The network for 'engulfment of apoptotic cell' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

engulfment of apoptotic cell

The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.

Homo sapiens
Name Description Probability Func Analog Organism
MAPK8 mitogen-activated protein kinase 8 0.982
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.966
SH3KBP1 SH3-domain kinase binding protein 1 0.958
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.923
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 0.879
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.875
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.872
FGF1 fibroblast growth factor 1 (acidic) 0.858
MAP2K4 mitogen-activated protein kinase kinase 4 0.821
ATF2 activating transcription factor 2 0.657
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.645
FYN FYN oncogene related to SRC, FGR, YES 0.638
FN1 fibronectin 1 0.596
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.564
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.561
CFLAR CASP8 and FADD-like apoptosis regulator 0.525
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.485
CTGF connective tissue growth factor 0.470
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.463
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.458
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.449
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.447
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.444
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.415
NXF1 nuclear RNA export factor 1 0.409
SOS1 son of sevenless homolog 1 (Drosophila) 0.407
ADAM19 ADAM metallopeptidase domain 19 0.382
JUN jun proto-oncogene 0.377
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.358
DYNLT3 dynein, light chain, Tctex-type 3 0.354
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.348
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.339
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.325
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.314
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.285
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.283
NCKAP1 NCK-associated protein 1 0.261
EGFR epidermal growth factor receptor 0.256
ARRB1 arrestin, beta 1 0.250
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.249
PXN paxillin 0.247
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa 0.246
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.244
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.242
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.230
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.230
ABI1 abl-interactor 1 0.197
BCOR BCL6 corepressor 0.188
IQGAP1 IQ motif containing GTPase activating protein 1 0.185
TCF4 transcription factor 4 0.164
FADD Fas (TNFRSF6)-associated via death domain 0.161
FGF2 fibroblast growth factor 2 (basic) 0.158
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.154
RIN1 Ras and Rab interactor 1 0.152
SPRR2A small proline-rich protein 2A 0.150
DNM1 dynamin 1 0.144
S100A10 S100 calcium binding protein A10 0.144
CORO1C coronin, actin binding protein, 1C 0.143
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.142
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.139
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.138
PDCD6 programmed cell death 6 0.135
NAV1 neuron navigator 1 0.133
ANXA1 annexin A1 0.131
KIF5B kinesin family member 5B 0.131
SS18 synovial sarcoma translocation, chromosome 18 0.129
VCL vinculin 0.128
WASL Wiskott-Aldrich syndrome-like 0.128
ANXA5 annexin A5 0.122
HSPG2 heparan sulfate proteoglycan 2 0.119
NME3 non-metastatic cells 3, protein expressed in 0.116
GOLGA2 golgin A2 0.111
RHOA ras homolog gene family, member A 0.111
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.101
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.100
MYL12B myosin, light chain 12B, regulatory 0.100
SNX9 sorting nexin 9 0.100
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.092
NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1 0.090
SOS2 son of sevenless homolog 2 (Drosophila) 0.089
CBFB core-binding factor, beta subunit 0.087
WASF1 WAS protein family, member 1 0.087
NCK1 NCK adaptor protein 1 0.085
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) 0.085
FBXW11 F-box and WD repeat domain containing 11 0.085
ORC1 origin recognition complex, subunit 1 0.083
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.082
ADAM9 ADAM metallopeptidase domain 9 0.080
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.080
MSN moesin 0.079
GLOD4 glyoxalase domain containing 4 0.079
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.078
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.078
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.074
XPO7 exportin 7 0.073
PICALM phosphatidylinositol binding clathrin assembly protein 0.073
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.073
RAB14 RAB14, member RAS oncogene family 0.073
FGFR1 fibroblast growth factor receptor 1 0.072
EPS8 epidermal growth factor receptor pathway substrate 8 0.069
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
gei-18 Protein GEI-18 0.260
mig-2 Protein MIG-2 0.117
rab-5 Protein RAB-5 0.113
sem-5 Protein SEM-5 0.107
pat-2 Protein PAT-2 0.086
T19A5.3 Protein T19A5.3 0.084
hpo-22 Protein HPO-22 0.074
ina-1 Protein INA-1 0.073
ptr-11 Protein PTR-11 0.070
F59A3.4 Protein F59A3.4 0.068
mam-3 Protein MAM-3 0.067
CELE_Y39B6A.1 Protein Y39B6A.1 0.067
npp-7 Protein NPP-7 0.061
cka-1 Protein CKA-1 0.061
ubc-20 Protein UBC-20 0.061
epg-8 Protein EPG-8 0.060
sptl-3 Protein SPTL-3 0.059
oac-46 Protein OAC-46 0.059
F13B12.1 Protein F13B12.1 0.059
C33A11.1 Protein C33A11.1 0.057
cdc-42 Protein CDC-42 0.057
pat-3 Protein PAT-3 0.055
praf-3 Protein PRAF-3 0.055
mex-1 Protein MEX-1 0.054
K10C8.3 Protein K10C8.3 0.054
lat-1 Protein LAT-1 0.052
acl-14 Protein ACL-14 0.052
ung-1 Protein UNG-1 0.051
acy-3 Protein ACY-3 0.051
CELE_C12D8.1 Protein C12D8.1 0.049
pry-1 Protein PRY-1 0.049
ced-10 Protein CED-10 0.049
erp-1 Protein ERP-1 0.048
let-60 Protein LET-60 0.048
hpo-28 Protein HPO-28 0.047
mdt-19 Protein MDT-19 0.047
sar-1 Protein SAR-1 0.047
dyn-1 Protein DYN-1 0.046
aph-2 Protein APH-2 0.046
swd-2.2 Protein SWD-2.2 0.046
CELE_Y37A1B.17 Protein Y37A1B.17 0.045
F44B9.5 Protein F44B9.5 0.045
R02F11.1 Protein R02F11.1 0.045
ttr-6 Protein TTR-6 0.045
R10E11.6 Protein R10E11.6 0.045
chc-1 Protein CHC-1 0.044
Y25C1A.5 Protein Y25C1A.5 0.044
vms-1 Protein VMS-1 0.044
Y106G6A.1 Protein Y106G6A.1 0.043
ZC247.2 Protein ZC247.2 0.043
F57B10.8 Protein F57B10.8 0.042
rgl-1 Protein RGL-1 0.042
sas-4 Protein SAS-4 0.041
msh-6 Protein MSH-6 0.041
CELE_C29F7.3 Protein C29F7.3 0.041
unc-73 Protein UNC-73 0.041
plc-3 Protein PLC-3 0.041
C49H3.6 Protein C49H3.6 0.040
F16F9.4 Protein F16F9.4 0.040
mig-1 Protein MIG-1 0.040
F10G8.6 Protein F10G8.6 0.040
dpf-7 Protein DPF-7 0.040
rsp-2 Protein RSP-2 0.040
cki-1 Protein CKI-1 0.040
CELE_Y69H2.3 Protein Y69H2.3 0.040
K10D3.4 Protein K10D3.4 0.039
R74.8 Protein R74.8 0.039
ehbp-1 Protein EHBP-1 0.039
Y55F3AM.3 Protein Y55F3AM.3 0.038
rab-10 Protein RAB-10 0.038
snap-1 Protein SNAP-1 0.038
rnf-121 Protein RNF-121 0.037
ced-6 Protein CED-6 0.037
bus-18 Protein BUS-18 0.037
slo-1 Protein SLO-1 0.037
dcn-1 Protein DCN-1 0.037
acs-20 Protein ACS-20 0.037
F13D12.3 Protein F13D12.3 0.037
D2085.5 Protein D2085.5 0.037
T27E9.2 Protein T27E9.2 0.037
abu-13 Protein ABU-13 0.036
unc-43 Protein UNC-43 0.036
ets-6 Protein ETS-6 0.036
unc-6 Protein UNC-6 0.036
vav-1 Protein VAV-1 0.036
cyk-3 Protein CYK-3 0.036
mup-4 Protein MUP-4 0.036
B0336.3 Protein B0336.3 0.036
Y43F4B.10 Protein Y43F4B.10 0.036
ttx-1 Protein TTX-1 0.036
CELE_Y64G10A.7 Protein Y64G10A.7 0.036
T24B8.3 Protein T24B8.3 0.035
cex-1 Protein CEX-1 0.035
C13C4.5 Protein C13C4.5 0.035
pcaf-1 Protein PCAF-1 0.035
scpl-2 Protein SCPL-2 0.035
pbs-2 Protein PBS-2 0.035
pxf-1 Protein PXF-1 0.035
nhx-9 Protein NHX-9 0.035
pcf-11 Protein PCF-11 0.035
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rab5 Rab-protein 5 0.156
Cdc42 CG12530 gene product from transcript CG12530-RA 0.113
Arp66B Actin-related protein 66B 0.108
mbc myoblast city 0.102
ena enabled 0.068
Pvr PDGF- and VEGF-receptor related 0.065
Rho1 CG8416 gene product from transcript CG8416-RB 0.065
chic chickadee 0.052
Hem HEM-protein 0.045
Lis-1 Lissencephaly-1 0.040
Eb1 CG3265 gene product from transcript CG3265-RF 0.037
gek genghis khan 0.031
cno canoe 0.029
mop myopic 0.025
Rac2 CG8556 gene product from transcript CG8556-RA 0.025
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.023
Rel Relish 0.023
bsk basket 0.023
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.021
Moe Moesin 0.020
Vrp1 Verprolin 1 0.019
BG4 CG12297 gene product from transcript CG12297-RA 0.016
kst karst 0.016
Chc Clathrin heavy chain 0.015
Smox Smad on X 0.014
Rab11 Rab-protein 11 0.014
stc shuttle craft 0.013
Arf51F ADP ribosylation factor 51F 0.013
Rab6 Rab-protein 6 0.013
Dlic Dynein light intermediate chain 0.012
rhea CG6831 gene product from transcript CG6831-RA 0.012
mts microtubule star 0.012
Rac1 CG2248 gene product from transcript CG2248-RA 0.012
rok Rho-kinase 0.012
imd immune deficiency 0.012
Rala Ras-related protein 0.012
Vps16A Vacuolar protein sorting 16A 0.011
WASp CG1520 gene product from transcript CG1520-RA 0.011
Arf79F ADP ribosylation factor 79F 0.011
kel kelch 0.011
fng fringe 0.010
CG16718 CG16718 gene product from transcript CG16718-RA 0.010
bnl branchless 0.010
S6k RPS6-p70-protein kinase 0.010
Dcr-2 Dicer-2 0.010
mew multiple edematous wings 0.010
G-oalpha47A G protein oalpha 47A 0.010
zip zipper 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.979
Pten phosphatase and tensin homolog 0.974
Bmpr1a bone morphogenetic protein receptor, type 1A 0.882
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.875
Dysf dysferlin 0.871
Rac1 RAS-related C3 botulinum substrate 1 0.856
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.814
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.795
Gbp5 guanylate binding protein 5 0.769
Smad3 MAD homolog 3 (Drosophila) 0.745
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.705
Eng endoglin 0.696
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.682
Hif1a hypoxia inducible factor 1, alpha subunit 0.678
Ltb lymphotoxin B 0.671
Pak1 p21 protein (Cdc42/Rac)-activated kinase 1 0.671
Efnb2 ephrin B2 0.645
Axin1 axin 1 0.629
Apc adenomatosis polyposis coli 0.601
Smad4 MAD homolog 4 (Drosophila) 0.581
Casp1 caspase 1 0.569
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.541
Msn moesin 0.518
Sox9 SRY-box containing gene 9 0.501
Mapk14 mitogen-activated protein kinase 14 0.489
Vcl vinculin 0.485
Ptk2 PTK2 protein tyrosine kinase 2 0.472
Tmem38b transmembrane protein 38B 0.470
Shh sonic hedgehog 0.448
Fstl1 follistatin-like 1 0.432
S100a11 S100 calcium binding protein A11 (calgizzarin) 0.400
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.397
Cxcr4 chemokine (C-X-C motif) receptor 4 0.395
Il1b interleukin 1 beta 0.370
Itgb3 integrin beta 3 0.359
Tnf tumor necrosis factor 0.354
Apoe apolipoprotein E 0.353
Add1 adducin 1 (alpha) 0.346
Rdh8 retinol dehydrogenase 8 0.337
Ric8 resistance to inhibitors of cholinesterase 8 homolog (C. elegans) 0.320
Lta lymphotoxin A 0.318
Anxa1 annexin A1 0.314
Lgals3 lectin, galactose binding, soluble 3 0.303
Becn1 beclin 1, autophagy related 0.302
Npc1 Niemann Pick type C1 0.298
Thbs2 thrombospondin 2 0.297
Nf2 neurofibromatosis 2 0.286
Csf1 colony stimulating factor 1 (macrophage) 0.283
Lrp6 low density lipoprotein receptor-related protein 6 0.280
Mapk9 mitogen-activated protein kinase 9 0.275
Tox thymocyte selection-associated high mobility group box 0.273
Osmr oncostatin M receptor 0.271
Il7 interleukin 7 0.271
Pacsin1 protein kinase C and casein kinase substrate in neurons 1 0.268
Klc2 kinesin light chain 2 0.261
Il6st interleukin 6 signal transducer 0.261
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.261
S100a6 S100 calcium binding protein A6 (calcyclin) 0.260
Cycs cytochrome c, somatic 0.258
Ikbkb inhibitor of kappaB kinase beta 0.258
Lrp1 low density lipoprotein receptor-related protein 1 0.251
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.251
Tpm4 tropomyosin 4 0.249
Cstb cystatin B 0.247
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.242
Alox5ap arachidonate 5-lipoxygenase activating protein 0.229
Arhgdib Rho, GDP dissociation inhibitor (GDI) beta 0.223
Lyz2 lysozyme 2 0.218
Nid1 nidogen 1 0.215
Rbl2 retinoblastoma-like 2 0.215
Trp53 transformation related protein 53 0.214
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.211
Klf5 Kruppel-like factor 5 0.209
Dlg4 discs, large homolog 4 (Drosophila) 0.208
Nde1 nuclear distribution gene E homolog 1 (A nidulans) 0.204
Atf2 activating transcription factor 2 0.204
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.202
Anxa2 annexin A2 0.193
Bsn bassoon 0.193
Cxcr5 chemokine (C-X-C motif) receptor 5 0.192
Grb2 growth factor receptor bound protein 2 0.189
Lgals1 lectin, galactose binding, soluble 1 0.189
Aplp2 amyloid beta (A4) precursor-like protein 2 0.189
Il18 interleukin 18 0.188
S100a10 S100 calcium binding protein A10 (calpactin) 0.188
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.187
Orai1 ORAI calcium release-activated calcium modulator 1 0.187
Wdr1 WD repeat domain 1 0.186
Abcg1 ATP-binding cassette, sub-family G (WHITE), member 1 0.183
Pxn paxillin 0.182
Gsk3b glycogen synthase kinase 3 beta 0.181
Rhoa ras homolog gene family, member A 0.181
Efna1 ephrin A1 0.172
Arhgap1 Rho GTPase activating protein 1 0.172
Pik3cb phosphatidylinositol 3-kinase, catalytic, beta polypeptide 0.171
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.170
Anxa5 annexin A5 0.170
Fgfr1 fibroblast growth factor receptor 1 0.168
Bmp1 bone morphogenetic protein 1 0.168
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism