The network for 'integrin mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

integrin mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FN1 fibronectin 1 1.000
FLNA filamin A, alpha 0.998
FYN FYN oncogene related to SRC, FGR, YES 0.996
FHL2 four and a half LIM domains 2 0.985
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.980
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.978
NME2 non-metastatic cells 2, protein (NM23B) expressed in 0.976
LCK lymphocyte-specific protein tyrosine kinase 0.964
HCK hemopoietic cell kinase 0.875
TLN1 talin 1 0.870
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.857
CD63 CD63 molecule 0.817
VCL vinculin 0.809
PXN paxillin 0.801
COL1A1 collagen, type I, alpha 1 0.776
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.742
COL4A1 collagen, type IV, alpha 1 0.715
LGALS1 lectin, galactoside-binding, soluble, 1 0.709
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.700
COL1A2 collagen, type I, alpha 2 0.676
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.657
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.653
PTK2 PTK2 protein tyrosine kinase 2 0.649
THBS1 thrombospondin 1 0.614
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.571
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.539
FLNB filamin B, beta 0.533
ILK integrin-linked kinase 0.528
PDIA3 protein disulfide isomerase family A, member 3 0.519
COL3A1 collagen, type III, alpha 1 0.491
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.476
SYK spleen tyrosine kinase 0.417
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.409
GRB2 growth factor receptor-bound protein 2 0.407
BCAR1 breast cancer anti-estrogen resistance 1 0.403
IGFBP3 insulin-like growth factor binding protein 3 0.372
BLNK B-cell linker 0.361
COL5A2 collagen, type V, alpha 2 0.351
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.351
EGFR epidermal growth factor receptor 0.323
SPRR2A small proline-rich protein 2A 0.320
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.317
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.303
ITGB4 integrin, beta 4 0.299
DDR2 discoidin domain receptor tyrosine kinase 2 0.290
ABI2 abl-interactor 2 0.262
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.256
ACTN1 actinin, alpha 1 0.248
TIMP1 TIMP metallopeptidase inhibitor 1 0.237
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.233
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.227
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.222
PLEC plectin 0.205
DLG1 discs, large homolog 1 (Drosophila) 0.200
COL4A2 collagen, type IV, alpha 2 0.194
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.193
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.181
VAV1 vav 1 guanine nucleotide exchange factor 0.179
GAB1 GRB2-associated binding protein 1 0.176
PTPRC protein tyrosine phosphatase, receptor type, C 0.173
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.172
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.163
SNX33 sorting nexin 33 0.156
ZNF746 zinc finger protein 746 0.154
VCAM1 vascular cell adhesion molecule 1 0.141
SNX9 sorting nexin 9 0.136
HP haptoglobin 0.135
FYB FYN binding protein 0.131
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.125
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.123
HSPG2 heparan sulfate proteoglycan 2 0.122
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.122
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.112
FBN1 fibrillin 1 0.112
PARVA parvin, alpha 0.103
COL6A1 collagen, type VI, alpha 1 0.101
NME1 non-metastatic cells 1, protein (NM23A) expressed in 0.101
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.097
ANXA5 annexin A5 0.092
COL6A2 collagen, type VI, alpha 2 0.091
PLCG1 phospholipase C, gamma 1 0.091
ALB albumin 0.090
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.088
PDLIM5 PDZ and LIM domain 5 0.088
TCF4 transcription factor 4 0.085
TGFBI transforming growth factor, beta-induced, 68kDa 0.082
ENG endoglin 0.082
ITGA6 integrin, alpha 6 0.082
ITGB5 integrin, beta 5 0.079
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.072
LAMB1 laminin, beta 1 0.072
APOC1 apolipoprotein C-I 0.069
MED28 mediator complex subunit 28 0.068
UBASH3B ubiquitin associated and SH3 domain containing B 0.064
PTN pleiotrophin 0.064
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.063
TNS3 tensin 3 0.061
CALD1 caldesmon 1 0.060
FERMT2 fermitin family member 2 0.060
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
unc-112 Protein UNC-112 0.572
C44C1.1 Protein C44C1.1 0.284
unc-68 Protein UNC-68 0.184
pat-4 Protein PAT-4 0.130
unc-97 Protein UNC-97 0.128
pat-6 Protein PAT-6 0.125
unc-120 Protein UNC-120 0.108
sup-12 Protein SUP-12 0.060
K03B8.6 Protein K03B8.6 0.054
unc-95 Protein UNC-95 0.053
pat-2 Protein PAT-2 0.046
lgc-34 Protein LGC-34 0.039
ttr-6 Protein TTR-6 0.030
B0303.2 Protein B0303.2 0.028
nos-3 Protein NOS-3 0.027
lam-2 Protein LAM-2 0.024
somi-1 Protein SOMI-1 0.022
ina-1 Protein INA-1 0.020
CELE_M04F3.5 Protein M04F3.5 0.020
meg-2 Protein MEG-2 0.020
pat-3 Protein PAT-3 0.020
twk-18 Protein TWK-18 0.019
wrk-1 Protein WRK-1 0.018
hsf-1 Protein HSF-1 0.018
F36A2.3 Protein F36A2.3 0.018
gpb-2 Protein GPB-2 0.017
CELE_B0238.10 Protein B0238.10 0.017
let-268 Protein LET-268 0.017
W03G11.3 Protein W03G11.3 0.017
sur-2 Protein SUR-2 0.016
klp-3 Protein KLP-3 0.016
CELE_M05D6.5 Protein M05D6.5 0.016
unc-18 Protein UNC-18 0.015
C18A3.4 Protein C18A3.4 0.015
unc-1 Protein UNC-1 0.014
let-60 Protein LET-60 0.014
klp-7 Protein KLP-7 0.014
pssy-1 Protein PSSY-1 0.014
stn-2 Protein STN-2 0.013
B0395.3 Protein B0395.3 0.013
car-1 Protein CAR-1 0.013
pqe-1 Protein PQE-1 0.012
T05G5.1 Protein T05G5.1 0.012
fzr-1 Protein FZR-1 0.012
ost-1 Protein OST-1 0.012
C46C11.3 Protein C46C11.3 0.012
bath-40 Protein BATH-40 0.011
ZK899.2 Protein ZK899.2 0.011
T22D1.11 Protein T22D1.11 0.011
lip-1 Protein LIP-1 0.011
ptp-3 Protein PTP-3 0.011
tsp-11 Protein TSP-11 0.011
tag-163 Protein TAG-163 0.011
rsu-1 Protein RSU-1 0.010
CELE_T04H1.2 Protein T04H1.2 0.010
Y45G5AM.6 Protein Y45G5AM.6 0.010
lbp-3 Protein LBP-3 0.010
fln-2 Protein FLN-2 0.010
cas-1 Protein CAS-1 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
stck steamer duck 0.803
if inflated 0.595
wun wunen 0.193
por porcupine 0.118
LamC Lamin C 0.105
sgl sugarless 0.090
Shc SHC-adaptor protein 0.085
Arp66B Actin-related protein 66B 0.080
mys myospheroid 0.065
lqf liquid facets 0.062
zfh1 Zn finger homeodomain 1 0.060
htl heartless 0.055
insc inscuteable 0.054
baz bazooka 0.050
mol moladietz 0.050
pcx pecanex 0.048
dia diaphanous 0.038
Mo25 CG4083 gene product from transcript CG4083-RA 0.035
Ilk Integrin linked kinase 0.034
betaInt-nu beta[nu] integrin 0.033
RhoGAP68F CG6811 gene product from transcript CG6811-RA 0.033
Vrp1 Verprolin 1 0.032
pgant3 polypeptide GalNAc transferase 3 0.031
NT1 Neurotrophin 1 0.029
CG11299 CG11299 gene product from transcript CG11299-RA 0.026
Hip14 Huntingtin-interacting protein 14 0.025
cnk connector enhancer of ksr 0.024
Pax Paxillin 0.023
drk downstream of receptor kinase 0.022
Hem HEM-protein 0.022
RhoGAP15B CG4937 gene product from transcript CG4937-RC 0.022
pfk piefke 0.021
CG32528 CG32528 gene product from transcript CG32528-RA 0.021
Mical Molecule interacting with CasL 0.021
Sema-1a CG18405 gene product from transcript CG18405-RD 0.021
dos daughter of sevenless 0.020
Rac2 CG8556 gene product from transcript CG8556-RA 0.019
SH3PX1 CG6757 gene product from transcript CG6757-RA 0.018
c11.1 CG12132 gene product from transcript CG12132-RA 0.018
CG14782 CG14782 gene product from transcript CG14782-RA 0.018
CG1572 CG1572 gene product from transcript CG1572-RA 0.018
cdi center divider 0.018
vps2 CG14542 gene product from transcript CG14542-RA 0.018
fu fused 0.017
CG8709 CG8709 gene product from transcript CG8709-RK 0.017
cg combgap 0.017
Dab Disabled 0.016
RhoL rho-like 0.016
Pgk Phosphoglycerate kinase 0.016
cno canoe 0.016
Smox Smad on X 0.015
Flo-2 flotillin 2 0.015
Mmp1 Matrix metalloproteinase 1 0.015
ics icarus 0.015
Sara Smad anchor for receptor activation 0.015
CG30159 CG30159 gene product from transcript CG30159-RC 0.015
eve even skipped 0.014
CG10103 CG10103 gene product from transcript CG10103-RA 0.014
shn schnurri 0.014
CG10627 CG10627 gene product from transcript CG10627-RA 0.014
sra sarah 0.013
Marf Mitochondrial assembly regulatory factor 0.013
Vinc Vinculin 0.013
bun bunched 0.013
byn brachyenteron 0.012
CG6194 CG6194 gene product from transcript CG6194-RA 0.012
AnnIX Annexin IX 0.012
comt comatose 0.012
blow blown fuse 0.012
par-1 CG8201 gene product from transcript CG8201-RA 0.012
Gap1 GTPase-activating protein 1 0.012
spz spatzle 0.012
rost rolling stone 0.012
kst karst 0.012
egl egalitarian 0.012
drongo CG3365 gene product from transcript CG3365-RH 0.012
Rab7 Rab-protein 7 0.011
Dap160 Dynamin associated protein 160 0.011
PyK Pyruvate kinase 0.011
spict spichthyin 0.011
frc fringe connection 0.011
Myo31DF Myosin 31DF 0.011
ImpL3 Ecdysone-inducible gene L3 0.011
flr flare 0.011
Fak56D Focal Adhesion Kinase 0.010
ptip CG32133 gene product from transcript CG32133-RA 0.010
mth methuselah 0.010
gek genghis khan 0.010
slow slowdown 0.010
CG6191 CG6191 gene product from transcript CG6191-RA 0.010
Hr46 Hormone receptor-like in 46 0.010
fng fringe 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.967
Rag1 recombination activating gene 1 0.939
Ptprc protein tyrosine phosphatase, receptor type, C 0.930
Ilk integrin linked kinase 0.888
Ptk2 PTK2 protein tyrosine kinase 2 0.876
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.840
Cd247 CD247 antigen 0.836
Ikzf1 IKAROS family zinc finger 1 0.750
Vav1 vav 1 oncogene 0.723
Itga3 integrin alpha 3 0.710
Pxn paxillin 0.616
Fyn Fyn proto-oncogene 0.586
Rag2 recombination activating gene 2 0.556
Cbl Casitas B-lineage lymphoma 0.553
Csf1r colony stimulating factor 1 receptor 0.533
Grb2 growth factor receptor bound protein 2 0.490
Src Rous sarcoma oncogene 0.473
Parva parvin, alpha 0.408
Vcl vinculin 0.403
Nos2 nitric oxide synthase 2, inducible 0.398
Hcst hematopoietic cell signal transducer 0.393
Il2rg interleukin 2 receptor, gamma chain 0.361
Ncf1 neutrophil cytosolic factor 1 0.351
Ctnnb1 catenin (cadherin associated protein), beta 1 0.306
Csf1 colony stimulating factor 1 (macrophage) 0.279
Cd19 CD19 antigen 0.265
Cd151 CD151 antigen 0.252
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.247
Lyz2 lysozyme 2 0.230
Lck lymphocyte protein tyrosine kinase 0.216
Bcar1 breast cancer anti-estrogen resistance 1 0.202
Inpp5d inositol polyphosphate-5-phosphatase D 0.193
Amotl2 angiomotin-like 2 0.188
Hcls1 hematopoietic cell specific Lyn substrate 1 0.179
Lcp2 lymphocyte cytosolic protein 2 0.175
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.175
Cyr61 cysteine rich protein 61 0.160
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.158
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.155
Col1a1 collagen, type I, alpha 1 0.152
Fas Fas (TNF receptor superfamily member 6) 0.145
Tcra T-cell receptor alpha chain 0.144
Rhoc ras homolog gene family, member C 0.143
Was Wiskott-Aldrich syndrome homolog (human) 0.139
Vegfa vascular endothelial growth factor A 0.135
Grap2 GRB2-related adaptor protein 2 0.132
Fyb FYN binding protein 0.131
Tagln transgelin 0.130
Laptm5 lysosomal-associated protein transmembrane 5 0.129
Tln1 talin 1 0.129
Wwtr1 WW domain containing transcription regulator 1 0.128
Axl AXL receptor tyrosine kinase 0.117
Lepr leptin receptor 0.114
Egr2 early growth response 2 0.104
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.103
Tgfb1 transforming growth factor, beta 1 0.101
Plat plasminogen activator, tissue 0.095
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.094
Nf1 neurofibromatosis 1 0.094
Lat linker for activation of T cells 0.094
Fkbp9 FK506 binding protein 9 0.093
Itk IL2-inducible T-cell kinase 0.091
Phldb2 pleckstrin homology-like domain, family B, member 2 0.090
Clec4n C-type lectin domain family 4, member n 0.083
Bgn biglycan 0.078
Bmpr1a bone morphogenetic protein receptor, type 1A 0.074
Fn1 fibronectin 1 0.073
Flna filamin, alpha 0.073
Plcg2 phospholipase C, gamma 2 0.072
Ifngr1 interferon gamma receptor 1 0.071
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.069
Cd3e CD3 antigen, epsilon polypeptide 0.068
Alox5ap arachidonate 5-lipoxygenase activating protein 0.067
Sh3bgrl3 SH3 domain binding glutamic acid-rich protein-like 3 0.065
Ptplad2 protein tyrosine phosphatase-like A domain containing 2 0.064
Mrc1 mannose receptor, C type 1 0.063
Chst14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.063
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.063
Vav2 vav 2 oncogene 0.061
Col4a5 collagen, type IV, alpha 5 0.061
Cd68 CD68 antigen 0.060
Fcgr2b Fc receptor, IgG, low affinity IIb 0.060
Apoe apolipoprotein E 0.060
Enah enabled homolog (Drosophila) 0.060
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.059
Vim vimentin 0.059
Zap70 zeta-chain (TCR) associated protein kinase 0.059
Gab1 growth factor receptor bound protein 2-associated protein 1 0.059
Wipf1 WAS/WASL interacting protein family, member 1 0.057
Fermt2 fermitin family homolog 2 (Drosophila) 0.057
Cd22 CD22 antigen 0.057
Plcg1 phospholipase C, gamma 1 0.054
Lama5 laminin, alpha 5 0.053
Igf1 insulin-like growth factor 1 0.052
Met met proto-oncogene 0.050
Hif1a hypoxia inducible factor 1, alpha subunit 0.049
Ptgs2 prostaglandin-endoperoxide synthase 2 0.049
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.049
Nab2 Ngfi-A binding protein 2 0.048
Ctgf connective tissue growth factor 0.048
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Rattus norvegicus
Name Description Probability Func Analog Organism
Bgn biglycan 0.148
Vim vimentin 0.091
Fn1 fibronectin 1 0.054
Col1a2 collagen, type I, alpha 2 0.052
Nme1 non-metastatic cells 1, protein (NM23A) expressed in 0.035
Col5a2 collagen, type V, alpha 2 0.034
Capn2 calpain 2 0.031
Mgp matrix Gla protein 0.025
Lox lysyl oxidase 0.023
Ptafr platelet-activating factor receptor 0.022
Anxa5 annexin A5 0.020
Plat plasminogen activator, tissue 0.020
RGD1309537 similar to Myosin regulatory light chain 2-A, smooth muscle isoform (Myosin RLC-A) 0.018
Calu calumenin 0.018
Lrrc33 leucine rich repeat containing 33 0.014
Vasp vasodilator-stimulated phosphoprotein 0.010
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism