v-ski sarcoma viral oncogene homolog (avian) 0.037
JAG2 jagged 2 0.037
ATN1 atrophin 1 0.037
PITX1 paired-like homeodomain 1 0.036
NR5A1 nuclear receptor subfamily 5, group A, member 1 0.034
MEOX2 mesenchyme homeobox 2 0.034
HTT huntingtin 0.034
KLF5 Kruppel-like factor 5 (intestinal) 0.034
TSC22D1 TSC22 domain family, member 1 0.034
PTPRF protein tyrosine phosphatase, receptor type, F 0.034
EYA2 eyes absent homolog 2 (Drosophila) 0.034
NOG noggin 0.033
MCC mutated in colorectal cancers 0.033
HOXC8 homeobox C8 0.032
BAHD1 bromo adjacent homology domain containing 1 0.032
SOX1 SRY (sex determining region Y)-box 1 0.032
NOTCH2 notch 2 0.031
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 0.030
PITX2 paired-like homeodomain 2 0.030
FUNDC2 FUN14 domain containing 2 0.030
MYST2 MYST histone acetyltransferase 2 0.029
APC adenomatous polyposis coli 0.029
EYA1 eyes absent homolog 1 (Drosophila) 0.029
PDX1 pancreatic and duodenal homeobox 1 0.029
DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae) 0.029
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.028
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.028
FOXE1 forkhead box E1 (thyroid transcription factor 2) 0.028
HCFC1 host cell factor C1 (VP16-accessory protein) 0.028
RPL41 ribosomal protein L41 0.028
FOXO3 forkhead box O3 0.028
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.028
CIR1 corepressor interacting with RBPJ, 1 0.027
BMP4 bone morphogenetic protein 4 0.027
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.998
bmp2b bone morphogenetic protein 2b 0.956
ndr2 nodal-related 2 0.952
ntla no tail a 0.930
lft2 lefty2 0.927
nkx2.5 NK2 transcription factor related 5 0.924
chd chordin 0.920
bmp4 bone morphogenetic protein 4 0.899
tbx16 T-box gene 16 0.886
shha sonic hedgehog a 0.868
tbx5a T-box 5a 0.818
lft1 lefty1 0.814
flh floating head 0.783
fn1 fibronectin 1 0.775
myf5 myogenic factor 5 0.774
wnt5b wingless-type MMTV integration site family, member 5b 0.753
tbx20 T-box 20 0.749
spaw southpaw 0.657
sox32 SRY-box containing gene 32 0.646
dld deltaD 0.588
foxi1 forkhead box I1 0.580
smo smoothened homolog (Drosophila) 0.557
gata4 GATA-binding protein 4 0.557
dkk1b dickkopf 1b 0.500
oep one-eyed pinhead 0.494
six4b sine oculis homeobox homolog 4b 0.475
ndr1 nodal-related 1 0.457
myl7 myosin, light polypeptide 7, regulatory 0.440
hand2 heart and neural crest derivatives expressed transcript 2 0.433
dharma dharma 0.430
cdh2 cadherin 2, neuronal 0.430
mib mind bomb 0.428
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.400
nkx3.2 NK3 homeobox 2 0.394
fgf10a fibroblast growth factor 10a 0.384
hhex hematopoietically expressed homeobox 0.345
pcdh8 protocadherin 8 0.292
myod1 myogenic differentiation 1 0.255
foxd5 forkhead box D5 0.250
wnt11 wingless-type MMTV integration site family, member 11 0.242
fgf8a fibroblast growth factor 8 a 0.234
axin1 axin 1 0.226
nkx2.2b NK2 transcription factor related 2b 0.221
pitx2 paired-like homeodomain transcription factor 2 0.221
ptch2 patched 2 0.216
mespa mesoderm posterior a 0.206
bmp7a bone morphogenetic protein 7a 0.198
pkd2 polycystic kidney disease 2 0.187
has2 hyaluronan synthase 2 0.170
foxa1 forkhead box A1 0.156
bon bonnie and clyde 0.153
foxa2 forkhead box A2 0.149
igf1rb insulin-like growth factor 1b receptor 0.149
nog1 noggin 1 0.148
six4a sine oculis homeobox homolog 4a 0.148
tnnt2a troponin T2a, cardiac 0.147
plcg1 phospholipase C, gamma 1 0.139
tnnc1a troponin C type 1a (slow) 0.134
her7 hairy and enhancer of split related-7 0.118
gata5 GATA-binding protein 5 0.115
admp anti-dorsalizing morphogenic protein 0.115
her1 hairy-related 1 0.114
runx2b runt-related transcription factor 2b 0.112
nppa natriuretic peptide precursor A 0.111
wif1 wnt inhibitory factor 1 0.107
pomca proopiomelanocortin a 0.106
ptch1 patched 1 0.105
fgf3 fibroblast growth factor 3 0.099
sox17 SRY-box containing gene 17 0.098
vasa vasa homolog 0.096
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.095
cmlc1 cardiac myosin light chain-1 0.094
gro2 groucho 2 0.091
hnf1ba HNF1 homeobox Ba 0.088
vmhcl ventricular myosin heavy chain-like 0.086
klf4 Kruppel-like factor 4 0.085
snai1a snail homolog 1a (Drosophila) 0.084
eya1 eyes absent homolog 1 0.082
msgn1 mesogenin 1 0.080
lhx1a LIM homeobox 1a 0.077
gli1 GLI-Kruppel family member 1 0.076
cdh1 cadherin 1, epithelial 0.076
tbx5b T-box 5b 0.074
fzd10 frizzled homolog 10 0.071
shhb sonic hedgehog b 0.068
foxh1 forkhead box H1 0.067
waca WW domain containing adaptor with coiled-coil a 0.067
rx3 retinal homeobox gene 3 0.067
elk4 ELK4, ETS-domain protein 0.065
acvr1b activin A receptor, type IB 0.064
szl sizzled 0.063
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.063
nkx2.1a NK2 homeobox 1a 0.062
lhx5 LIM homeobox 5 0.060
tcf21 transcription factor 21 0.057
aplnrb apelin receptor b 0.057
hoxd11a homeo box D11a 0.056
her5 hairy-related 5 0.055
pax2a paired box gene 2a 0.055
tbx2a T-box gene 2a 0.055
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Drosophila melanogaster
Name Description Probability Func Analog Organism
hh hedgehog 0.998
dpp decapentaplegic 0.991
tin tinman 0.944
Egfr Epidermal growth factor receptor 0.940
wg wingless 0.870
ci cubitus interruptus 0.869
N Notch 0.859
hth homothorax 0.856
en engrailed 0.837
eya eyes absent 0.640
Rac1 CG2248 gene product from transcript CG2248-RA 0.607
so sine oculis 0.601
brk brinker 0.589
Ser Serrate 0.529
sna snail 0.474
fz frizzled 0.392
vg vestigial 0.363
Ubx Ultrabithorax 0.344
hkb huckebein 0.316
Moe Moesin 0.303
Mef2 Myocyte enhancer factor 2 0.282
gbb glass bottom boat 0.275
Dl Delta 0.259
ush u-shaped 0.257
ft fat 0.253
sd scalloped 0.249
ey eyeless 0.245
kni knirps 0.228
fas faint sausage 0.218
gro groucho 0.214
slou slouch 0.208
pnr pannier 0.207
Su(H) Suppressor of Hairless 0.198
dsh dishevelled 0.193
rib ribbon 0.180
tsh teashirt 0.167
crb crumbs 0.146
hyd hyperplastic discs 0.145
shn schnurri 0.130
disco disconnected 0.124
slp1 sloppy paired 1 0.119
nau nautilus 0.117
Lim1 CG11354 gene product from transcript CG11354-RA 0.115
pb proboscipedia 0.113
twi twist 0.111
opa odd paired 0.107
sr stripe 0.105
dally division abnormally delayed 0.104
slp2 sloppy paired 2 0.103
fj four-jointed 0.101
tll tailless 0.097
Wnt4 Wnt oncogene analog 4 0.096
ptc patched 0.096
sog short gastrulation 0.088
fkh fork head 0.085
fng fringe 0.084
argos CG4531 gene product from transcript CG4531-RA 0.084
lz lozenge 0.082
scny scrawny 0.080
Dad Daughters against dpp 0.080
HLH54F CG5005 gene product from transcript CG5005-RA 0.080
kn knot 0.078
al aristaless 0.073
tld tolloid 0.072
l(2)gl lethal (2) giant larvae 0.068
Gsc Goosecoid 0.066
Antp Antennapedia 0.065
pan pangolin 0.063
nkd naked cuticle 0.062
bin biniou 0.061
bi bifid 0.058
stmA stambha A 0.057
tkv thickveins 0.055
run runt 0.052
if inflated 0.049
dock dreadlocks 0.048
srp serpent 0.046
Adam CG12131 gene product from transcript CG12131-RA 0.044
bab2 CG9102 gene product from transcript CG9102-RA 0.044
crp cropped 0.043
ap apterous 0.043
sbb scribbler 0.042
byn brachyenteron 0.040
vav CG7893 gene product from transcript CG7893-RB 0.039
lab labial 0.039
pcx pecanex 0.038
pasha partner of drosha 0.038
gcm glial cells missing 0.038
eve even skipped 0.038
Med Medea 0.037
ds dachsous 0.037
nullo CG14426 gene product from transcript CG14426-RB 0.037
stumps CG31317 gene product from transcript CG31317-RC 0.035
tth toothrin 0.035
dy dusky 0.034
arm armadillo 0.034
Notum CG13076 gene product from transcript CG13076-RB 0.034
ara araucan 0.033
aop anterior open 0.032
kirre kin of irre 0.031
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Bmp4 bone morphogenetic protein 4 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Eya1 eyes absent 1 homolog (Drosophila) 1.000
Foxc2 forkhead box C2 1.000
Pax3 paired box gene 3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Foxc1 forkhead box C1 1.000
Pax2 paired box gene 2 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Pax6 paired box gene 6 0.999
Foxg1 forkhead box G1 0.998
Bmp7 bone morphogenetic protein 7 0.997
Fgf8 fibroblast growth factor 8 0.996
Sox2 SRY-box containing gene 2 0.996
Tbx1 T-box 1 0.994
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.994
Rarg retinoic acid receptor, gamma 0.993
Tcfap2a transcription factor AP-2, alpha 0.993
Msx1 homeobox, msh-like 1 0.993
Ctnnb1 catenin (cadherin associated protein), beta 1 0.991
Tbx3 T-box 3 0.987
Fgfr1 fibroblast growth factor receptor 1 0.987
Vangl2 vang-like 2 (van gogh, Drosophila) 0.985
Hand1 heart and neural crest derivatives expressed transcript 1 0.985
Sox9 SRY-box containing gene 9 0.971
Tgfb2 transforming growth factor, beta 2 0.970
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.967
Gata4 GATA binding protein 4 0.967
Nog noggin 0.950
Prrx1 paired related homeobox 1 0.945
Lmx1a LIM homeobox transcription factor 1 alpha 0.932
Hoxa1 homeobox A1 0.931
Dlx5 distal-less homeobox 5 0.913
Jag1 jagged 1 0.893
Isl1 ISL1 transcription factor, LIM/homeodomain 0.887
Gsc goosecoid homeobox 0.887
Emx2 empty spiracles homolog 2 (Drosophila) 0.886
Pitx1 paired-like homeodomain transcription factor 1 0.882
Gbx2 gastrulation brain homeobox 2 0.875
Emx1 empty spiracles homolog 1 (Drosophila) 0.870
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.866
Hes1 hairy and enhancer of split 1 (Drosophila) 0.856
Hoxd13 homeobox D13 0.825
Msx2 homeobox, msh-like 2 0.804
Hoxa13 homeobox A13 0.796
Meox2 mesenchyme homeobox 2 0.784
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.781
Smo smoothened homolog (Drosophila) 0.779
Zic3 zinc finger protein of the cerebellum 3 0.772
Vegfa vascular endothelial growth factor A 0.766
Prrx2 paired related homeobox 2 0.747
Lmx1b LIM homeobox transcription factor 1 beta 0.746
Zeb1 zinc finger E-box binding homeobox 1 0.745
Smad6 MAD homolog 6 (Drosophila) 0.741
Pbx1 pre B-cell leukemia transcription factor 1 0.717
Gli2 GLI-Kruppel family member GLI2 0.704
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.677
Runx2 runt related transcription factor 2 0.656
Alx4 aristaless-like homeobox 4 0.655
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.647
Fgf10 fibroblast growth factor 10 0.631
Chd7 chromodomain helicase DNA binding protein 7 0.623
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.619
Hmx1 H6 homeobox 1 0.580
En1 engrailed 1 0.571
Pax8 paired box gene 8 0.554
Wnt3a wingless-related MMTV integration site 3A 0.534
Otx1 orthodenticle homolog 1 (Drosophila) 0.523
Hoxd11 homeobox D11 0.512
Rarb retinoic acid receptor, beta 0.502
Sox11 SRY-box containing gene 11 0.493
Lrp6 low density lipoprotein receptor-related protein 6 0.487
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.484
Neurog2 neurogenin 2 0.471
Neurod1 neurogenic differentiation 1 0.457
Hoxa2 homeobox A2 0.453
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.452
Snai1 snail homolog 1 (Drosophila) 0.448
Hoxa10 homeobox A10 0.448
Foxa2 forkhead box A2 0.446
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.393
Fgfr3 fibroblast growth factor receptor 3 0.375
Smad4 MAD homolog 4 (Drosophila) 0.373
Tbx15 T-box 15 0.360
Sox3 SRY-box containing gene 3 0.350
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.338
Gata6 GATA binding protein 6 0.320
Tlx3 T-cell leukemia, homeobox 3 0.319
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.314
Gdf5 growth differentiation factor 5 0.303
Notch2 Notch gene homolog 2 (Drosophila) 0.302
Dlx6 distal-less homeobox 6 0.301
Axin1 axin 1 0.293
Smad1 MAD homolog 1 (Drosophila) 0.290
Ednra endothelin receptor type A 0.290
Notch1 Notch gene homolog 1 (Drosophila) 0.290
Alx3 aristaless-like homeobox 3 0.286
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Rattus norvegicus
Name Description Probability Func Analog Organism
Laptm5 lysosomal protein transmembrane 5 0.027
Arpc1b actin related protein 2/3 complex, subunit 1B 0.022
Fcer1g Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.021
C1s complement component 1, s subcomponent 0.017
RT1-Da RT1 class II, locus Da 0.017
Ctss cathepsin S 0.014
Ifitm3 interferon induced transmembrane protein 3 0.014
Cd53 Cd53 molecule 0.014
C1qa complement component 1, q subcomponent, A chain 0.014
Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.013
Tyrobp Tyro protein tyrosine kinase binding protein 0.013
C1qb complement component 1, q subcomponent, B chain 0.013
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.013
Vim vimentin 0.013
Mgp matrix Gla protein 0.012
Lyz2 lysozyme 2 0.012
Grn granulin 0.012
Ear11 eosinophil-associated, ribonuclease A family, member 11 0.012
Lgals3 lectin, galactoside-binding, soluble, 3 0.012
Rpl11 ribosomal protein L11 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism