IMP
Process View
The network for 'transforming growth factor beta production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
transforming growth factor beta production
The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| SMAD3 | SMAD family member 3 | 0.999 | |
| SMAD1 | SMAD family member 1 | 0.992 | |
| TAL1 | T-cell acute lymphocytic leukemia 1 | 0.967 | |
| SMAD5 | SMAD family member 5 | 0.960 | |
| SMAD2 | SMAD family member 2 | 0.955 | |
| SMAD7 | SMAD family member 7 | 0.954 | |
| CCR5 | chemokine (C-C motif) receptor 5 | 0.949 | |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.934 | |
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.807 | |
| SMAD4 | SMAD family member 4 | 0.754 | |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.751 | |
| ATN1 | atrophin 1 | 0.620 | |
| FBLN5 | fibulin 5 | 0.591 | |
| ENG | endoglin | 0.503 | |
| DPP4 | dipeptidyl-peptidase 4 | 0.502 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.492 | |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.425 | |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.349 | |
| DSG2 | desmoglein 2 | 0.339 | |
| ARNT | aryl hydrocarbon receptor nuclear translocator | 0.282 | |
| CCL18 | chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) | 0.267 | |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.254 | |
| ELN | elastin | 0.242 | |
| LOXL1 | lysyl oxidase-like 1 | 0.233 | |
| RUNX1 | runt-related transcription factor 1 | 0.204 | |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.198 | |
| CD164 | CD164 molecule, sialomucin | 0.183 | |
| FSTL1 | follistatin-like 1 | 0.180 | |
| JUP | junction plakoglobin | 0.179 | |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.175 | |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.174 | |
| IDE | insulin-degrading enzyme | 0.171 | |
| CPD | carboxypeptidase D | 0.163 | |
| CCL3 | chemokine (C-C motif) ligand 3 | 0.148 | |
| SKIL | SKI-like oncogene | 0.148 | |
| DARC | Duffy blood group, chemokine receptor | 0.118 | |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | 0.115 | |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.111 | |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.109 | |
| AR | androgen receptor | 0.108 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.105 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.096 | |
| EGLN1 | egl nine homolog 1 (C. elegans) | 0.089 | |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.087 | |
| CXXC5 | CXXC finger protein 5 | 0.086 | |
| LOX | lysyl oxidase | 0.084 | |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.079 | |
| VCAM1 | vascular cell adhesion molecule 1 | 0.079 | |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.074 | |
| VHL | von Hippel-Lindau tumor suppressor | 0.068 | |
| COL6A2 | collagen, type VI, alpha 2 | 0.067 | |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.066 | |
| FBLN1 | fibulin 1 | 0.065 | |
| BGN | biglycan | 0.063 | |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.063 | |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.062 | |
| LAMB2 | laminin, beta 2 (laminin S) | 0.058 | |
| IL6 | interleukin 6 (interferon, beta 2) | 0.057 | |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.055 | |
| SMAD6 | SMAD family member 6 | 0.054 | |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.053 | |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.051 | |
| DMPK | dystrophia myotonica-protein kinase | 0.050 | |
| WWP2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.050 | |
| FBN1 | fibrillin 1 | 0.047 | |
| NNMT | nicotinamide N-methyltransferase | 0.047 | |
| TCF4 | transcription factor 4 | 0.046 | |
| GFI1B | growth factor independent 1B transcription repressor | 0.046 | |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.046 | |
| EGLN3 | egl nine homolog 3 (C. elegans) | 0.045 | |
| PRELP | proline/arginine-rich end leucine-rich repeat protein | 0.043 | |
| MMP12 | matrix metallopeptidase 12 (macrophage elastase) | 0.043 | |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.042 | |
| SELE | selectin E | 0.041 | |
| DSP | desmoplakin | 0.037 | |
| DAB2 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | 0.034 | |
| CBLB | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 0.034 | |
| IL8 | interleukin 8 | 0.034 | |
| IFNG | interferon, gamma | 0.032 | |
| PLSCR4 | phospholipid scramblase 4 | 0.032 | |
| GATA2 | GATA binding protein 2 | 0.032 | |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.032 | |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.031 | |
| SP1 | Sp1 transcription factor | 0.031 | |
| RGS1 | regulator of G-protein signaling 1 | 0.030 | |
| IL1B | interleukin 1, beta | 0.029 | |
| UHRF2 | ubiquitin-like with PHD and ring finger domains 2 | 0.028 | |
| FBLN2 | fibulin 2 | 0.028 | |
| HDAC9 | histone deacetylase 9 | 0.028 | |
| MMP2 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | 0.027 | |
| IKZF3 | IKAROS family zinc finger 3 (Aiolos) | 0.027 | |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.027 | |
| ITM2B | integral membrane protein 2B | 0.027 | |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.027 | |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.027 | |
| CCL7 | chemokine (C-C motif) ligand 7 | 0.026 | |
| IL10 | interleukin 10 | 0.026 | |
| ZFPM1 | zinc finger protein, multitype 1 | 0.026 | |
| RHOXF2 | Rhox homeobox family, member 2 | 0.026 | |
| ECM1 | extracellular matrix protein 1 | 0.025 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Fos | FBJ osteosarcoma oncogene | 0.074 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.055 | |
| Fgf8 | fibroblast growth factor 8 | 0.047 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.034 | |
| Gata4 | GATA binding protein 4 | 0.033 | |
| Stat3 | signal transducer and activator of transcription 3 | 0.025 | |
| Wnt4 | wingless-related MMTV integration site 4 | 0.022 | |
| Smad1 | MAD homolog 1 (Drosophila) | 0.018 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.016 | |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.014 | |
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.013 | |
| Il6st | interleukin 6 signal transducer | 0.013 | |
| Il2 | interleukin 2 | 0.012 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.012 | |
| Apc | adenomatosis polyposis coli | 0.011 | |
| Atf3 | activating transcription factor 3 | 0.010 | |
| Foxp1 | forkhead box P1 | 0.010 |