The network for 'positive regulation of natural killer cell mediated immunity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of natural killer cell mediated immunity

Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.

Mus musculus
Name Description Probability Func Analog Organism
Klrk1 killer cell lectin-like receptor subfamily K, member 1 1.000
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.997
Slamf1 signaling lymphocytic activation molecule family member 1 0.985
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.985
Fasl Fas ligand (TNF superfamily, member 6) 0.959
Gzmk granzyme K 0.955
Stat5b signal transducer and activator of transcription 5B 0.932
H2-D1 histocompatibility 2, D region locus 1 0.893
Stat5a signal transducer and activator of transcription 5A 0.866
Xcl1 chemokine (C motif) ligand 1 0.866
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.864
Irf9 interferon regulatory factor 9 0.859
Gzma granzyme A 0.837
Ncr1 natural cytotoxicity triggering receptor 1 0.799
Tapbp TAP binding protein 0.768
Stat1 signal transducer and activator of transcription 1 0.716
Gzmb granzyme B 0.703
Il18r1 interleukin 18 receptor 1 0.666
H2-K1 histocompatibility 2, K1, K region 0.630
Stat3 signal transducer and activator of transcription 3 0.611
Cd7 CD7 antigen 0.581
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.520
Il2rb interleukin 2 receptor, beta chain 0.514
Klrb1a killer cell lectin-like receptor subfamily B member 1A 0.409
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.377
Il6 interleukin 6 0.349
Klra3 killer cell lectin-like receptor, subfamily A, member 3 0.336
Cd244 CD244 natural killer cell receptor 2B4 0.325
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.289
Trim21 tripartite motif-containing 21 0.272
Ctsw cathepsin W 0.270
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.249
Spna1 spectrin alpha 1 0.233
Cd180 CD180 antigen 0.207
Il10 interleukin 10 0.205
B2m beta-2 microglobulin 0.185
Il18rap interleukin 18 receptor accessory protein 0.174
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.163
Usp18 ubiquitin specific peptidase 18 0.157
Itk IL2-inducible T-cell kinase 0.149
Cxcl9 chemokine (C-X-C motif) ligand 9 0.149
Gzmc granzyme C 0.142
Ccr3 chemokine (C-C motif) receptor 3 0.141
Cd84 CD84 antigen 0.134
Cd96 CD96 antigen 0.134
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.132
Itgax integrin alpha X 0.129
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.128
Sh2d1b1 SH2 domain protein 1B1 0.128
Il2ra interleukin 2 receptor, alpha chain 0.124
H2-Q7 histocompatibility 2, Q region locus 7 0.121
Parp10 poly (ADP-ribose) polymerase family, member 10 0.120
Klra8 killer cell lectin-like receptor, subfamily A, member 8 0.119
Icos inducible T-cell co-stimulator 0.114
Klre1 killer cell lectin-like receptor family E member 1 0.114
Sh2d1a SH2 domain protein 1A 0.110
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.106
Trem3 triggering receptor expressed on myeloid cells 3 0.102
Ctsb cathepsin B 0.101
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.097
Bex6 brain expressed gene 6 0.095
Lgals9 lectin, galactose binding, soluble 9 0.094
Prf1 perforin 1 (pore forming protein) 0.091
Cd160 CD160 antigen 0.089
Slamf7 SLAM family member 7 0.084
H2-Eb1 histocompatibility 2, class II antigen E beta 0.082
Nkg7 natural killer cell group 7 sequence 0.080
Cd28 CD28 antigen 0.078
Ifng interferon gamma 0.076
Lepr leptin receptor 0.072
Nckap1l NCK associated protein 1 like 0.070
Plbd2 phospholipase B domain containing 2 0.069
Sh2d2a SH2 domain protein 2A 0.067
Camk4 calcium/calmodulin-dependent protein kinase IV 0.066
Parp14 poly (ADP-ribose) polymerase family, member 14 0.064
Igk immunoglobulin kappa chain complex 0.064
Lair1 leukocyte-associated Ig-like receptor 1 0.058
Irgm2 immunity-related GTPase family M member 2 0.057
Ccr9 chemokine (C-C motif) receptor 9 0.056
Lcn4 lipocalin 4 0.051
Xcr1 chemokine (C motif) receptor 1 0.051
Irgm1 immunity-related GTPase family M member 1 0.051
Cxcr3 chemokine (C-X-C motif) receptor 3 0.051
Stat2 signal transducer and activator of transcription 2 0.050
Gbp2 guanylate binding protein 2 0.048
Clec2i C-type lectin domain family 2, member i 0.047
Il4ra interleukin 4 receptor, alpha 0.047
Cd14 CD14 antigen 0.047
Ccl3 chemokine (C-C motif) ligand 3 0.045
Slc11a2 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 0.043
Txk TXK tyrosine kinase 0.042
Cp ceruloplasmin 0.039
Gbp7 guanylate binding protein 7 0.038
Ctsd cathepsin D 0.038
Aoah acyloxyacyl hydrolase 0.038
H2-Q5 histocompatibility 2, Q region locus 5 0.036
Tor3a torsin family 3, member A 0.036
Gm2a GM2 ganglioside activator protein 0.035
Lgals8 lectin, galactose binding, soluble 8 0.035
Ccl5 chemokine (C-C motif) ligand 5 0.034
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ptk6a PTK6 protein tyrosine kinase 6a 0.034
defbl3 defensin, beta-like 3 0.026
itln1 intelectin 1 0.023
zgc:101598 zgc:101598 0.022
mst1rb macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b 0.018
tlr22 toll-like receptor 22 0.018
nitr8 novel immune-type receptor 8 0.016
fcho2 FCH domain only 2 0.015
dmrt1 doublesex and mab-3 related transcription factor 1 0.014
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.013
nitr5 novel immune-type receptor 5 and immune-type receptor 5-like 0.012
itln3 intelectin 3 0.012
illr3 immune-related, lectin-like receptor 3 0.012
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-A major histocompatibility complex, class I, A 1.000
HLA-C major histocompatibility complex, class I, C 1.000
B2M beta-2-microglobulin 1.000
HLA-B major histocompatibility complex, class I, B 1.000
HLA-G major histocompatibility complex, class I, G 1.000
HLA-E major histocompatibility complex, class I, E 1.000
HLA-F major histocompatibility complex, class I, F 1.000
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.990
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.810
CD84 CD84 molecule 0.750
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.748
IL2RB interleukin 2 receptor, beta 0.743
TPP1 tripeptidyl peptidase I 0.567
SLAMF1 signaling lymphocytic activation molecule family member 1 0.516
IL23A interleukin 23, alpha subunit p19 0.420
TAPBP TAP binding protein (tapasin) 0.348
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.335
ITM2B integral membrane protein 2B 0.279
SH2D1A SH2 domain containing 1A 0.269
PVRL4 poliovirus receptor-related 4 0.239
SH2D1B SH2 domain containing 1B 0.200
INSR insulin receptor 0.181
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.175
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.172
GBA glucosidase, beta, acid 0.169
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.121
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.104
PVRL3 poliovirus receptor-related 3 0.090
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.079
PSAP prosaposin 0.077
GZMK granzyme K (granzyme 3; tryptase II) 0.072
CTSA cathepsin A 0.069
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.067
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.055
TJP1 tight junction protein 1 (zona occludens 1) 0.055
CCL5 chemokine (C-C motif) ligand 5 0.053
BTN3A1 butyrophilin, subfamily 3, member A1 0.048
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.047
IFITM3 interferon induced transmembrane protein 3 (1-8U) 0.043
IFNG interferon, gamma 0.039
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.039
BTN3A2 butyrophilin, subfamily 3, member A2 0.034
CLEC4A C-type lectin domain family 4, member A 0.032
GRN granulin 0.031
ITK IL2-inducible T-cell kinase 0.030
STAP2 signal transducing adaptor family member 2 0.028
BTN3A3 butyrophilin, subfamily 3, member A3 0.026
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.025
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.025
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.025
BCR breakpoint cluster region 0.025
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.023
ISG20 interferon stimulated exonuclease gene 20kDa 0.021
NCSTN nicastrin 0.021
CD226 CD226 molecule 0.021
HCST hematopoietic cell signal transducer 0.020
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.020
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.020
IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) 0.020
KLRF1 killer cell lectin-like receptor subfamily F, member 1 0.019
CCR5 chemokine (C-C motif) receptor 5 0.018
CD3D CD3d molecule, delta (CD3-TCR complex) 0.018
HCP5 HLA complex P5 0.017
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.016
IL18RAP interleukin 18 receptor accessory protein 0.016
SYNRG synergin, gamma 0.016
PRF1 perforin 1 (pore forming protein) 0.015
KLRB1 killer cell lectin-like receptor subfamily B, member 1 0.014
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.014
GRB10 growth factor receptor-bound protein 10 0.014
CD2 CD2 molecule 0.014
GPR171 G protein-coupled receptor 171 0.014
HFE hemochromatosis 0.013
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.013
CTSS cathepsin S 0.013
GHR growth hormone receptor 0.013
CD80 CD80 molecule 0.013
IRF1 interferon regulatory factor 1 0.013
HLA-DRA major histocompatibility complex, class II, DR alpha 0.013
FYB FYN binding protein 0.012
FASLG Fas ligand (TNF superfamily, member 6) 0.012
PYHIN1 pyrin and HIN domain family, member 1 0.012
SKAP1 src kinase associated phosphoprotein 1 0.011
CD160 CD160 molecule 0.011
TXK TXK tyrosine kinase 0.011
IRS1 insulin receptor substrate 1 0.011
EPHB3 EPH receptor B3 0.011
CD96 CD96 molecule 0.011
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.011
CD244 CD244 molecule, natural killer cell receptor 2B4 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd247 Cd247 molecule 0.131
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.058
Cd2 Cd2 molecule 0.052
Cd5 Cd5 molecule 0.045
Mcpt8 mast cell protease 8 0.039
Gzmk granzyme K 0.039
Nkg7 natural killer cell group 7 sequence 0.031
Cd3g CD3 molecule, gamma 0.030
Gimap4 GTPase, IMAP family member 4 0.029
Gzmb granzyme B 0.020
Dcaf7 DDB1 and CUL4 associated factor 7 0.019
Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein 0.019
Il2rb interleukin 2 receptor, beta 0.018
Prf1 perforin 1 (pore forming protein) 0.017
Sh2d1a SH2 domain protein 1A 0.017
Apol3 apolipoprotein L, 3 0.016
Gimap5 GTPase, IMAP family member 5 0.014
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.013
Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a 0.013
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.013
Cd8a CD8a molecule 0.013
Itgb7 integrin, beta 7 0.012
LOC100361706 lambda-chain C1-region-like 0.012
Spn sialophorin 0.011
Zap70 zeta-chain (TCR) associated protein kinase 0.011
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.011
Txnrd1 thioredoxin reductase 1 0.011
Rhoh ras homolog gene family, member H 0.010
Sox7 SRY (sex determining region Y)-box 7 0.010
Dusp2 dual specificity phosphatase 2 0.010
LOC100363783 rCG53773-like 0.010
Gimap1 GTPase, IMAP family member 1 0.010
Ccr6 chemokine (C-C motif) receptor 6 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism