The network for 'regulation of protein localization to plasma membrane' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein localization to plasma membrane

Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.

Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FHL2 four and a half LIM domains 2 1.000
BCL2 B-cell CLL/lymphoma 2 1.000
BCL2L1 BCL2-like 1 0.997
SNAP23 synaptosomal-associated protein, 23kDa 0.995
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.989
STX8 syntaxin 8 0.977
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.969
FN1 fibronectin 1 0.967
FLNA filamin A, alpha 0.943
VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 0.934
PXN paxillin 0.926
VTI1B vesicle transport through interaction with t-SNAREs homolog 1B (yeast) 0.904
PSEN2 presenilin 2 (Alzheimer disease 4) 0.884
SORBS3 sorbin and SH3 domain containing 3 0.882
STX12 syntaxin 12 0.822
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.817
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.812
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.802
NOXA1 NADPH oxidase activator 1 0.755
BAD BCL2-associated agonist of cell death 0.736
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.728
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.724
GDA guanine deaminase 0.708
EPS8 epidermal growth factor receptor pathway substrate 8 0.699
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.658
FYN FYN oncogene related to SRC, FGR, YES 0.657
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.654
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.648
PTPRC protein tyrosine phosphatase, receptor type, C 0.638
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.616
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.596
STX6 syntaxin 6 0.578
PRKCZ protein kinase C, zeta 0.568
GRB7 growth factor receptor-bound protein 7 0.568
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.560
PTK2B PTK2B protein tyrosine kinase 2 beta 0.538
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.525
SNAP25 synaptosomal-associated protein, 25kDa 0.521
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.490
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.479
RAB5A RAB5A, member RAS oncogene family 0.475
IER3 immediate early response 3 0.440
MAPK1 mitogen-activated protein kinase 1 0.413
OCRL oculocerebrorenal syndrome of Lowe 0.391
KLHL3 kelch-like 3 (Drosophila) 0.374
RAB22A RAB22A, member RAS oncogene family 0.366
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.360
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.350
NEK9 NIMA (never in mitosis gene a)- related kinase 9 0.319
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.309
BAK1 BCL2-antagonist/killer 1 0.294
EFNA1 ephrin-A1 0.289
CYTH1 cytohesin 1 0.274
CD63 CD63 molecule 0.272
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.267
FLNB filamin B, beta 0.263
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.260
BAX BCL2-associated X protein 0.260
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 0.259
PDIA3 protein disulfide isomerase family A, member 3 0.247
VAMP8 vesicle-associated membrane protein 8 (endobrevin) 0.245
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.241
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.238
RANBP9 RAN binding protein 9 0.228
ENG endoglin 0.225
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.224
ITGB5 integrin, beta 5 0.219
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.217
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.210
TLN1 talin 1 0.192
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.189
NSF N-ethylmaleimide-sensitive factor 0.187
STX4 syntaxin 4 0.184
SFN stratifin 0.166
ADAM17 ADAM metallopeptidase domain 17 0.162
SPAG9 sperm associated antigen 9 0.161
TSC22D4 TSC22 domain family, member 4 0.161
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.159
MYO10 myosin X 0.154
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.151
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.150
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.150
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.143
EFNA5 ephrin-A5 0.142
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.128
ILK integrin-linked kinase 0.124
ITGA6 integrin, alpha 6 0.123
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.121
PTCH1 patched 1 0.119
RALBP1 ralA binding protein 1 0.119
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.117
EPS15 epidermal growth factor receptor pathway substrate 15 0.113
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.112
CD9 CD9 molecule 0.106
AGTPBP1 ATP/GTP binding protein 1 0.102
CDCP1 CUB domain containing protein 1 0.099
WASL Wiskott-Aldrich syndrome-like 0.096
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.094
SH3RF1 SH3 domain containing ring finger 1 0.094
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
itgb1a integrin, beta 1a 0.153
itgb1b.2 integrin, beta 1b.2 0.123
esyt3 extended synaptotagmin-like protein 3 0.063
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.061
acvr1b activin A receptor, type IB 0.056
msxd muscle segment homeobox D 0.055
elovl1b elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b 0.054
svil supervillin 0.050
far1 fatty acyl CoA reductase 1 0.047
asb8 ankyrin repeat and SOCS box-containing 8 0.046
b3galt2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 0.045
lamb1a laminin, beta 1a 0.044
ncf1 neutrophil cytosolic factor 1 0.044
mpzl2 myelin protein zero-like 2 0.043
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.042
atp6v1d ATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D 0.041
lrrc33 leucine rich repeat containing 33 0.041
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.040
mib mind bomb 0.039
hmcn1 hemicentin 1 0.036
b2m beta-2-microglobulin 0.033
prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.033
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.033
tcea2 transcription elongation factor A (SII), 2 0.033
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.032
vsg1 vessel-specific 1 0.031
clic1 chloride intracellular channel 1 0.030
igfbp6a insulin-like growth factor binding protein 6a 0.030
clgn calmegin 0.030
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.028
stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.028
ptprc protein tyrosine phosphatase, receptor type, C 0.027
alg9 asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase) 0.027
lamc1 laminin, gamma 1 0.027
marveld2b MARVEL domain containing 2b 0.027
itgb1b integrin, beta 1b 0.027
sulf1 sulfatase 1 0.026
rab22a RAB22A, member RAS oncogene family 0.026
arpc5b actin related protein 2/3 complex, subunit 5B 0.026
stxbp2 syntaxin binding protein 2 0.025
g6pd glucose-6-phosphate dehydrogenase 0.025
zgc:63831 zgc:63831 0.025
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.025
igfbp6b insulin-like growth factor binding protein 6b 0.025
ca10a carbonic anhydrase Xa 0.025
s1pr2 sphingosine-1-phosphate receptor 2 0.025
ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.024
sh3bgrl3 SH3 domain binding glutamic acid-rich protein like 3 0.024
zgc:162964 zgc:162964 0.024
nrarpa notch-regulated ankyrin repeat protein a 0.024
pak2a p21 (CDKN1A)-activated kinase 2a 0.024
zgc:101724 zgc:101724 0.024
gpr182 G protein-coupled receptor 182 0.024
tbx1 T-box 1 0.024
coro1a coronin, actin binding protein, 1A 0.024
zgc:110259 zgc:110259 0.024
yrk Yes-related kinase 0.024
adipor1b adiponectin receptor 1b 0.024
slc8a4a solute carrier family 8 (sodium/calcium exchanger), member 4a 0.024
prkcd protein kinase C, delta 0.024
dao.2 D-amino-acid oxidase 2 0.023
ptgs1 prostaglandin-endoperoxide synthase 1 0.023
ccz1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) 0.023
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.023
abcb5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 0.023
opa1 optic atrophy 1 (human) 0.023
tmbim1 transmembrane BAX inhibitor motif containing 1 0.023
mcl1a myeloid cell leukemia sequence 1a 0.023
heg heart of glass 0.023
taldo1 transaldolase 1 0.023
sdf2 stromal cell-derived factor 2 0.023
zgc:110788 zgc:110788 0.022
rps6ka1 ribosomal protein S6 kinase a, polypeptide 1 0.022
sypl2b synaptophysin-like 2b 0.022
atp6v1c1b ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1b 0.022
ap1s3b adaptor-related protein complex 1, sigma 3 subunit, b 0.022
cflar CASP8 and FADD-like apoptosis regulator 0.022
atp6v1c1a ATPase, H+ transporting, lysosomal, V1 subunit C, isoform 1a 0.022
tnikb TRAF2 and NCK interacting kinase b 0.022
wnt5b wingless-type MMTV integration site family, member 5b 0.022
lmbrd2a LMBR1 domain containing 2a 0.022
snx6 sorting nexin 6 0.021
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.021
zgc:63962 zgc:63962 0.021
fcho2 FCH domain only 2 0.021
ext2 exostoses (multiple) 2 0.021
atp6v1ba ATPase, H+ transporting, lysosomal, V1 subunit B, member a 0.021
mtmr8 myotubularin related protein 8 0.021
thy1 Thy-1 cell surface antigen 0.021
btr30 bloodthirsty-related gene family, member 30 0.021
dnm1l dynamin 1-like 0.020
zgc:113200 zgc:113200 0.020
slc43a1a solute carrier family 43, member 1a 0.020
rock2a rho-associated, coiled-coil containing protein kinase 2a 0.020
zfpl1 zinc finger protein-like 1 0.020
actr1 ARP1 actin-related protein 1, centractin (yeast) 0.020
itgb1b.1 integrin, beta 1b.1 0.020
tmem161b transmembrane protein 161B 0.020
mitd1 MIT, microtubule interacting and transport, domain containing 1 0.020
plekhf2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 0.020
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Mad Mothers against dpp 0.486
Stat92E Signal-transducer and activator of transcription protein at 92E 0.096
Pk61C Protein kinase 61C 0.071
Ephrin CG1862 gene product from transcript CG1862-RA 0.049
Cip4 CG15015 gene product from transcript CG15015-RA 0.048
Pten CG5671 gene product from transcript CG5671-RB 0.040
stai stathmin 0.037
Pp2A-29B Protein phosphatase 2A at 29B 0.035
Rheb CG1081 gene product from transcript CG1081-RA 0.032
tws twins 0.032
G-oalpha47A G protein oalpha 47A 0.029
Fak56D Focal Adhesion Kinase 0.028
PP2A-B' CG7913 gene product from transcript CG7913-RK 0.028
usp ultraspiracle 0.027
CaMKII Calcium/calmodulin-dependent protein kinase II 0.026
par-1 CG8201 gene product from transcript CG8201-RA 0.025
sax saxophone 0.022
Gug Grunge 0.021
cpa capping protein alpha 0.021
crb crumbs 0.021
insc inscuteable 0.019
Pkn Protein kinase related to protein kinase N 0.018
wun wunen 0.018
unk unkempt 0.018
sec6 CG5341 gene product from transcript CG5341-RA 0.017
Kap-alpha3 karyopherin alpha3 0.016
Rme-8 Receptor mediated endocytosis 8 0.015
mys myospheroid 0.015
pasha partner of drosha 0.014
plexA plexin A 0.014
Nrx-IV Neurexin IV 0.014
Tsc1 CG6147 gene product from transcript CG6147-RA 0.014
scu scully 0.014
hdc headcase 0.013
Arc-p34 CG10954 gene product from transcript CG10954-RA 0.013
kon kon-tiki 0.013
CG13089 CG13089 gene product from transcript CG13089-RA 0.013
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.012
Arp66B Actin-related protein 66B 0.012
shot short stop 0.012
Mtl Mig-2-like 0.011
Stim Stromal interaction molecule 0.011
gig gigas 0.010
milt milton 0.010
Rala Ras-related protein 0.010
sdt stardust 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Nrxn1 neurexin I 0.392
Nrxn3 neurexin III 0.251
Nrxn2 neurexin II 0.217
Vhl von Hippel-Lindau tumor suppressor 0.127
Gsk3b glycogen synthase kinase 3 beta 0.109
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.094
Ctnnb1 catenin (cadherin associated protein), beta 1 0.074
Stx7 syntaxin 7 0.072
Apc adenomatosis polyposis coli 0.060
Rpl6 ribosomal protein L6 0.059
Stx12 syntaxin 12 0.059
Chrd chordin 0.056
Psen1 presenilin 1 0.054
Vegfa vascular endothelial growth factor A 0.051
Rps2 ribosomal protein S2 0.049
Ptk2 PTK2 protein tyrosine kinase 2 0.048
Src Rous sarcoma oncogene 0.046
Lama5 laminin, alpha 5 0.042
Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma 0.040
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.039
App amyloid beta (A4) precursor protein 0.035
Bmp7 bone morphogenetic protein 7 0.035
Lmna lamin A 0.031
Foxc2 forkhead box C2 0.030
Cd151 CD151 antigen 0.029
Ctnna1 catenin (cadherin associated protein), alpha 1 0.028
Ctnnd1 catenin (cadherin associated protein), delta 1 0.027
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.027
Dlg4 discs, large homolog 4 (Drosophila) 0.027
Pard3 par-3 (partitioning defective 3) homolog (C. elegans) 0.027
Emx1 empty spiracles homolog 1 (Drosophila) 0.027
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.026
Eml3 echinoderm microtubule associated protein like 3 0.025
Ilk integrin linked kinase 0.025
Zeb1 zinc finger E-box binding homeobox 1 0.024
Bmpr1a bone morphogenetic protein receptor, type 1A 0.023
Slc4a2 solute carrier family 4 (anion exchanger), member 2 0.023
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.023
Rb1 retinoblastoma 1 0.023
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.021
Stxbp5 syntaxin binding protein 5 (tomosyn) 0.021
Prkce protein kinase C, epsilon 0.021
Ltbr lymphotoxin B receptor 0.021
Kif3a kinesin family member 3A 0.021
Pppde2 PPPDE peptidase domain containing 2 0.020
Itga6 integrin alpha 6 0.019
Nf1 neurofibromatosis 1 0.019
Vldlr very low density lipoprotein receptor 0.019
Rps3 ribosomal protein S3 0.018
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.018
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.017
Txndc17 thioredoxin domain containing 17 0.017
Fgfr1 fibroblast growth factor receptor 1 0.017
Capn1 calpain 1 0.016
Nostrin nitric oxide synthase trafficker 0.016
Rhog ras homolog gene family, member G 0.016
Klc1 kinesin light chain 1 0.016
Chmp2b chromatin modifying protein 2B 0.015
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.015
Rarg retinoic acid receptor, gamma 0.015
Vti1b vesicle transport through interaction with t-SNAREs 1B homolog 0.015
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.015
Axin1 axin 1 0.015
Atp6v1c1 ATPase, H+ transporting, lysosomal V1 subunit C1 0.014
Ldb3 LIM domain binding 3 0.014
Cdh1 cadherin 1 0.014
Crkl v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.014
Dok1 docking protein 1 0.014
Spag9 sperm associated antigen 9 0.013
Chmp5 chromatin modifying protein 5 0.013
Vamp7 vesicle-associated membrane protein 7 0.013
Cbln1 cerebellin 1 precursor protein 0.013
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.013
Clock circadian locomotor output cycles kaput 0.013
Tax1bp3 Tax1 (human T-cell leukemia virus type I) binding protein 3 0.013
Rock2 Rho-associated coiled-coil containing protein kinase 2 0.013
Cdh5 cadherin 5 0.013
Ptch1 patched homolog 1 0.013
Qk quaking 0.013
Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform 0.012
Chmp2a chromatin modifying protein 2A 0.012
Rrm2b ribonucleotide reductase M2 B (TP53 inducible) 0.012
Nsf N-ethylmaleimide sensitive fusion protein 0.012
Gja1 gap junction protein, alpha 1 0.012
Slc12a4 solute carrier family 12, member 4 0.012
Adrbk1 adrenergic receptor kinase, beta 1 0.012
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.011
Plxna1 plexin A1 0.011
Spint1 serine protease inhibitor, Kunitz type 1 0.011
Bcl2 B-cell leukemia/lymphoma 2 0.011
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.011
Mtmr6 myotubularin related protein 6 0.011
Vamp3 vesicle-associated membrane protein 3 0.011
Hspb1 heat shock protein 1 0.011
Lamc1 laminin, gamma 1 0.011
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.011
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.011
Fgfr2 fibroblast growth factor receptor 2 0.010
Itsn1 intersectin 1 (SH3 domain protein 1A) 0.010
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rpl10a ribosomal protein L10A 0.020
Rpl6 ribosomal protein L6 0.018
Rps26 ribosomal protein S26 0.018
Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.015
Rpl18 ribosomal protein L18 0.015
Gnb2l1 guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1 0.014
Cyc1 cytochrome c-1 0.013
Rpl34 ribosomal protein L34 0.013
Atp5h ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d 0.012
LOC688869 similar to cytochrome c oxidase, subunit VIb polypeptide 1 0.012
Cox5b cytochrome c oxidase subunit Vb 0.011
Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 0.011
Cox7c cytochrome c oxidase, subunit VIIc 0.011
Cox7a2 cytochrome c oxidase subunit VIIa polypeptide 2 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism