The network for 'mesenchymal cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesenchymal cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pax3 paired box gene 3 1.000
Fgfr2 fibroblast growth factor receptor 2 0.999
Tbx3 T-box 3 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Bmp4 bone morphogenetic protein 4 0.998
Gli2 GLI-Kruppel family member GLI2 0.997
Nodal nodal 0.997
Pitx1 paired-like homeodomain transcription factor 1 0.989
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.986
Otx2 orthodenticle homolog 2 (Drosophila) 0.982
Meox2 mesenchyme homeobox 2 0.979
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.972
Gsc goosecoid homeobox 0.959
Fgf10 fibroblast growth factor 10 0.954
Tgfb2 transforming growth factor, beta 2 0.949
Prrx2 paired related homeobox 2 0.949
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.946
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.939
Fgf8 fibroblast growth factor 8 0.934
Prrx1 paired related homeobox 1 0.929
Alx4 aristaless-like homeobox 4 0.913
Bmp7 bone morphogenetic protein 7 0.904
Pax2 paired box gene 2 0.899
Pitx2 paired-like homeodomain transcription factor 2 0.887
Fgfr1 fibroblast growth factor receptor 1 0.873
Smad6 MAD homolog 6 (Drosophila) 0.870
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.855
Wnt3a wingless-related MMTV integration site 3A 0.834
Pten phosphatase and tensin homolog 0.833
Chrd chordin 0.827
Twist2 twist homolog 2 (Drosophila) 0.813
Tgfbr2 transforming growth factor, beta receptor II 0.812
Sox2 SRY-box containing gene 2 0.804
Msx1 homeobox, msh-like 1 0.790
Foxc1 forkhead box C1 0.788
Foxc2 forkhead box C2 0.785
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.783
Acvr1 activin A receptor, type 1 0.777
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.776
Zeb1 zinc finger E-box binding homeobox 1 0.773
Sox9 SRY-box containing gene 9 0.734
Hoxa1 homeobox A1 0.727
Nos3 nitric oxide synthase 3, endothelial cell 0.721
Twist1 twist homolog 1 (Drosophila) 0.698
Ptch1 patched homolog 1 0.693
Trp53 transformation related protein 53 0.692
Sox7 SRY-box containing gene 7 0.692
Tbx2 T-box 2 0.664
Apc adenomatosis polyposis coli 0.658
Smad4 MAD homolog 4 (Drosophila) 0.634
Kdr kinase insert domain protein receptor 0.605
Fgfr3 fibroblast growth factor receptor 3 0.601
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.590
Gbx2 gastrulation brain homeobox 2 0.588
Lhx1 LIM homeobox protein 1 0.578
Hoxd13 homeobox D13 0.573
Zic3 zinc finger protein of the cerebellum 3 0.571
Emx2 empty spiracles homolog 2 (Drosophila) 0.570
Tbx1 T-box 1 0.562
Vegfa vascular endothelial growth factor A 0.558
Flt4 FMS-like tyrosine kinase 4 0.547
Foxf1a forkhead box F1a 0.535
Vangl2 vang-like 2 (van gogh, Drosophila) 0.529
Gdf5 growth differentiation factor 5 0.525
Lrp6 low density lipoprotein receptor-related protein 6 0.507
Lhx3 LIM homeobox protein 3 0.493
Dlx5 distal-less homeobox 5 0.491
Lef1 lymphoid enhancer binding factor 1 0.484
Gata4 GATA binding protein 4 0.477
Pax6 paired box gene 6 0.474
Ret ret proto-oncogene 0.448
Npr3 natriuretic peptide receptor 3 0.444
Hoxa11 homeobox A11 0.433
Tbx15 T-box 15 0.425
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.417
En1 engrailed 1 0.415
Neurog2 neurogenin 2 0.414
Hoxa13 homeobox A13 0.407
Ptprb protein tyrosine phosphatase, receptor type, B 0.393
Nog noggin 0.391
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.388
Kiss1 KiSS-1 metastasis-suppressor 0.385
Wnt5a wingless-related MMTV integration site 5A 0.366
Pou3f3 POU domain, class 3, transcription factor 3 0.364
Ctnnb1 catenin (cadherin associated protein), beta 1 0.358
Smad3 MAD homolog 3 (Drosophila) 0.346
Hes1 hairy and enhancer of split 1 (Drosophila) 0.340
Pax9 paired box gene 9 0.335
Alx1 ALX homeobox 1 0.335
Gas1 growth arrest specific 1 0.320
Snai1 snail homolog 1 (Drosophila) 0.316
Fgf18 fibroblast growth factor 18 0.316
Hoxd11 homeobox D11 0.316
Eya1 eyes absent 1 homolog (Drosophila) 0.314
Fzd8 frizzled homolog 8 (Drosophila) 0.311
Wnt4 wingless-related MMTV integration site 4 0.310
Gdnf glial cell line derived neurotrophic factor 0.302
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.292
She src homology 2 domain-containing transforming protein E 0.289
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dlx5a distal-less homeobox gene 5a 0.915
bmp2a bone morphogenetic protein 2a 0.815
nkx3.2 NK3 homeobox 2 0.735
bmp4 bone morphogenetic protein 4 0.733
foxi1 forkhead box I1 0.661
tbx1 T-box 1 0.652
bmp7b bone morphogenetic protein 7b 0.613
boc brother of CDO 0.603
sulf1 sulfatase 1 0.595
chd chordin 0.588
bmp2b bone morphogenetic protein 2b 0.559
shha sonic hedgehog a 0.539
rarga retinoic acid receptor gamma a 0.530
fgf10a fibroblast growth factor 10a 0.514
twist3 twist3 0.513
edn1 endothelin 1 0.512
col2a1a collagen type II, alpha-1a 0.511
fgfrl1a fibroblast growth factor receptor-like 1a 0.487
nkx2.3 NK2 transcription factor related 3 0.456
runx2b runt-related transcription factor 2b 0.443
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.438
sparc secreted acidic cysteine rich glycoprotein 0.432
dlx3b distal-less homeobox gene 3b 0.425
foxa1 forkhead box A1 0.420
satb2 SATB homeobox 2 0.397
lhx2b LIM homeobox 2b 0.397
cdon cell adhesion molecule-related/down-regulated by oncogenes 0.377
grem2 gremlin 2, cysteine knot superfamily 0.369
prrx1a paired related homeobox 1a 0.353
ptch1 patched 1 0.351
fgf3 fibroblast growth factor 3 0.339
hoxd4a homeo box D4a 0.336
wnt9a wingless-type MMTV integration site family, member 9A 0.319
dlx2a distal-less homeobox gene 2a 0.316
nkx2.1a NK2 homeobox 1a 0.304
fzd7a frizzled homolog 7a 0.291
fn1 fibronectin 1 0.286
myod1 myogenic differentiation 1 0.280
mab21l2 mab-21-like 2 0.271
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.268
wnt9b wingless-type MMTV integration site family, member 9B 0.260
cdh1 cadherin 1, epithelial 0.244
pcdh18b protocadherin 18b 0.240
acvr1l activin A receptor, type I like 0.232
barx1 BarH-like homeobox 1 0.228
fli1a friend leukemia integration 1a 0.221
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.214
fgfr4 fibroblast growth factor receptor 4 0.213
six4b sine oculis homeobox homolog 4b 0.211
osr2 odd-skipped related 2 (Drosophila) 0.209
nkx2.5 NK2 transcription factor related 5 0.205
ihha Indian hedgehog homolog a 0.196
tbx5a T-box 5a 0.190
jag1b jagged 1b 0.186
gli1 GLI-Kruppel family member 1 0.186
gsc goosecoid 0.182
fgfrl1b fibroblast growth factor receptor-like 1b 0.178
dlx6a distal-less homeobox gene 6a 0.169
notch2 notch homolog 2 0.166
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.166
slit3 slit (Drosophila) homolog 3 0.164
ndr2 nodal-related 2 0.157
wif1 wnt inhibitory factor 1 0.155
col8a1a collagen, type VIII, alpha 1a 0.150
acvr2b activin receptor IIb 0.147
npnt nephronectin 0.141
tgfb2 transforming growth factor, beta 2 0.140
wnt5b wingless-type MMTV integration site family, member 5b 0.139
sema3aa semaphorin 3aa 0.138
tp53bp2 tumor protein p53 binding protein, 2 0.137
oprd1b opioid receptor, delta 1b 0.136
lamb1a laminin, beta 1a 0.134
tbx2a T-box gene 2a 0.133
ptgs1 prostaglandin-endoperoxide synthase 1 0.132
hand2 heart and neural crest derivatives expressed transcript 2 0.129
pmp22a peripheral myelin protein 22a 0.127
irx5a iroquois homeobox protein 5a 0.120
gli3 GLI-Kruppel family member GLI3 0.120
pdlim7 PDZ and LIM domain 7 0.116
bmp3 bone morphogenetic protein 3 0.114
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.111
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.109
cdx1b caudal type homeobox 1 b 0.108
dlx4a distal-less homeobox gene 4a 0.106
tbx15 T-box 15 0.106
pax9 paired box gene 9 0.104
wls wntless homolog (Drosophila) 0.104
fras1 Fraser syndrome 1 0.098
dcc deleted in colorectal carcinoma 0.097
emp2 epithelial membrane protein 2 0.096
hoxa13b homeo box A13b 0.095
eya1 eyes absent homolog 1 0.094
lama5 laminin, alpha 5 0.094
spry1 sprouty homolog 1 (Drosophila) 0.094
foxa2 forkhead box A2 0.093
hoxc4a homeo box C4a 0.092
pitx3 paired-like homeodomain transcription factor 3 0.091
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.090
pcdh8 protocadherin 8 0.088
sept7b septin 7b 0.088
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.999
FGF1 fibroblast growth factor 1 (acidic) 0.733
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.647
NRP1 neuropilin 1 0.512
BMPR1A bone morphogenetic protein receptor, type IA 0.463
INSR insulin receptor 0.328
BMP2 bone morphogenetic protein 2 0.214
FGF10 fibroblast growth factor 10 0.179
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.113
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.110
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.109
GRB10 growth factor receptor-bound protein 10 0.096
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.068
PLCG1 phospholipase C, gamma 1 0.064
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.061
JUP junction plakoglobin 0.061
PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.051
FSTL1 follistatin-like 1 0.048
APP amyloid beta (A4) precursor protein 0.037
NOG noggin 0.034
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.033
FGFR1 fibroblast growth factor receptor 1 0.031
FGF7 fibroblast growth factor 7 0.031
BMP1 bone morphogenetic protein 1 0.024
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.021
MAX MYC associated factor X 0.021
CABLES1 Cdk5 and Abl enzyme substrate 1 0.020
CDH5 cadherin 5, type 2 (vascular endothelium) 0.018
PDGFC platelet derived growth factor C 0.018
SIRT1 sirtuin 1 0.017
SMAD3 SMAD family member 3 0.016
IGF1R insulin-like growth factor 1 receptor 0.016
ZFYVE9 zinc finger, FYVE domain containing 9 0.016
IRS2 insulin receptor substrate 2 0.015
HOXD9 homeobox D9 0.014
SMAD7 SMAD family member 7 0.013
EGFR epidermal growth factor receptor 0.012
FZD1 frizzled homolog 1 (Drosophila) 0.012
FGF8 fibroblast growth factor 8 (androgen-induced) 0.012
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.011
LRP6 low density lipoprotein receptor-related protein 6 0.011
CAPRIN2 caprin family member 2 0.011
TGFB1 transforming growth factor, beta 1 0.011
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.010
FGF2 fibroblast growth factor 2 (basic) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.544
Unc5b unc-5 homolog B (C. elegans) 0.474
Socs3 suppressor of cytokine signaling 3 0.409
Timp3 TIMP metallopeptidase inhibitor 3 0.406
Myh9 myosin, heavy chain 9, non-muscle 0.383
Olfml2b olfactomedin-like 2B 0.278
Myo1c myosin IC 0.259
Notch2 Notch homolog 2 (Drosophila) 0.247
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.239
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.215
LOC100365106 rCG32755-like 0.214
Tgfbr2 transforming growth factor, beta receptor II 0.213
Rnf213 ring finger protein 213 0.196
F13a1 coagulation factor XIII, A1 polypeptide 0.183
Ednra endothelin receptor type A 0.153
Igfbp5 insulin-like growth factor binding protein 5 0.147
Ptma prothymosin alpha 0.147
Irs1 insulin receptor substrate 1 0.141
Glg1 golgi apparatus protein 1 0.141
Acvr1 activin A receptor, type I 0.136
Prrx1 paired related homeobox 1 0.134
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.132
Myf6 myogenic factor 6 0.129
LOC100360403 ATP-binding cassette, sub-family C, member 9-like 0.129
LOC100362108 poly (ADP-ribose) polymerase family, member 10 0.121
Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.120
Stx2 syntaxin 2 0.119
Anpep alanyl (membrane) aminopeptidase 0.117
Rxra retinoid X receptor alpha 0.116
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.104
Dchs1 dachsous 1 (Drosophila) 0.102
Sirpa signal-regulatory protein alpha 0.101
Pik3r1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.100
Clic4 chloride intracellular channel 4 0.100
Msn moesin 0.099
Smad1 SMAD family member 1 0.097
Tgfb2 transforming growth factor, beta 2 0.096
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.095
Efnb1 ephrin B1 0.091
Capn5 calpain 5 0.091
Calcrl calcitonin receptor-like 0.090
Col12a1 collagen, type XII, alpha 1 0.090
Myo1d myosin ID 0.088
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.081
Pcna proliferating cell nuclear antigen 0.079
LOC100360986 mCG1035404-like 0.077
Nfya nuclear transcription factor-Y alpha 0.076
Thbd thrombomodulin 0.075
Smad3 SMAD family member 3 0.074
Arnt aryl hydrocarbon receptor nuclear translocator 0.073
Utrn utrophin 0.073
Hnrnpk heterogeneous nuclear ribonucleoprotein K 0.071
Flt1 FMS-related tyrosine kinase 1 0.071
Scarf2 scavenger receptor class F, member 2 0.071
Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.070
Sod3 superoxide dismutase 3, extracellular 0.067
Hdac7 histone deacetylase 7 0.066
Cdon Cdon homolog (mouse) 0.065
Ubtf upstream binding transcription factor, RNA polymerase I 0.064
A2m alpha-2-macroglobulin 0.064
Nab1 Ngfi-A binding protein 1 0.060
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.060
Gper G protein-coupled estrogen receptor 1 0.059
Lamc1 laminin, gamma 1 0.058
Stat6 signal transducer and activator of transcription 6 0.058
Insr insulin receptor 0.058
Maf v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 0.056
Smad7 SMAD family member 7 0.055
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.055
Pik3r3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.053
Ptbp1 polypyrimidine tract binding protein 1 0.053
LOC64038 sertolin 0.053
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.052
Srebf1 sterol regulatory element binding transcription factor 1 0.052
Il6st interleukin 6 signal transducer 0.051
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.049
Itga6 integrin, alpha 6 0.049
Map3k3 mitogen activated protein kinase kinase kinase 3 0.049
Antxr1 anthrax toxin receptor 1 0.048
Ptprd protein tyrosine phosphatase, receptor type, D 0.047
Slc20a2 solute carrier family 20 (phosphate transporter), member 2 0.047
Sept8 septin 8 0.047
Rab3il1 RAB3A interacting protein (rabin3)-like 1 0.047
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.047
Ssb Sjogren syndrome antigen B 0.046
Abcc1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 0.046
Stat1 signal transducer and activator of transcription 1 0.045
LOC100362331 rCG59612-like 0.045
Wnt5a wingless-type MMTV integration site family, member 5A 0.045
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.045
Dhx9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.045
Nkd1 naked cuticle homolog 1 (Drosophila) 0.044
Met met proto-oncogene 0.042
Gdf11 growth differentiation factor 11 0.042
Nras neuroblastoma ras oncogene 0.042
Ece1 endothelin converting enzyme 1 0.041
Figf c-fos induced growth factor 0.041
Cpxm2 carboxypeptidase X (M14 family), member 2 0.040
Tcfe2a transcription factor E2a 0.040
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.039
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism