The network for 'smad protein import into nucleus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

smad protein import into nucleus

The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

Homo sapiens
Name Description Probability Func Analog Organism
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.998
TGFB1 transforming growth factor, beta 1 0.981
KPNB1 karyopherin (importin) beta 1 0.876
SP1 Sp1 transcription factor 0.861
BMPR1A bone morphogenetic protein receptor, type IA 0.858
BMP2 bone morphogenetic protein 2 0.766
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.761
FOS FBJ murine osteosarcoma viral oncogene homolog 0.615
NUP85 nucleoporin 85kDa 0.542
AHCTF1 AT hook containing transcription factor 1 0.512
NUP153 nucleoporin 153kDa 0.500
JUN jun proto-oncogene 0.447
FSTL1 follistatin-like 1 0.427
SOX10 SRY (sex determining region Y)-box 10 0.381
BMPR1B bone morphogenetic protein receptor, type IB 0.376
SMAD7 SMAD family member 7 0.279
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.249
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.249
NUP133 nucleoporin 133kDa 0.245
SMAD2 SMAD family member 2 0.241
ENG endoglin 0.230
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.221
SMAD3 SMAD family member 3 0.221
GDF5 growth differentiation factor 5 0.189
FOXD3 forkhead box D3 0.124
BMP4 bone morphogenetic protein 4 0.108
ZFYVE9 zinc finger, FYVE domain containing 9 0.096
NRP1 neuropilin 1 0.075
JDP2 Jun dimerization protein 2 0.074
SOX2 SRY (sex determining region Y)-box 2 0.065
APC adenomatous polyposis coli 0.057
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.049
ATF3 activating transcription factor 3 0.048
TGFBR1 transforming growth factor, beta receptor 1 0.047
TGFB3 transforming growth factor, beta 3 0.044
ACVR1 activin A receptor, type I 0.042
SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.037
SEC31A SEC31 homolog A (S. cerevisiae) 0.036
NOG noggin 0.035
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.033
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.033
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.032
NUP98 nucleoporin 98kDa 0.031
NLK nemo-like kinase 0.025
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.025
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.024
BTRC beta-transducin repeat containing 0.024
AMOTL1 angiomotin like 1 0.023
NUP160 nucleoporin 160kDa 0.021
ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 0.020
MYO6 myosin VI 0.020
QKI quaking homolog, KH domain RNA binding (mouse) 0.020
DUSP1 dual specificity phosphatase 1 0.019
PRKG1 protein kinase, cGMP-dependent, type I 0.018
TUBA1C tubulin, alpha 1c 0.018
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.018
HEYL hairy/enhancer-of-split related with YRPW motif-like 0.017
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.016
CHD6 chromodomain helicase DNA binding protein 6 0.016
NXF1 nuclear RNA export factor 1 0.016
SKIL SKI-like oncogene 0.016
DAZAP2 DAZ associated protein 2 0.016
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.016
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.016
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.015
ERBB2IP erbb2 interacting protein 0.015
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.015
C19orf10 chromosome 19 open reading frame 10 0.015
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.015
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.015
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.015
ACVR2B activin A receptor, type IIB 0.014
RUNX1 runt-related transcription factor 1 0.014
TPR translocated promoter region (to activated MET oncogene) 0.014
E2F3 E2F transcription factor 3 0.014
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.013
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.013
CKAP5 cytoskeleton associated protein 5 0.012
SMAD4 SMAD family member 4 0.012
CALD1 caldesmon 1 0.011
IER2 immediate early response 2 0.011
SENP1 SUMO1/sentrin specific peptidase 1 0.011
SOX21 SRY (sex determining region Y)-box 21 0.011
MAPK8 mitogen-activated protein kinase 8 0.011
HIPK2 homeodomain interacting protein kinase 2 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Nup214 Nucleoporin 214 0.782
Mtor Megator 0.517
Mad Mothers against dpp 0.334
Nup98 Nucleoporin 98 0.191
pic piccolo 0.184
hpo hippo 0.139
msn misshapen 0.118
Dad Daughters against dpp 0.105
enok enoki mushroom 0.088
PNUTS CG33526 gene product from transcript CG33526-RD 0.082
Nup160 Nucleoporin 160 0.082
Bap170 Brahma associated protein 170kD 0.065
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.046
Smox Smad on X 0.046
myoglianin CG1838 gene product from transcript CG1838-RD 0.039
Mcm2 Minichromosome maintenance 2 0.036
hipk homeodomain interacting protein kinase 0.035
CG8709 CG8709 gene product from transcript CG8709-RK 0.035
babo baboon 0.033
kay kayak 0.033
hig hikaru genki 0.032
Nopp140 CG7421 gene product from transcript CG7421-RB 0.032
FBX011 FBX011 ortholog 0.032
Egfr Epidermal growth factor receptor 0.032
CG5857 CG5857 gene product from transcript CG5857-RA 0.031
pnt pointed 0.029
fj four-jointed 0.028
Prp19 CG5519 gene product from transcript CG5519-RA 0.028
mys myospheroid 0.028
kibra kibra ortholog 0.027
Nup154 Nucleoporin 154 0.026
ex expanded 0.026
Stat92E Signal-transducer and activator of transcription protein at 92E 0.024
tai taiman 0.024
pont pontin 0.023
Su(H) Suppressor of Hairless 0.023
CG10080 CG10080 gene product from transcript CG10080-RA 0.023
MEP-1 CG1244 gene product from transcript CG1244-RG 0.022
Lam Lamin 0.020
Med Medea 0.019
Mat89Ba Maternal transcript 89Ba 0.019
mib1 mind bomb 1 0.019
CG4849 CG4849 gene product from transcript CG4849-RA 0.018
Akt1 CG4006 gene product from transcript CG4006-RA 0.018
sev sevenless 0.017
InR Insulin-like receptor 0.017
Tango14 Transport and Golgi organization 14 0.017
dm diminutive 0.016
CG9776 CG9776 gene product from transcript CG9776-RA 0.016
CG5931 CG5931 gene product from transcript CG5931-RA 0.015
Mef2 Myocyte enhancer factor 2 0.015
tws twins 0.015
AGO1 Argonaute-1 0.015
RnrL Ribonucleoside diphosphate reductase large subunit 0.014
Nup133 Nucleoporin 133 0.014
spi spitz 0.014
CG12084 CG12084 gene product from transcript CG12084-RA 0.014
Rpn2 CG11888 gene product from transcript CG11888-RA 0.014
glu gluon 0.014
trpml transient receptor potential mucolipin 0.013
nop5 CG10206 gene product from transcript CG10206-RA 0.013
fray frayed 0.013
CG6905 CG6905 gene product from transcript CG6905-RA 0.013
Rel Relish 0.013
os outstretched 0.013
gbb glass bottom boat 0.012
l(3)L1231 lethal (3) L1231 0.012
cact cactus 0.012
Nup107 Nucleoporin 107 0.012
Uba1 Ubiquitin activating enzyme 1 0.012
bin3 bicoid-interacting protein 3 0.012
eIF-4B Eukaryotic initiation factor 4B 0.012
esc extra sexcombs 0.012
Rab5 Rab-protein 5 0.011
Manf Mesencephalic astrocyte-derived neurotrophic factor 0.011
CG16941 CG16941 gene product from transcript CG16941-RA 0.011
Bj1 Bj1 protein 0.010
cbt cabut 0.010
CG2931 CG2931 gene product from transcript CG2931-RA 0.010
Bre1 CG10542 gene product from transcript CG10542-RA 0.010
lid little imaginal discs 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Smad4 MAD homolog 4 (Drosophila) 0.856
Smad3 MAD homolog 3 (Drosophila) 0.442
Smad1 MAD homolog 1 (Drosophila) 0.327
Trp53 transformation related protein 53 0.254
Axin1 axin 1 0.201
Ctnnb1 catenin (cadherin associated protein), beta 1 0.192
Apc adenomatosis polyposis coli 0.151
Tgfbr2 transforming growth factor, beta receptor II 0.134
Acvr1 activin A receptor, type 1 0.129
Yap1 yes-associated protein 1 0.103
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.065
Vegfa vascular endothelial growth factor A 0.064
Smad2 MAD homolog 2 (Drosophila) 0.060
Smad7 MAD homolog 7 (Drosophila) 0.056
Foxc1 forkhead box C1 0.048
Pten phosphatase and tensin homolog 0.044
Erbb2ip Erbb2 interacting protein 0.043
Bmpr1a bone morphogenetic protein receptor, type 1A 0.040
Bmpr2 bone morphogenic protein receptor, type II (serine/threonine kinase) 0.036
Skil SKI-like 0.034
Gsk3b glycogen synthase kinase 3 beta 0.022
Thbs1 thrombospondin 1 0.020
Prkg1 protein kinase, cGMP-dependent, type I 0.020
Il6st interleukin 6 signal transducer 0.019
Smad6 MAD homolog 6 (Drosophila) 0.019
Kitl kit ligand 0.019
Col1a1 collagen, type I, alpha 1 0.017
Tgfb2 transforming growth factor, beta 2 0.016
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.016
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.015
Meox2 mesenchyme homeobox 2 0.014
Stk11 serine/threonine kinase 11 0.013
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.013
Smurf1 SMAD specific E3 ubiquitin protein ligase 1 0.012
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.012
Braf Braf transforming gene 0.012
Fgfr1 fibroblast growth factor receptor 1 0.012
Ece1 endothelin converting enzyme 1 0.011
Stat3 signal transducer and activator of transcription 3 0.011
Tgfbr1 transforming growth factor, beta receptor I 0.011
Tgfb1 transforming growth factor, beta 1 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100359498 ribosomal protein L35a-like 0.035
Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.029
Rpl27 ribosomal protein L27 0.027
Fau Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.023
Atp5e ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 0.021
Rps10 ribosomal protein S10 0.021
LOC100360491 60S ribosomal protein L13-like 0.021
Rps21 ribosomal protein S21 0.020
Rpl18a ribosomal protein L18A 0.020
RGD1304704 similar to Hypothetical protein CGI-99 0.019
Rpl26 ribosomal protein L26 0.019
Rpl10a ribosomal protein L10A 0.019
Rps26 ribosomal protein S26 0.019
Rpl19 ribosomal protein L19 0.019
Rpl35 ribosomal protein L35 0.018
Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI 0.018
Rpsa ribosomal protein SA 0.018
Rps15 ribosomal protein S15 0.018
Rpl31 ribosomal protein L31 0.018
Tceb1 transcription elongation factor B (SIII), polypeptide 1 0.018
Rpl29 ribosomal protein L29 0.017
Rpl13a ribosomal protein L13A 0.017
Rps12 ribosomal protein S12 0.017
Rps11 ribosomal protein S11 0.017
Rpl34 ribosomal protein L34 0.016
Rps16 ribosomal protein S16 0.016
Rps7 ribosomal protein S7 0.016
Hpca hippocalcin 0.016
Rpl36a ribosomal protein L36a 0.015
Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 0.015
Rps14 ribosomal protein S14 0.015
Rpl27a ribosomal protein L27a 0.015
Rps8 ribosomal protein S8 0.015
Rpl17 ribosomal protein L17 0.014
LOC499782 similar to 60S ribosomal protein L12 0.014
Rps27a ribosomal protein S27a 0.014
Ndufa2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 0.014
Rpl37 ribosomal protein L37 0.014
Rps19 ribosomal protein S19 0.014
Rps15a ribosomal protein S15a 0.014
Rpl38 ribosomal protein L38 0.013
Rpl18 ribosomal protein L18 0.013
Rpl4 ribosomal protein L4 0.013
Rpl15 ribosomal protein L15 0.013
Rps3a ribosomal protein S3a 0.013
Rps20 ribosomal protein S20 0.013
Rps5 ribosomal protein S5 0.013
Rpl22 ribosomal protein L22 0.013
Tceb2 transcription elongation factor B (SIII), polypeptide 2 0.013
Churc1 churchill domain containing 1 0.013
Rps23 ribosomal protein S23 0.013
Flna filamin A, alpha 0.013
LOC100362298 ribosomal protein S18-like 0.013
Rps25 ribosomal protein s25 0.013
Rps6 ribosomal protein S6 0.012
S100a11 S100 calcium binding protein A11 (calizzarin) 0.012
Rpl28 ribosomal protein L28 0.012
Rpl23a ribosomal protein L23a 0.012
Rps17 ribosomal protein S17 0.012
Rpl11 ribosomal protein L11 0.012
Ndufb2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 0.012
Rps4x ribosomal protein S4, X-linked 0.012
Rpl23 ribosomal protein L23 0.012
Rpl6 ribosomal protein L6 0.012
Rpl21 ribosomal protein L21 0.011
Mrpl23 mitochondrial ribosomal protein L23 0.011
Rplp1 ribosomal protein, large, P1 0.011
Rps27 ribosomal protein S27 0.011
Rpl5 ribosomal protein L5 0.011
Rps28 ribosomal protein S28 0.011
Rpl8 ribosomal protein L8 0.011
Rpl41 ribosomal protein L41 0.011
Rpl9 ribosomal protein L9 0.011
RGD1306917 similar to RIKEN cDNA 2900010M23 0.011
Tomm6 translocase of outer mitochondrial membrane 6 homolog (yeast) 0.011
Rpl3 ribosomal protein L3 0.011
Rpl36al ribosomal protein L36a-like 0.011
Rpl10 ribosomal protein L10 0.010
Ndufb10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 0.010
LOC688869 similar to cytochrome c oxidase, subunit VIb polypeptide 1 0.010
Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism