The network for 'neural tube patterning' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

neural tube patterning

The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.

Homo sapiens
Name Description Probability Func Analog Organism
HDAC2 histone deacetylase 2 1.000
STK36 serine/threonine kinase 36 0.957
GSK3B glycogen synthase kinase 3 beta 0.944
BCOR BCL6 corepressor 0.876
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.870
NCSTN nicastrin 0.819
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.788
QPRT quinolinate phosphoribosyltransferase 0.786
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.778
SUFU suppressor of fused homolog (Drosophila) 0.773
RCN3 reticulocalbin 3, EF-hand calcium binding domain 0.670
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.655
VHL von Hippel-Lindau tumor suppressor 0.647
GLIS3 GLIS family zinc finger 3 0.617
AKAP11 A kinase (PRKA) anchor protein 11 0.609
SMO smoothened homolog (Drosophila) 0.559
FOXA2 forkhead box A2 0.527
GLI1 GLI family zinc finger 1 0.458
FLNB filamin B, beta 0.455
ZNF263 zinc finger protein 263 0.448
PEX26 peroxisomal biogenesis factor 26 0.430
EED embryonic ectoderm development 0.426
AR androgen receptor 0.369
LRP6 low density lipoprotein receptor-related protein 6 0.338
PUM2 pumilio homolog 2 (Drosophila) 0.331
BIK BCL2-interacting killer (apoptosis-inducing) 0.314
MID1IP1 MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) 0.294
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.285
NEK1 NIMA (never in mitosis gene a)-related kinase 1 0.280
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.254
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.212
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.204
LRRK2 leucine-rich repeat kinase 2 0.195
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.189
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.187
SIRT1 sirtuin 1 0.184
APC adenomatous polyposis coli 0.184
ZNF764 zinc finger protein 764 0.171
ZFYVE9 zinc finger, FYVE domain containing 9 0.161
MTA3 metastasis associated 1 family, member 3 0.152
RNF2 ring finger protein 2 0.147
BCL2L1 BCL2-like 1 0.145
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.144
BAD BCL2-associated agonist of cell death 0.143
RBBP4 retinoblastoma binding protein 4 0.142
KIFAP3 kinesin-associated protein 3 0.141
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.134
PKP4 plakophilin 4 0.127
AKIP1 A kinase (PRKA) interacting protein 1 0.118
AXIN1 axin 1 0.117
ZIC1 Zic family member 1 (odd-paired homolog, Drosophila) 0.110
PTEN phosphatase and tensin homolog 0.109
MAPK8 mitogen-activated protein kinase 8 0.107
APP amyloid beta (A4) precursor protein 0.098
BCL2 B-cell CLL/lymphoma 2 0.096
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.095
RCOR1 REST corepressor 1 0.093
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.092
TP53BP2 tumor protein p53 binding protein, 2 0.088
RYR2 ryanodine receptor 2 (cardiac) 0.084
FZD8 frizzled homolog 8 (Drosophila) 0.083
FZD1 frizzled homolog 1 (Drosophila) 0.082
FGF3 fibroblast growth factor 3 0.082
BTBD2 BTB (POZ) domain containing 2 0.080
SORBS3 sorbin and SH3 domain containing 3 0.077
PTK2 PTK2 protein tyrosine kinase 2 0.077
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.075
RAX retina and anterior neural fold homeobox 0.075
SETD7 SET domain containing (lysine methyltransferase) 7 0.074
GSC goosecoid homeobox 0.072
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.069
NPTN neuroplastin 0.068
ONECUT1 one cut homeobox 1 0.068
BMI1 BMI1 polycomb ring finger oncogene 0.065
WNT3A wingless-type MMTV integration site family, member 3A 0.065
CIB1 calcium and integrin binding 1 (calmyrin) 0.061
SIX3 SIX homeobox 3 0.061
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.060
ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 0.060
BMPR1A bone morphogenetic protein receptor, type IA 0.059
CDX2 caudal type homeobox 2 0.058
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.057
LBX1 ladybird homeobox 1 0.057
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.055
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.054
EPS15 epidermal growth factor receptor pathway substrate 15 0.053
CREBL2 cAMP responsive element binding protein-like 2 0.053
HOXC8 homeobox C8 0.052
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.052
CTCF CCCTC-binding factor (zinc finger protein) 0.051
BICD1 bicaudal D homolog 1 (Drosophila) 0.050
MYOD1 myogenic differentiation 1 0.049
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.049
ZFPM1 zinc finger protein, multitype 1 0.049
SOX1 SRY (sex determining region Y)-box 1 0.049
BBS10 Bardet-Biedl syndrome 10 0.049
SKI v-ski sarcoma viral oncogene homolog (avian) 0.048
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.047
LHX2 LIM homeobox 2 0.047
BTRC beta-transducin repeat containing 0.046
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
lef1 lymphocyte enhancer binding factor 1 0.998
wnt1 wingless-type MMTV integration site family, member 1 0.995
cobl cordon-bleu homolog (mouse) 0.990
her5 hairy-related 5 0.989
tp53 tumor protein p53 0.971
shha sonic hedgehog a 0.970
wnt8b wingless-type MMTV integration site family, member 8b 0.968
tbx1 T-box 1 0.958
eng2a engrailed 2a 0.956
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.943
gli1 GLI-Kruppel family member 1 0.941
mib mind bomb 0.941
fezf2 FEZ family zinc finger 2 0.931
hnf1ba HNF1 homeobox Ba 0.924
fgf8b fibroblast growth factor 8 b 0.922
wnt11 wingless-type MMTV integration site family, member 11 0.884
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.854
ptch2 patched 2 0.822
fgf8a fibroblast growth factor 8 a 0.821
ndr2 nodal-related 2 0.809
her15.1 hairy and enhancer of split-related 15.1 0.799
lhx1a LIM homeobox 1a 0.785
otx2 orthodenticle homolog 2 0.744
nkx2.2a NK2 transcription factor related 2a 0.728
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.719
flh floating head 0.704
gbx2 gastrulation brain homeo box 2 0.675
ascl1a achaete-scute complex-like 1a (Drosophila) 0.660
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.651
fgf3 fibroblast growth factor 3 0.649
hhip hedgehog interacting protein 0.634
osr2 odd-skipped related 2 (Drosophila) 0.567
dla deltaA 0.558
her11 hairy-related 11 0.536
hlxb9la homeo box HB9 like a 0.533
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.510
foxa2 forkhead box A2 0.509
vsx1 visual system homeobox 1 homolog, chx10-like 0.496
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.488
pax8 paired box gene 8 0.484
eng1a engrailed 1a 0.459
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.454
dlx2b distal-less homeobox gene 2b 0.431
shhb sonic hedgehog b 0.423
fgf17 fibroblast growth factor 17 0.409
atp1b1b ATPase, Na+/K+ transporting, beta 1b polypeptide 0.407
wnt7ba wingless-type MMTV integration site family, member 7Ba 0.404
her3 hairy-related 3 0.402
tal2 T-cell acute lymphocytic leukemia 2 0.397
dusp6 dual specificity phosphatase 6 0.388
foxj1b forkhead box J1b 0.385
cdh2 cadherin 2, neuronal 0.380
lhx6 LIM homeobox 6 0.379
eng2b engrailed 2b 0.371
bmp4 bone morphogenetic protein 4 0.361
dlx3b distal-less homeobox gene 3b 0.359
six3a sine oculis homeobox homolog 3a 0.339
pou5f1 POU domain, class 5, transcription factor 1 0.338
foxa1 forkhead box A1 0.335
nkd1 naked cuticle homolog 1 (Drosophila) 0.334
fgf20a fibroblast growth factor 20a 0.334
barhl2 BarH-like 2 0.325
dkk1b dickkopf 1b 0.320
tbx16 T-box gene 16 0.319
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.313
wnt3a wingless-type MMTV integration site family, member 3A 0.310
wnt4a wingless-type MMTV integration site family, member 4a 0.304
atp1b2b ATPase, Na+/K+ transporting, beta 2b polypeptide 0.303
epha4b eph receptor A4b 0.302
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.301
dbx1a developing brain homeobox 1a 0.298
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.287
notch1a notch homolog 1a 0.272
otx1b orthodenticle homolog 1b 0.269
inab internexin neuronal intermediate filament protein, alpha b 0.269
oc90 otoconin 90 0.262
lhx5 LIM homeobox 5 0.255
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.252
sox19b SRY-box containing gene 19b 0.251
dld deltaD 0.249
lrp2 low density lipoprotein-related protein 2 0.248
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.241
dharma dharma 0.238
etv5b ets variant 5b 0.237
ins preproinsulin 0.237
gbx1 gastrulation brain homeobox 1 0.222
hmx4 H6 family homeobox 4 0.219
nkx2.5 NK2 transcription factor related 5 0.216
pax2b paired box gene 2b 0.216
appl1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.214
tll1 tolloid-like 1 0.212
dlc deltaC 0.211
foxd3 forkhead box D3 0.209
hes6 hairy and enhancer of split 6 (Drosophila) 0.208
lamc1 laminin, gamma 1 0.197
dcc deleted in colorectal carcinoma 0.196
rorca RAR-related orphan receptor C a 0.194
pax6a paired box gene 6a 0.193
fgfr1b fibroblast growth factor receptor 1b 0.191
hlxb9lb homeo box HB9 like b 0.191
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Foxc1 forkhead box C1 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Bmp4 bone morphogenetic protein 4 0.999
Pax3 paired box gene 3 0.999
Rnf2 ring finger protein 2 0.999
Msx2 homeobox, msh-like 2 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.999
Nodal nodal 0.998
Ctnnb1 catenin (cadherin associated protein), beta 1 0.998
Gbx2 gastrulation brain homeobox 2 0.997
Fgf8 fibroblast growth factor 8 0.997
Pax6 paired box gene 6 0.996
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.995
Psen1 presenilin 1 0.995
Otx1 orthodenticle homolog 1 (Drosophila) 0.995
Rarg retinoic acid receptor, gamma 0.995
Lmx1a LIM homeobox transcription factor 1 alpha 0.993
Fgfr1 fibroblast growth factor receptor 1 0.993
Nog noggin 0.992
Gli2 GLI-Kruppel family member GLI2 0.992
Sox2 SRY-box containing gene 2 0.991
Smo smoothened homolog (Drosophila) 0.991
Emx2 empty spiracles homolog 2 (Drosophila) 0.990
Lhx1 LIM homeobox protein 1 0.984
Foxc2 forkhead box C2 0.984
Alx4 aristaless-like homeobox 4 0.983
Hand1 heart and neural crest derivatives expressed transcript 1 0.982
Bmp7 bone morphogenetic protein 7 0.974
Zeb1 zinc finger E-box binding homeobox 1 0.967
Rybp RING1 and YY1 binding protein 0.966
Ptch1 patched homolog 1 0.963
Fgf10 fibroblast growth factor 10 0.963
Tbx1 T-box 1 0.956
Tcfap2a transcription factor AP-2, alpha 0.953
Sox9 SRY-box containing gene 9 0.941
Wnt3a wingless-related MMTV integration site 3A 0.936
Meox2 mesenchyme homeobox 2 0.934
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.931
Wnt1 wingless-related MMTV integration site 1 0.928
Dlx5 distal-less homeobox 5 0.926
Chd7 chromodomain helicase DNA binding protein 7 0.919
Eya1 eyes absent 1 homolog (Drosophila) 0.918
Nkx2-1 NK2 homeobox 1 0.903
En1 engrailed 1 0.900
Lrp6 low density lipoprotein receptor-related protein 6 0.900
Fgf3 fibroblast growth factor 3 0.899
Sox11 SRY-box containing gene 11 0.895
Chrd chordin 0.893
Prrx1 paired related homeobox 1 0.889
Nanog Nanog homeobox 0.887
Pax8 paired box gene 8 0.887
Foxa2 forkhead box A2 0.873
Emx1 empty spiracles homolog 1 (Drosophila) 0.868
Foxh1 forkhead box H1 0.852
Hes1 hairy and enhancer of split 1 (Drosophila) 0.822
Msx1 homeobox, msh-like 1 0.803
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.803
Zic3 zinc finger protein of the cerebellum 3 0.802
Hoxd11 homeobox D11 0.799
Isl1 ISL1 transcription factor, LIM/homeodomain 0.793
Sall4 sal-like 4 (Drosophila) 0.779
Fgfr3 fibroblast growth factor receptor 3 0.772
Vangl2 vang-like 2 (van gogh, Drosophila) 0.754
Rarb retinoic acid receptor, beta 0.754
Prrx2 paired related homeobox 2 0.747
Hmx3 H6 homeobox 3 0.733
Gdnf glial cell line derived neurotrophic factor 0.732
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.716
Lmx1b LIM homeobox transcription factor 1 beta 0.708
Tgfb2 transforming growth factor, beta 2 0.680
Rara retinoic acid receptor, alpha 0.653
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.652
Notch1 Notch gene homolog 1 (Drosophila) 0.644
Pou5f1 POU domain, class 5, transcription factor 1 0.625
T brachyury 0.610
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.604
Hand2 heart and neural crest derivatives expressed transcript 2 0.591
Sox3 SRY-box containing gene 3 0.566
Efnb2 ephrin B2 0.564
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.539
Mks1 Meckel syndrome, type 1 0.532
Apc adenomatosis polyposis coli 0.521
Gli1 GLI-Kruppel family member GLI1 0.514
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.513
Jag1 jagged 1 0.507
Foxd3 forkhead box D3 0.502
Foxg1 forkhead box G1 0.496
Pbx1 pre B-cell leukemia transcription factor 1 0.491
Cdx1 caudal type homeobox 1 0.490
Wt1 Wilms tumor 1 homolog 0.478
Ihh Indian hedgehog 0.472
Runx2 runt related transcription factor 2 0.467
Pcgf2 polycomb group ring finger 2 0.451
Tbx3 T-box 3 0.429
Hoxa1 homeobox A1 0.425
Notch2 Notch gene homolog 2 (Drosophila) 0.418
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism